Helen Brooke Taussig (May 24, 1898 – May 20, 1986) was an American
cardiologist
Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular hear ...
, working in Baltimore and Boston, who founded the field of pediatric cardiology. She is credited with developing the concept for a procedure that would extend the lives of children born with
Tetralogy of Fallot
Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are:
*pulmonary stenosis, which is narrowing of the exit from the ri ...
(the most common cause of
blue baby syndrome
Blue baby syndrome can refer to conditions that cause cyanosis, or blueness of the skin, in babies as a result of low oxygen levels in the blood. This term has traditionally been applied to cyanosis as a result of:
#Cyanotic heart disease, whi ...
). This concept was applied in practice as a procedure known as the
Blalock-Thomas-Taussig shunt. The procedure was developed by
Alfred Blalock
Alfred Blalock (April 5, 1899 – September 15, 1964) was an American surgeon most noted for his work on the medical condition of shock as well as Tetralogy of Fallot— commonly known as Blue baby syndrome. He created, with assistance from h ...
and
Vivien Thomas
Vivien Theodore Thomas (August 29, 1910 – November 26, 1985) was an American laboratory supervisor who developed a procedure used to treat blue baby syndrome (now known as cyanotic heart disease) in the 1940s. He was the assistant to surgeon ...
, who were Taussig's colleagues at the
Johns Hopkins Hospital
The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 mo ...
.
Taussig was partially deaf following an ear infection in childhood; in early adulthood this progressed to full
deafness
Deafness has varying definitions in cultural and medical contexts. In medical contexts, the meaning of deafness is hearing loss that precludes a person from understanding spoken language, an audiological condition. In this context it is written ...
.
To compensate for her loss of hearing, she learned to use
lip-reading techniques and
hearing aid
A hearing aid is a device designed to improve hearing by making sound audible to a person with hearing loss. Hearing aids are classified as medical devices in most countries, and regulated by the respective regulations. Small audio amplifiers su ...
s to speak with her patients. Taussing also developed a method of using her fingers, rather than a
stethoscope
The stethoscope is a medical device for auscultation, or listening to internal sounds of an animal or human body. It typically has a small disc-shaped resonator that is placed against the skin, and one or two tubes connected to two earpieces. ...
, to feel the rhythm of their heartbeats.
Some of her innovations have been attributed to her ability to diagnose heart problems by touch rather than by sound.
Taussig is also known for her work in banning
thalidomide
Thalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of ...
and was widely recognized as a highly skilled physician. She was the first woman to be elected head of the
American Heart Association
The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and death ...
. She was more proud of the fact that she was the first pediatrician to be elected head of the
AMA; and in 1964 she was awarded a
Presidential Medal of Freedom
The Presidential Medal of Freedom is the highest civilian award of the United States, along with the Congressional Gold Medal. It is an award bestowed by the president of the United States to recognize people who have made "an especially merito ...
.
Early life and education
Helen Brooke Taussig was born in
Cambridge, Massachusetts
Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. As part of the Boston metropolitan area, the cities population of the 2020 U.S. census was 118,403, making it the fourth most populous city in the state, behind Boston, ...
, on May 24, 1898, to
F. W. Taussig and Edith Thomas Guild, the youngest of four children. Her father was an economist at
Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
, and her mother was one of the first students at
Radcliffe College
Radcliffe College was a women's liberal arts college in Cambridge, Massachusetts, and functioned as the female coordinate institution for the all-male Harvard College. Considered founded in 1879, it was one of the Seven Sisters colleges and he ...
, a women's college.
She spent summers as a child in
Cotuit, Massachusetts
Cotuit ( ) is one of the villages of the Town of Barnstable on Cape Cod in Barnstable County, Massachusetts, United States. Located on a peninsula on the south side of Barnstable about midway between Falmouth and Hyannis, Cotuit is bounded by t ...
