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The ''Controlled Drugs and Substances Act'' (french: Loi réglementant certaines drogues et autres substances) (the ''Act'') is
Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tot ...
's federal drug control statute. Passed in 1996 under Prime Minister
Jean Chrétien Joseph Jacques Jean Chrétien (; born January 11, 1934) is a Canadian lawyer and politician who served as the 20th prime minister of Canada from 1993 to 2003. Born and raised in Shawinigan Falls, Quebec, Chrétien is a law graduate from Uni ...
's government, it repeals the ''
Narcotic Control Act The ''Narcotic Control Act'' (the ''Act''), passed in 1961, was one of Canada's national drug control statutes prior to its repeal by the 1996 ''Controlled Drugs and Substances Act.'' It implemented the provisions of the Single Convention on Nar ...
'' and Parts III and IV of the ''
Food and Drugs Act The ''Food and Drugs Act'' (the ''Act'') (formal title ''An Act respecting food, drugs, cosmetics and therapeutic devices'') is an act of the Parliament of Canada regarding the production, import, export, transport across provinces and sale of f ...
'', and establishes eight Schedules of controlled substances and two Classes of precursors. It provides that "The Governor in Council may, by order, amend any of Schedules I to VIII by adding to them or deleting from them any item or portion of an item, where the Governor in Council deems the amendment to be necessary in the public interest." The ''Act'' serves as the implementing legislation for the
Single Convention on Narcotic Drugs The Single Convention on Narcotic Drugs, 1961 (Single Convention, 1961 Convention, or C61) is an international treaty that controls activities (cultivation, production, supply, trade, transport) of specific narcotic drugs and lays down a syste ...
, the Convention on Psychotropic Substances, and the
United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances The United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 is one of three major drug control treaties currently in force. It provides additional legal mechanisms for enforcing the 1961 Single Con ...
.


Amendments to the act

In November 2007, the Justice Minister
Rob Nicholson Robert Douglas "Rob" Nicholson (born April 29, 1952) is a Canadian politician who represented the riding of Niagara Falls in the House of Commons of Canada from 2004 to 2019 as a member of the Conservative Party. Under Prime Minister Stephen Ha ...
introduced Bill C-26, which proposed a number of mandatory minimum penalties imposed on those who commit drug offences. On February 27, 2009, Bill C-15, a re-introduction of C-26 received first reading in the second session of the 40th Parliament of Canada. On June 9, 2009, the House of Commons passed Bill C-15 and it went to the Senate for study and approval. On December 14, 2009, the Senate passed Bill C-15, with some amendments, for approval by the House of Commons. When the Canadian Parliament dissolved in a prorogation on January 31, 2010, Bill C-15, along with all unpassed legislation then tabled before the Commons, fell. Early in 2012, the next parliament passed the ''
Safe Streets and Communities Act The ''Safe Streets and Communities Act'' is a bill that was passed by the 41st Canadian Parliament 154–129 on March 12, 2012. When Parliament re-convened in September 2011, the Minister of Justice introduced the ''Safe Streets and Communities ...
'', which received Royal Assent in March. The final legislation sees changes made to four areas of the ''Act'', outlining mandatory minimum sentences for offences relating to the trafficking and production of various controlled substances. Mandatory minimum sentencing does not apply to simple possession and trafficking in smaller amounts. On October 17, 2018, the federal ''
Cannabis Act The ''Cannabis Act'' (also known as Bill C-45) is a law which legalized recreational cannabis use in Canada in combination with its companion legislation Bill C-46, ''An Act to Amend the Criminal Code''. The law is a milestone in the legal hi ...
'' came into effect, legalizing the possession, sale and production of cannabis. Everyone with a criminal record for cannabis possession became eligible to apply for a
pardon A pardon is a government decision to allow a person to be relieved of some or all of the legal consequences resulting from a criminal conviction. A pardon may be granted before or after conviction for the crime, depending on the laws of the ju ...
on this date.


List of drugs

The list below reflects the list of drugs scheduled in Canada's ''Controlled Drugs and Substances Act''.


