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Inhalants are a broad range of household and industrial chemicals whose volatile vapors or pressurized gases can be concentrated and breathed in via the nose or mouth to produce
intoxication Intoxication — or poisoning, especially by an alcoholic or narcotic substance — may refer to: * Substance intoxication: ** Alcohol intoxication ** LSD intoxication ** Toxidrome ** Tobacco intoxication ** Cannabis intoxication ** Cocaine i ...
, in a manner not intended by the manufacturer. They are inhaled at room temperature through volatilization (in the case of gasoline or
acetone Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscib ...
) or from a pressurized container (e.g.,
nitrous oxide Nitrous oxide (dinitrogen oxide or dinitrogen monoxide), commonly known as laughing gas, nitrous, or nos, is a chemical compound, an oxide of nitrogen with the formula . At room temperature, it is a colourless non-flammable gas, and has ...
or butane), and do not include drugs that are sniffed after burning or heating. For example,
amyl nitrite Amyl nitrite is a chemical compound with the formula C5H11ONO. A variety of isomers are known, but they all feature an amyl group attached to the nitrite functional group. The alkyl group is unreactive and the chemical and biological properties ...
(
poppers Popper is a slang term given broadly to drugs of the chemical class called alkyl nitrites that are inhaled. Most widely sold products include the original isoamyl nitrite or isopentyl nitrite, and isopropyl nitrite. Isobutyl nitrite is al ...
), nitrous oxide and
toluene Toluene (), also known as toluol (), is a substituted aromatic hydrocarbon. It is a colorless, water-insoluble liquid with the smell associated with paint thinners. It is a mono-substituted benzene derivative, consisting of a methyl group (CH3) a ...
– a solvent widely used in
contact cement Impact glue, contact glue or neoprene glue, is a type of glue, used mainly to glue plastic foams, laminates, metal panels, etc. . It also allows the mounting of supports of different types (metal on wood, cork on plaster, wood on cement, etc ...
, permanent markers, and certain types of glue – are considered inhalants, but smoking tobacco,
cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: '' Cannabis sativa'', '' C. indica'', and '' C. ruderalis''. Alternative ...
, and crack are not, even though these drugs are inhaled as smoke or vapor. While a few inhalants are prescribed by medical professionals and used for medical purposes, as in the case of
inhaled anesthetics An inhalational anesthetic is a chemical compound possessing general anesthetic properties that can be delivered via inhalation. They are administered through a face mask, laryngeal mask airway or tracheal tube connected to an anesthetic vapo ...
and
nitrous oxide Nitrous oxide (dinitrogen oxide or dinitrogen monoxide), commonly known as laughing gas, nitrous, or nos, is a chemical compound, an oxide of nitrogen with the formula . At room temperature, it is a colourless non-flammable gas, and has ...
(an
anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
and pain relief agent prescribed by dentists), this article focuses on inhalant use of household and industrial propellants, glues, fuels, and other products in a manner not intended by the manufacturer, to produce
intoxication Intoxication — or poisoning, especially by an alcoholic or narcotic substance — may refer to: * Substance intoxication: ** Alcohol intoxication ** LSD intoxication ** Toxidrome ** Tobacco intoxication ** Cannabis intoxication ** Cocaine i ...
or other
psychoactive effect A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. T ...
s. These products are used as recreational drugs for their intoxicating effect. According to a 1995 report by the National Institute on Drug Abuse, the most serious inhalant use occurs among homeless children and teenagers who "... live on the streets completely without family ties." Inhalants are the only substance used more by younger teenagers than by older teenagers. Inhalant users inhale
vapor In physics, a vapor (American English) or vapour (British English and Canadian English; see spelling differences) is a substance in the gas phase at a temperature lower than its critical temperature,R. H. Petrucci, W. S. Harwood, and F. G. Her ...
or aerosol propellant gases using plastic bags held over the mouth or by breathing from a solvent-soaked rag or an open container. The practices are known colloquially as "sniffing", "huffing" or "bagging". The effects of inhalants range from an alcohol-like
intoxication Intoxication — or poisoning, especially by an alcoholic or narcotic substance — may refer to: * Substance intoxication: ** Alcohol intoxication ** LSD intoxication ** Toxidrome ** Tobacco intoxication ** Cannabis intoxication ** Cocaine i ...
and intense euphoria to vivid
hallucination A hallucination is a perception in the absence of an external stimulus that has the qualities of a real perception. Hallucinations are vivid, substantial, and are perceived to be located in external objective space. Hallucination is a combinati ...
s, depending on the substance and the dose. Some inhalant users are injured due to the harmful effects of the solvents or gases or due to other chemicals used in the products that they are inhaling. As with any recreational drug, users can be injured due to dangerous behavior while they are intoxicated, such as driving under the influence. In some cases, users have died from hypoxia (lack of oxygen),
pneumonia Pneumonia is an inflammatory condition of the lung primarily affecting the small air sacs known as alveoli. Symptoms typically include some combination of productive or dry cough, chest pain, fever, and difficulty breathing. The severi ...
, heart failure or arrest, or aspiration of vomit. Brain damage is typically seen with chronic long-term use of solvents as opposed to short-term exposure. Even though many inhalants are legal, there have been legal actions taken in some jurisdictions to limit access by minors. While solvent glue is normally a legal product, a Scottish court ruled that supplying glue to children is illegal if the store knows the children intend to inhale the glue. In the US, thirty-eight of 50 states have enacted laws making various inhalants unavailable to those under the age of 18 or making inhalant use illegal.


Classification

Inhalants can be classified by their intended function. Most inhalant drugs that are used non-medically are ingredients in household or industrial chemical products that are not intended to be concentrated and inhaled. A small number of recreational inhalant drugs are pharmaceutical products that are used illicitly.


Product category

Another way to categorize inhalants is by their product category. There are three main product categories: solvents; gases; and medical drugs which are used illicitly.


Solvents

A wide range of volatile solvents intended for household or industrial use are inhaled as recreational drugs. This includes petroleum products (gasoline and
kerosene Kerosene, paraffin, or lamp oil is a combustible hydrocarbon liquid which is derived from petroleum. It is widely used as a fuel in aviation as well as households. Its name derives from el, κηρός (''keros'') meaning "wax", and was regi ...
),
toluene Toluene (), also known as toluol (), is a substituted aromatic hydrocarbon. It is a colorless, water-insoluble liquid with the smell associated with paint thinners. It is a mono-substituted benzene derivative, consisting of a methyl group (CH3) a ...
(used in paint thinner, permanent markers, contact cement and model glue), and
acetone Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscib ...
(used in nail polish remover). These solvents vaporize at room temperature.
Ethanol Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a ...
(the alcohol which is normally drunk) is sometimes inhaled, but this cannot be done at room temperature. The ethanol must be converted from liquid into gaseous state (vapor) or aerosol (mist), in some cases using a
nebulizer In medicine, a nebulizer (American English) or nebuliser (British English) is a drug delivery device used to administer medication in the form of a mist inhaled into the lungs. Nebulizers are commonly used for the treatment of asthma, cystic fibro ...
, a machine that agitates the liquid into an aerosol. The sale of nebulizers for inhaling ethanol was banned in some US states due to safety concerns.


Gases

A number of gases intended for household or industrial use are inhaled as recreational drugs. This includes
chlorofluorocarbon Chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) are fully or partly halogenated hydrocarbons that contain carbon (C), hydrogen (H), chlorine (Cl), and fluorine (F), produced as volatile derivatives of methane, ethane, and pro ...
s used in aerosols and propellants (e.g., aerosol hair spray, aerosol deodorant). A gas used as a propellant in
whipped cream Whipped cream is liquid heavy cream that is whipped by a whisk or mixer until it is light and fluffy and holds its shape, or by the expansion of dissolved gas, forming a firm colloid. It is often sweetened, typically with white sugar, an ...
aerosol containers, nitrous oxide, is used as a recreational drug. Pressurized canisters of propane and butane gas, both of which are intended for use as fuels, are used as inhalants.