,
[Taussig, Helen Brooke (1898–1986) - Dictionary definition of Taussig, Helen Brooke (1898–1986) , Encyclopedia.com: FREE online dictionary](_blank)
Retrieved 2017-05-03. and later in life had a home there.
When Taussig was 11 years old, her mother died of
tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in ...
. Helen also contracted the disease and was ill for several years, severely affecting her ability to do schoolwork. She also struggled with severe dyslexia through her early school years and was partially deaf.
Despite this, she did well at school due to diligent work and extensive tutoring from her father.
She graduated from
Cambridge School for Girls in 1917,
then studied for two years at
Radcliffe College
Radcliffe College was a women's liberal arts college in Cambridge, Massachusetts, and functioned as the female coordinate institution for the all-male Harvard College. Considered founded in 1879, it was one of the Seven Sisters colleges and he ...
before earning a
bachelor's degree
A bachelor's degree (from Middle Latin ''baccalaureus'') or baccalaureate (from Modern Latin ''baccalaureatus'') is an undergraduate academic degree awarded by colleges and universities upon completion of a course of study lasting three to six ...
and
Phi Beta Kappa
The Phi Beta Kappa Society () is the oldest academic honor society in the United States, and the most prestigious, due in part to its long history and academic selectivity. Phi Beta Kappa aims to promote and advocate excellence in the liberal a ...
membership from the
University of California, Berkeley
The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...
in 1921.
After graduating, Taussig wished to study at
Harvard Medical School
Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
, but the medical programme did not accept women (this was the case until 1945, though the first woman had applied nearly 100 years earlier, in 1847).
The program actually did accept women in theory but would not give them a degree. When Taussig was told this by the dean of the medical school, she asked why anyone would want to attend without any hope of getting a degree, to which the dean replied, "That is what we are hoping." Taussig responded, "Well, I shall not be the first to disappoint you," and left. Instead she considered applying to study public health, partially because her father thought it a more suitable field for women,
but learned that as a woman she could attend the programme but would not be recognised with a degree. She later reported asking the dean "Who wants to study for four years and get no degree for all that work?", and his replying "Nobody, I hope."
Taussig ended up taking classes at
Boston University
Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original campu ...
in
histology
Histology,
also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures vis ...
,
bacteriology Bacteriology is the branch and specialty of biology that studies the morphology, ecology, genetics and biochemistry of bacteria as well as many other aspects related to them. This subdivision of microbiology involves the identification, classificat ...
, and
anatomy
Anatomy () is the branch of biology concerned with the study of the structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old science, having its ...
, without expecting to receive a degree.
She had to sit apart from her male colleagues at the back of lecture theatres and was not supposed to speak to them.
As an anatomy student at Boston University in 1925, she published her first scientific paper on studies of
ox heart muscles with
Alexander Begg. With the encouragement of her professor Alexander Begg, Taussig applied to transfer to the
Johns Hopkins University School of Medicine
The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
, one of the few medical schools to admit women at the time, and was accepted as a full-degree candidate.
[Kelly, Evelyn B (December 2000). "Helen Brook Taussig". ''Science and Its Times''. 6: 1900 to 1949: 387–388 – via Gale In Context: Global Issues.] After completing her MD degree in 1927 at Johns Hopkins, Taussig remained for one year as a cardiology fellow and for two years as a pediatrics intern,
and received two Archibald Fellowships, spanning 1927–1930.
Taussig wanted to specialise in
Internal Medicine, but there was only one position available for a woman in that field, and it was already taken; she therefore decided to specialise in pediatrics, and ended up working in pediatric cardiology, a field that was still in its infancy.
Blalock-Thomas-Taussig shunt
Concept
Taussig's early career in pediatric cardiology at Johns Hopkins consisted of studying babies with
congenital heart defect
A congenital heart defect (CHD), also known as a congenital heart anomaly and congenital heart disease, is a defect in the structure of the heart or great vessels that is present at birth. A congenital heart defect is classed as a cardiovascular ...
s and
rheumatic fever
Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful jo ...
