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Sangassou Virus
''Sangassou orthohantavirus'' (SANGV) is single-stranded, negative-sense RNA virus species of the genus ''Orthohantavirus'' in the ''Bunyavirales'' order. It was first isolated in an African wood mouse ('' Hylomyscus simus'') in the forest in Guinea, West Africa in 2010. It is named for the village near where the mouse was trapped. It is the first indigenous Murinae-associated African hantavirus to be discovered. Genome The virus genome consists of three segments of negative-stranded RNA; the large (L) segment encodes the viral RNA-dependent RNA polymerase, the medium (M) segment encodes the envelope glycoproteins Gn and Gc (cotranslationally cleaved from a glycoprotein precursor), and the small (S) segment encodes the nucleocapsid (N) protein. Renal syndrome In rodents, hantavirus produces a chronic infection with no adverse sequelae. In humans, hantavirus produces two major clinical syndromes: hemorrhagic fever or pulmonary syndrome. European, Asian, and African rodent-b ...
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Orthohantavirus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses. Orthohantaviruses typically cause chronic asymptomatic infection in rodents. Humans may become infected with hantaviruses through contact with rodent urine, saliva, or feces. Some strains cause potentially fatal diseases in humans, such as hantavirus hemorrhagic fever with renal syndrome (HFRS), or hantavirus pulmonary syndrome (HPS), also known as hantavirus cardiopulmonary syndrome (HCPS), while others have not been associated with known human disease (e.g. Prospect Hill virus). HPS (HCPS) is a "rare respiratory illness associated with the inhalation of aerosolized rodent excreta (urine and feces) contaminated by hantavirus particles." Human infections of hantaviruses have almost entirely been linked to human contact with rodent excrement; however, ...
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Four Corners
The Four Corners is a region of the Southwestern United States consisting of the southwestern corner of Colorado, southeastern corner of Utah, northeastern corner of Arizona, and northwestern corner of New Mexico. The Four Corners area is named after the quadripoint at the intersection of approximately 37° north latitude with 109° 03' west longitude, where the boundaries of the four states meet, and are marked by the Four Corners Monument. It is the only location in the United States where four states meet. Most of the Four Corners region belongs to semi-autonomous Native American nations, the largest of which is the Navajo Nation, followed by Hopi, Ute, and Zuni tribal reserves and nations. The Four Corners region is part of a larger region known as the Colorado Plateau and is mostly rural, rugged, and arid. In addition to the monument, commonly visited areas within Four Corners include Monument Valley, Mesa Verde National Park, Chaco Canyon, Canyons of the Ancie ...
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Neotominae
The Neotominae are a subfamily of the family Cricetidae. They consist of four tribes, 16 genera, and many species of New World rats and mice, predominantly found in North America. Among them are the well-known deer mice, white-footed mice, packrats, and grasshopper mice. Neotomines are related to the other two subfamilies of mice in the New World, the Sigmodontinae and Tylomyinae. Many authorities place them all in a single subfamily, Sigmodontinae. Taxonomy *SUBFAMILY NEOTOMINAE **Tribe Baiomyini ***Genus ''Baiomys'' - pygmy mice **** Southern pygmy mouse, ''Baiomys musculus'' **** Northern pygmy mouse, ''Baiomys taylori'' ***Genus ''Scotinomys'' - brown mice **** Alston's brown mouse, ''Scotinomys teguina'' **** Chiriqui brown mouse, ''Scotinomys xerampelinus'' **Tribe Neotomini ***Genus ''Neotoma'' - pack rats ****Subgenus ''Neotoma'' *****White-throated woodrat, ''Neotoma albigula'' ***** Tamaulipan woodrat, ''Neotoma angustapalata'' *****† Anthony's woodrat, ''Neotoma a ...
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Andes Virus
''Andes orthohantavirus'' (ANDV), a species of ''Orthohantavirus,'' is a major causative agent of hantavirus cardiopulmonary syndrome (HCPS) and hantavirus pulmonary syndrome (HPS) in South America. It is named for the Andes The Andes, Andes Mountains or Andean Mountains (; ) are the longest continental mountain range in the world, forming a continuous highland along the western edge of South America. The range is long, wide (widest between 18°S – 20°S ... mountains of Chile and Argentina, where it was first discovered. Originating in the reservoir of rodents, ''Andes orthohantavirus'' is easily transmitted to humans who come into contact with infected rodents or their fecal droppings. However, infected rodents do not appear ill, so there is no readily apparent indicator to determine whether the rodent is infected or not. Additionally, ''Andes orthohantavirus'', specifically, is the only hantavirus that can be spread by human to human contact via bodily fluids or ...
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Arvicolinae
The Arvicolinae are a subfamily of rodents that includes the voles, lemmings, and muskrats. They are most closely related to the other subfamilies in the Cricetidae (comprising the hamsters and New World rats and mice). Some authorities place the subfamily Arvicolinae in the family Muridae along with all other members of the superfamily Muroidea. Some refer to the subfamily as the Microtinae (yielding the adjective "microtine") or rank the taxon as a full family, the Arvicolidae. The Arvicolinae are the most populous group of Rodentia in the Northern Hemisphere. They often are found in fossil occlusions of bones cached by past predators such as owls and other birds of prey. Fossils of this group are often used for biostratigraphic dating of paleontological and archeological sites in North America and Europe. Description The most convenient distinguishing feature of the Arvicolinae is the nature of their molar teeth, which have prismatic cusps in the shape of alternati ...