Medical anesthetics

Several medical anesthetics are used as recreational drugs, including
diethyl ether Diethyl ether, or simply ether, is an organic compound in the ether class with the formula , sometimes abbreviated as (see Pseudoelement symbols). It is a colourless, highly volatile, sweet-smelling ("ethereal odour"), extremely flammable li ...
(a drug that is no longer used medically, due to its high flammability and the development of safer alternatives) and
nitrous oxide Nitrous oxide (dinitrogen oxide or dinitrogen monoxide), commonly known as laughing gas, nitrous, or nos, is a chemical compound, an oxide of nitrogen with the formula . At room temperature, it is a colourless non-flammable gas, and has ...
, which is widely used in the 2010s by dentists as an anti-anxiety drug during dental procedures. Diethyl ether has a long history of use as a recreational drug. The effects of ether intoxication are similar to those of alcohol intoxication, but more potent. Also, due to NMDA antagonism, the user may experience all the psychedelic effects present in classical dissociatives such as
ketamine Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ...
in the forms of thought loops and the feeling of the mind being disconnected from one's body. Nitrous oxide is a dental anesthetic that is used as a recreational drug, either by users who have access to medical-grade gas canisters (e.g., dental hygienists or dentists) or by using the gas contained in
whipped cream Whipped cream is liquid heavy cream that is whipped by a whisk or mixer until it is light and fluffy and holds its shape, or by the expansion of dissolved gas, forming a firm colloid. It is often sweetened, typically with white sugar, an ...
aerosol containers. Nitrous oxide inhalation can cause
pain relief Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging. Most physicians and other health professional ...
,
depersonalisation Depersonalization can consist of a detachment within the self, regarding one's mind or body, or being a detached observer of oneself. Subjects feel they have changed and that the world has become vague, dreamlike, less real, lacking in significa ...
, derealisation,
dizziness Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness. It can also refer to disequilibrium or a non-specific feeling, such as giddiness or foolishness. Dizziness is a common medical c ...
, euphoria, and some sound distortion.


Classification by effect

It is also possible to classify inhalants by the effect they have on the body. Some solvents act as
depressant A depressant, or central depressant, is a drug that lowers neurotransmission levels, which is to depress or reduce arousal or stimulation, in various areas of the brain. Depressants are also colloquially referred to as downers as they lower the ...
s, causing users to feel relaxed or drowsy while others act as stimulants. All commonly abused inhalants act as
asphyxiant gas An asphyxiant gas, also known as a simple asphyxiant, is a nontoxic or minimally toxic gas which reduces or displaces the normal oxygen concentration in breathing air. Breathing of oxygen-depleted air can lead to death by asphyxiation (suffocation ...
es, although a common myth is that their primary effects are only due to
oxygen deprivation Asphyxia or asphyxiation is a condition of deficient supply of oxygen to the body which arises from abnormal breathing. Asphyxia causes generalized hypoxia, which affects primarily the tissues and organs. There are many circumstances that can ...
. In reality, the majority of abused inhalants still exhibit psychoactive effects, although oxygen deprivation does add to the notable effects.
Nitrous oxide Nitrous oxide (dinitrogen oxide or dinitrogen monoxide), commonly known as laughing gas, nitrous, or nos, is a chemical compound, an oxide of nitrogen with the formula . At room temperature, it is a colourless non-flammable gas, and has ...
can be categorized as a dissociative drug, as it can cause visual and auditory hallucinations. Other agents may have more direct effects at receptors, as inhalants exhibit a variety of mechanisms of action. The mechanisms of action of many non-medical inhalants have not been well elucidated. Anesthetic gases used for surgery, such as nitrous oxide or
enflurane Enflurane (2-chloro-1,1,2-trifluoroethyl difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but ...
, are believed to induce anesthesia primarily by acting as
NMDA receptor antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce ...
s, open-channel blockers that bind to the inside of the calcium channels on the outer surface of the
neuron A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. ...
, and provide high levels of NMDA receptor blockade for a short period of time. This makes inhaled anesthetic gases different from other NMDA antagonists, such as
ketamine Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ...
, which bind to a regulatory site on the NMDA-sensitive calcium transporter complex and provide slightly lower levels of NMDA blockade, but for a longer and much more predictable duration. This makes a deeper level of anesthesia achievable more easily using anesthetic gases but can also make them more dangerous than other drugs used for this purpose.


Chemical structure

Inhalants can also be classified by chemical structure. Classes include:


Administration and effects

Inhalant users inhale vapors or aerosol propellant gases using plastic bags held over the mouth or by breathing from an open container of solvents, such as gasoline or paint thinner. Nitrous oxide gases from whipped cream aerosol cans, aerosol hairspray or non-stick frying spray are sprayed into plastic bags. Some nitrous oxide users spray the gas into balloons. When inhaling non-stick cooking spray or other aerosol products, some users may filter the aerosolized particles out with a rag. Some gases, such as propane and butane gases, are inhaled directly from the canister. Once these solvents or gases are inhaled, the extensive capillary surface of the lungs rapidly absorbs the solvent or gas, and blood levels peak rapidly. The intoxication effects occur so quickly that the effects of inhalation can resemble the intensity of effects produced by intravenous injection of other psychoactive drugs. Ethanol is also inhaled, either by vaporizing it by pouring it over
dry ice Dry ice is the solid form of carbon dioxide. It is commonly used for temporary refrigeration as CO2 does not have a liquid state at normal atmospheric pressure and sublimates directly from the solid state to the gas state. It is used primarily ...
in a narrow container and inhaling with a straw or by pouring alcohol in a corked bottle with a pipe, and then using a bicycle pump to make a spray. Alcohol can be vaporized using a simple container and open-flame heater. Medical devices such as asthma nebulizers and inhalers were also reported as means of application. The practice gained popularity in 2004, with the marketing of the device dubbed AWOL (Alcohol without liquid), a play on the military term
AWOL Desertion is the abandonment of a military duty or post without permission (a pass, liberty or leave) and is done with the intention of not returning. This contrasts with unauthorized absence (UA) or absence without leave (AWOL ), which ...
(Absent Without Leave). AWOL, created by British businessman Dominic Simler, was first introduced in Asia and Europe, and then in the United States in August 2004. AWOL was used by nightclubs, at gatherings and parties, and it garnered attraction as a
novelty Novelty (derived from Latin word ''novus'' for "new") is the quality of being new, or following from that, of being striking, original or unusual. Novelty may be the shared experience of a new cultural phenomenon or the subjective perception of an ...
, as people 'enjoyed passing it around in a group'. AWOL uses a
nebulizer In medicine, a nebulizer (American English) or nebuliser (British English) is a drug delivery device used to administer medication in the form of a mist inhaled into the lungs. Nebulizers are commonly used for the treatment of asthma, cystic fibro ...
, a machine that agitates the liquid into an aerosol. AWOL's official website states that "AWOL and AWOL 1 are powered by ''Electrical Air Compressors'' while AWOL 2 and AWOL 3 are powered by ''electrical oxygen generators''", which refer to a couple of mechanisms used by the nebulizer drug delivery device for inhalation. Although the AWOL machine is marketed as having no downsides, such as the lack of calories or hangovers, Amanda Shaffer of '' Slate'' describes these claims as "dubious at best". Although inhaled alcohol does reduce the caloric content, the savings are minimal. After expressed safety and health concerns, sale or use of AWOL machines was banned in a number of American states. The effects of
solvent A solvent (s) (from the Latin '' solvō'', "loosen, untie, solve") is a substance that dissolves a solute, resulting in a solution. A solvent is usually a liquid but can also be a solid, a gas, or a supercritical fluid. Water is a solvent for ...
intoxication can vary widely depending on the dose and what type of solvent or gas is inhaled. A person who has inhaled a small amount of rubber cement or paint thinner vapor may be impaired in a manner resembling alcohol inebriation. A person who has inhaled a larger quantity of solvents or gases, or a stronger chemical, may experience stronger effects such as distortion in perceptions of time and space,
hallucination A hallucination is a perception in the absence of an external stimulus that has the qualities of a real perception. Hallucinations are vivid, substantial, and are perceived to be located in external objective space. Hallucination is a combinati ...
s, and emotional disturbances. The effects of inhalant use are also modified by the combined use of inhalants and alcohol or other drugs. In the short term, many users experience headaches, nausea and vomiting, slurred speech, loss of motor coordination, and wheezing. A characteristic "glue sniffer's rash" around the nose and mouth is sometimes seen after prolonged use. An odor of paint or solvents on clothes, skin, and breath is sometimes a sign of inhalant abuse, and paint or solvent residues can sometimes emerge in sweat. According to NIH, even a single session of inhalant use "can disrupt heart rhythms and lower oxygen levels", which can lead to death. "Regular abuse can result in serious harm to the brain, heart, kidneys, and liver."


Dangers and health problems

Statistics on deaths caused by heavy inhalant use are difficult to determine. It may be severely under-reported because death is often attributed to a discrete event such as a stroke or a heart attack, even if the event happened because of inhalant use. Inhalant use was mentioned on 144 death certificates in
Texas Texas (, ; Spanish: ''Texas'', ''Tejas'') is a state in the South Central region of the United States. At 268,596 square miles (695,662 km2), and with more than 29.1 million residents in 2020, it is the second-largest U.S. state by ...
during the period 1988–1998 and was reported in 39 deaths in Virginia between 1987 and 1996 from acute voluntary exposure to used inhalants.