,
an inflammation of the heart and other organs resulting from bacterial infection, which was at the time a major source of child mortality. In the early 20th century, rheumatic heart disease made up the majority of clinical cardiology work: congenital heart defects were considered hopeless curiosities as the surgical means to correct them were extremely undeveloped so relatively little could be done to prevent the early deaths of patients with these conditions.
She then was hired by the pediatric department of Johns Hopkins, the Harriet Lane Home, as its chief, where she served from 1930 until 1963. Taussig made use of
fluoroscopy
Fluoroscopy () is an imaging technique that uses X-rays to obtain real-time moving images of the interior of an object. In its primary application of medical imaging, a fluoroscope () allows a physician to see the internal structure and functio ...
as a diagnostic tool, and developed a particular interest in infants with
cyanosis
Cyanosis is the change of body tissue color to a bluish-purple hue as a result of having decreased amounts of oxygen bound to the hemoglobin in the red blood cells of the capillary bed. Body tissues that show cyanosis are usually in locations ...
(blue-tinged appearance), often caused by the heart defect
Tetralogy of Fallot
Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are:
*pulmonary stenosis, which is narrowing of the exit from the ri ...
.
Cyanosis is caused when insufficient oxygenated blood is circulating around the body; in infants it can be known as "
blue baby syndrome
Blue baby syndrome can refer to conditions that cause cyanosis, or blueness of the skin, in babies as a result of low oxygen levels in the blood. This term has traditionally been applied to cyanosis as a result of:
#Cyanotic heart disease, whi ...
". Taussig is most remembered for her role in the development of a surgical treatment for this condition, the
Blalock-Thomas-Taussig shunt.
A new surgery first performed in 1939 by
Robert Gross corrected a common pediatric heart problem:
patent ductus arteriosus
''Patent ductus arteriosus'' (PDA) is a medical condition in which the ''ductus arteriosus'' fails to close after birth: this allows a portion of oxygenated blood from the left heart to flow back to the lungs by flowing from the aorta, which has ...
. The
ductus arteriosus
The ''ductus arteriosus'', also called the ''ductus Botalli'', named after the Italian physiologist Leonardo Botallo, is a blood vessel in the developing fetus connecting the trunk of the pulmonary artery to the proximal descending aorta. It allo ...
is a small blood vessel connecting the
pulmonary artery
A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs. The largest pulmonary artery is the ''main pulmonary artery'' or ''pulmonary trunk'' from the heart, and t ...
to the
aorta
The aorta ( ) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes ...
of a
foetus
A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal develo ...
. Since the foetus obtains oxygen via the mother's
placenta
The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mater ...
and not via its own lungs, which are fluid-filled and not yet functional, this vessel provides a shortcut, bypassing the lungs and allowing more efficient delivery of oxygenated blood around the foetus' body. In most infants, the ductus arteriosus closes within a few weeks of birth so that blood flows to the lungs to be oxygenated; if it remains open or 'patent', the normal flow of blood is disrupted. This new surgical procedure artificially closed the blood vessel.
While this was going on, Taussig observed that infants with
cyanotic heart defect
A cyanotic heart defect is any congenital heart defect (CHD) that occurs due to deoxygenated blood bypassing the lungs and entering the systemic circulation, or a mixture of oxygenated and unoxygenated blood entering the systemic circulation. It is ...
s such as
Tetralogy of Fallot
Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are:
*pulmonary stenosis, which is narrowing of the exit from the ri ...
or
pulmonary atresia
Pulmonary atresia is a congenital malformation of the pulmonary valve in which the valve orifice fails to develop. The valve is completely closed thereby obstructing the outflow of blood from the heart to the lungs. The pulmonary valve is located ...
often fared remarkably better if they also had a
patent ductus arteriosus
''Patent ductus arteriosus'' (PDA) is a medical condition in which the ''ductus arteriosus'' fails to close after birth: this allows a portion of oxygenated blood from the left heart to flow back to the lungs by flowing from the aorta, which has ...