Schedule I

* Opium Poppy (
Papaver somniferum ''Papaver somniferum'', commonly known as the opium poppy or breadseed poppy, is a species of flowering plant in the family Papaveraceae. It is the species of plant from which both opium and poppy seeds are derived and is also a valuable orname ...
), its preparations, derivatives, alkaloids and salts, including: #
Opium Opium (or poppy tears, scientific name: ''Lachryma papaveris'') is dried latex obtained from the seed capsules of the opium poppy ''Papaver somniferum''. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which i ...
# Codeine (methylmorphine) #
Morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a analgesic, pain medication, and is also commonly used recreational drug, recreationally, or to make ...
(7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol) #
Thebaine Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, '' Thēbai'' (Thebes), an ancient city in Upper Egypt. A minor constituent of opium, thebaine is chemically similar ...
(paramorphine)and the salts, derivatives and salts of derivatives of the substances set out in subitems (1) to (4), including: #
Acetorphine Acetorphine is a potent opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of the more well-known opioid etorphine, which is used as a very potent veterinary painkiller and anesthetic medication, primarily f ...
(acetyletorphine) #
Acetyldihydrocodeine Acetyldihydrocodeine is an opiate derivative discovered in Germany in 1914 and was used as a cough suppressant and analgesic. It is not commonly used, but has activity similar to other opiates. Acetyldihydrocodeine is a very close relative de ...
(4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol acetate) #
Benzylmorphine Benzylmorphine (Peronine) is a semi-synthetic opioid narcotic introduced to the international market in 1896 and that of the United States very shortly thereafter. It is much like codeine, containing a benzyl group attached to the morphine molecu ...
(7,8-didehydro-4,5-epoxy-17-methyl-3-(phenylmethoxy) morphinan-6-ol) #
Codoxime Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6- ketone group has been replaced by carboxymethyloxime. It has primarily antitussive Cold medicines are a group of medications taken individually ...
(dihydrocodeinone O-(carboxymethyl) oxime) #
Desomorphine Desomorphine is a semi-synthetic opioid commercialized by Roche, with powerful, fast-acting effects, such as sedation and analgesia. It was first discovered and patented by a German team working for Knoll in 1920 but was not generally recognize ...
(dihydrodeoxymorphine) # Diacetylmorphine (
heroin Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and brow ...
) #
Dihydrocodeine Dihydrocodeine is a semi-synthetic opioid analgesic prescribed for pain or severe dyspnea, or as an antitussive, either alone or compounded with paracetamol (acetaminophen) (as in co-dydramol) or aspirin. It was developed in Germany in 1908 a ...
(4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol) #
Dihydromorphine Dihydromorphine (Paramorfan, Paramorphan) is a semi-synthetic opioid structurally related to and derived from morphine. The 7,8-double bond in morphine is reduced to a single bond to get dihydromorphine.Rama Rao Nadendla. Principles Of Organic ...
(4,5-epoxy-17-methylmorphinan-3,6-diol) #
Ethylmorphine Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive. Side effects Adverse effects are similar to other opioids and include drowsiness, constipation, vertigo, nausea, vomiting, and respira ...
(7,8-didehydro-4,5-epoxy-3-ethoxy-17-methylmorphinan-6-ol) #
Etorphine Etorphine (M99) is a semi-synthetic opioid possessing an analgesic potency approximately 1,000–3,000 times that of morphine. It was first prepared in 1960 from oripavine, which does not generally occur in opium poppy extract but rather the r ...
(tetrahydro-7α-(1-hydroxy-1-methyl-butyl)-6,14-endo-ethenooripavine) #
Hydrocodone Hydrocodone, also known as dihydrocodeinone, is an opioid used to treat pain and as a cough suppressant. It is taken by mouth. Typically it is dispensed as the combination acetaminophen/hydrocodone or ibuprofen/hydrocodone for pain severe eno ...
