General transcription factor IIF subunit 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''GTF2F1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
GTF2F1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the ''CTDP1'' gene.
This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription ...
,
*
GTF2H4
General transcription factor IIH subunit 4 is a protein that in humans is encoded by the ''GTF2H4'' gene.
Interactions
GTF2H4 has been shown to interact with:
* GTF2F1,
* MED21,
* POLR2A,
* TATA binding protein,
* Transcription Factor II B ...
,
*
HNRPU
Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the ''HNRNPU'' gene.
Function
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RN ...
,
*
MED21
Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the ''MED21'' gene.
Interactions
MED21 has been shown to interact with:
* BRCA1,
* CDK8,
* GTF2F1,
* GTF2H4,
* MED6, and
* POLR2A
DNA-directed ...
,
POLR2A
DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the ''POLR2A'' gene.
Function
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing me ...
,Serum response factor
Serum response factor, also known as SRF, is a transcription factor protein.
Function
Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum ...
TAF11
Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the ''TAF11'' gene.
Function
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptid ...
,[
* ]TAF1
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the ''TAF1'' gene.
Function
Init ...
,TATA binding protein
The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene p ...
,[ and
* ]Transcription Factor II B
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC) and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and pro ...
.
See also
* Transcription factor II F
Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.
TFIIF is encoded by the , , and genes.
TFIIF binds to RNA polymerase II
RNA polymerase II (RNAP II ...
References
Further reading
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External links
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{{NLM content
Transcription factors