''Chelidonium majus'', the greater celandine, is a

perennial A perennial plant or simply perennial is a plant that lives more than two years. The term ('' per-'' + '' -ennial'', "through the years") is often used to differentiate a plant from shorter-lived annuals and biennials. The term is also wide ...

herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of t ...

flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...

in the poppy family Papaveraceae. One of two species in the genus ''

Chelidonium ''Chelidonium'', commonly known as celandines, is a small genus of flowering plants in the poppy family The Poppy Family was a Canadian psychedelic pop group based in Vancouver. They had a number of international hit records in the late 1960 ...

'', it is native to Europe and western Asia and introduced widely in North America. The plant known as lesser celandine (''

Ficaria verna ''Ficaria verna'' (formerly ''Ranunculus ficaria'' ), commonly known as lesser celandine or pilewort, is a low-growing, hairless perennial flowering plant in the buttercup family Ranunculaceae native to Europe and Western Asia. It has fleshy dar ...

'') is not closely related, as it belongs to the buttercup family Ranunculaceae.

Description

Greater celandine is a perennial herbaceous plant with an erect habit, and reaches high. The blue-green leaves are

pinnate Pinnation (also called pennation) is the arrangement of feather-like or multi-divided features arising from both sides of a common axis. Pinnation occurs in biological morphology, in crystals, such as some forms of ice or metal crystals, and in ...

with lobed and wavy margins, up to long. When injured, the plant exudes a yellow to orange

latex Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latexes are found in nature, but synthetic latexes are common as well. In nature, latex is found as a milky fluid found in 10% of all flowering plants (angiosperms ...

. The flowers consist of four yellow petals, each about long, with two

sepal A sepal () is a part of the flower of angiosperms (flowering plants). Usually green, sepals typically function as protection for the flower in bud, and often as support for the petals when in bloom., p. 106 The term ''sepalum'' was coined b ...

s. A double-flowered variety occurs naturally. The flowers appear from late spring to summer, May to September (in the UK), in umbelliform cymes of about 4 flowers. The seeds are small and black, borne in a long, cylindrical capsule. Each has an

elaiosome Elaiosomes ( grc, ἔλαιον ''élaion'' "oil" + ''sóma'' "body") are fleshy structures that are attached to the seeds of many plant species. The elaiosome is rich in lipids and proteins, and may be variously shaped. Many plants have elaio ...

, which attracts ants to disperse the seeds (

myrmecochory Myrmecochory ( (sometimes myrmechory); from grc, μύρμηξ, mýrmēks ("ant") and ''khoreíā'' ("circular dance") is seed dispersal by ants, an ecologically significant ant–plant interaction with worldwide distribution. Most myrmeco ...

Taxonomy and naming

The greater celandine is one of the many species described by the father of taxonomy,

Carl Linnaeus Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the ...

, in volume one of his ''

Species Plantarum ' (Latin for "The Species of Plants") is a book by Carl Linnaeus, originally published in 1753, which lists every species of plant known at the time, classified into genera. It is the first work to consistently apply binomial names and was the ...

'' in 1753. According to the

Oxford English Dictionary The ''Oxford English Dictionary'' (''OED'') is the first and foundational historical dictionary of the English language, published by Oxford University Press (OUP). It traces the historical development of the English language, providing a com ...

, the name ''celandine'' comes from

Late Latin Late Latin ( la, Latinitas serior) is the scholarly name for the form of Literary Latin of late antiquity.Roberts (1996), p. 537. English dictionary definitions of Late Latin date this period from the , and continuing into the 7th century in t ...

''celidonia'', from earlier Latin ''chelidonia'' or ''chelidonium'', and ultimately from

Ancient Greek Ancient Greek includes the forms of the Greek language used in ancient Greece and the ancient world from around 1500 BC to 300 BC. It is often roughly divided into the following periods: Mycenaean Greek (), Dark Ages (), the Archaic peri ...

, from (''chelidṓn'') "

swallow The swallows, martins, and saw-wings, or Hirundinidae, are a family of passerine songbirds found around the world on all continents, including occasionally in Antarctica. Highly adapted to aerial feeding, they have a distinctive appearance. The ...

", hence the common name "swallowwort". Ancient writers said that the flower bloomed when the swallows returned and faded when they left. ''Chelidonium majus'' has also been called great celandine,, nipplewort, tetterwort, or simply "celandine". The common name tetterwort also refers to ''

Sanguinaria canadensis ''Sanguinaria canadensis'', bloodroot, is a perennial, herbaceous flowering plant native to eastern North America. It is the only species in the genus ''Sanguinaria'', included in the poppy family Papaveraceae, and is most closely related to ...