(dihydrocodeinone) #
Hydromorphinol Hydromorphinol (RAM-320, 14-Hydroxydihydromorphine), also is an opiate analogue that is a derivative of morphine, where the 14-position has been hydroxylated and the 7,8- double bond saturated. It has similar effects to morphine such as sedati ...
(dihydro-14-hydroxymorphine) #
Hydromorphone Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is an opioid used to treat moderate to severe pain. Typically, long-term use is only recommended for pain due to cancer. It may be used by mou ...
(dihydromorphinone) # Methyldesorphine (Δ6-deoxy-6-methylmorphine) # Methyldihydromorphine (dihydro-6-methylmorphine) #
Metopon Metopon (5-methylhydromorphone) is an opioid analogue that is a methylated derivative of hydromorphone which was invented in 1929 as an analgesic. Metopon is sometimes used in medicine, although longer acting than hydromorphone, Metopon is less ...
(dihydromethylmorphinone) #
Morphine-N-oxide Morphine-''N''-oxide (genomorphine) is an active opioid metabolite of morphine. Morphine itself, in trials with rats, is 11–22 times more potent than morphine-''N''-oxide subcutaneously and 39–89 times more potent intraperitoneally. However ...
(morphine oxide) # Myrophine (benzylmorphine myristate) #
Nalorphine Nalorphine () (brand names Lethidrone, Nalline), also known as ''N''-allylnormorphine, is a mixed opioid agonist–antagonist with opioid antagonist and analgesic properties. It was introduced in 1954 and was used as an antidote to reverse op ...
(N-allylnormorphine) # Nicocodine (6-nicotinylcodeine) #
Nicomorphine Nicomorphine (Vilan, Subellan, Gevilan, MorZet) is the 3,6-dinicotinate ester of morphine. It is a strong opioid agonist analgesic two to three times as potent as morphine with a side effect profile similar to that of dihydromorphine, morphine, a ...
(dinicotinylmorphine) #
Norcodeine Norcodeine is an opiate analogue that is the N-demethylated derivative of codeine. It has relatively little opioid Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pa ...
(N-desmethylcodeine) # Normorphine (N-desmethylmorphine) #
Oxycodone Oxycodone, sold under various brand names such as Roxicodone and OxyContin (which is the extended release form), is a strong, semi-synthetic opioid used medically for treatment of moderate to severe pain. It is highly addictive and a commonly ...
(dihydrohydroxycodeinone) #
Oxymorphone Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it beg ...
(dihydrohydroxymorphinone) #
Pholcodine Pholcodine is an opioid cough suppressant (antitussive). It helps suppress unproductive coughs and also has a mild sedative effect, but has little or no analgesic effects. It is also known as morpholinylethylmorphine and homocodeine. Pholcodine is ...
(3- -(4-morpholinyl)ethylorphine) #
Thebacon Thebacon (INN; pronounced ), or dihydrocodeinone enol acetate, is a semisynthetic opioid that is similar to hydrocodone and is most commonly synthesised from thebaine. Thebacon was invented in Germany in 1924, four years after the first synthe ...
(acetyldihydrocodeinone)but not including: #
Apomorphine Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non- selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. It also acts as an antag ...
(5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo e,guinoline-10,11-diol) and its salts # Cyprenorphine (N-(cyclopropylmethyl)-6,7,8,14-tetrahydro-7α-(1-hydroxy-1-methylethyl)-6,14-endo-ethenonororipavine) and its salts #
Nalmefene Nalmefene is an opioid antagonist medication used in the management of opioid overdose and alcohol dependence. It is taken by mouth. Nalmefene is an opiate derivative similar in both structure and activity to the opioid antagonist naltrexone. ...
(17-(cyclopropylmethyl)-4,5α-epoxy-6-methylenemorphinan-3,14-diol) and its salts ##
Naloxone Naloxone, sold under the brand names Narcan (4 mg) and Kloxxado (8 mg) among others, is a medication used to reverse or reduce the effects of opioids. It is commonly used to counter decreased breathing in opioid overdose. Effects begin withi ...
