''Imjin thottimvirus'' (MJNV) is a single-stranded, enveloped, negative-sense RNA virus of the
orthohantavirus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses.
Orthohantavi ...
genus in the
Bunyavirales
''Bunyavirales'' is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class ''Ellioviricetes''. The name ''Bunyavir ...
order. It is a newly identified hantavirus isolated from the lung tissues of
Ussuri white-toothed shrews of the species ''Crocidura lasiura'' (order
Soricomorpha
Soricomorpha (from Greek "shrew-form") is a formerly used taxon within the class of mammals. In the past it formed a significant group within the former order Insectivora. However, Insectivora was shown to be polyphyletic and various new orders w ...
, family
Soricidae, subfamily
Crocidurinae
The white-toothed shrews or Crocidurinae are one of three subfamilies of the shrew family Soricidae.
The outer layer of these shrews' teeth is white, unlike that of the red-toothed shrews. These species are typically found in Africa and souther ...
) captured near the
demilitarized zone
A demilitarized zone (DMZ or DZ) is an area in which treaties or agreements between nations, military powers or contending groups forbid military installations, activities, or personnel. A DZ often lies along an established frontier or bounda ...
in the
Republic of Korea
South Korea, officially the Republic of Korea (ROK), is a country in East Asia, constituting the southern part of the Korean Peninsula and sharing a land border with North Korea. Its western border is formed by the Yellow Sea, while its east ...
during 2004 and 2005.
Virology
Phylogenetic analyses demonstrates a common ancestry with ''
Thottopalayam thottimvirus'' suggesting early evolutionary divergence. It is still unknown if MJNV is pathogenic for humans.
MJNV has been shown to be a genetically unique hantavirus. Multiple strains have been isolated from the lung tissues of Ussuri white-toothed shrews captured between 2004 and 2010. Partial M- and L-segment sequences from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive shrews revealed that the 12 MJNV strains differed by 0–12.2% and 0–2.3% at the nucleotide and amino acid levels. A similar degree of nucleotide and amino acid difference was found in a 632-nucleotide length of the L segment of nine MJNV strains. Phylogenetic analyses demonstrated a geographic relationship similar to the phylogeography of rodent-borne hantaviruses.
See also
*
Sangassou virus
''Sangassou orthohantavirus'' (SANGV) is single-stranded, negative-sense RNA virus species of the genus ''Orthohantavirus'' in the ''Bunyavirales'' order. It was first isolated in an African wood mouse ('' Hylomyscus simus'') in the forest in Gu ...
*
Sweating sickness
Sweating sickness, also known as the sweats, English sweating sickness, English sweat or ''sudor anglicus'' in Latin, was a mysterious and contagious disease that struck England and later continental Europe in a series of epidemics beginning ...
, which may have been caused by a hantavirus
*
1993 Four Corners hantavirus outbreak
The 1993 Four Corners hantavirus outbreak was an outbreak of hantavirus that caused the first known human cases of hantavirus disease in the United States. It occurred within the Four Corners region – the geographic intersection of the U.S. sta ...
References
External links
"Hantaviruses, with emphasis on Four Corners Hantavirus"by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
{{Taxonbar, from=Q57756471, from2=Q29002512, from3=Q16983548
Viral diseases
Hantaviridae
Hemorrhagic fevers