''. In

Devon Devon ( , historically known as Devonshire , ) is a ceremonial and non-metropolitan county in South West England. The most populous settlement in Devon is the city of Plymouth, followed by Devon's county town, the city of Exeter. Devon is ...

it is also known as St John's wort.

Distribution and habitat

''Chelidonium majus'' is

native Native may refer to: People * Jus soli, citizenship by right of birth * Indigenous peoples, peoples with a set of specific rights based on their historical ties to a particular territory ** Native Americans (disambiguation) In arts and entert ...

in most regions of Europe. It is also found in North Africa in

Macaronesia Macaronesia (Portuguese: ''Macaronésia,'' Spanish: ''Macaronesia'') is a collection of four volcanic archipelagos in the North Atlantic, off the coasts of Africa and Europe. Each archipelago is made up of a number of List of islands in the At ...

Algeria ) , image_map = Algeria (centered orthographic projection).svg , map_caption = , image_map2 = , capital = Algiers , coordinates = , largest_city = capital , relig ...

and

Morocco Morocco (),, ) officially the Kingdom of Morocco, is the westernmost country in the Maghreb region of North Africa. It overlooks the Mediterranean Sea to the north and the Atlantic Ocean to the west, and has land borders with Algeria to ...

. In Western Asia it is found in the

Caucasus The Caucasus () or Caucasia (), is a region between the Black Sea and the Caspian Sea, mainly comprising Armenia, Azerbaijan, Georgia, and parts of Southern Russia. The Caucasus Mountains, including the Greater Caucasus range, have historically ...

Armenia Armenia (), , group=pron officially the Republic of Armenia,, is a landlocked country in the Armenian Highlands of Western Asia.The UNbr>classification of world regions places Armenia in Western Asia; the CIA World Factbook , , and ''Ox ...

Azerbaijan Azerbaijan (, ; az, Azərbaycan ), officially the Republic of Azerbaijan, , also sometimes officially called the Azerbaijan Republic is a transcontinental country located at the boundary of Eastern Europe and Western Asia. It is a part of th ...

Georgia Georgia most commonly refers to: * Georgia (country), a country in the Caucasus region of Eurasia * Georgia (U.S. state), a state in the Southeast United States Georgia may also refer to: Places Historical states and entities * Related to the ...

Kazakhstan Kazakhstan, officially the Republic of Kazakhstan, is a transcontinental country located mainly in Central Asia and partly in Eastern Europe. It borders Russia to the north and west, China to the east, Kyrgyzstan to the southeast, Uzbeki ...

Mongolia Mongolia; Mongolian script: , , ; lit. "Mongol Nation" or "State of Mongolia" () is a landlocked country in East Asia, bordered by Russia to the north and China to the south. It covers an area of , with a population of just 3.3 million, ...

Siberia Siberia ( ; rus, Сибирь, r=Sibir', p=sʲɪˈbʲirʲ, a=Ru-Сибирь.ogg) is an extensive geographical region, constituting all of North Asia, from the Ural Mountains in the west to the Pacific Ocean in the east. It has been a part of ...

Iran Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...

and

Turkey Turkey ( tr, Türkiye ), officially the Republic of Türkiye ( tr, Türkiye Cumhuriyeti, links=no ), is a list of transcontinental countries, transcontinental country located mainly on the Anatolia, Anatolian Peninsula in Western Asia, with ...

Ecology

It is considered an aggressive invasive plant in parts of North America, and an invasive plant in other areas. In

Wisconsin Wisconsin () is a state in the upper Midwestern United States. Wisconsin is the 25th-largest state by total area and the 20th-most populous. It is bordered by Minnesota to the west, Iowa to the southwest, Illinois to the south, Lake M ...

, for example, it is a restricted plant. Control is obtained mainly via pulling or spraying the plant before seed dispersal.

Constituents and pharmacology

The whole plant is toxic in moderate doses as it contains a range of

isoquinoline alkaloids Isoquinoline alkaloids are natural products of the group of alkaloids, which are chemically derived from isoquinoline. They form the largest group among the alkaloids. Isoquinoline alkaloids can be further classified based on their different chem ...

