Neurothekeoma2

Neurothekeoma (NT) is a rare benign cutaneous tumor, superficial soft tissue tumors that frequently develop on the head and neck. They often occur in the second and early third decades of life and tend to afflict women more frequently than men. First described by Gallager and Helwig, who proposed the term in order to reflect the presumed origin of the lesion from nerve sheath. Microscopically, the lesions described closely resembled the tumor, "nerve sheath myxoma (NSM)", an entity first described by Harkin and Reed. The latter had, through the years, been variously described as "Bizarre cutaneous neurofibroma", "Myxoma of nerve sheath", and "Pacinian neurofibroma".

Clinically, neurothekeomas present as a solitary nodule of the skin. The most common sites of occurrence are the head and neck and the extremities. The lesions range in size from about 0.5 cm. to more than 3 cm. The average patient age is about 25 years, but neurothkeomas may occur at any age. Women are affected about more often; the male to female ratio is approximately 1:2.

Microscopically, neurothekeoma consists of closely aggregated bundles or fascicles of spindle-shaped cells. The fascicles may or may not have a myxoid background.

Since the time of their first description, it has been reported that neurothekeomas are likely not of nerve sheath origin, as implied by the term. Consequently, neurothekeoma and nerve sheath myxoma are likely not related histogenetically, although they are similar in appearance and in behavior.Based mostly on the quantity of myxoid matrix present, neurothekeomas can have a variety of histologic characteristics, including myxoid, cellular, or mixed-type. The myxoid variety of neurothekeoma has inadvertently included nerve sheath myxoma because to similarity in clinical presentation and histology. However, it appears that the neurothekeoma that Barnhill and Mihm reported in 1990 is a separate and distinct entity from true nerve sheath myxoma.It has been proposed that neurothekeomas are derived from fibrohistiocytic cells rather than the peripheral nerve sheath.Fetsch JF, Laskin WB, Hallman JR, Lupton GP, Miettinen M. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007 Jul;31(7):1103-14.Hornick JL, Fletcher CD. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol. 2007 Mar;31(3):329-40.Despite having a different histologic appearance, neurothekeoma does not respond with the S100 protein while nerve sheath myxoma does (myxoid, mixed, or cellular).

Difference from nerve sheath myxoma

A rare neuro-ectodermal tumor known as a benign nerve sheath myxoma (NSM) was originally identified in 1969. In contrast, a cellular variation known as Neurothekeoma (NT) was characterized in 1980 by Gallager and Helwig. Later on, it was common to use both Neurothekeoma (NT) and nerve sheath myxoma (NSM) interchangeably.In 2011, Sheth et al. used microarray analysis to distinguish between Neurothekeoma and Nerve Sheath Myxoma based on the genetic expression of the cells. NSM is more frequent among young people without gender preference. Between 30 and 40 years of age is when the incidence peaks. The head and neck are rarely affected by the tumor, which is more usually seen in the upper limb. Young women are twice as likely as males to get NT, and it usually affects the head and neck rather than the hands. While NT can afflict females from infancy to old age with a peak incidence in the twenties, NSM has a peak incidence in the fourth decade.

Clinical features

Lesions are often a singular subcutaneous dome-shaped papule or nodule measuring less than 2 cm and may be skin-colored, pink to tan, or red to brown. Most lesions are asymptomatic although some may present with pain upon pressure. The lesions tend to grow slowly and are usually superficially located, with rare, deeper involvement of subcutaneous fat or skeletal muscle. The head and neck are the most common locations, but neurothekeomas may also be seen on the shoulder or upper extremities, while involvement of the mucosa is rare. Text was copied from this source, which is available under
Creative Commons Attribution 4.0 International License

Treatment

Surgical excision is the treatment of choice.Boukovalas S, Rogers H, Boroumand N, Cole EL. Cellular Neurothekeoma: A Rare Tumor with a Common Clinical Presentation. Plast Reconstr Surg Glob Open. 2016 Aug;4(8):e1006. There have been reports of neurothekeomas exhibiting atypical features, raising concern for their potential for aggression even though the majority of these tumors are small (less than 1 cm), have relatively bland histology, scant to no cytologic atypia, and only minimal extension into surrounding fat or skeletal muscle. Clinical size more than 1 cm, pleomorphism and enhanced mitotic activity in the cytology, infiltration into skeletal muscle or subcutaneous fat, and vascular invasion are reported as unusual characteristics. Despite the presence of unusual characteristics, documented recurrence rates after total surgical excision are very low.Busam KJ, Mentzel T, Colpaert C, Barnhill RL, Fletcher CD. Atypical or worrisome features in cellular neurothekeoma: a study of 10 cases. Am J Surg Pathol. 1998 Sep;22(9):1067-72.Wilson AD, Rigby H, Orlando A. Atypical cellular neurothekeoma--a diagnosis to be aware of. J Plast Reconstr Aesthet Surg. 2008;61(2):186-8.

See also

* List of cutaneous conditions
* List of histologic stains that aid in diagnosis of cutaneous conditions
* Myxoid tumor

References

Dermal and subcutaneous growths

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