Michael Levitt

Michael Levitt, ( he, מיכאל לויט; born 9 May 1947) is a South African-born biophysicist and a professor of structural biology at Stanford University, a position he has held since 1987. Levitt received the 2013 Nobel Prize in Chemistry, together with Martin Karplus and Arieh Warshel, for "the development of multiscale models for complex chemical systems". In 2018, Levitt was a founding co-editor of the '' Annual Review of Biomedical Data Science''.

Early life and education

Michael Levitt was born in Pretoria, South Africa, to a Jewish family from Plungė, Lithuania; his father was from Lithuania and his mother from the Czech Republic. He attended Sunnyside Primary School and then Pretoria Boys High School between 1960 and 1962. The family moved to England when he was 15. Levitt spent 1963 studying applied mathematics at the University of Pretoria. He attended King's College London, graduating with a first-class honours degree in Physics in 1967.

In 1967, he visited Israel for the first time. Together with his Israeli wife, Rina, a multimedia artist, he left to study at Cambridge, where their three children were born. Levitt was a PhD student in Computational biology at Peterhouse, Cambridge, and was based at the Laboratory of Molecular Biology from 1968 to 1972, where he developed a computer program for studying the conformations of molecules that underpinned much of his later work.

Career and research

In 1979, he returned to Israel and conducted research at the Weizmann Institute of Science in Rehovot, becoming an Israeli citizen in 1980. He served in the Israel Defense Forces for six weeks in 1985. In 1986, he began teaching at Stanford University, and since then has split his time between Israel and California. He went on to gain a research fellowship at Gonville and Caius College, Cambridge.

From 1980 to 1987, he was Professor of Chemical Physics at the Weizmann Institute of Science, Rehovot. Thereafter, he served as Professor of Structural biology, at Stanford University, California.

*Royal Society Exchange Fellow, Weizmann Institute, Israel, 1967–68
*Staff Scientist, MRC Laboratory of Molecular Biology, Cambridge, 1973–80
*Professor of Chemical Physics, Weizmann Institute, 1980–87 (dept. chair 1980–83)
*Professor of Structural Biology, Stanford University, 1987–present

Levitt was one of the first researchers to conduct molecular dynamics simulations of DNA and proteins and developed the first software for this purpose. He is currently well known for developing approaches to predict macromolecular structures, having participated in many Critical Assessment of Techniques for Protein Structure Prediction (CASP) competitions, where he criticised molecular dynamics for inability to refine protein structures.CASP participants usually did not try to use MD to avoid "a central embarrassment of molecular mechanics, namely that energy minimization or molecular dynamics generally leads to a model that is less like the experimental structure", He has also worked on simplified representations of protein structure for analysing folding and packing, as well as developing scoring systems for large-scale sequence-structure comparisons. He has mentored many successful scientists, including Mark Gerstein and Ram Samudrala. Cyrus Chothia was one of his colleagues.

Industrial collaboration

Levitt has served on the Scientific Advisory Boards of the following companies: Dupont Merck Pharmaceuticals, AMGEN, Protein Design Labs, Affymetrix, Molecular Applications Group, 3D Pharmaceuticals, Algodign, Oplon Ltd, Cocrystal Discovery, InterX, and StemRad, Ltd,.

COVID-19

Levitt has been outspoken during the ongoing COVID-19 pandemic, and made a number of predictions on the disease's spread based on his own modelling. On March 18, 2020, he predicted that Israel would see less than ten deaths from COVID-19, and on July 25, 2020, he incorrectly predicted that the outbreak in the U.S. would be over by the end of August 2020 with a total of fewer than 170,000 deaths. As of November 2021, the U.S. was recording COVID-19 deaths at the rate of about 1,000 per day, while Israel has reported over 8,000 COVID-19 deaths since the start of the pandemic.
However also in March 2020, when community spread of COVID-19 had dropped to zero in China, the Los Angeles Times reported that Levitt had forecast a month earlier that the worst of the COVID-19 pandemic in the country would be over long before when many health experts had predicted. As of December 2021, China has only added 40,000 additional COVID-19 cases to its total, which at the beginning of March 2020 had stood at 80,000 cases.

Levitt has also raised concerns about potential damaging effects of COVID-19 lockdown orders on economic activity as well in increasing suicide and abuse rates, and has signed the Great Barrington Declaration, a statement supported by a group of academics advocating for alternatives to lockdowns which has been criticized by the WHO and other public health organizations as dangerous and lacking in sound scientific basis.

Critics have expressed concern regarding Levitt's incorrect or potentially misleading predictions as well as his anti-lockdown positions, in part due to his status as a Nobel laureate and his large following on Twitter. Maia Majumder, a computational epidemiologist at Harvard Medical School, stated that "Michael Levitt has a huge, huge following, so this creates lots of problems when he’s tweeting something that may be misinformative." Randy Schekman, a 2013 Nobel Prize in Physiology or Medicine winner, wrote of Levitt's expressed positions that "in this instance, I believe he crossed a boundary from data to public policy where the impact of his word as a Nobel laureate has undue influence."

Awards and honors

Levitt was elected an EMBO Member in 1983, a Fellow of the Royal Society (FRS) in 2001, One or more of the preceding sentences incorporates text from the royalsociety.org website where: and a member of the National Academy of Sciences in 2002, and received the 2013 Nobel Prize in Chemistry, together with Martin Karplus and Arieh Warshel, "for the development of multiscale models for complex chemical systems". He received the DeLano Award for Computational Biosciences in 2014. He was elected an ISCB Fellow by the International Society for Computational Biology in 2015.

Personal life

Levitt holds South African, American, British and Israeli citizenship.

His wife Rina died on 23 January 2017.

He is the sixth Israeli to be awarded the Nobel Prize in Chemistry in under a decade.

References

External links

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{{DEFAULTSORT:Levitt, Michael
1947 births
Nobel laureates in Chemistry
Israeli Nobel laureates
American Nobel laureates
British Nobel laureates
Israeli bioinformaticians
American biophysicists
Structural biologists
Members of the European Molecular Biology Organization
Fellows of the Royal Society
20th-century British biologists
21st-century British biologists
British Jews
Israeli Jews
Naturalized citizens of Israel
Jewish American scientists
Alumni of Pretoria Boys High School
Alumni of King's College London
Alumni of Peterhouse, Cambridge
Stanford University School of Medicine faculty
Living people
Weizmann Institute of Science faculty
Members of the United States National Academy of Sciences
Fellows of the International Society for Computational Biology
Computational chemists
South African emigrants to the United Kingdom
Annual Reviews (publisher) editors
South African people of Lithuanian-Jewish descent
South African people of Czech descent
South African Jews