; use in herbal medicine requires the correct dose. The main alkaloid present in the

herb In general use, herbs are a widely distributed and widespread group of plants, excluding vegetables and other plants consumed for macronutrients, with savory or aromatic properties that are used for flavoring and garnishing food, for medicinal ...

and

root In vascular plants, the roots are the organs of a plant that are modified to provide anchorage for the plant and take in water and nutrients into the plant body, which allows plants to grow taller and faster. They are most often below the sur ...

coptisine Coptisine is an alkaloid found in Chinese goldthread (''Coptis chinensis''), greater celandine, and opium. Famous for the bitter taste that it produces, it is used in Chinese herbal medicine along with the related compound berberine Berberine ...

. Other alkaloids present include methyl 2'-(7,8-dihydrosanguinarine-8-yl)acetate,

allocryptopine Allocryptopine is a bioactive alkaloid found in plants of the Papaveraceae family, including '' Glaucium arabicum'' ''Argemone mexicana'' , '' Eschscholtzia'' , '' Corydalis'' , ''Fumaria ''Fumaria'' (fumitory or fumewort, from Latin ', "sm ...

stylopine Tetrahydrocoptisine (also known as stylopine) is an alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and eve ...

protopine Protopine is an alkaloid occurring in opium poppy, ''Corydalis'' tubers and other plants of the family papaveraceae, like ''Fumaria officinalis''. Protopine is metabolically derived from the benzylisoquinoline alkaloid ''(S)''- Reticuline through ...

, norchelidonine,

berberine Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as ''Berberis vulgaris'' (barberry), '' Berberis aristata'' (tree turmeric), '' Mahonia aquifolium'' (Oregon grape), '' Hyd ...

chelidonine Chelidonine is an isolate of ''Papaveraceae'' with acetylcholinesterase and butyrylcholinesterase inhibitory activity. Introduction Chelidonine is the major alkaloid component of '' Chelidonium majus''. ''Chelidonium majus L''. is the only spec ...

sanguinarine Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose taxonomic name, ''Sanguinaria canadensis,'' its name is drawn; the Mexican prickly poppy (''Argemone mexicana''); ''Chel ...

chelerythrine Chelerythrine is a benzophenanthridine alkaloid present in the plant ''Chelidonium majus'' (greater celandine). It is a potent, selective, and cell-permeable protein kinase C inhibitor ''in vitro''. And an efficacious antagonist of G-protein-cou ...

, and 8-hydroxydihydrosanguinarine. Sanguinarine is particularly toxic with an of 18 mg per kg body weight (IP in rats).

Caffeic acid Caffeic acid is an organic compound that is classified as a hydroxycinnamic acid. This yellow solid consists of both phenolic and acrylic functional groups. It is found in all plants because it is an intermediate in the biosynthesis of lignin, one ...

derivatives, such as

caffeoylmalic acid Caffeoylmalic acid is an ester of caffeic acid and malic acid found in the leaves and flowers of '' Parietaria officinalis''. It is also found in ''Chelidonium majus'' and ''Urtica dioica ''Urtica dioica'', often known as common nettle, burn ...

, are also present. The characteristic latex also contains

proteolytic enzymes Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called protease ...

and the phyto

cystatin The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below. Cystatins sho ...

chelidostatin, a

cysteine protease Cysteine proteases, also known as thiol proteases, are hydrolase enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad. Discovered by Gopal Chund ...

inhibitor. It is a traditional folk remedy against

wart Warts are typically small, rough, hard growths that are similar in color to the rest of the skin. They typically do not result in other symptoms, except when on the bottom of the feet, where they may be painful. While they usually occur on the ...

s in France and the UK. It is used in the preparation of a range of off-the-shelf treatments for warts and skin conditions. ''Chelidonium'' is used to make Ukrain, a drug that has been promoted for, but is not known to be effective for, the treatment of cancer and viral infections. The fresh herb is no longer used officially. No dose-finding studies exist and the reported clinical studies are characterised by a considerable heterogeneity. Except for homeopathic medicines, the drug is no longer used in most English-speaking countries. In Germany and Switzerland, extracts of Chelidoni herba are a controversial component of the gastric remedy "Iberogast". The OTC-preparation is a top-selling product for the company

Bayer Bayer AG (, commonly pronounced ; ) is a German multinational corporation, multinational pharmaceutical and biotechnology company and one of the largest pharmaceutical companies in the world. Headquartered in Leverkusen, Bayer's areas of busi ...

, which is now under investigation for not warning consumers from possible hepatotoxic side-effects when taking the drug. Elevated liver-enzymes and toxic hepatitis with a documented fatality have been reported. The plant is poisonous to chickens.