General risks

Regardless of which inhalant is used, inhaling vapors or gases can lead to injury or death. One major risk is hypoxia (lack of oxygen), which can occur due to inhaling fumes from a plastic bag, or from using proper inhalation mask equipment (e.g., a medical mask for nitrous oxide) but not adding oxygen or room air. Another danger is freezing the throat. When a gas that was stored under high pressure is released, it cools abruptly and can cause
frostbite Frostbite is a skin injury that occurs when exposed to extreme low temperatures, causing the freezing of the skin or other tissues, commonly affecting the fingers, toes, nose, ears, cheeks and chin areas. Most often, frostbite occurs in the ha ...
if it is inhaled directly from the container. This can occur, for example, with inhaling nitrous oxide. When nitrous oxide is used as an automotive power adder, its cooling effect is used to make the fuel-air charge denser. In a person, this effect is potentially lethal. Many inhalants are volatile
organic chemicals In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The s ...
and can catch fire or explode, especially when combined with smoking. As with many other drugs, users may also injure themselves due to loss of coordination or impaired judgment, especially if they attempt to operate machinery. Solvents have many potential risks in common, including pneumonia,
cardiac failure Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome, a group of signs and symptoms caused by an impairment of the heart's blood pumping function. Symptoms typically include shortness of breath, excessive fatigue, a ...
or arrest, and aspiration of vomit. The inhaling of some solvents can cause hearing loss, limb spasms, and damage to the central nervous system and brain. Serious but potentially reversible effects include liver and kidney damage and blood-oxygen depletion. Death from inhalants is generally caused by a very high concentration of fumes. Deliberately inhaling solvents from an attached paper or plastic bag or in a closed area greatly increases the chances of suffocation. Brain damage is typically seen with chronic long-term use as opposed to short-term exposure.
Parkinsonism Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. These are the four motor symptoms found in Parkinson's disease (PD), after which it is named, dementia with Lewy b ...
(see: Signs and symptoms of Parkinson's disease) has been associated with huffing. Female inhalant users who are pregnant may have adverse effects on the fetus, and the baby may be smaller when it is born and may need additional health care (similar to those seen with alcohol – fetal alcohol syndrome). There is some evidence of birth defects and disabilities in babies born to women who sniffed solvents such as gasoline. In the short term, death from solvent use occurs most commonly from aspiration of vomit while unconscious or from a combination of respiratory depression and hypoxia, the second cause being especially a risk with heavier-than-air vapors such as butane or gasoline vapor. Deaths typically occur from complications related to excessive sedation and vomiting. Actual overdose from the drug does occur, however, and inhaled solvent use is statistically more likely to result in life-threatening respiratory depression than intravenous use of opioids such as heroin. Most deaths from solvent use could be prevented if individuals were resuscitated quickly when they stopped breathing and their airways cleared if they vomited. However, most inhalant use takes place when people inhale solvents by themselves or in groups of people who are intoxicated. Certain solvents are more hazardous than others, such as gasoline. In contrast, a few inhalants like amyl nitrate and
diethyl ether Diethyl ether, or simply ether, is an organic compound in the ether class with the formula , sometimes abbreviated as (see Pseudoelement symbols). It is a colourless, highly volatile, sweet-smelling ("ethereal odour"), extremely flammable li ...
have medical applications and are not toxic in the same sense as solvents, though they can still be dangerous when used recreationally. Nitrous oxide is thought to be particularly non-toxic, though heavy long-term use can lead to a variety of serious health problems linked to the destruction of
vitamin B12 Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. ...
and
folic acid Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and ...
.


Risks of specific agents

The hypoxic effect of inhalants can cause damage to many organ systems (particularly the brain, which has a very low tolerance for oxygen deprivation), but there can also be additional toxicity resulting from either the physical properties of the compound itself or additional ingredients present in a product. Organochlorine solvents are particularly hazardous; many of these are now restricted in developed countries due to their environmental impact. *
Methylene chloride Dichloromethane (DCM or methylene chloride, methylene bichloride) is an organochlorine compound with the formula . This colorless, volatile liquid with a chloroform-like, sweet odour is widely used as a solvent. Although it is not miscible with ...
, after being metabolized, can cause
carbon monoxide poisoning Carbon monoxide poisoning typically occurs from breathing in carbon monoxide (CO) at excessive levels. Symptoms are often described as " flu-like" and commonly include headache, dizziness, weakness, vomiting, chest pain, and confusion. Large ...
. * Gasoline sniffing can cause lead poisoning, in locations where leaded gas is not banned. * Ingestion of alkyl nitrites can cause methemoglobinemia, and by inhalation it has not been ruled out. * Carbon tetrachloride can cause significant damage to multiple systems, but its association with
liver The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it ...
damage is so strong that it is used in animal models to induce liver injury. * Use of butane, propane,
nitrous oxide Nitrous oxide (dinitrogen oxide or dinitrogen monoxide), commonly known as laughing gas, nitrous, or nos, is a chemical compound, an oxide of nitrogen with the formula . At room temperature, it is a colourless non-flammable gas, and has ...
and other inhalants can create a risk of freezing
burn A burn is an injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or ultraviolet radiation (like sunburn). Most burns are due to heat from hot liquids (called scalding), solids, or fire. Burns occur ma ...
s from contact with the extremely cold liquid (See
aerosol burn An aerosol frostbite of the skin is an injury to the body caused by the pressurized gas within an aerosol spray cooling quickly, with the sudden drop in temperature sufficient to cause frostbite to the applied area. Medical studies have noted an i ...
). The risk of such contact is greatly increased by the impaired judgement and motor coordination brought on by inhalant intoxication. *
Benzene Benzene is an organic chemical compound with the molecular formula C6H6. The benzene molecule is composed of six carbon atoms joined in a planar ring with one hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms ...
use can cause bone marrow depression. It is also a known
carcinogen A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis (the formation of cancer). This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive subs ...
. *
Toluene Toluene (), also known as toluol (), is a substituted aromatic hydrocarbon. It is a colorless, water-insoluble liquid with the smell associated with paint thinners. It is a mono-substituted benzene derivative, consisting of a methyl group (CH3) a ...
can damage
myelin Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be ...
. Toxicity may also result from the pharmacological properties of the drug; excess
NMDA ''N''-methyl--aspartic acid or ''N''-methyl--aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike ...
antagonism can completely block calcium influx into neurons and provoke cell death through apoptosis, although this is more likely to be a long-term result of chronic solvent use than a consequence of short-term use.


Sudden sniffing death syndrome

Sudden sniffing death syndrome is commonly known as SSDS. Inhaling butane gas can cause drowsiness,
unconsciousness Unconsciousness is a state in which a living individual exhibits a complete, or near-complete, inability to maintain an awareness of self and environment or to respond to any human or environmental stimulus. Unconsciousness may occur as the re ...
,
asphyxia Asphyxia or asphyxiation is a condition of deficient supply of oxygen to the body which arises from abnormal breathing. Asphyxia causes generalized hypoxia, which affects primarily the tissues and organs. There are many circumstances that ca ...
, and cardiac arrhythmia. Butane is the most commonly misused volatile solvent in the UK and caused 52% of solvent-related deaths in 2000. When butane is sprayed directly into the throat, the jet of fluid can cool rapidly to −20 °C by
adiabatic expansion In thermodynamics, an adiabatic process (Greek: ''adiábatos'', "impassable") is a type of thermodynamic process that occurs without transferring heat or mass between the thermodynamic system and its environment. Unlike an isothermal process ...
, causing prolonged
laryngospasm Laryngospasm is an uncontrolled or involuntary muscular contraction (spasm) of the vocal folds. The condition typically lasts less than 60 seconds, but in cases partial blocking it may last 20 to 30 minutes and hinder inspiration, while exhala ...
. Some inhalants can also indirectly cause sudden death by cardiac arrest, in a syndrome known as "sudden sniffing death". The anaesthetic gases present in the inhalants appear to sensitize the user to adrenaline and, in this state, a sudden surge of adrenaline (e.g., from a frightening hallucination or run-in with aggressors), may cause fatal
cardiac arrhythmia Arrhythmias, also known as cardiac arrhythmias, heart arrhythmias, or dysrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. A resting heart rate that is too fast – above 100 beats per minute in adults ...
. Furthermore, the inhalation of any gas that is capable of displacing oxygen in the lungs (especially gases heavier than oxygen) carries the risk of hypoxia as a result of the very mechanism by which breathing is triggered. Since reflexive breathing is prompted by elevated carbon dioxide levels (rather than diminished blood oxygen levels), breathing a concentrated, relatively inert gas (such as computer-duster
tetrafluoroethane 1,1,1,2-Tetrafluoroethane (also known as norflurane ( INN), R-134a, Freon 134a, Forane 134a, Genetron 134a, Green Gas, Florasol 134a, Suva 134a, or HFC-134a) is a hydrofluorocarbon (HFC) and haloalkane refrigerant with thermodynamic properties s ...
or nitrous oxide) that removes carbon dioxide from the blood without replacing it with oxygen will produce no outward signs of suffocation even when the brain is experiencing hypoxia. Once full symptoms of hypoxia appear, it may be too late to breathe without assistance, especially if the gas is heavy enough to lodge in the lungs for extended periods. Even completely inert gases, such as
argon Argon is a chemical element with the symbol Ar and atomic number 18. It is in group 18 of the periodic table and is a noble gas. Argon is the third-most abundant gas in Earth's atmosphere, at 0.934% (9340 ppmv). It is more than twice as ...
, can have this effect if oxygen is largely excluded.


