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Natural skin care uses topical creams and lotions made of ingredients available in nature. Much of the recent literature reviews plant-derived ingredients, which may include herbs,
root In vascular plants, the roots are the organs of a plant that are modified to provide anchorage for the plant and take in water and nutrients into the plant body, which allows plants to grow taller and faster. They are most often below the su ...
s,
flower A flower, sometimes known as a bloom or blossom, is the reproductive structure found in flowering plants (plants of the division Angiospermae). The biological function of a flower is to facilitate reproduction, usually by providing a mechani ...
s and essential oils, but natural substances in skin care products include animal-derived products such as
beeswax Beeswax (''cera alba'') is a natural wax produced by honey bees of the genus ''Apis''. The wax is formed into scales by eight wax-producing glands in the abdominal segments of worker bees, which discard it in or at the hive. The hive work ...
, and minerals. These substances may be combined with various carrier agents,
preservative A preservative is a substance or a chemical that is added to products such as food products, beverages, pharmaceutical drugs, paints, biological samples, cosmetics, wood, and many other products to prevent decomposition by microbial growth or by ...
s, surfactants, humectants and emulsifiers. There are no legal definitions in the U.S. for advertising terms "natural" or "organic" when applied to personal care products. Consumers often express a preference for skin products with organic and natural ingredients. The personal skin care market based on natural products has shown strong growth. Clinical and laboratory studies have identified activities in many natural ingredients that have potential beneficial activities for personal skin care, but there is a shortage of convincing evidence for natural product efficacy in medical problems. Some natural products and therapies may be harmful, either to the skin or systemically. People prone to allergies should pay careful attention to what they use on their skin. Dermatologists may feel that there is enough scientific evidence to assist in the selection or avoidance of particular natural ingredients.


Background

Many countries require that the ingredient composition of skin care products is listed on the product, using the
International Nomenclature of Cosmetic Ingredients The International Nomenclature of Cosmetic Ingredients, abbreviated INCI, are the unique identifiers for cosmetic ingredients such as waxes, oils, pigments, and other chemicals that are assigned in accordance with rules established by the Personal ...
(INCI) conventions. Ingredients are listed in the order of their percentage within the product; natural ingredients are listed in Latin and synthetic ingredients are listed by technical name. "The U.S. government has documented more than 10,500 ingredients in cosmetic products, but only a small percentage of those chemicals have been tested for safety. Of those that have been tested, some have been identified as carcinogens (causes cancer), teratogens (causes birth defects), and reproductive toxicants (damages the ability to reproduce)." The FDA surveyed 1,687 consumers ages 14 and older in 1994 about their use of cosmetics. Nearly half of these consumers felt that a product claiming to be "natural" should contain all natural ingredients. However, although the United States Department of Agriculture (USDA) has designated within its certain requirements within its specific area of regulation for organic products, the U.S.
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
(FDA) does not recognize a definition for natural products. Accordingly, there are no legal definitions in the U.S. for the advertising terms "natural" or "organic" in personal care products. The FDA prohibits certain ingredients in cosmetics. Some organic products which are designated organic may be intensely modified, sometimes considerably more so than conventional products.


History

Plant extracts and herbs have been used by many cultures as cosmetics and perfumes since ancient times.Lucas A
''Cosmetics, Perfumes and Incense in Ancient Egypt''.
The Journal of Egyptian Archaeology. May, 1930; Vol. 16, No. 1/2, pp. 41–53. Published by: Egypt Exploration Society. Stable URL:
Research is scientifically assessing natural products, selected based on experience in the ancient era. Validated use of these materials and products awaits further assessment.


Cosmetics


Consumer preference

Consumers often express a preference for skin products with organic and natural ingredients. The skin care market based on natural products has shown strong growth. Clinical and laboratory studies have identified activities in many natural ingredients that have potential beneficial activities for the skin. Dermatologists may feel that there is enough scientific evidence to assist in the selection of particular natural ingredients. Consumers expected products to perform as advertised.


Industry response

Voluntary discontinuation of precursor substances that release small quantities of formaldehyde, which is a carcinogen, as well as reducing levels of the potentially carcinogenic impurity 1,4-dioxane. Polycyclic musk fragrance ingredients, which have raised concerns as persistent and bioaccumulative endocrine disruptors, are being discontinued.