Herbalism

The aerial parts and roots of greater celandine are used in herbalism. The above-ground parts are gathered during the flowering season and dried at high temperatures. The root is harvested in autumn between August and October and dried. The fresh rhizome is also used. Celandine has a hot and bitter taste. Preparations are made from

alcoholic Alcoholism is, broadly, any drinking of alcohol that results in significant mental or physical health problems. Because there is disagreement on the definition of the word ''alcoholism'', it is not a recognized diagnostic entity. Predomin ...

and hot aqueous extractions (

tea Tea is an aromatic beverage prepared by pouring hot or boiling water over cured or fresh leaves of ''Camellia sinensis'', an evergreen shrub native to East Asia which probably originated in the borderlands of southwestern China and north ...

). The related plant

bloodroot ''Sanguinaria canadensis'', bloodroot, is a Perennial plant, perennial, herbaceous flowering plant native to eastern North America. It is the monotypic genus, only species in the genus ''Sanguinaria'', included in the poppy family Papaveraceae, ...

has similar chemical composition and uses as greater celandine. As far back as

Pliny the Elder Gaius Plinius Secundus (AD 23/2479), called Pliny the Elder (), was a Roman author, naturalist and natural philosopher, and naval and army commander of the early Roman Empire, and a friend of the emperor Vespasian. He wrote the encyclopedic '' ...

and

Dioscorides Pedanius Dioscorides ( grc-gre, Πεδάνιος Διοσκουρίδης, ; 40–90 AD), “the father of pharmacognosy”, was a Greek physician, pharmacologist, botanist, and author of ''De materia medica'' (, On Medical Material) —a 5-vol ...

(1st century CE) this herb has been recognized as a useful detoxifying agent. The root has been chewed to relieve toothache.

John Gerard John Gerard (also John Gerarde, c. 1545–1612) was an English herbalist with a large garden in Holborn, now part of London. His 1,484-page illustrated ''Herball, or Generall Historie of Plantes'', first published in 1597, became a popular gard ...

's ''Herball'' (1597) states that "the juice of the herbe is good to sharpen the sight, for it cleanseth and consumeth away slimie things that cleave about the ball of the eye and hinder the sight and especially being boiled with honey in a brasen vessell." It was formerly used by some

Romani people The Romani (also spelled Romany or Rromani , ), colloquially known as the Roma, are an Indo-Aryan ethnic group, traditionally nomadic itinerants. They live in Europe and Anatolia, and have diaspora populations located worldwide, with sig ...

as a foot refresher; modern herbalists use its

purgative Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubri ...

properties. The modern

herbalist Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are a basis of traditional medicine. With worldwide research into pharmacology, some herbal medicines have been translated into modern remed ...

Juliette de Baïracli Levy Juliette de Baïracli Levy (11 November 1912 – 28 May 2009) was an English Herbalism, herbalist and author noted for her pioneering work in Holistic#Holism in medicine, holistic veterinary medicine. After studying veterinary medicine at the Uni ...

recommended greater celandine diluted with milk for the eyes and the latex for getting rid of warts. ''Chelidonium'' was a favourite herb of the French herbalist Maurice Mességué. ''Chelidonium majus'' has traditionally been used for treatment of various inflammatory diseases including

atopic dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a long-term type of inflammation of the skin (dermatitis). It results in puritis, itchy, red, swollen, and cracked skin. Clear fluid may come from the affected areas, which often thickens o ...

. It is also traditionally used in the treatment of gallstones and dyspepsia. The

Iroquois The Iroquois ( or ), officially the Haudenosaunee ( meaning "people of the longhouse"), are an Iroquoian-speaking confederacy of First Nations peoples in northeast North America/ Turtle Island. They were known during the colonial years to ...

give an

infusion Infusion is the process of extracting chemical compounds or flavors from plant material in a solvent such as water, oil or alcohol, by allowing the material to remain suspended in the solvent over time (a process often called steeping). An inf ...

of whole plant, another plant and milk to pigs that drool and have sudden movements.Rousseau, Jacques 1945 Le Folklore Botanique De Caughnawaga. Contributions de l'Institut botanique l'Universite de Montreal 55:7-72 (p. 45) It was also once used to treat liver disorders, owing to the juice's resemblance to bile.

Gallery

Flower October 2008-1.jpg, A leaf and an open flower Chelidonium majus20100511 10.jpg, Flowers Chelidonium majus by Danny S. - 001.jpg, Fruits

References

{{Taxonbar, from1=Q156807, from2=Q12723971 Papaveroideae Flora of Europe Flora of Africa Flora of Asia Medicinal plants of Asia Medicinal plants of Europe Plants used in traditional Native American medicine Taxa named by Joseph Pitton de Tournefort