Ram Samudrala
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Ram Samudrala
Ram Samudrala is a professor of computational biology and bioinformatics at the University at Buffalo, United States. He researches protein folding, structure, function, interaction, design, and evolution. Education and career Samudrala received his undergraduate degrees in Computing Science and Genetics from Ohio Wesleyan University as a Wesleyan Scholar, and completed his Ph.D. in Computational Biology with John Moult at the University of Maryland in 1997 as a Life Technologies Fellow. From 1997-2000, he was a postdoctoral fellow with Michael Levitt at Stanford University. In 2001, Samudrala became the first faculty member to be recruited to the University of Washington under the Advanced Technology Initiative in Infectious Diseases created by the Washington State Legislature "as a bridge between cutting-edge research and education, and new economic activity." He was promoted to Associate Professor in 2006. In 2014, he became professor and chief of the Division of Bioinformati ...
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Computational Biology
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting ...
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Computational Biology
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting ...
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Peru
, image_flag = Flag of Peru.svg , image_coat = Escudo nacional del Perú.svg , other_symbol = Great Seal of the State , other_symbol_type = Seal (emblem), National seal , national_motto = "Firm and Happy for the Union" , national_anthem = "National Anthem of Peru" , march = "March of Flags" , image_map = PER orthographic.svg , map_caption = , image_map2 = , capital = Lima , coordinates = , largest_city = capital , official_languages = Peruvian Spanish, Spanish , languages_type = Co-official languages , languages = , ethnic_groups = , ethnic_groups_year = 2017 , demonym = Peruvians, Peruvian , government_type = Unitary state, Unitary Semi-presidential system, semi-presidential republic , leader_title1 = President of Peru, President ...
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Yautan District
Yautan District is one of four districts of the province Casma in Peru. Instituto Nacional de Estadística e Informática The Instituto Nacional de Estadística e Informática (INEI) ("National Institute of Statistics and Informatics") is a semi-autonomous Peruvian government agency which coordinates, compiles, and evaluates statistical information for the country .... Banco de Información Distrital'. Retrieved April 11, 2008. References Districts of the Casma Province Districts of the Ancash Region {{Ancash-geo-stub ...
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Casma
Casma is a city in the coastal desert of Peru, located northwest of Lima. It is the capital of Casma Province and the third most populous city in the Ancash Region with an estimated population of 29,343 (2015). It is located in the lower Casma Valley The Casma River, which upstream is called Río Grande, is a river that crosses northern Casma province in the Ancash Region of Peru. It originates in the Black Mountain Range and drains into the Pacific Ocean. Major tributaries include the Sechí ..., covering an area of 1,205 km². The name of the city may derive from the extinct ''Quingman'' language. Santa Maria Magdalena is the city's patron saint, whose day is celebrated on July 22. Some of the largest prehistoric monuments around the world are situated around the city, in the Casma and Sechin valleys. These include Sechin, Chanquillo, Mojeque and Las Aldas. The nearby Pacific coastline boasts beaches such as La Gramita, El Litro, Punta el Huaro and Tortugas. Arc ...
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Alberta Heritage Foundation For Medical Research
Alberta Innovates (AI) is an Alberta government provincial corporation whose appointed Board of Directors is accountable to the Minister of Jobs, Economy and Innovation and is responsible for promoting innovation in the province. AI was created from a variety of predecessor research and development organizations including the Alberta Research Council, the Alberta Heritage Foundation for Medical Research and the Alberta Energy Research Institute. History Scientific and Industrial Research Council of Alberta (SIRCA) In the early 1900s, Henry Marshall Tory, the first president of the University of Alberta, lobbied the Alberta government to create an organization to promote research and development (R&D) in the province. In 1921, the government created the Scientific and Industrial Research Council of Alberta (SIRCA). SIRCA was the first provincial R&D organization in Canada. SIRCA's initial mandate was " upportindustries in developing new research, apout Alberta’s geological ...
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CAREER Award
The National Science Foundation CAREER awards, presented by the National Science Foundation (NSF), are in support of junior faculty who exemplify the role of teacher-scholars through research and education, and the integration of these endeavors in the context of their organizations' missions. The awards, presented once each year, include a federal grant for research and education activities for five consecutive years. History The Presidential Young Investigators (PYI) program was initiated in 1983, and remained active until the NSF New Young Investigators (NYI) program replaced it in 1992. Both programs were research-oriented, and funded an average of 200 faculty members per year. Another, more selective program began in 1992, when the White House asked NSF to institute the Presidential Faculty Fellows (PFF) program. It awarded young faculty up to $100,000 per year for five years, with no matching-fund option, and put more emphasis on education and outreach. In 1994, the Faculty ...
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Technology Review
''MIT Technology Review'' is a bimonthly magazine wholly owned by the Massachusetts Institute of Technology, and editorially independent of the university. It was founded in 1899 as ''The Technology Review'', and was re-launched without "The" in its name on April 23, 1998 under then publisher R. Bruce Journey. In September 2005, it was changed, under its then editor-in-chief and publisher, Jason Pontin, to a form resembling the historical magazine. Before the 1998 re-launch, the editor stated that "nothing will be left of the old magazine except the name." It was therefore necessary to distinguish between the modern and the historical ''Technology Review''. The historical magazine had been published by the MIT Alumni Association, was more closely aligned with the interests of MIT alumni, and had a more intellectual tone and much smaller public circulation. The magazine, billed from 1998 to 2005 as "MIT's Magazine of Innovation," and from 2005 onwards as simply "published by MIT" ...
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Nutritious Rice For The World
Nutritious Rice for the World is a World Community Grid research project in the field of agronomy led by the Samudrala Computational Biology Research Group at the University of Washington. It was launched on May 12, 2008. The objective of this project is to predict the structure of proteins of major strains of rice. The intent is to help farmers breed better rice strains with higher crop yields, promote greater disease and pest resistance, and utilize a full range of bioavailable nutrients that can benefit people around the world, especially in regions where malnutrition is a critical concern. Determining the structure of proteins is an extremely difficult and expensive process. Though it is possible to computationally predict a protein's structure from its corresponding DNA sequence, there are thousands of distinct proteins found in rice. This presents a computational challenge that a single computer cannot solve within a reasonable timeframe. Once that the entire rice genome ...
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Drug Discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Modern drug discovery involves the ...
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CASP
Critical Assessment of Structure Prediction (CASP), sometimes called Critical Assessment of Protein Structure Prediction, is a community-wide, worldwide experiment for protein structure prediction taking place every two years since 1994. CASP provides research groups with an opportunity to objectively test their structure prediction methods and delivers an independent assessment of the state of the art in protein structure modeling to the research community and software users. Even though the primary goal of CASP is to help advance the methods of identifying protein three-dimensional structure from its amino acid sequence many view the experiment more as a “world championship” in this field of science. More than 100 research groups from all over the world participate in CASP on a regular basis and it is not uncommon for entire groups to suspend their other research for months while they focus on getting their servers ready for the experiment and on performing the detailed predic ...
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Proteomics
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics. ...
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