Alternative medicine

There are significant reservations about complementary and alternative medicine (CAM) including a "shortage of evidence supporting the efficacy and safety of CAM" for skin problems. However, patients express a desire to utilize natural ingredients as treatment. A literature search found a growing prevalence of CAM use for skin conditions. A number of textbooks address CAM perspectives of skin care. The purpose of this section is to review botanical compounds in skin care; a broader review the history and theory behind other CAM modalities such as psychocutaneous therapies, acupuncture and homeopathy can be found in recent reviews.


Western

The plant monographs with dermatological relevance of the former German Commission E have recently been reviewed. According to Baumann, "Botanical compounds for which dermatologic and cosmetic applications have emerged include: olive oil, chamomile, colloidal oatmeal, oat kernel extract, feverfew, acai berry,
coffee berry Coffee berry may refer to: * Coffee cherry, the fruit of coffee plants * ''Frangula californica'', or California coffeeberry, a plant in the buckthorn family, native to western North America * ''Frangula rubra'', or Sierra coffeeberry, another pl ...
,
curcumin Curcumin is a bright yellow chemical produced by plants of the ''Curcuma longa'' species. It is the principal curcuminoid of turmeric (''Curcuma longa''), a member of the ginger family, Zingiberaceae. It is sold as a herbal supplement, cosmet ...
, green tea, pomegranate,
licorice Liquorice (British English) or licorice (American English) ( ; also ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring can be extracted. The liq ...
,
paper mulberry The paper mulberry (''Broussonetia papyrifera'', syn. ''Morus papyrifera'' L.) is a species of flowering plant in the family Moraceae. It is native to Asia,arbutin Arbutin is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus ''Arctostaphylos'' among many other medicinal plants, primarily in the family Ericaceae. Applied topically, it inhibits tyrosinase and thus prev ...
, and soy. "Many of these botanical sources offer biologically active components that require further in vitro and in vivo investigation". A review of 35 plant
families Family (from la, familia) is a group of people related either by consanguinity (by recognized birth) or affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its members and of society. Ideal ...
found that a "variety of phytomolecules, derived in particular from polyphenols, triterpenes and sterols classes, demonstrated a promising activity." Colloidal oatmeal may be beneficial in psoriasis. Aloe vera may help in atopic dermatitis. In both these conditions, the benefit may arise from anti-inflammatory properties. "For combating acne and rosacea, green tea, niacinamide and feverfew are considered efficacious. For
hyperpigmentation Hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin. Causes Hyperpigmentation can be caused by sun damage, inflammation, or other skin injuries, including those related to acne vulgaris.James, William; Ber ...
and antioxidative capabilities, licorice, green tea, arbutin, soy, acai berry, turmeric and pomegranate are among those plants and compounds found to be most beneficial. Additional research is needed to determine to confirm and elucidate the benefits of these ingredients in the prevention and management of skin disease." An assessment of clinical trials on green tea preparations and their uses in dermatology found some evidence for potential benefits.


Ayurveda

Ayurvedic skincare is derived from medicinal practices that began over 5,000-years ago in India. Ayurvedic medicine and healing practices are based on Indian philosophical, psychological, conventional, and medicinal understandings. Most of the ayurvedic skincare products contain the following herbs—aloe vera, almond, avocado, carrot, castor, clay, cocoa, coconut oil, cornmeal, cucumber, cutch tree, emu oil, ginkgo biloba, ginseng, grape seed oil, ground almond and walnut shell, horse chestnut, witch hazel, and honey. Ayurvedic approaches have been used in
molluscum contagiosum Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results in small raised pink lesions with a dimple in the center. They may become itchy or sore, and occur singularly or in groups. Any area of the sk ...
, lymphatic filariasis,
vitiligo Vitiligo is a disorder that causes the skin to lose its color. Specific causes are unknown but studies suggest a link to immune system changes. Signs and symptoms The only sign of vitiligo is the presence of pale patchy areas of depigmen ...
and
lichen planus Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, fla ...
. ''
Phyllanthus emblica ''Phyllanthus emblica'', also known as emblic, emblic myrobalan, myrobalan, Indian gooseberry, Malacca tree, or amla, from the Sanskrit आमलकी (āmalakī), is a deciduous tree of the family Phyllanthaceae. Its native range is tropical a ...
'' (amla, Indian gooseberry) has been used in ayurvedic medicine. Standardized extracts of Phyllanthus emblica have a long-lasting and broad-spectrum antioxidant activity. This may be suitable for use in Anti-aging cream, sunscreen and general purpose skin care products.