Legal aspects


Solvent glue

Even though solvent glue is normally a legal product, there is a case where a court has ruled that supplying glue to children is illegal.
Khaliq v HM Advocate ''Khaliq and Anor v HMA'' was a Scottish criminal case decided by the High Court of Justiciary on appeal, in which it was decided that it was an offence at common law to supply materials that were otherwise legal in the knowledge that they wo ...
was a Scottish criminal case decided by the
High Court of Justiciary The High Court of Justiciary is the supreme criminal court in Scotland. The High Court is both a trial court and a court of appeal. As a trial court, the High Court sits on circuit at Parliament House or in the adjacent former Sheriff Cour ...
on appeal, in which it was decided that it was an offense at
common law In law, common law (also known as judicial precedent, judge-made law, or case law) is the body of law created by judges and similar quasi-judicial tribunals by virtue of being stated in written opinions."The common law is not a brooding omnipres ...
to supply glue-sniffing materials that were otherwise legal in the knowledge that they would be used recreationally by children. Two shopkeepers in
Glasgow Glasgow ( ; sco, Glesca or ; gd, Glaschu ) is the most populous city in Scotland and the fourth-most populous city in the United Kingdom, as well as being the 27th largest city by population in Europe. In 2020, it had an estimated popul ...
were arrested and charged for supplying children with "glue-sniffing kits" consisting of a quantity of petroleum-based glue in a plastic bag. They argued there was nothing illegal about the items that they had supplied. On appeal, the High Court took the view that, even though glue and plastic bags might be perfectly legal, everyday items, the two shopkeepers knew perfectly well that the children were going to use the articles as inhalants and the charge on the indictment should stand. When the case came to trial at Glasgow High Court the two were sentenced to three years' imprisonment. "Thirty-eight of 50 Sstates have enacted laws making various inhalants unavailable to those under the age of 18. Other states prohibit the sale of these items to anyone without recognition of purpose for the purchase. Some states mandate laws against using these products for purposes of getting high, while some states have laws about possessing certain inhalants. Nearly every state imposes fines and jail terms for violation of their specific laws." "Connecticut law bans the unauthorized manufacture or compounding, possession, control, sale, delivery, or administration of any "restricted substance". It defines restricted substances as... specific volatile substances if they are sold, compounded, possessed or controlled, or delivered or administered to another person for breathing, inhaling, sniffing, or drinking to induce a stimulant, depressant, or hallucinogenic effect. Violators can be fined up to $100." As well, 24 states "ban the use, possession, or sale or other distribution of inhalants... like glue and solvents." "Louisiana prohibits the sale, transfer, or possession of model glue and inhalable toluene substances to minors. In Ohio, it is illegal to inhale certain compounds for intoxication—a common, general prohibition other states have enacted. Some states draw their prohibitions more narrowly... In Massachusetts, retailers must ask minors for identification before selling them glue or cement that contains a solvent that can release toxic vapors."


Propellant gases

"New Jersey... prohibits selling or offering to sell minors products containing chlorofluorocarbon that is used in refrigerant."


Poppers

The sale of alkyl nitrite-based poppers was banned in Canada in 2013. Although not considered a narcotic and not illegal to possess or use, they are considered a drug. Sales that are not authorized can now be punished with fines and prison. Since 2007, reformulated poppers containing
isopropyl nitrite The chemical compound isopropyl nitrite (or 2-propyl nitrite) is an alkyl nitrite made from isopropanol. It is a clear pale yellow oil that is insoluble in water. Applications Isopropyl nitrite is one of the compounds used as poppers, an inha ...
are sold in Europe because only isobutyl nitrite is prohibited. In France, the sale of products containing butyl nitrite, pentyl nitrite, or isomers thereof, has been prohibited since 1990 on grounds of danger to consumers. In 2007, the government extended this prohibition to all alkyl nitrites that were not authorized for sale as drugs. After litigation by sex shop owners, this extension was quashed by the
Council of State A Council of State is a governmental body in a country, or a subdivision of a country, with a function that varies by jurisdiction. It may be the formal name for the cabinet or it may refer to a non-executive advisory body associated with a head o ...
on the grounds that the government had failed to justify such a blanket prohibition: according to the court, the risks cited, concerning rare accidents often following abnormal usage, rather justified compulsory warnings on the packaging. In the United Kingdom, poppers are widely available and frequently (legally) sold in gay clubs/bars,
sex shops A sex shop is a retailer that sells products related to adult sexual or erotic entertainment, such as sex toys, lingerie, pornography, and other related products. An early precursor of the modern sex shop was a chain of stores set up in th ...
, drug paraphernalia
head shops A head shop is a retail outlet specializing in paraphernalia used for consumption of cannabis and tobacco and items related to cannabis culture and related countercultures. They emerged from the hippie counterculture in the late 1960s, and ...
, over the Internet and on markets. It is illegal under
Medicines Act 1968 The Medicines Act 1968 is an Act of Parliament of the United Kingdom, more properly: An Act to make new provision with respect to medicinal products and related matters, and for purposes connected therewith. It governs the control of medicines for ...
to sell them advertised for human consumption, and to bypass this, they are usually sold as odorizers. In the U.S., originally marketed as a prescription drug in 1937, amyl nitrite remained so until 1960, when the
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
removed the prescription requirement due to its safety record. This requirement was reinstated in 1969, after observation of an increase in recreational use. Other alkyl nitrites were outlawed in the U.S. by Congress through the Anti-Drug Abuse Act of 1988. The law includes an exception for commercial purposes. The term ''commercial purpose'' is defined to mean any use other than for the production of consumer products containing volatile alkyl nitrites meant for inhaling or otherwise introducing volatile alkyl nitrites into the human body for euphoric or physical effects. The law came into effect in 1990. Visits to retail outlets selling these products reveal that some manufacturers have since reformulated their products to abide by the regulations, through the use of the legal
cyclohexyl nitrite Cyclohexyl nitrite is an organic compound, with formula C6H11NO2. It is the ester of cyclohexanol and nitrous acid, i.e. it is an alkyl nitrite. Like amyl nitrite and butyl nitrite, it acts as an antianginal due to vasodilation. The compound is ...
as the primary ingredient in their products, which are sold as video head cleaners, polish removers, or room odorants.


Nitrous oxide

In the United States, possession of nitrous oxide is legal under federal law and is not subject to
DEA The Drug Enforcement Administration (DEA; ) is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating drug trafficking and distribution within the U.S. It is the lead agency for domestic en ...
purview. It is, however, regulated by the
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
under the Food Drug and Cosmetics Act; prosecution is possible under its "misbranding" clauses, prohibiting the sale or distribution of nitrous oxide for the purpose of human consumption as a recreational drug. Many states have laws regulating the possession, sale, and distribution of nitrous oxide. Such laws usually ban distribution to minors or limit the amount of nitrous oxide that may be sold without a special license. For example, in the state of California, possession for recreational use is prohibited and qualifies as a misdemeanor. In New Zealand, the Ministry of Health has warned that nitrous oxide is a prescription medicine, and its sale or possession without a prescription is an offense under the Medicines Act. This statement would seemingly prohibit all non-medicinal uses of the chemical, though it is implied that only recreational use will be legally targeted. In
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
, for general anesthesia purposes, nitrous oxide is available as Nitrous Oxide IP. India's gas cylinder rules (1985) permit the transfer of gas from one cylinder to another for breathing purposes. Because India's Food & Drug Authority (FDA-India) rules state that transferring a drug from one container to another (refilling) is equivalent to manufacturing, anyone found doing so must possess a drug manufacturing license.


