MAM domain is an evolutionary conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...

. It is an extracellular domain found in many receptors. A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins. These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include

meprin Meprin A (, ''endopeptidase-2'', ''meprin-a'', ''meprin'', ''N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase'', ''PABA-peptide hydrolase'', ''PPH'') is an enzyme Enzymes () are proteins that act as biological catalysts by accelerating che ...

(a cell surface glycoprotein); A5 antigen (a developmentally-regulated cell surface protein; ''Xenopus''

nrp1 Neuropilin-1 is a protein that in humans is encoded by the ''NRP1'' gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins. Function NRP1 is a membrane-bound coreceptor to a tyrosine kinase recepto ...

; ); and receptor-like tyrosine protein phosphatase. The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.

Human proteins containing this domain

ALK; EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2;

MEP1A Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the ''MEP1A'' gene. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice. ...

;

MEP1B Meprin A subunit beta is a protein that in humans is encoded by the ''MEP1B'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''bi ...

; NPNT;

NRP1 Neuropilin-1 is a protein that in humans is encoded by the ''NRP1'' gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins. Function NRP1 is a membrane-bound coreceptor to a tyrosine kinase recepto ...

;

NRP2 Neuropilin 2 (NRP2) is a protein that in humans is encoded by the ''NRP2'' gene. This gene encodes a member of the neuropilin Neuropilin is a protein receptor active in neurons. There are two forms of Neuropilins, NRP-1 and NRP-2. Neuropili ...

; PRSS7;

PTPRK Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the ''PTPRK'' gene. PTPRK is also known as PTPkappa and PTPκ. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase ( ...

;

PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the ''PTPRM'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases a ...

;

PTPRO Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the ''PTPRO'' gene. This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic sign ...

;

PTPRT Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the ''PTPRT'' gene. PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome that ...

;

PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the ''PTPRU'' gene. Function The protein encoded by this gene is a member of the protein t ...

;

ZAN Zan or ZAN, may refer to: Geography * Zhan, Kurdistan, Iran, also known as Zān * Zhan, Lorestan, Iran, also known as Žān * Zan, Tehran, a village in Tehran Province, Iran Ethnicity and language * Zans, the Zan People, people who speak the Za ...

References

Protein domains Single-pass transmembrane proteins {{membrane-protein-stub