Traditional Chinese medicine


Substances

Natural skin care ingredients include
jojoba Jojoba (; botanical name: ''Simmondsia chinensis'')also commonly called goat nut, deer nut, pignut, wild hazel, quinine nut, coffeeberry, and gray box bushis native to the Southwestern United States. ''Simmondsia chinensis'' is the sole specie ...
,
safflower oil Safflower (''Carthamus tinctorius'') is a highly branched, herbaceous, thistle-like annual plant in the family Asteraceae. It is commercially cultivated for vegetable oil extracted from the seeds and was used by the early Spanish colonies along ...
, rose hip seed oil, shea butter,
beeswax Beeswax (''cera alba'') is a natural wax produced by honey bees of the genus ''Apis''. The wax is formed into scales by eight wax-producing glands in the abdominal segments of worker bees, which discard it in or at the hive. The hive work ...
,
witch hazel Witch-hazels or witch hazels (''Hamamelis'') are a genus of flowering plants in the family Hamamelidaceae, with three species in North America ('' H. ovalis'', '' H. virginiana'', and '' H. vernalis''), and one each in Japan ('' H.&nb ...
, aloe vera,
tea tree oil Tea tree oil, also known as melaleuca oil, is an essential oil with a fresh camphoraceous odor and a colour that ranges from pale yellow to nearly colourless and clear. It is derived from the leaves of the tea tree, '' Melaleuca alternifolia'', ...
, coconut oil, and chamomile. *
Egg oil Egg oil ( CAS No. 8001–17–0, INCI: egg oil), also known as egg yolk oil or ovum oil, is derived from the yolk of chicken eggs consisting mainly of triglycerides with traces of lecithin, cholesterol, biotin, xanthophylls lutein and zeaxanthin ...
can be used as an excipient/carrier in a variety of cosmetic preparations such as creams, ointments, sun-screen products, or lotions. In Indian, Japanese,
Unani Unani or Yunani medicine (Urdu: ''tibb yūnānī'') is Perso-Arabic traditional medicine as practiced in Muslim culture in South Asia and modern day Central Asia. Unani medicine is pseudoscientific. The Indian Medical Association describes U ...
(Roghan Baiza Murgh) and Chinese
traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the ...
, egg oil was traditionally used as a treatment for hair care. *
Jojoba Jojoba (; botanical name: ''Simmondsia chinensis'')also commonly called goat nut, deer nut, pignut, wild hazel, quinine nut, coffeeberry, and gray box bushis native to the Southwestern United States. ''Simmondsia chinensis'' is the sole specie ...
is used for skin care because it is a natural moisturizer for the skin. Jojoba is actually a liquid wax that becomes solid below room temperature, but is known as an oil. * Shea butter is derived from the kernel of the shea tree (''Vitellaria paradoxa''). Shea butter is known for its cosmetic properties as a
moisturizer A moisturizer, or emollient, is a cosmetic preparation used for protecting, moisturizing, and lubricating the skin. These functions are normally performed by sebum produced by healthy skin. The word "emollient" is derived from the Latin verb ''m ...
and
emollient A moisturizer, or emollient, is a cosmetic preparation used for protecting, moisturizing, and lubricating the skin. These functions are normally performed by sebum produced by healthy skin. The word "emollient" is derived from the Latin verb ''m ...
.