, with less severe symptoms and longer survival.
In general, cyanotic symptoms would often begin or worsen shortly after birth, a change which Taussig suspected was caused by the natural closure of the ductus arteriosus.
In cyanotic children, bloodflow from the heart to the lungs via the pulmonary artery is often compromised; Taussig thought that surgically creating an artificial ductus linking these two vessels could increase bloodflow to the lungs and alleviate this problem, increasing survival.
She broached the idea to Robert Gross, and he was skeptical, reportedly telling her ""I have enough trouble closing the ductus arteriosus. I certainly don't want to try to make an artificial one."
The first surgeries
Two years later, Taussig obtained the collaboration of Johns Hopkins' new chief of surgery
Alfred Blalock
Alfred Blalock (April 5, 1899 – September 15, 1964) was an American surgeon most noted for his work on the medical condition of shock as well as Tetralogy of Fallot— commonly known as Blue baby syndrome. He created, with assistance from h ...
and his laboratory assistant
Vivien Thomas
Vivien Theodore Thomas (August 29, 1910 – November 26, 1985) was an American laboratory supervisor who developed a procedure used to treat blue baby syndrome (now known as cyanotic heart disease) in the 1940s. He was the assistant to surgeon ...
. The three of them developed a surgery now known as the
Blalock-Thomas-Taussig shunt. Originally, it was referred to as the Blalock-Taussig shunt: the critical input of
Vivien Thomas
Vivien Theodore Thomas (August 29, 1910 – November 26, 1985) was an American laboratory supervisor who developed a procedure used to treat blue baby syndrome (now known as cyanotic heart disease) in the 1940s. He was the assistant to surgeon ...
was overlooked because of his non-academic role and because of his race.
Following extensive experimentation on about 200 dogs,
on November 9, 1944, Blalock and Thomas performed the surgery on the first human patient.
Eileen Saxon, a 15-month-old baby, had arrived at the emergency department earlier that month severely underweight at just 5 kg, purplish blue in colour and hardly able to drink a sip without gasping for breath. Taussig diagnosed her with
Tetralogy of Fallot
Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are:
*pulmonary stenosis, which is narrowing of the exit from the ri ...
, a diagnosis which meant that without intervention she certainly would not survive to adulthood.
The procedure was an immediate success: Eileen's colour quickly returned to normal, she could drink milk more easily and gained a few kilograms. Two months after the surgery she was discharged from hospital.
However, she became cyanotic again a few months later and died shortly before her second birthday.
Despite Eileen's death, the operation was proof that the Blalock-Thomas-Taussig shunt could in principle be used to extend the lives of children with cyanotic heart disease.
By 1945, this operation had been performed on a total of three infants with
pulmonary stenosis
Pulmonic stenosis, is a dynamic or fixed obstruction of flow from the right ventricle of the heart to the pulmonary artery. It is usually first diagnosed in childhood. Signs and symptoms
Cause
Pulmonic stenosis is usually due to isolated valvula ...
and
pulmonary atresia
Pulmonary atresia is a congenital malformation of the pulmonary valve in which the valve orifice fails to develop. The valve is completely closed thereby obstructing the outflow of blood from the heart to the lungs. The pulmonary valve is located ...
. As Alfred Blalock and Helen Taussig wrote in ''
Journal of the American Medical Association
''The Journal of the American Medical Association'' (''JAMA'') is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of bio ...
'', "Heretofore there has been no satisfactory treatment for pulmonary stenosis and pulmonary atresia. A "blue" baby with a malformed heart was considered beyond the reach of surgical aid. During the past three months we have operated on 3 children with severe degrees of pulmonary stenosis and each of the patients appears to be greatly benefited. In the second and third cases, in which there was deep persistent cyanosis, the cyanosis has greatly diminished or has disappeared and the general condition of the patients is proportionally improved." Following this report, and lectures given by Blalock and Taussig at conferences around Europe and America, the procedure quickly gained worldwide acceptance.