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Tula Orthohantavirus
''Tula orthohantavirus'', formerly ''Tula virus'', (TULV) is a single-stranded, negative-sense RNA virus species of orthohantavirus first isolated from a European common vole (''Microtus arvalis'') found in Central Russia. It causes Hantavirus hemorrhagic fever with renal syndrome. The ''Microtus'' species are also found in North America, Europe, Scandinavia, Slovenia, Asia, and Western Russia. Human cases of ''Tula orthohantavirus'' have also been reported in Switzerland and Germany. See also *Sweating sickness Sweating sickness, also known as the sweats, English sweating sickness, English sweat or ''sudor anglicus'' in Latin, was a mysterious and contagious disease that struck England and later continental Europe in a series of epidemics beginning ... References External linksSloan Science and Film / Short Films / Muerto Canyonby Jen Peel 29 minutes * Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae Viral diseases Hantaviridae Hemorrhagic feve ...
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Puumala Orthohantavirus
''Puumala orthohantavirus'' (PUUV) is a species of ''Orthohantavirus''. Humans infected with the virus may develop a haemorrhagic fever with renal syndrome (HFRS) known as nephropathia epidemica. ''Puumala orthohantavirus'' HFRS is lethal in less than 0.5% of the cases.Discertation for doctoral exam; Distribution of Puumalavirus in Sweden
, by C. Ahlm, second paragraph; latest access 2012-06-04
Rarely, PUUV infection can cause Guillain-Barré syndrome. ''Puumala orthohantavirus'' was discovered and named in 1980 named after

Dobrava-Belgrade Orthohantavirus
''Dobrava-Belgrade orthohantavirus'' (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World ''Orthohantavirus''. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated in 1985 from a yellow-necked mouse (''Apodemus flavicollis'') found in the village of Dobrava, southeastern Slovenia. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown. Phylogeny Four genotypes are described: * Dobrava, observed mostly in southeastern Europe * Kurkino, observed throughout northern and eastern Europe * Saaremaa, observed in Estonia and Slovakia * Sochi, observed in the Black Sea coast region of Russia Disease Clinical presentation varies between the four genotypes. Dobrava is the most virulent, with a case-fatality rate (C ...
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Seoul Orthohantavirus
''Seoul orthohantavirus'' (SEOV) is a member of the ''Orthohantavirus'' family of rodent-borne viruses and is one of the 4 hantaviruses that are known to be able to cause Hantavirus hemorrhagic fever with renal syndrome (HFRS).US Centers for Disease Control''Virology, Hantaviruses''Page last reviewed: August 29, 2012. It is an Old World hantavirus; a negative sense, single-stranded, tri-segmented RNA virus. Seoul virus is found in ''Rattus'' species rats, most commonly ''Rattus norvegicus,'' but occasionally ''Rattus rattus''. The two distinct hantaviruses have been identified in Korea in 1976, from '' Apodemus agrarius'', and in 1980, from ''Rattus norvegicus''. In 1994, a genetically different hantavirus was identified from '' Apodemus peninsulae''. Rats do not show physiological symptoms when carrying the virus, but humans can be infected through exposure to infected rodent body fluids (blood, saliva, urine), exposure to aerosolized rat excrement, or bites from infected rats. W ...
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Hantaan Orthohantavirus
''Hantaan orthohantavirus'' (HTNV) is an enveloped, single-stranded, negative-sense RNA virus species of Old World ''Orthohantavirus''. It is the causative agent of Korean hemorrhagic fever in humans. It is named for the Hantan River in South Korea, and in turn lends the name to its genus ''Orthohantavirus'' and family ''Hantaviridae''. Natural reservoir '' Apodemus agrarius'', also known as striped field mouse, is the etiological vector of ''Hantaan orthohantavirus''. Transmission Transmission is believed to be through inhalation of aerosolized rodent urine and feces. Morbidity and mortality In hantavirus induced hemorrhagic fever, incubation time is between two and four weeks in humans before symptoms of infection present. Severity of symptoms depends on the viral load. Like Dobrava-Belgrade virus, Hantaan virus has a mortality rate of 10 to 12%. History During the Korean War (1951–1953), more than 3000 American and Korean troops fell ill with kidney failure, bl ...
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Clade
A clade (), also known as a monophyletic group or natural group, is a group of organisms that are monophyletic – that is, composed of a common ancestor and all its lineal descendants – on a phylogenetic tree. Rather than the English term, the equivalent Latin term ''cladus'' (plural ''cladi'') is often used in taxonomical literature. The common ancestor may be an individual, a population, or a species (extinct or extant). Clades are nested, one in another, as each branch in turn splits into smaller branches. These splits reflect evolutionary history as populations diverged and evolved independently. Clades are termed monophyletic (Greek: "one clan") groups. Over the last few decades, the cladistic approach has revolutionized biological classification and revealed surprising evolutionary relationships among organisms. Increasingly, taxonomists try to avoid naming taxa that are not clades; that is, taxa that are not monophyletic. Some of the relationships between organisms ...
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Shrew
Shrews (family Soricidae) are small mole-like mammals classified in the order Eulipotyphla. True shrews are not to be confused with treeshrews, otter shrews, elephant shrews, West Indies shrews, or marsupial shrews, which belong to different families or orders. Although its external appearance is generally that of a long-nosed mouse, a shrew is not a rodent, as mice are. It is, in fact, a much closer relative of hedgehogs and moles; shrews are related to rodents only in that both belong to the Boreoeutheria magnorder. Shrews have sharp, spike-like teeth, whereas rodents have gnawing front incisor teeth. Shrews are distributed almost worldwide; among the major tropical and temperate land masses, only New Guinea, Australia, and New Zealand have no native shrews; in South America shrews appeared only relatively recently, as a result of the Great American Interchange, and are present only in the northern Andes. The shrew family has 385 known species, making it the fourth-most spec ...
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