Patterns of non-medical use

Inhalant drugs are often used by children, teenagers, incarcerated or institutionalized people, and impoverished people, because these solvents and gases are ingredients in hundreds of legally available, inexpensive products, such as
deodorant A deodorant is a substance applied to the body to prevent or mask body odor due to bacterial breakdown of perspiration or vaginal secretions, for example in the armpits, groin, or feet. A subclass of deodorants, called antiperspirants, prevents ...
sprays,
hair spray Hair spray (also hair lacquer or spritz) is a common cosmetic hairstyling product that is sprayed onto hair to protect against humidity and wind. Hair sprays typically consist of several components for the hair as well as a propellant. Ingr ...
,
contact cement Impact glue, contact glue or neoprene glue, is a type of glue, used mainly to glue plastic foams, laminates, metal panels, etc. . It also allows the mounting of supports of different types (metal on wood, cork on plaster, wood on cement, etc ...
and aerosol air fresheners. However, most users tend to be "... adolescents (between the ages of 12 and 17)." In some countries, chronic, heavy inhalant use is concentrated in marginalized, impoverished communities. Young people who become used to heavy amounts of inhalants chronically are also more likely to be those who are isolated from their families and community. The article "Epidemiology of Inhalant Abuse: An International Perspective" notes that " e most serious form of obsession with inhalant use probably occurs in countries other than the United States where young children live on the streets completely without family ties. These groups almost always use inhalants at very high levels (Leal et al. 1978). This isolation can make it harder to keep in touch with the sniffer and encourage him or her to stop sniffing." The article also states that "... high nhalant userates among barrio
Hispanics The term ''Hispanic'' ( es, hispano) refers to people, cultures, or countries related to Spain, the Spanish language, or Hispanidad. The term commonly applies to countries with a cultural and historical link to Spain and to viceroyalties forme ...
almost undoubtedly are related to the poverty, lack of opportunity, and social dysfunction that occur in barrios" and states that the "... same general tendency appears for Native-American youth" because "... Indian reservations are among the most disadvantaged environments in the United States; there are high rates of unemployment, little opportunity, and high rates of alcoholism and other health problems." There are a wide range of social problems associated with inhalant use, such as feelings of distress,
anxiety Anxiety is an emotion which is characterized by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. Anxiety is different than fear in that the former is defined as the anticipation of a future threat wh ...
and grief for the community; violence and damage to property; violent crime; stresses on the
juvenile justice system A juvenile court, also known as young offender's court or children's court, is a tribunal having special authority to pass judgements for crimes that are committed by children who have not attained the age of majority. In most modern legal s ...
; and stresses on youth agencies and support services.


Africa and Asia

Glue and gasoline (petrol) sniffing is also a problem in parts of Africa, especially with street children. In India and South Asia, three of the most widely used inhalants are the
Dendrite Dendrites (from Greek δένδρον ''déndron'', "tree"), also dendrons, are branched protoplasmic extensions of a nerve cell that propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the ...
brand and other forms of contact adhesives and rubber cement manufactured in
Kolkata Kolkata (, or , ; also known as Calcutta , the official name until 2001) is the capital of the Indian state of West Bengal, on the eastern bank of the Hooghly River west of the border with Bangladesh. It is the primary business, comme ...
, and
toluene Toluene (), also known as toluol (), is a substituted aromatic hydrocarbon. It is a colorless, water-insoluble liquid with the smell associated with paint thinners. It is a mono-substituted benzene derivative, consisting of a methyl group (CH3) a ...
s in
paint thinner A paint thinner is a solvent used to thin oil-based paints. Solvents labeled "paint thinner" are usually mineral spirits having a flash point at about 40 °C (104 °F), the same as some popular brands of charcoal starter. Common solv ...
s. Genkem is a brand of glue, which had become the generic name for all the glues used by glue-sniffing children in Africa before the manufacturer replaced
n-hexane Hexane () is an organic compound, a straight-chain alkane with six carbon atoms and has the molecular formula C6H14. It is a colorless liquid, odorless when pure, and with boiling points approximately . It is widely used as a cheap, relatively ...
in its ingredients in 2000.Cassere, Di (14 November 2000)
Glue loses high to save street-kid addicts.
''The Independent'' (South Africa)
The
United Nations Office on Drugs and Crime The United Nations Office on Drugs and Crime (UNODC; French: ''Office des Nations unies contre la drogue et le crime'') is a United Nations office that was established in 1997 as the Office for Drug Control and Crime Prevention by combining the ...
has reported that glue sniffing is at the core of "street culture" in
Nairobi Nairobi ( ) is the capital and largest city of Kenya. The name is derived from the Maasai phrase ''Enkare Nairobi'', which translates to "place of cool waters", a reference to the Nairobi River which flows through the city. The city proper h ...
,
Kenya ) , national_anthem = " Ee Mungu Nguvu Yetu"() , image_map = , map_caption = , image_map2 = , capital = Nairobi , coordinates = , largest_city = Nairobi ...
, and that the majority of street children in the city are habitual solvent users. Research conducted by Cottrell-Boyce for the African Journal of Drug and Alcohol Studies found that glue sniffing amongst Kenyan street children was primarily functional – dulling the senses against the hardship of life on the street – but it also provided a link to the support structure of the "street family" as a potent symbol of shared experience. Similar incidents of glue sniffing among destitute youth in the
Philippines The Philippines (; fil, Pilipinas, links=no), officially the Republic of the Philippines ( fil, Republika ng Pilipinas, links=no), * bik, Republika kan Filipinas * ceb, Republika sa Pilipinas * cbk, República de Filipinas * hil, Republ ...
have also been reported, most commonly from groups of street children and teenagers collectively known as "Rugby" boys, which were named after a brand of toluene-laden contact cement. Other toluene-containing substances have also been used, most notably the Vulca Seal brand of roof sealants.
Bostik Bostik is a manufacturer and distributor of adhesives and sealants for the construction, industrial and consumer markets. With annual sales of €2.1 billion, the company employs 6,000 people and has a presence in more than 40 countries. Bo ...
Philippines, which currently owns the Rugby and Vulca Seal brands, has since responded to the issue by adding
bitterant A bitterant (or bittering agent) is a chemical that is added to a product to make it smell or taste bitter. Bitterants are commonly used as aversive agents to discourage the inhalation or ingestion of toxic substances. Examples of use *The add ...
s such as
mustard oil Mustard oil can mean either the pressed oil used for cooking, or a pungent essential oil also known as volatile oil of mustard. The essential oil results from grinding mustard seed, mixing the grounds with water, and extracting the resulting vola ...
to their Rugby line, as well as reformulating it by replacing toluene with
xylene In organic chemistry, xylene or xylol (; IUPAC name: dimethylbenzene) are any of three organic compounds with the formula . They are derived from the substitution of two hydrogen atoms with methyl groups in a benzene ring; which hydrogens are s ...
. Several other manufacturers have also followed suit. Another very common inhalant is Erase-X, a
correction fluid A correction fluid is an opaque, usually white fluid applied to paper to mask errors in text. Once dried, it can be handwritten or typed upon. It is typically packaged in small bottles, lids attached to brushes (or triangular pieces of foam) th ...
that contains toluene. It has become very common for school and college students to use it, because it is easily available in stationery shops in India. This fluid is also used by street and working children in Delhi.