Legacy
With the international fame this surgery drew, parents worldwide began coming to
Baltimore
Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...
to have their "blue babies" treated by Blalock and Taussig. The rapid influx of prospective patients was so great that the clinic struggled to cope, and medical visitors from around the world came to assist and to share knowledge.
By 1951, the team had operated on over 1,000 children and the surgery had a mortality rate of only 5%.
One of the major benefits of this surgery was that children gained the ability to play actively without the rapid exhaustion and frequent loss of consciousness that usually results from cyanotic heart defects. Helen Taussig reportedly kept a letter on her mantelpiece from twelve year old Jean-Pierre Cablan, written after undergoing the procedure: "''Je suis maintenant un tout autre petit garcon ... je vais pouvoir aller jouer avec mes petits camarades.''"
(''"''I am now a completely new boy... I will be able to play with the other children''."'') Often, an immediate improvement in the level of cyanosis could be seen as well. Taussig later recalled, "I suppose nothing would ever give me as much delight as seeing the first patient change from blue to pink in the operating room... bright pink cheeks and bright lips."
Nowadays, the Blalock-Thomas-Taussig shunt is useful for prolonging life and improving health in infants before heart defects can be definitively repaired, commonly as the first stage of the three-step
Norwood Procedure
The Norwood procedure is the first of three surgeries intended to create a new functional systemic circuit in patients with hypoplastic left heart syndrome and other complex heart defects with single ventricle physiology. The first successful Norw ...
. It allows infants to survive and gain weight before more complex surgeries are later attempted, and is used in the care of patients with
Tetralogy of Fallot
Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are:
*pulmonary stenosis, which is narrowing of the exit from the ri ...
,
pulmonary atresia
Pulmonary atresia is a congenital malformation of the pulmonary valve in which the valve orifice fails to develop. The valve is completely closed thereby obstructing the outflow of blood from the heart to the lungs. The pulmonary valve is located ...
, and more rare and complex abnormalities.
At the time of Taussig's death, tens of thousands of children's lives had been saved by the shunt procedure.
Further career
As a physician, Taussig pioneered the use of
x-ray
An X-ray, or, much less commonly, X-radiation, is a penetrating form of high-energy electromagnetic radiation. Most X-rays have a wavelength ranging from 10 picometers to 10 nanometers, corresponding to frequencies in the range 30&nb ...
s and
fluoroscopy
Fluoroscopy () is an imaging technique that uses X-rays to obtain real-time moving images of the interior of an object. In its primary application of medical imaging, a fluoroscope () allows a physician to see the internal structure and functio ...
simultaneously to examine changes in a baby's heart and lungs in a less invasive manner,
and was very skilled in diagnosing heart conditions by feeling the heartbeat with her fingertips, rather than listening with a
stethoscope
The stethoscope is a medical device for auscultation, or listening to internal sounds of an animal or human body. It typically has a small disc-shaped resonator that is placed against the skin, and one or two tubes connected to two earpieces. ...
.
As well as her day to day clinical work as a paediatrician, Taussig was also an accomplished academic clinician. She published 100 academic articles over her career, considering various aspects of cardiology including biomedical ethics and the evolutionary origins of heart disease. In her research into the long-term outcomes of recipients of the shunt, Taussig remained in touch with many of her patients as they grew to adulthood and middle age.
In 1947, after a decade of gathering material,
Taussig published her magnum opus, ''Congenital Malformations of the Heart'', considered to be the foundational text of pediatric cardiology as an independent field.
The book was expanded into two volumes for a second edition published in 1960.
Taussig later became an associate professor at the Johns Hopkins School of Medicine; she was promoted to full professor in 1959. At the time, she was only the second woman to reach full professor status at the university.
