ERDRP-0519 is an

antiviral drug Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do n ...

which is the first drug specifically developed to target the

measles Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...

morbillivirus ''Morbillivirus'' is a genus of viruses in the order ''Mononegavirales'', in the family ''Paramyxoviridae''. Humans, dogs, cats, cattle, seals, and cetaceans serve as natural hosts. This genus includes seven species. Diseases in humans associate ...

. It acts as an inhibitor of the viral enzyme

RNA polymerase In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template. Using the enzyme helicase, RNAP locally opens the ...

which is essential for viral replication, and in animal studies showed good oral bioavailability and protected

ferret The ferret (''Mustela furo'') is a small, Domestication, domesticated species belonging to the family Mustelidae. The ferret is most likely a domesticated form of the wild European polecat (''Mustela putorius''), evidenced by their Hybrid (biol ...

s from otherwise lethal doses of a morbillivirus when administered up to three days after infection.

History

The research was done at

Georgia State University Georgia State University (Georgia State, State, or GSU) is a Public university, public research university in Atlanta, Atlanta, Georgia. Founded in 1913, it is one of the University System of Georgia's four research universities. It is also the ...

and the

Paul Ehrlich Institute The Paul Ehrlich Institute (German: ''Paul-Ehrlich-Institut – Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel'', PEI) is a German federal agency, medical regulatory body and research institution for vaccines and biomedicines. It ...

References

Antiviral drugs Experimental drugs Trifluoromethyl compounds Pyrazoles Sulfonamides 4-Morpholinyl compunds Anilides Piperidines {{antiinfective-drug-stub

History

See also

References