Europe and North America

In the UK, marginalized youth use a number of inhalants, such as solvents and propellants. In Russia and Eastern Europe, gasoline sniffing became common on Russian ships following attempts to limit the supply of alcohol to ship crews in the 1980s. The documentary '' Children Underground'' depicts the huffing of a solvent called
Aurolac Aurolac is an industrial adhesive sold in Romania, designed for use in repairing terracotta stoves, which is commonly abused as an inhalant. The law HG 767/2001 applies restrictions on where and how aurolac, which it uses as a generic term for a var ...
(a product used in chroming) by Romanian homeless children. During the interwar period, the inhalation of
ether In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be ...
( etheromania) was widespread in some regions of Poland, especially in
Upper Silesia Upper Silesia ( pl, Górny Śląsk; szl, Gůrny Ślůnsk, Gōrny Ślōnsk; cs, Horní Slezsko; german: Oberschlesien; Silesian German: ; la, Silesia Superior) is the southeastern part of the historical and geographical region of Silesia, locate ...
. Tens of thousands of people were affected by this problem. In Canada, Native children in the isolated Northern Labrador community of
Davis Inlet Davis Inlet was a Naskapi community in the Canadian province of Newfoundland and Labrador, formerly inhabited by the Mushuau Innu First Nation. It was named for its adjacent fjord, itself named for English explorer, John Davis, who in 1587 char ...
were the focus of national concern in 1993, when many were found to be sniffing gasoline. The Canadian and provincial
Newfoundland and Labrador Newfoundland and Labrador (; french: Terre-Neuve-et-Labrador; frequently abbreviated as NL) is the easternmost provinces and territories of Canada, province of Canada, in the country's Atlantic Canada, Atlantic region. The province comprises t ...
governments intervened on a number of occasions, sending many children away for treatment. Despite being moved to the new community of Natuashish in 2002, serious inhalant use problems have continued. Similar problems were reported in
Sheshatshiu Sheshatshiu () is an Innu federal reserve and designated place in the Canadian province of Newfoundland and Labrador. The reserve is approximately north of Happy Valley-Goose Bay. Some references may spell the community's name as Sheshatshit, ...
in 2000 and also in
Pikangikum First Nation The Pikangikum First Nation (, Ojibwe: ''Bigaanjigamiing'', unpointed ᐱᑲᐣᒋᑲᒥᐠ,,pointed ᐱᑳᐣᒋᑲᒦᐣᐠ) is an Ojibwe First Nation located on the Pikangikum 14 Reserve, in Unorganized Kenora District in Northwestern Ontar ...
. In 2012, the issue once again made the news media in Canada. In Mexico, the inhaling of a mixture of gasoline and industrial solvents, known locally as "Activo" or "Chemo", has risen in popularity among the homeless and among the street children of
Mexico City Mexico City ( es, link=no, Ciudad de México, ; abbr.: CDMX; Nahuatl: ''Altepetl Mexico'') is the capital city, capital and primate city, largest city of Mexico, and the List of North American cities by population, most populous city in North Amer ...
in recent years. The mixture is poured onto a handkerchief and inhaled while held in one's fist. In the US,
ether In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be ...
was used as a recreational drug during the 1930s
Prohibition era Prohibition is the act or practice of forbidding something by law; more particularly the term refers to the banning of the manufacture, storage (whether in barrels or in bottles), transportation, sale, possession, and consumption of alcoholic be ...
, when alcohol was made illegal. Ether was either sniffed or drunk and, in some towns, replaced alcohol entirely. However, the risk of death from excessive sedation or overdose is greater than that with alcohol, and ether drinking is associated with damage to the stomach and gastrointestinal tract. Use of glue, paint and gasoline became more common after the 1950s. Model airplane glue-sniffing as problematic behavior among youth was first reported in 1959 and increased in the 1960s. Use of aerosol sprays became more common in the 1980s, as older propellants such as
CFCs Chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) are fully or partly halogenated hydrocarbons that contain carbon (C), hydrogen (H), chlorine (Cl), and fluorine (F), produced as volatile derivatives of methane, ethane, and propan ...
were phased out and replaced by more environmentally friendly compounds such as propane and butane. Most inhalant solvents and gases are not regulated under drug laws such as the United States Controlled Substances Act. However, many US states and Canadian cities have placed restrictions on the sale of some solvent-containing products to minors, particularly for products widely associated with sniffing, such as model cement. The practice of inhaling such substances is sometimes colloquially referred to as huffing, sniffing (or glue sniffing), dusting, or chroming.


Australia

Australia has long faced a petrol (gasoline) sniffing problem in isolated and impoverished aboriginal communities. Although some sources argue that sniffing was introduced by United States
servicemen The term serviceman, alternatively service member, refers to enlisted members of a nation's armed forces. More generally, the term can be applied to officers as well. For more information see: *Soldier *Sailor *Airman *Marine *Coast guard ...
stationed in the nation's
Top End The Top End of Australia's Northern Territory is a geographical region encompassing the northernmost section of the Northern Territory, which aside from the Cape York Peninsula is the northernmost part of the Australian continent. It covers a ra ...
during
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing ...
or through experimentation by 1940s-era
Cobourg Peninsula The Cobourg Peninsula is located east of Darwin in the Northern Territory, Australia. It is deeply indented with coves and bays, covers a land area of about , and is virtually uninhabited with a population ranging from about 20 to 30 in five ...
sawmill workers, other sources claim that inhalant abuse (such as glue inhalation) emerged in Australia in the late 1960s. Chronic, heavy petrol sniffing appears to occur among remote, impoverished
indigenous Indigenous may refer to: *Indigenous peoples *Indigenous (ecology), presence in a region as the result of only natural processes, with no human intervention *Indigenous (band), an American blues-rock band *Indigenous (horse), a Hong Kong racehorse ...
communities, where the ready accessibility of petrol has helped to make it a common addictive substance. In Australia, petrol sniffing now occurs widely throughout remote Aboriginal communities in the
Northern Territory The Northern Territory (commonly abbreviated as NT; formally the Northern Territory of Australia) is an Australian territory in the central and central northern regions of Australia. The Northern Territory shares its borders with Western Aust ...
,
Western Australia Western Australia (commonly abbreviated as WA) is a state of Australia occupying the western percent of the land area of Australia excluding external territories. It is bounded by the Indian Ocean to the north and west, the Southern Ocean to th ...
, northern parts of
South Australia South Australia (commonly abbreviated as SA) is a state in the southern central part of Australia. It covers some of the most arid parts of the country. With a total land area of , it is the fourth-largest of Australia's states and territories ...
, and
Queensland ) , nickname = Sunshine State , image_map = Queensland in Australia.svg , map_caption = Location of Queensland in Australia , subdivision_type = Country , subdivision_name = Australia , established_title = Before federation , establishe ...
. The number of people sniffing petrol goes up and down over time as young people experiment or sniff occasionally. "Boss", or chronic, sniffers may move in and out of communities; they are often responsible for encouraging young people to take it up. A 1983 survey of 4,165 secondary students in New South Wales showed that solvents and aerosols ranked just after analgesics (e.g., codeine pills) and alcohol for drugs that were inappropriately used. This 1983 study did not find any common usage patterns or social class factors. The causes of death for inhalant users in Australia included pneumonia, cardiac failure/arrest, aspiration of vomit, and burns. In 1985, there were 14 communities in Central Australia reporting young people sniffing. In July 1997, it was estimated that there were around 200 young people sniffing petrol across 10 communities in Central Australia. Approximately 40 were classified as chronic sniffers. There have been reports of young Aboriginal people sniffing petrol in the urban areas around Darwin and Alice Springs. In 2005, the Government of Australia and BP Australia began the usage of
opal fuel Opal is a variety of low-aromatic 91 RON petrol developed in 2005 by BP Australia to combat the rising use of petrol as an inhalant in remote Indigenous Australian communities. Though more expensive to produce, requiring a $0.33/litre Federal sub ...
in remote areas prone to petrol sniffing. Opal is a non-sniffable fuel (which is much less likely to cause a high) and has made a difference in some indigenous communities.


