''Nyamiviridae'' is a family of negative-strand RNA viruses in the order ''

Mononegavirales ''Mononegavirales'' is an order of negative-strand RNA viruses which have nonsegmented genomes. Some common members of the order are Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. A ...

''. Ecdysozoa and

birds Birds are a group of warm-blooded vertebrates constituting the class Aves (), characterised by feathers, toothless beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart, and a strong yet lightweigh ...

serve as natural hosts. The name is a

portmanteau A portmanteau word, or portmanteau (, ) is a blend of wordstype species In zoological nomenclature, a type species (''species typica'') is the species name with which the name of a genus or subgenus is considered to be permanently taxonomically associated, i.e., the species that contains the biological type specimen ...

Nyamanini virus in South Africa) and ''Mi''dway Atoll (place of isolation of Midway virus in the United States) and the suffix -''viridae'' used to denote a virus family. There are seven genera in this family.

History

Nyamanini virus (NYMV) and Midway virus (MDWV) were first isolated in 1957 and 1966 respectively. NYMV has been isolated from cattle egrets (species ''

Bubulcus ibis The western cattle egret (''Bubulcus ibis'') is a species of heron (family Ardeidae) found in the tropics, subtropics and warm temperate zones. Most taxonomic authorities lump this species and the eastern cattle egret together (called the catt ...

'') and

tick Ticks (order Ixodida) are parasitic arachnids that are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, species, and "fullness". Ticks are external parasites, living by ...

s (species '' Argas walkerae'') in

Egypt Egypt ( ar, مصر , ), officially the Arab Republic of Egypt, is a transcontinental country spanning the northeast corner of Africa and southwest corner of Asia via a land bridge formed by the Sinai Peninsula. It is bordered by the Mediter ...

India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...

Nigeria Nigeria ( ), , ig, Naìjíríyà, yo, Nàìjíríà, pcm, Naijá , ff, Naajeeriya, kcg, Naijeriya officially the Federal Republic of Nigeria, is a country in West Africa. It is situated between the Sahel to the north and the Gulf o ...

South Africa South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countri ...

, and

Thailand Thailand ( ), historically known as Siam () and officially the Kingdom of Thailand, is a country in Southeast Asia, located at the centre of the Indochinese Peninsula, spanning , with a population of almost 70 million. The country is bo ...

. MDWV has been isolated from ticks of the genus ''

Ornithodoros ''Ornithodoros'' is a genus in the soft-bodied tick family, Argasidae. Physiology The opening between the midgut and hindgut has been lost, making the ticks unable to pass digestive waste products out of their bodies. Taxonomy The Linnean nam ...

'' collected in Midway,

Kure is a port and major shipbuilding city situated on the Seto Inland Sea in Hiroshima Prefecture, Japan. With a strong industrial and naval heritage, Kure hosts the second-oldest naval dockyard in Japan and remains an important base for the Japan ...

and Manana islands and northern

Honshu , historically called , is the largest and most populous island of Japan. It is located south of Hokkaidō across the Tsugaru Strait, north of Shikoku across the Inland Sea, and northeast of Kyūshū across the Kanmon Straits. The island separ ...

Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...

Antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...

to this virus have been found in the black-tailed gull (species '' Larus crassirostris'') and black-crowned night heron (species ''

Nycticorax nycticorax The black-crowned night heron (''Nycticorax nycticorax''), or black-capped night heron, commonly shortened to just night heron in Eurasia, is a medium-sized heron found throughout a large part of the world, including parts of Europe, Asia, and N ...

'').

Structure

Nyamivirions are enveloped, with spherical geometries. Their diameters are around 100 to 130 nm. Nyamiviral genomes are linear, nonsegmented and bisegmented, and around 11.6 kbp in total length. The nyamiviral genome codes for six proteins. Of these, only two have been assigned a function: the putative nucleo

capsid A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may ...

protein and

RNA-dependent RNA polymerase RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral GP glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus progeny are released by budding from the infected cells. Ticks and birds serve as the natural host.

Taxonomy

The family contains the following genera: *'' Berhavirus'' *'' Crustavirus'' *'' Formlvirus'' *'' Nyavirus'' *'' Orinovirus'' *'' Socyvirus'' *'' Tapwovirus''

References

External links

ICTV Online (10th) Report ''Nyamiviridae''

{{Taxonbar, from=Q18810466 Mononegavirales Virus families