(4,5α-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one) and its salts ##
Naltrexone Naltrexone, sold under the brand name Revia among others, is a medication primarily used to manage alcohol or opioid use disorder by reducing cravings and feelings of euphoria associated with substance use disorder. It has also been found t ...
(17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one) and its salts ##
Methylnaltrexone Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid dr ...
(17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium) and its salts ##
Naloxegol Naloxegol (INN; PEGylated naloxol; trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. It was a ...
(4,5α-epoxy-6α-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propenyl)morphinan-3,14-diol) and its salts # Narcotine (6,7-dimethoxy-3-(5,6,7,8-tetra-hydro-4-methoxy-6-methyl-1,3-dioxolos ,5-gsoquinolin-5-yl)-1(3H)-isobenzofuranone) and its salts #
Papaverine Papaverine (Latin '' papaver'', "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasms and vasospasms (especially those involving the intestines, heart, or brain), occasionally in the treatment of e ...
(1- 3,4-dimethoxyphenyl)methyl6,7-dimethoxyisoquinoline) and its salts #
Poppy seed Poppy seed is an oilseed obtained from the opium poppy (''Papaver somniferum''). The tiny, kidney-shaped seeds have been harvested from dried seed pods by various civilizations for thousands of years. It is still widely used in many countries, ...
*
Coca Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. The plant is grown as a cash crop in the Argentine Northwest, Bolivia, ...
(
Erythroxylon ''Erythroxylum'' (''Erythroxylon'') is a genus of tropical flowering plants in the family Erythroxylaceae. Many of the approximately 200 species contain the substance cocaine,Bieri S, Brachet A, Veuthey J, Christen P. Cocaine distribution in wild ...
), its preparations, derivatives, alkaloids and salts, including: #
Coca leaves Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. The plant is grown as a cash crop in the Argentine Northwest, Bolivia, ...
#
Cocaine Cocaine (from , from , ultimately from Quechuan languages, Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly recreational drug use, used recreationally for its euphoria, euphoric effects. It is primarily obtained from t ...
(benzoylmethylecgonine) #
Ecgonine Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves. It has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance in many jurisdictions, as are s ...
(3-hydroxy-2-tropane carboxylic acid) *
Phenylpiperidine Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity or other central nervous system effects ...
s, their intermediates, salts, derivatives and analogues and salts of intermediates, derivatives and analogues, including: #
Allylprodine Allylprodine is an opioid analgesic that is an analog of prodine. It was discovered by Hoffman-La Roche in 1957 during research into the related drug pethidine. Derivatives were tested to prove the theory that phenolic & non-phenolic opioids bi ...
(3-allyl-1-methyl-4-phenyl-4-piperidinol propionate) # Alpha meprodine (α-3-ethyl-1-methyl-4-phenyl-4-piperidinol propionate) # Alpha
prodine Prodine (trade names Prisilidine and Nisentil) is an opioid analgesic that is an analog of pethidine (meperidine). It was developed in Germany in the late 1940s. There are two isomers of the trans form of prodine, alphaprodine and betaprodine ...
(α-1,3-dimethyl-4-phenyl-4-piperidinol propionate) #
Anileridine Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s. It differs from pethidine (meperidine) in that the ''N''-methyl group of meperidi ...
(ethyl 1- -(p-aminophenyl)ethyl4-phenylpiperidine-4-carboxylate) # Beta meprodine (β-3-ethyl-1-methyl-4-phenyl-4-piperidinol propionate) # Beta
prodine Prodine (trade names Prisilidine and Nisentil) is an opioid analgesic that is an analog of pethidine (meperidine). It was developed in Germany in the late 1940s. There are two isomers of the trans form of prodine, alphaprodine and betaprodine ...
(β-1,3-dimethyl-4-phenyl-4-piperidinol propionate) #
Benzethidine Benzethidine is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (''meperidine'', or ''Demerol''). Benzethidine is not currently used in medicine and is a Class A/ Schedule I drug which is c ...