Research

Dermatological research suggests that the bioactive ingredients used in cosmeceuticals have benefits beyond the traditional moisturizer (e.g., Chen et al., 2005;Zhou Chen, Jin Young Seo, Yeon Kyung Kim, Se Rah Lee, Kyu Han Kim, Kwang Hyun Cho, Hee Chul Eun, and Jin Ho Chung, Heat Modulation of Tropoelastin, Fibrillin-1, and MatrixMetalloproteinase-12 in Human Skin In VivoJ Invest Dermatol 124:70 –78, 2005 Zettersten, Ghadially, Feingold, Crumrine, & Elias, 1997). However, despite reports of benefits from some cosmeceutical products, there are no formal requirements to prove that these products live up to their claims. Biocompatible and environmentally friendly natural compounds have the potential to provide materials with photoresistant and thermoresistant properties. Dehydroabietic acid (DAA), a naturally occurring
diterpene Diterpenes are a class of chemical compounds composed of four isoprene units, often with the molecular formula C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being ...
resin acid, "has lifespan extension effects in ''Caenorhabditis elegans'', prevents lipofuscin accumulation, and prevents collagen secretion in human dermal fibroblasts. We found that these anti-aging effects are primarily mediated by
SIRT1 Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 ('' S. cerevisiae''), referring to the fact ...
activation." DAA may activate SIRT1 enzymatic activity, which may have a preventive effect against the aging process. Validated use of these materials and products awaits further assessment.


Related products

Cosmeceutical Cosmeceuticals are cosmetic products with bioactive ingredients purported to have medical benefits. In America, there are no legal requirements to prove that these products live up to their claims. The name is a portmanteau of "cosmetics" and " ...
s are topically applied, combination products that bring together
cosmetics Cosmetics are constituted mixtures of chemical compounds derived from either natural sources, or synthetically created ones. Cosmetics have various purposes. Those designed for personal care and skin care can be used to cleanse or protect ...
and "biologically active ingredients". Products which are similar in perceived benefits but ingested orally are known as nutricosmetics. According to the
United States Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food s ...
(FDA), the
Food, Drug, and Cosmetic Act The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C) is a set of laws passed by the United States Congress in 1938 giving authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of f ...
"does not recognize any such category as "cosmeceuticals". A product can be a drug, a cosmetic, or a combination of both, but the term "
cosmeceutical Cosmeceuticals are cosmetic products with bioactive ingredients purported to have medical benefits. In America, there are no legal requirements to prove that these products live up to their claims. The name is a portmanteau of "cosmetics" and " ...
" has no meaning under the law". Drugs are subject to an intensive review and approval process by FDA. Cosmetics, and these related products, although regulated, are not approved by FDA prior to sale.


Cautions

Some alternative and natural products and therapies may be harmful, either to the skin or systemically. The FDA recommends understanding the ingredient label and says "There is no list of ingredients that can be guaranteed not to cause allergic reactions, so consumers who are prone to allergies should pay careful attention to what they use on their skin", further warning that " ere is no basis in fact or scientific legitimacy to the notion that products containing natural ingredients are good for the skin". Food preservatives are commonly used to preserve the safety and efficacy in these products. Alternative remedies may increase the prevalence of
eczema Dermatitis is inflammation of the skin, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. The area of skin involved can ...
. Bhuchar recommends that "ingestible substances including most homeopathic, Ayurvedic, and traditional Chinese medicine herbal formulations that are not US FDA regulated should be viewed with caution as they may cause severe adverse effects" such as
arsenic poisoning Arsenic is a chemical element with the symbol As and atomic number 33. Arsenic occurs in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. Arsenic is a metalloid. It has various allotropes, bu ...
and liver failure." Given the shortage of evidence for natural skin care efficacy, if applied it may often need to be used in combination with conventional treatment, rather than independently. According to Bhuchar, there is a consensus in the literature that dermatologists need more information about CAM. Wu advises that "dermatologists should be aware of what patients may be using and be able to advise them about the efficacy of these ingredients or the potential for adverse effects". Many patients fail to inform their physicians about their use of herbal ingredients.