She continued to serve as the director of the Harriet Lane Home (the children's treatment and research centre at Johns Hopkins) until her retirement in 1963. Most paediatric clinics at the time focussed on
rheumatic fever
Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful jo ...
, which was the major source of child mortality, but because of Taussig's experience, the Harriet Lane Home was also able to provide specialist care for children with congenital heart disease. It became a world-leading centre that aspiring surgeons flocked to.
Together with the cardiologist
Richard Bing
Richard John Bing (October 12, 1909 in Nuremberg, Germany – November 8, 2010 in La Cañada Flintridge, California) was a cardiologist who made significant contributions to his field of study. He was elected to the American Philosophical Socie ...
, Taussig was in 1949 the first to describe a heart condition now known as
Taussig-Bing syndrome.
This is the second most common type of
double-outlet right ventricle (DORV), a set of rare congenital heart conditions in which the
aorta
The aorta ( ) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes ...
, which is supposed to carry oxygen-rich blood from the left
ventricle of the heart, instead is connected to the right ventricle and supplies oxygen-poor blood to the body. Several alternative methods for surgically correcting this defect have been tried over the decades since the problem was first described, and survival rates following surgical intervention are greatly improved in recent decades.
Banning of thalidomide
Around 1960, many more babies than usual began to be born in
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
,
Belgium
Belgium, ; french: Belgique ; german: Belgien officially the Kingdom of Belgium, is a country in Northwestern Europe. The country is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeast, France to th ...
and the
Netherlands
)
, anthem = ( en, "William of Nassau")
, image_map =
, map_caption =
, subdivision_type = Sovereign state
, subdivision_name = Kingdom of the Netherlands
, established_title = Before independence
, established_date = Spanish Netherl ...
with
phocomelia
Phocomelia is a condition that involves malformations of human arms and legs. Although many factors can cause phocomelia, the prominent roots come from the use of the drug thalidomide scandal, thalidomide and from genes, genetic inheritance.
Occu ...
, a previously very rare condition in which limbs are absent or small and abnormally formed. The German paediatrician
Widukind Lenz Widukind Lenz (4 February 1919, Eichenau – 25 February 1995) was a distinguished German pediatrician, medical geneticist and dysmorphologist who was among the first to recognize the thalidomide syndrome in 1961 and alert the world to the da ...
was the first to draw a link to the increasing frequency of this condition and
thalidomide
Thalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of ...
, a drug which was a popular sleeping medication at the time with the trade name
Softenon, and was often taken by pregnant women to counter
morning sickness
Morning sickness, also called nausea and vomiting of pregnancy (NVP), is a symptom of pregnancy that involves nausea or vomiting. Despite the name, nausea or vomiting can occur at any time during the day. Typically the symptoms occur between th ...
. However, when it is taken between days 35 and 49 of a pregnancy, it blocks normal limb development and causes phocomelia.
After hearing about this issue from one of her students in January 1962, Taussig travelled to Germany and examined some of these children for herself. She reached the same conclusion as Lenz: that thalidomide taken during pregnancy was causing phocomelia.
She flew back to America and launched a campaign to try to stop the pending approval of thalidomide by the
FDA
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...
, speaking at the
American College of Physicians
The American College of Physicians (ACP) is a national organization of internists, who specialize in the diagnosis, treatment, and care of adults.Sokanu "What is an Internist?" Retrieved October 20, 2014 With 161,000 members, ACP is the largest ...
, writing in journals and magazines, and testifying before Congress in 1967.
Her and others' efforts paid off: the drug was banned in the United States and Europe.
Retirement and death
Taussig formally retired from Johns Hopkins in 1963, but continued to teach, give lectures, and lobby for various causes. In addition, she kept writing scientific papers (of the 129 total that Taussig wrote, 41 were after her retirement from Johns Hopkins).