In popular culture


Music and musical culture

One of the early musical references to inhalant use occurs in the 1974 Elton John song "
The Bitch Is Back "The Bitch Is Back" is a rock song written by English musician Elton John and songwriter Bernie Taupin, and performed by John. It was the second single released from John's 1974 album '' Caribou'', and reached number 1 in Canada (his sixth i ...
", in the line "I get high in the evening sniffing pots of glue." Inhalant use, especially glue-sniffing, is widely associated with the late-1970s
punk Punk or punks may refer to: Genres, subculture, and related aspects * Punk rock, a music genre originating in the 1970s associated with various subgenres * Punk subculture, a subculture associated with punk rock, or aspects of the subculture s ...
youth subculture in the UK and North America. Raymond Cochrane and Douglas Carroll claim that when glue sniffing became widespread in the late 1970s, it was "adopted by punks because public egativeperceptions of sniffing fitted in with their self-image" as rebels against societal values.Raymond Cochrane, Douglas Carroll, ''Psychology and Social Issues: A Tutorial Text'', published 1991, Routledge 227 pages While punks at first used inhalants "experimentally and as a cheap high, adult disgust and hostility
o the practice O, or o, is the fifteenth Letter (alphabet), letter and the fourth vowel letter in the Latin alphabet, used in the English alphabet, modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in ...
encouraged punks to use glue sniffing as a way of shocking society." As well, using inhalants was a way of expressing their anti-corporatist
DIY "Do it yourself" ("DIY") is the method of building, modifying, or repairing things by oneself without the direct aid of professionals or certified experts. Academic research has described DIY as behaviors where "individuals use raw and sem ...
(do it yourself) credo; by using inexpensive household products as inhalants, punks did not have to purchase industrially manufactured liquor or beer. One history of the punk subculture argues that "substance abuse was often referred to in the music and did become synonymous with the genre, glue-sniffing especially" because the youths' "faith in the future had died and that the youth just didn't care anymore" due to the "awareness of the threat of nuclear war and a pervasive sense of doom." In a BBC interview with a person who was a punk in the late 1970s, they said that "there was a real fear of imminent nuclear war—people were sniffing glue knowing that it could kill them, but they didn't care because they believed that very soon everybody would be dead anyway." A number of 1970s punk rock and 1980s
hardcore punk Hardcore punk (also known as simply hardcore) is a punk rock music genre and subculture that originated in the late 1970s. It is generally faster, harder, and more aggressive than other forms of punk rock. Its roots can be traced to earlier p ...
songs refer to inhalant use. The Ramones, an influential early US punk band, referred to inhalant use in several of their songs. The song " Now I Wanna Sniff Some Glue" describes adolescent boredom, and the song "Carbona not Glue" states, "My brain is stuck from shooting glue." An influential punk fanzine about the subculture and music took its name (''
Sniffin' Glue ''Sniffin' Glue and Other Rock 'N' Roll Habits...'', widely known as simply ''Sniffin' Glue'', was a monthly punk zine started by Mark Perry in July 1976 and released for about a year. The name is derived from a Ramones song " Now I Wanna Sniff ...
'') from the Ramones song. The 1980s punk band
The Dead Milkmen The Dead Milkmen is an American punk rock band formed in 1983 in Philadelphia. Their original lineup consisted of vocalist and keyboardist Rodney Linderman ("Rodney Anonymous"), guitarist and vocalist Joe Genaro ("Joe Jack Talcum"), bassist Da ...
wrote a song, "Life is Shit" from their album '' Beelzebubba'', about two friends hallucinating after sniffing glue. Punk-band-turned-hip-hop group the Beastie Boys penned a song "Hold it Now – Hit It", which includes the line "cause I'm beer drinkin, breath stinkin, sniffing glue." Their song "Shake Your Rump" includes the lines, "Should I have another sip no skip it/In the back of the ride and bust with the whippits".
Pop punk Pop punk (or punk pop) is a rock music genre that combines elements of punk rock with power pop or pop. It is defined for its emphasis on classic pop songcraft, as well as adolescent and anti- suburbia themes, and is distinguished from other p ...
band Sum 41 wrote a song, "
Fat Lip "Fat Lip" is a song by Canadian rock band Sum 41. It is the fourth track on their debut album, ''All Killer No Filler'' (2001), and was released as the lead single in April 2001. It is the band's most successful single to date, topping the '' B ...
", which refers to a character who does not "make sense from all the gas you be huffing..." The song ''Lança-perfume'', written and performed by Brazilian pop star
Rita Lee Rita Lee Jones (; born 31 December 1947) is a Brazilian rock singer, composer and writer. She is a former member of the Brazilian band Os Mutantes and is a popular figure in Brazilian entertainment, where she is also known for being an animal ...
, became a national hit in 1980. The song is about chloroethane and its widespread recreational sale and use during the rise of Brazil's carnivals. Inhalants are referred to by bands from other genres, including several grunge bands—an early 1990s genre that was influenced by punk rock. The 1990s grunge band
Nirvana ( , , ; sa, निर्वाण} ''nirvāṇa'' ; Pali: ''nibbāna''; Prakrit: ''ṇivvāṇa''; literally, "blown out", as in an oil lampRichard Gombrich, ''Theravada Buddhism: A Social History from Ancient Benāres to Modern Colombo.' ...
, which was influenced by punk music, penned a song, " Dumb", in which Kurt Cobain sings "my heart is broke / But I have some glue/help me inhale / And mend it with you". L7, an all-female grunge band, penned a song titled "Scrap" about a skinhead who inhales spray-paint fumes until his mind "starts to gel". Also in the 1990s, the
Britpop Britpop was a mid-1990s British-based music culture movement that emphasised Britishness. It produced brighter, catchier alternative rock, partly in reaction to the popularity of the darker lyrical themes of the US-led grunge music and to the ...
band
Suede Suede (pronounced ) is a type of leather with a fuzzy, napped finish, commonly used for jackets, shoes, fabrics, purses, furniture, and other items. The term comes from the French , which literally means "gloves from Sweden". The term was firs ...
had a UK hit with their song "
Animal Nitrate "Animal Nitrate" is the third single by English rock band Suede, released through Nude Records on 22 February 1993 and later included on the band's debut album ''Suede''. It charted at 7 on the UK Singles Chart, making it the highest-charting ...
" whose title is a thinly veiled reference to
amyl nitrite Amyl nitrite is a chemical compound with the formula C5H11ONO. A variety of isomers are known, but they all feature an amyl group attached to the nitrite functional group. The alkyl group is unreactive and the chemical and biological properties ...
. The Beck song "Fume" from his "Fresh Meat and Old Slabs" release is about inhaling
nitrous oxide Nitrous oxide (dinitrogen oxide or dinitrogen monoxide), commonly known as laughing gas, nitrous, or nos, is a chemical compound, an oxide of nitrogen with the formula . At room temperature, it is a colourless non-flammable gas, and has ...
. Another Beck song, "Cold Ass Fashion", contains the line "O.G. – Original Gluesniffer!" Primus's 1998 song " Lacquer Head" is about adolescents who use inhalants to get high. Hip hop performer Eminem wrote a song, "Bad Meets Evil", which refers to breathing "... ether in three lethal amounts." The Brian Jonestown Massacre, a retro-rock band from the 1990s, has a song "Hyperventilation", which is about sniffing model-airplane cement. Frank Zappa's song "Teenage Wind" from 1981 has a reference to glue sniffing: "Nothing left to do but get out the 'ol glue; Parents, parents; Sniff it good now..."


Films

A number of films have depicted or referred to the use of solvent inhalants. In the 1980 comedy film ''
Airplane! ''Airplane!'' (alternatively titled ''Flying High!'') is a 1980 American parody film written and directed by the brothers David Zucker, David and Jerry Zucker, and Jim Abrahams in their directorial debuts, and produced by Jon Davison (film prod ...
'', the character of McCroskey (
Lloyd Bridges Lloyd Vernet Bridges Jr. (January 15, 1913 – March 10, 1998) was an American film, stage and television actor who starred in a number of television series and appeared in more than 150 feature films. He was the father of four children, includi ...
) refers to his inhalant use when he states, "I picked the wrong week to quit sniffing glue." In the 1996 film ''
Citizen Ruth ''Citizen Ruth'' is a 1996 American satirical black comedy film directed by Alexander Payne, in his feature film directorial debut, and starring Laura Dern, Swoosie Kurtz, Kelly Preston, Burt Reynolds, Kurtwood Smith, Mary Kay Place, Kenneth ...
'', the character Ruth (
Laura Dern Laura Elizabeth Dern (born February 10, 1967) is an American actress. She is the recipient of numerous accolades, including an Academy Award, a Primetime Emmy Award, a BAFTA Award, and five Golden Globe Awards. Born to actor Bruce Dern and a ...
), a homeless drifter, is depicted inhaling patio sealant from a paper bag in an alleyway. In the tragicomedy ''
Love Liza ''Love Liza'' is a 2002 American tragicomedic drama directed by Todd Louiso and starring Philip Seymour Hoffman, Kathy Bates, Jack Kehler, Wayne Duvall, Sarah Koskoff and Stephen Tobolowsky. The film is written by Gordy Hoffman, a playwright and t ...
'', the main character, played by
Philip Seymour Hoffman Philip Seymour Hoffman (July 23, 1967 – February 2, 2014) was an American actor. Known for his distinctive supporting and character roles—typically lowlifes, eccentrics, underdogs, and misfits—he acted in many films and theatrical produ ...
, plays a man who takes up building remote-controlled airplanes as a hobby to give him an excuse to sniff the fuel in the wake of his wife's suicide.
Harmony Korine Harmony Korine (born January 4, 1973, some sources report September 1, 1974)
" Retrieved on 2009-10-26.
is an Ame ...
's 1997 ''
Gummo ''Gummo'' is a 1997 American experimental drama film written and directed by Harmony Korine, starring Jacob Reynolds, Nick Sutton, Jacob Sewell, and Chloë Sevigny. The film is set (but was not filmed) in Xenia, Ohio, a Midwestern American tow ...
'' depicts adolescent boys inhaling contact cement for a high. Edet Belzberg's 2001 documentary '' Children Underground'' chronicles the lives of Romanian street children addicted to inhaling paint. In '' The Basketball Diaries'', a group of boys is huffing Carbona cleaning liquid at 3 minutes and 27 seconds into the movie; further on, a boy is reading a diary describing the experience of sniffing the cleaning liquid. In the David Lynch film '' Blue Velvet'', the bizarre and manipulative character played by Dennis Hopper uses a mask to inhale amyl nitrite. In '' Little Shop of Horrors'',
Steve Martin Stephen Glenn Martin (born August 14, 1945) is an American actor, comedian, writer, producer, and musician. He has won five Grammy Awards, a Primetime Emmy Award, and was awarded an Honorary Academy Award in 2013. Additionally, he was nominate ...
's character dies from nitrous oxide inhalation. The 1999 independent film '' Boys Don't Cry'' depicts two young low-income women inhaling aerosol computer cleaner (compressed gas) for a buzz. In ''
The Cider House Rules ''The Cider House Rules'' (1985) is a novel by American writer John Irving, a ''Bildungsroman'' that was later adapted into a 1999 film and a stage play by Peter Parnell. The story, set in the pre– and post–World War II era, tells of a youn ...
'',
Michael Caine Sir Michael Caine (born Maurice Joseph Micklewhite; 14 March 1933) is an English actor. Known for his distinctive Cockney accent, he has appeared in more than 160 films in a career spanning seven decades, and is considered a British film ico ...
's character is addicted to inhaling ether vapors. In ''
Thirteen Thirteen or 13 may refer to: * 13 (number), the natural number following 12 and preceding 14 * One of the years 13 BC, AD 13, 1913, 2013 Music * 13AD (band), an Indian classic and hard rock band Albums * ''13'' (Black Sabbath album), 2013 * ...
'', the main character, a teen, uses a can of aerosol computer cleaner to get high. In the action movie ''
Shooter Shooting is the act or process of discharging a projectile from a ranged weapon (such as a gun, bow, crossbow, slingshot, or blowpipe). Even the acts of launching flame, artillery, darts, harpoons, grenades, rockets, and guided missiles can ...
'', an ex-serviceman on the run from the law (
Mark Wahlberg Mark Robert Michael Wahlberg (born June 5, 1971), former stage name Marky Mark, is an American actor, businessman, and former rapper. He has received multiple accolades, including a BAFTA Award, and nominations for two Academy Awards, three ...
) inhales nitrous oxide gas from a number of Whip-It! whipped cream canisters until he becomes unconscious. The South African film '' The Wooden Camera'' also depicts the use of inhalants by one of the main characters, a homeless teen, and their use in terms of socio-economic stratification. The title characters in ''
Samson and Delilah Samson and Delilah are Biblical figures. Samson and Delilah may also refer to: In music * ''Samson and Delilah'' (opera), an opera by Camille Saint-Saëns * ''Samson & Delilah'' (album), released in 2013 by V V Brown * "Samson and Delilah" (t ...
'' sniff petrol; in Samson's case, possibly causing brain damage. In the 2004 film ''
Taxi A taxi, also known as a taxicab or simply a cab, is a type of vehicle for hire with a driver, used by a single passenger or small group of passengers, often for a non-shared ride. A taxicab conveys passengers between locations of their choic ...
'',
Queen Latifah Dana Elaine Owens (born March 18, 1970), known professionally as Queen Latifah, is an American rapper, actress, and singer. Born in Newark, New Jersey, she signed with Tommy Boy Records in 1989 and released her debut album '' All Hail the Qu ...
and Jimmy Fallon are trapped in a room with a burst tank containing nitrous oxide. Queen Latifah's character curses at Fallon while they both laugh hysterically. Fallon's character asks if it is possible to die from nitrous oxide, to which Queen Latifah's character responds with "It's laughing gas, stupid!" Neither of them had any side effects other than their voices becoming much deeper while in the room. In the French horror film '' Them'', (2006) a French couple living in Romania are pursued by a gang of street children who break into their home at night. Olivia Bonamy's character is later tortured and forced to inhale
aurolac Aurolac is an industrial adhesive sold in Romania, designed for use in repairing terracotta stoves, which is commonly abused as an inhalant. The law HG 767/2001 applies restrictions on where and how aurolac, which it uses as a generic term for a var ...
from a silver-colored bag. During a flashback scene in the 2001 film '' Hannibal'', Hannibal Lecter gets Mason Verger high on amyl nitrite poppers, then convinces Verger to cut off his own face and feed it to his dogs.