References

{{reflist, 2, refs= {{Cite journal, url=http://www.nature.com/articles/news990513-8, title=Phytotherapy - good science or big business?, first=Sara, last=Abdulla, date=May 13, 1999, journal=Nature, pages=news990513–8, via=DOI.org (Crossref), doi=10.1038/news990513-8 {{cite journal , vauthors=Ayegnon BP, Kayodé AP, Tchobo FP, etal , title=Profiling the quality characteristics of the butter of Pentadesma butyracea with reference to shea butter , journal=J. Sci. Food Agric. , volume= 95, issue= 15, pages= 3137–43, year=2014 , pmid=25523343 , doi=10.1002/jsfa.7052 {{cite journal , authors=Baumann L, Woolery-Lloyd H, Friedman A , title="Natural" ingredients in cosmetic dermatology , journal= Journal of Drugs in Dermatology , volume=8 , issue=6 Suppl , pages=s5–9 , year=2009 , pmid=19562883 , url=https://jddonline.com/articles/dermatology/S154596169S0061X Berton H. ''The Essential Guide to Natural Skin Care''. Llewellyn Worldwide, 2012. {{ISBN, 9780738730561 {{cite journal , vauthors=Binic I, Lazarevic V, Ljubenovic M, etal , title=Skin ageing: natural weapons and strategies , journal=Evid Based Complement Alternat Med , volume=2013 , pages=1–10 , year=2013 , pmid=23431351 , pmc=3569896 , doi=10.1155/2013/827248 , doi-access=free {{cite journal , authors=Bowe WP, Pugliese S , title=Cosmetic benefits of natural ingredients , journal= Journal of Drugs in Dermatology , volume=13 , issue=9 , pages=1021–5; quiz 26–7 , year=2014 , pmid=25226001 , url= https://jddonline.com/articles/dermatology/S1545961614P1021X {{cite journal , authors=Bhuchar S, Katta R, Wolf J , title=Complementary and alternative medicine in dermatology: an overview of selected modalities for the practicing dermatologist , journal=Am J Clin Dermatol , volume=13 , issue=5 , pages=311–7 , year=2012 , pmid=22668453 , doi=10.2165/11597560-000000000-00000 , s2cid=34734099 {{cite journal , authors=Chaudhuri RK , title=Emblica cascading antioxidant: a novel natural skin care ingredient , journal=Skin Pharmacol. Appl. Skin Physiol. , volume=15 , issue=5 , pages=374–80 , year=2002 , pmid=12239434 , doi= 10.1159/000064544, s2cid=43763682 {{cite journal , vauthors=Epstein H , title=Cosmeceutical vehicles , journal=Clin. Dermatol. , volume=27 , issue=5 , pages=453–60 , year=2009 , pmid=19695476 , doi=10.1016/j.clindermatol.2009.05.007 {{cite journal , vauthors=Fernandes SC, Alonso-Varona A, Palomares T, etal , title=Exploiting Mycosporines as Natural Molecular Sunscreens for the Fabrication of UV-Absorbing Green Materials , journal=ACS Appl Mater Interfaces , volume=7 , issue=30 , pages=16558–64 , year=2015 , pmid=26168193 , doi=10.1021/acsami.5b04064 {{cite journal , authors=Fowler JF, Woolery-Lloyd H, Waldorf H, Saini R , title=Innovations in natural ingredients and their use in skin care , journal= Journal of Drugs in Dermatology , volume=9 , issue=6 Suppl , pages=S72–81; quiz s82–3 , year=2010 , pmid=20626172 , url=https://jddonline.com/articles/dermatology/S1545961610S0071X {{cite journal , authors=Kalasannavar SB, Sawalgimath MP , title=Molluscum contagiosum: A novel Ayurvedic approach , journal=Anc Sci Life , volume=33 , issue=1 , pages=49–51 , year=2013 , pmid=25161331 , pmc=4140023 , doi=10.4103/0257-7941.134606 Kessler R. More than Cosmetic Changes: Taking Stock of Personal Care Product Safety. Environ Health Perspect; DOI:10.1289/ehp.123-A12

