Cumulina (October 3, 1997-May 5, 2000), a mouse, was the first animal

cloned Cloning is the process of producing individual organisms with identical or virtually identical DNA, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction. In the field of biotechnology, c ...

from adult cells that survived to adulthood. She was cloned using the Honolulu technique developed by "Team Yana", the

Ryuzo Yanagimachi is a Japanese-born, American-based scientist. He has made numerous key contributions to the study of mammalian fertilization. He is a pioneer of assisted fertilization technologies such as in vitro fertilization and direct sperm injection into ...

research group at the former campus of the

John A. Burns School of Medicine The John A. Burns School of Medicine (JABSOM) is part of the University of Hawai‘i at Mānoa, and is located on the island of O‘ahu, approximately three miles west of the university's Mānoa campus. The school was named after former Hawaiia ...

located at the

University of Hawai'i at Mānoa A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase ''universitas magistrorum et scholarium'', which rou ...

. Cumulina was a brown '' Mus musculus'' or common house mouse. She was named after the

cumulus cells Cumulus clouds are clouds which have flat bases and are often described as "puffy", "cotton-like" or "fluffy" in appearance. Their name derives from the Latin ''cumulo-'', meaning ''heap'' or ''pile''. Cumulus clouds are low-level clouds, gener ...

surrounding the developing

oocyte An oocyte (, ), oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature ovum, or egg cell. An oocyte is produced in a female fetus in the ovary during female gametogenesis. The female ...

in the

ovarian follicle An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle. At the time of puberty, women have approximately 200,000 to 300,000 follicles, each with th ...

in mice. Nuclei from these cells were put into egg cell devoid of their original nuclei in the Honolulu cloning technique. All other mice produced by the Yanagimachi lab are just known by a number. Cumulina was able to produce two healthy litters. She was retired after the second. Cumulina's preserved remains can be visited at the Institute for Biogenesis Research, a part of the John A. Burns School of Medicine laboratory, in Honolulu, Hawaii. Some of her descendants have been displayed at the

Bishop Museum The Bernice Pauahi Bishop Museum, designated the Hawaii State Museum of Natural and Cultural History, is a museum of history and science in the historic Kalihi district of Honolulu on the Hawaiian island of Oʻahu. Founded in 1889, it is the lar ...

and the Museum of Science and Industry in Chicago, Illinois.Honolulu Star-Bulletin Hawaii News
/ref>

References

External links

1997 animal births 2000 animal deaths Individual mice Cloned animals Individual animals in the United States {{developmental-biology-stub