The GHKL domain (
Gyrase,
Hsp90,
Histidine Kinase,
MutL) is an evolutionary conserved
protein domain.
This family represents the structurally related
ATPase
ATPases (, Adenosine 5'-TriPhosphatase, adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) are ...
domains of histidine kinase, DNA gyrase B and HSP90. This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases,
heat shock protein HSP90,
phytochrome-like ATPases and DNA mismatch repair proteins. More information about this protein can be found at Protein of the Month: DNA Topoisomerase.
Subfamilies
* Histidine kinase related protein, C-terminal
Members
*
BCKDK
Branched chain ketoacid dehydrogenase kinase (BCKDK) is an enzyme encoded by the BCKDK gene on chromosome 16. This enzyme is part of the mitochondrial protein kinases family and it is a regulator of the valine, leucine, and isoleucine catabolism, ...
*
HSP90AA1
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the ''HSP90AA1'' gene.
Function
The gene, HSP90AA1, encodes the human stress-inducible 90-kDa heat shock protein alpha (Hsp90A). Complemented by the constitutively expr ...
,
HSP90AB1
Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the ''HSP90AB1'' gene.
Function
HSP90AB1 is a molecular chaperone. Chaperones are proteins that bind to other proteins, thereby stabilizing them in an ...
,
HSP90B1
*
MLH1
DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer. Orthologs of human MLH1 h ...
,
MLH3,
MORC1,
MORC2,
MORC3,
MORC4
*
PDK1,
PDK2
Pyruvate dehydrogenase kinase isoform 2 (PDK2) also known as pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the ''PDK2'' gene. PDK2 is an isozyme of pyruvate dehydrogenase kinase.
Struct ...
,
PDK3
Pyruvate dehydrogenase lipoamide kinase isozyme 3, mitochondrial is an enzyme that in humans is encoded by the ''PDK3'' gene.
It codes for an isozyme of pyruvate dehydrogenase kinase.The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded m ...
,
PDK4
*
PMS1,
PMS2
Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the ''PMS2'' gene.
Function
This gene is one of the PMS2 gene family members which are found in clusters on chromosome 7. Human PMS2 related genes are located at bands ...
,
PMS2L1,
PMS2L11,
PMS2L3,
PMS4L
*
TOP2A,
TOP2B
*
TRAP1
Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the ''TRAP1'' gene.
Interactions
TRAP1 has been shown to interact with EXT2, EXT1 and Retinoblastoma protein
The retinoblastoma protein (protein name abbrevi ...
,
TRRAP
References
Protein domains
{{protein-stub