/ref> {{cite journal , authors=Krishnaveni M, Mirunalini S , title=Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder , journal=J Basic Clin Physiol Pharmacol , volume=21 , issue=1 , pages=93–105 , year=2010 , pmid=20506691 , doi= 10.1515/jbcpp.2010.21.1.93, s2cid=5729282 {{cite journal , vauthors=Kim J, Kang YG, Lee JY, etal , title=The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1 , journal=Mol. Cell. Endocrinol. , volume=412 , pages=216–25 , year=2015 , pmid=25976661 , doi=10.1016/j.mce.2015.05.006 , s2cid=2357873 Leach M. ''Clinical Decision Making in Complementary & Alternative Medicine''. Publisher: Churchill Livingstone; 1 edition (July 30, 2010) pages 67-72 and 228-237 {{ISBN, 9780729539333 {{cite journal , authors=Meier L, Stange R, Michalsen A, Uehleke B , title=Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study , journal=Forsch Komplementärmed , volume=19 , issue=2 , pages=75–9 , year=2012 , pmid=22585103 , doi=10.1159/000338076 , s2cid=31083201 , url=https://www.zora.uzh.ch/id/eprint/66594/1/Meier_et_al_Jojoba_Oil_FOKOM_19%282%29_2012_75-79.pdf {{cite journal , authors=Mukherjee PK, Maity N, Nema NK, Sarkar BK , title=Bioactive compounds from natural resources against skin aging , journal=Phytomedicine , volume=19 , issue=1 , pages=64–73 , year=2011 , pmid=22115797 , doi=10.1016/j.phymed.2011.10.003 {{cite journal , authors=Narahari SR, Prasanna KS, Sushma KV , title=Evidence-based integrative dermatology , journal=Indian J Dermatol , volume=58 , issue=2 , pages=127–31 , year=2013 , pmid=23716802 , pmc=3657212 , doi=10.4103/0019-5154.108046 {{cite journal , authors=Pazyar N, Feily A, Kazerouni A , title=Green tea in dermatology , journal=Skinmed , volume=10 , issue=6 , pages=352–5 , year=2012 , pmid=23346663 {{cite journal , vauthors=Pazyar N, Yaghoobi R, Ghassemi MR, etal , title=Jojoba in dermatology: a succinct review , journal=G Ital Dermatol Venereol , volume=148 , issue=6 , pages=687–91 , year=2013 , pmid=24442052 {{cite journal , authors=Ranzato E, Martinotti S, Burlando B , title=Wound healing properties of jojoba liquid wax: an in vitro study , journal=J Ethnopharmacol , volume=134 , issue=2 , pages=443–9 , year=2011 , pmid=21211559 , doi=10.1016/j.jep.2010.12.042 {{cite journal , authors=Reuter J, Merfort I, Schempp CM , title=Botanicals in dermatology: an evidence-based review , journal=Am J Clin Dermatol , volume=11 , issue=4 , pages=247–67 , year=2010 , pmid=20509719 , doi=10.2165/11533220-000000000-00000 , s2cid=207298809 {{cite journal , authors=Reuter J, Wölfle U, Weckesser S, Schempp C , title=Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex , journal=J Dtsch Dermatol Ges , volume=8 , issue=10 , pages=788–96 , year=2010 , pmid=20707875 , doi=10.1111/j.1610-0387.2010.07496.x , s2cid=3778742 {{cite journal , authors=Routh HB, Bhowmik KR , title=Traditional Indian medicine in dermatology , journal=Clin. Dermatol. , volume=17 , issue=1 , pages=41–7 , year=1999 , pmid=10089584 , doi= 10.1016/s0738-081x(98)00070-4 {{cite journal , authors=Silverberg JI, Lee-Wong M, Silverberg NB , title=Complementary and alternative medicines and childhood eczema: a US population-based study , journal=Dermatitis , volume=25 , issue=5 , pages=246–54 , year=2014 , pmid=25207686 , doi=10.1097/DER.0000000000000072 , s2cid=6910026 {{cite journal , authors=Tundis R, Loizzo MR, Bonesi M, Menichini F , title=Potential role of natural compounds against skin aging , journal=Curr. Med. Chem. , volume=22 , issue=12 , pages=1515–38 , year=2015 , pmid=25723509 , doi= 10.2174/0929867322666150227151809 {{cite journal , authors=Wu J , title=Treatment of rosacea with herbal ingredients , journal= Journal of Drugs in Dermatology , volume=5 , issue=1 , pages=29–32 , year=2006 , pmid=16468289 , url=http://jddonline.com/articles/dermatology/S1545961614P1021X {{cite journal , vauthors=Zhang J, Kurita M, Shinozaki T, etal , title=Triterpene glycosides and other polar constituents of shea (Vitellaria paradoxa) kernels and their bioactivities , journal=Phytochemistry , volume=108 , pages=157–70 , year=2014 , pmid=25446237 , doi=10.1016/j.phytochem.2014.09.017 {{cite journal , authors=Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM , title=Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin , journal=J. Am. Acad. Dermatol. , volume=37 , issue=3 Pt 1 , pages=403–8 , year=1997 , pmid=9308554 , doi= 10.1016/s0190-9622(97)70140-3 Skin care