(ethyl 1-(2-benzyloxyethyl)-4-phenylpiperidine-4-carboxylate) #
Diphenoxylate Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine ...
(ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate) #
Difenoxin Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate. It was first approved in the US in 1978 and in 1980 in the former West Germany. Difeno ...
(1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate) # Etoxeridine (ethyl 1- -(2-hydroxyethoxy) ethyl4-phenylpiperidine-4-carboxylate) #
Furethidine Furethidine is a 4-phenylpiperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine), but with around 25x higher potency. According to another source, Furethidine is 500/30 = 16.7 x the potency of pe ...
(ethyl 1-(2-tetrahydrofurfury loxyethyl)-4-phenylpiperidine-4-carboxylate) #
Hydroxypethidine Hydroxypethidine (Bemidone) is an opioid analgesic that is an analogue of the more commonly used pethidine (meperidine). Hydroxypethidine is slightly more potent than meperidine as an analgesic, 1.5x meperidine in potency, and it also has NMDA a ...
(ethyl 4-(m-hydroxyphenyl)-1-methylpiperidine-4-carboxylate) #
Ketobemidone Ketobemidone, sold under the brand name Ketogan among others, is a powerful synthetic opioid painkiller. Its effectiveness against pain is in the same range as morphine, and it also has some NMDA-antagonist properties imparted, in part, by its m ...
(1- -(m-hydroxyphenyl)-1-methyl-4-piperidyl1-propanone) # Methylphenylisonipecotonitrile (4-cyano-1-methyl-4-phenylpiperidine) # Morpheridine (ethyl 1-(2-morpholinoethyl)-4-phenylpiperidine-4-carboxylate) #
Norpethidine Norpethidine (normeperidine, pethidine intermediate B) is a 4-phenylpiperidine derivative that is both a precursor to, and the toxic metabolite of, pethidine (meperidine). It is scheduled by UN Single Convention on Narcotic Drugs. It is a Sched ...
(ethyl 4-phenylpiperidine-4-carboxylate) #
Pethidine Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid analgesic, pain medication of the phenylpiperidine class. Synthesized in 1938 as a potential anticholinergic agent by the German chemis ...
(ethyl 1-methyl-4-phenylpiperidine-4-carboxylate) #
Phenoperidine Phenoperidine(Operidine or Lealgin), is an opioid analgesic which is structurally related to pethidine and is used clinically as a general anesthetic. Medical use Phenoperidine is an opioid pain killer -- narcotic analgesic. Pharmacology It i ...
(ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate) #
Piminodine Piminodine (Alvodine) is an opioid analgesic that is an analog (chemistry), analogue of pethidine (meperidine). It was used in medicine briefly during the 1960s and 70s, but has largely fallen out of clinical use. It was used particularly for ob ...
(ethyl 1- -(phenylamino)propyl4-phenylpiperidine-4-carboxylate) # Properidine (isopropyl 1-methyl-4-phenylpiperidine-4-carboxylate) #
Trimeperidine Trimeperidine (Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the early 1950s in the USSR during research into the related drug pethidine. Trimeperidine has four structural isomers, of which two are acti ...
(1,2,5-trimethyl-4-phenyl-4-piperidinol propionate) #
Pethidine Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid analgesic, pain medication of the phenylpiperidine class. Synthesized in 1938 as a potential anticholinergic agent by the German chemis ...
Intermediate C (1-methyl-4-phenylpiperidine-4-carboxylate)but not including: # Carbamethidine (ethyl 1-(2-carbamylethyl)-4-phenylpiperidine-4-carboxylate) and its salts #
Oxpheneridine OxpheneridineCS Patent 109234 is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). Oxpheneridine is not currently used in medicine. Presumably it has similar effects to other opioid derivatives ...
(ethyl 1-(2-hydroxy-2-phenylethyl)-4-phenylpiperidine-4-carboxylate) and its salts * Phenazepines, their salts, derivatives and salts of derivatives including: #
Proheptazine Proheptazine is an opioid analgesic from the phenazepine family. It was invented in the 1960s. Proheptazine produces similar effects to other opioids, including analgesia, sedation, euphoria, dizziness and nausea Nausea is a diffuse sensat ...