Books

The science fiction story "
Waterspider "Waterspider" is a science fiction short story by American writer Philip K. Dick, first published in the January 1964 edition of ''If'' magazine. Dick's story "Waterspider" features Poul Anderson as one of the main characters. The author refers t ...
" by Philip K. Dick (first published in January 1964 in ''If'' magazine) contains a scene in which characters from the future are discussing the culture of the early 1950s. One character says: "You mean he sniffed what they called 'airplane dope'? He was a 'glue-sniffer'?", to which another character replies: "Hardly. That was a mania among adolescents and did not become widespread in fact until a decade later. No, I am speaking about imbibing alcohol."Philip K. Dick: ''Minority Report'', Millennium Books, 2000 (). See page 221. The book ''
Fear and Loathing in Las Vegas ''Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream'' is a 1971 novel in the gonzo journalism style by Hunter S. Thompson. The book is a ''roman à clef'', rooted in autobiographical incidents. The story follo ...
'' describes how the two main characters inhale
diethyl ether Diethyl ether, or simply ether, is an organic compound in the ether class with the formula , sometimes abbreviated as (see Pseudoelement symbols). It is a colourless, highly volatile, sweet-smelling ("ethereal odour"), extremely flammable li ...
and
amyl nitrite Amyl nitrite is a chemical compound with the formula C5H11ONO. A variety of isomers are known, but they all feature an amyl group attached to the nitrite functional group. The alkyl group is unreactive and the chemical and biological properties ...
.


Television

In the comedy series '' Newman and Baddiel in Pieces'', Rob Newman's inhaling gas from a foghorn was a running joke in the series. One episode of the '' Jeremy Kyle Show'' featured a woman with a 20-year butane gas addiction. In the series ''
It's Always Sunny in Philadelphia ''It's Always Sunny in Philadelphia'' is an American sitcom created by Rob McElhenney and developed by McElhenney and Glenn Howerton that premiered on August 4, 2005 on FX and later FXX beginning with the ninth season in 2013. It stars Char ...
'', Charlie Kelly has an addiction to huffing glue. Additionally, season nine episode 8 shows Dennis, Mac, and Dee getting a can of gasoline to use as a solvent, but instead end up taking turns huffing from the canister. A 2008 episode of the reality show '' Intervention'' (season 5, episode 9) featured Allison, who was addicted to huffing computer duster for the short-lived, psychoactive effects. Allison has since achieved a small but significant cult following among bloggers and YouTube users. Several
remixes A remix (or reorchestration) is a piece of media which has been altered or contorted from its original state by adding, removing, or changing pieces of the item. A song, piece of artwork, book, video, poem, or photograph can all be remixes. The o ...
of scenes from Allison's episode can be found online. Since 2009, Allison has worked with drug and alcohol treatment centers in Los Angeles County. In the third episode of season 5 of '' American Dad!'', titled "Home Adrone",
Roger Roger is a given name, usually masculine, and a surname. The given name is derived from the Old French personal names ' and '. These names are of Germanic origin, derived from the elements ', ''χrōþi'' ("fame", "renown", "honour") and ', ' ( ...
asks a flight attendant to bring him industrial adhesive and a plastic bag. In the seventh episode of the fourteenth season of South Park, Towelie, an anthropomorphic towel, develops an addiction to inhaling computer duster. In the show '' Squidbilles'', the main character Early Cuyler is often seen inhaling gas or other substances.


See also

*
Inhaler An inhaler (also known as a puffer, pump or allergy spray) is a medical device used for delivering medicines into the lungs through the work of a person's breathing. This allows medicines to be delivered to and absorbed in the lungs, which prov ...
or puffer, a medical device used for delivering medication into the body via the lungs (often used in the treatment of asthma) * ''
Khaliq v HM Advocate ''Khaliq and Anor v HMA'' was a Scottish criminal case decided by the High Court of Justiciary on appeal, in which it was decided that it was an offence at common law to supply materials that were otherwise legal in the knowledge that they wo ...
'', a Scottish criminal case in which the court ruled that it is an offense to supply materials that were used for sniffing *
Mt Theo Program The Warlpiri Youth Development Aboriginal Corporation (WYDAC), formerly known as the Mt Theo Program and then the Mt Theo-Yuendumu Substance Misuse Aboriginal Corporation, is a provider of youth services and programs for young Warlpiri people, f ...
, a successful petrol-sniffing prevention program run by the indigenous Warlpiri community in Central Australia *
Jenkem Jenkem is a purported inhalant and hallucinogen created from fermented human waste. In the mid-1990s, it was reported to be a popular street drug among Zambian youth. They would reportedly put the feces and urine in a jar or a bucket and seal ...
, a purported inhalant and hallucinogen supposedly created from fermented human waste *
List of medical inhalants {{Short description, none Drugs and therapeutic agents administered by inhalation Inhalational anesthetic agents * aliflurane * chloroform * cyclopropane * desflurane * diethyl ether * halothane * isoflurane * methoxyflurane * methoxypropane * n ...


References

;Notes


Further reading

* * *


External links


Inhalants
at National Institute on Drug Abuse *
NIDA for Teens: Inhalants
at National Institute on Drug Abuse *
Alt URL
{{DEFAULTSORT:Inhalant Abuse Substance-related disorders Drugs acting on the nervous system Drugs acting on the respiratory system Euphoriants Household chemicals Sedatives Hypnotics Psychedelic drugs Dissociative drugs Aerosol propellants Industrial gases General anesthetics