She advocated for the use of animals in medical research and for legalized abortion, as well as the benefits of
palliative care
Palliative care (derived from the Latin root , or 'to cloak') is an interdisciplinary medical caregiving approach aimed at optimizing quality of life and mitigating suffering among people with serious, complex, and often terminal illnesses. Wit ...
and
hospice
Hospice care is a type of health care that focuses on the palliation of a terminally ill patient's pain and symptoms and attending to their emotional and spiritual needs at the end of life. Hospice care prioritizes comfort and quality of life by ...
.
In 1977, Taussig moved to a retirement community in Kennett Square, Pennsylvania. Ever active, she continued making periodic trips to the
University of Delaware
The University of Delaware (colloquially UD or Delaware) is a public land-grant research university located in Newark, Delaware. UD is the largest university in Delaware. It offers three associate's programs, 148 bachelor's programs, 121 mas ...
for research work. At the time of her death, she was researching the genetic basis for congenital heart defects in birds.
On May 20, 1986, four days short of her 88th birthday, Taussig was driving a group of friends to vote in a local election when her car collided with another vehicle at an intersection. She died about an hour later at Chester County Hospital, and donated her body to Johns Hopkins.
Honors
* 1947: Chevalier (knight) of the
Legion d'Honneur
The National Order of the Legion of Honour (french: Ordre national de la Légion d'honneur), formerly the Royal Order of the Legion of Honour ('), is the highest French order of merit, both military and civil. Established in 1802 by Napoleon B ...
* 1948: Passano Foundation Award for an outstanding contribution to medical science, shared with
Alfred Blalock
Alfred Blalock (April 5, 1899 – September 15, 1964) was an American surgeon most noted for his work on the medical condition of shock as well as Tetralogy of Fallot— commonly known as Blue baby syndrome. He created, with assistance from h ...
- the first time this award was shared, and the first time it was awarded to a woman
* 1953: Honorary medal from the
American College of Chest Physicians
The American College of Chest Physicians (CHEST) is a medical association in the United States consisting of physicians and non-physician specialists in the field of chest medicine, which includes pulmonology, critical care medicine, and sleep med ...
* 1954: Feltrinelli Award
* 1954: Albert Lasker Award for Outstanding Contributions to Medicine
* 1957: Fellow of the
American Academy of Arts and Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
* 1957: Eleanor Roosevelt Achievement Award
* 1960: Honorary fellow of the
American College of Cardiology
The American College of Cardiology (ACC), based in Washington, D.C., is a nonprofit medical association established in 1949. It bestows credentials upon cardiovascular specialists who meet its qualifications. Education is a core component of the ...
* 1963: Gold Heart Award
* 1963: Achievement Award from the
American Association of University Women
The American Association of University Women (AAUW), officially founded in 1881, is a non-profit organization that advances equity for women and girls through advocacy, education, and research. The organization has a nationwide network of 170,000 ...
*1964: Presidential Medal of Freedom awarded by President
Lyndon Johnson
Lyndon Baines Johnson (; August 27, 1908January 22, 1973), often referred to by his initials LBJ, was an American politician who served as the 36th president of the United States from 1963 to 1969. He had previously served as the 37th vice ...
* 1965: The
University of Göttingen
The University of Göttingen, officially the Georg August University of Göttingen, (german: Georg-August-Universität Göttingen, known informally as Georgia Augusta) is a public research university in the city of Göttingen, Germany. Founded ...
named its cardiac clinic in honor of Taussig
* 1965: First woman and first pediatrician to be elected president of the
American Heart Association
The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and death ...
* 1970: Blackwell Award from
Hobart and William Smith Colleges
Hobart and William Smith Colleges are Private college, private Liberal arts colleges in the United States, liberal arts colleges in Geneva, New York. They trace their origins to Geneva Academy established in 1797. Students can choose from 45 maj ...
* 1971: Howland Award from the
American Pediatric Society
The American Pediatric Society (APS) is the first pediatric society established in North America. Created in 1888, the APS pursues a vision of an engaged, inclusive, and impactful community of pediatric thought leaders. The APS mission is to sha ...