(hexahydro-1,3-dimethyl-4-phenyl-1H-azepin-4-ol propionate)but not including: #
Ethoheptazine Ethoheptazine (trade name Zactane) is an opioid analgesic from the phenazepane family. It was invented in the 1950s and is a ring expanded analogue of pethidine. Ethoheptazine produces similar effects to other opioids, including analgesia, sedat ...
(ethyl hexahydro-1-methyl-4-phenyl-azepine-4-carboxylate) and its salts # Metethoheptazine (ethyl hexahydro-1,3-dimethyl-4-phenylazepine-4-carboxylate) and its salts # Metheptazine () and its salts * Amidones, their intermediates, salts, derivatives and salts of intermediates and derivatives including: #
Dimethylaminodiphenylbutanonitrile Methadone intermediate is a methadone precursor scheduled by UN Single Convention on Narcotic Drugs The Single Convention on Narcotic Drugs, 1961 (Single Convention, 1961 Convention, or C61) is an international treaty that controls acti ...
(4-cyano-2-dimethylamino-4,4-diphenylbutane) #
Dipipanone Dipipanone (Pipadone) is a strong opioid analgesic drug, used for acute pain by mouth (PO) for adults - initially 10 mg every 6 hours, then increased if necessary up to 30 mg every 6 hours, with the dose to be increased gradually. It is often use ...
(4,4-diphenyl-6-piperidino-3-heptanone) # Isomethadone (6-dimethylamino-5-methyl-4,4-diphenyl-3-hexanone) #
Methadone Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid agonist used for chronic pain and also for opioid dependence. It is used to treat chronic pain, and it is also used to treat addiction to heroin ...
(6-dimethylamino-4,4-diphenyl-3-heptanone) # Normethadone (6-dimethylamino-4,4-diphenyl-3-hexanone) # Norpipanone (4,4-diphenyl-6-piperidino-3-hexanone) #
Phenadoxone Phenadoxone (trade names Heptalgin, Morphidone, and Heptazone) is an opioid analgesic of the open chain class (methadone and relatives) invented in Germany by Hoechst in 1947. It is one of a handful of useful synthetic analgesics which were used ...
(6-morpholino-4,4-diphenyl-3-heptanone) * Methadols, their salts, derivatives and salts of derivatives including: #
Acetylmethadol Acetylmethadol, also known as methadyl acetate, is a synthetic opioid analgesic. It is a racemic mixture of alphacetylmethadol (α-acetylmethadol) and betacetylmethadol (β-acetylmethadol), which are in turn racemic mixtures of levacetylmethado ...
(6-dimethylamino-4,4-diphenyl-3-heptanol acetate) #
Alphacetylmethadol Alphacetylmethadol ( INN), or α-acetylmethadol (AAM), is a synthetic opioid analgesic. Its levorotary enantiomer, levacetylmethadol, is an FDA-approved treatment for opioid addiction. Alphacetylmethadol is very similar in structure to methad ...
(α-6-dimethylamino-4,4-diphenyl-3-heptanol acetate) #
Alphamethadol Alphamethadol ( INN), or α-methadol, also known as alfametadol, is a synthetic opioid analgesic. It is an isomer of dimepheptanol (methadol), the other being betamethadol (β-methadol). Alphamethadol is composed of two isomers itself, L-α-met ...
(α-6-dimethylamino-4,4-diphenyl-3-heptanol) #
Betacetylmethadol Betacetylmethadol is a Chemical synthesis, synthetic opioid. It is a diastereoisomer of alphacetylmethadol (as well as levacetylmethadol). In the United States, betacetylmethadol is a List of Schedule I drugs (US), Schedule I drug Narcotic under ...
(β-6-dimethylamino-4,4-diphenyl-3-heptanol acetate) #
Betamethadol Betamethadol ( INN), or β-methadol, also known as betametadol, is a synthetic opioid analgesic. It is an isomer of dimepheptanol (methadol), the other being alphamethadol (α-methadol). Betamethadol is composed of two isomers itself, L-β-meth ...