* 1973: Elected to the
National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
,
27 years after Blalock was elected for their joint work on the Blalock-Taussig shunt
* 1973: Elected to the
American Philosophical Society
The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...
* 1973: Inducted into the
National Women's Hall of Fame
The National Women's Hall of Fame (NWHF) is an American institution incorporated in 1969 by a group of men and women in Seneca Falls, New York, although it did not induct its first enshrinees until 1973. As of 2021, it had 303 inductees.
Induc ...
* 1976: Awarded the Milton S. Eisenhower Medal for Distinguished Service by
Johns Hopkins
Johns Hopkins (May 19, 1795 – December 24, 1873) was an American merchant, investor, and philanthropist. Born on a plantation, he left his home to start a career at the age of 17, and settled in Baltimore, Maryland where he remained for most ...
* 1982: Elizabeth Blackwell Medal awarded by the American Medical Women's Association
* 2005:
Johns Hopkins School of Medicine
The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
named one of its four colleges in her honor, as well as the Helen B. Taussig Congenital Heart Disease Center
* 2018: The Helen B. Taussig Research Award began to be given out to postdoctoral fellows holding appointments in the Basic Sciences and clinical Departments at the Johns Hopkins School of Medicine
Throughout her career, Taussig earned more than 20 honorary degrees.
Taussig was a member of several professional societies during her career. She was a member of the
American Pediatric Society
The American Pediatric Society (APS) is the first pediatric society established in North America. Created in 1888, the APS pursues a vision of an engaged, inclusive, and impactful community of pediatric thought leaders. The APS mission is to sha ...
, the
Society for Pediatric Research
A society is a group of individuals involved in persistent social interaction, or a large social group sharing the same spatial or social territory, typically subject to the same political authority and dominant cultural expectations. Socie ...
, and the
American College of Physicians
The American College of Physicians (ACP) is a national organization of internists, who specialize in the diagnosis, treatment, and care of adults.Sokanu "What is an Internist?" Retrieved October 20, 2014 With 161,000 members, ACP is the largest ...
.
Film portrayals
In the 2004 HBO movie ''
Something the Lord Made
''Something the Lord Made'' is a 2004 American television film, made-for-television biographical film, biographical drama (film and television), drama film about the black cardiac pioneer Vivien Thomas (1910–1985) and his complex and volatile pa ...
'' about the life of
Vivien Thomas
Vivien Theodore Thomas (August 29, 1910 – November 26, 1985) was an American laboratory supervisor who developed a procedure used to treat blue baby syndrome (now known as cyanotic heart disease) in the 1940s. He was the assistant to surgeon ...
, Dr. Taussig was portrayed by
Mary Stuart Masterson
Mary Stuart Masterson (born June 28, 1966) is an American actress and director. She has starred in the films '' At Close Range'' (1986), '' Some Kind of Wonderful'' (1987), '' Chances Are'' (1989), ''Fried Green Tomatoes'' (1991) and '' Benny & ...
. The movie was nominated for many awards and won several.
References
Further reading
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{{DEFAULTSORT:Taussig, Helen
1898 births
1986 deaths
American pediatric cardiologists
Johns Hopkins Hospital physicians
Harvard Medical School alumni
University of California, Berkeley alumni
Johns Hopkins University alumni
Boston University alumni
20th-century American women physicians
20th-century American physicians
Fellows of the American Academy of Arts and Sciences
Members of the United States National Academy of Sciences
Road incident deaths in Massachusetts
People from Cambridge, Massachusetts
American people with disabilities
Burials at Mount Auburn Cemetery
Recipients of the Lasker-DeBakey Clinical Medical Research Award
Presidential Medal of Freedom recipients
People from Cotuit, Massachusetts
Fellows of the American College of Cardiology
Deaf people from the United States
20th-century American people
Members of the American Philosophical Society