(β-6-dimethylamino-4,4-diphenyl-3-heptanol) #
Dimepheptanol Dimepheptanol (International nonproprietary name, INN; Amidol, Pangerin), also known as methadol or racemethadol, is a Chemical synthesis, synthetic opioid analgesic related to methadone. It has similar effects to other opioids, including Analge ...
(6-dimethylamino-4,4-diphenyl-3-heptanol) #
Noracymethadol Noracymethadol (INN) is a synthetic opioid analgesic related to methadone that was never marketed. In a clinical trial of postpartum patients it was reported to produce analgesia comparable to that of morphine but with less nausea, dizziness ...
(α-6-methylamino-4,4-diphenyl-3-heptanol acetate) * Phenalkoxams, their salts, derivatives and salts of derivatives including: # Dimenoxadol (dimethylaminoethyl 1-ethoxy-1,1-diphenylacetate) # Dioxaphetyl butyrate (ethyl 2,2-diphenyl-4-morpholinobutyrate) #
Dextropropoxyphene Dextropropoxyphene is an analgesic in the opioid category, patented in 1955 and manufactured by Eli Lilly and Company. It is an optical isomer of levopropoxyphene. It is intended to treat mild pain and also has antitussive (cough suppressant) ...
( -(R*,S*)α- -(dimethylamino)-1-methylethylα-phenylbenzeneethanol, propanoate ester) * Thiambutenes, their salts, derivatives and salts of derivatives including: #
Diethylthiambutene Diethylthiambutene (Thiambutene, Themalon, Diethibutin, ''N'',''N''-Diethyl-1-methyl-3,3-di-2-thienylallylamine) is an opioid analgesic drug developed in the 1950s which was mainly used as an anesthetic in veterinary Veterinary medicine is th ...
(N,N-diethyl-1-methyl-3,3-di-2-thienylallylamine) # Dimethylthiambutene (N,N,1-trimethyl-3,3-di-2-thienylallylamine) #
Ethylmethylthiambutene Ethylmethylthiambutene (; Emethibutin) is an opioid analgesic drug from the thiambutene family, around 1.3x the potency of morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies ('' Papaver ...
(N-ethyl-N,1-dimethyl-3,3-di-2-thienylallylamine) * Moramides, their intermediates, salts, derivatives and salts of intermediates and derivatives including: #
Dextromoramide Dextromoramide (Palfium, Palphium, Jetrium, Dimorlin) is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties and b ...
(d-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine) # Diphenylmorpholinoisovaleric acid (2-methyl-3-morpholino-1,1-diphenylpropionic acid) #
Levomoramide Levomoramide is the inactive isomer of the opioid analgesic dextromoramide, invented by the chemist Paul Janssen in 1956. Unlike dextromoramide, which is a potent analgesic with high abuse potential, levomoramide is virtually without activity. ...
(l-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine) #
Racemoramide Racemoramide (INN, BAN), or simply moramide, is an opioid analgesic and a racemic mixture of the substances dextromoramide (the active component) and levomoramide (which is inactive), two enantiomers of a chiral molecule. Racemoramide is it ...
(d,l-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl) pyrrolidine) *
Morphinans Morphinan is the prototype chemical structure of a large chemical class of psychoactive drugs, consisting of opiate analgesics, cough suppressants, and dissociative hallucinogens, among others. Structure Morphinan has a phenanthrene core struct ...
, their salts, derivatives and salts of derivatives including: #
Buprenorphine Buprenorphine is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal ...
(17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol) # Drotebanol (6β,14-dihydroxy-3,4-dimethoxy-17-methylmorphinan) #
Levomethorphan Levomethorphan (LVM) ( INN, BAN) is an opioid analgesic of the morphinan family that has never been marketed. It is the L-stereoisomer of racemethorphan (methorphan). The effects of the two isomers of the racemethorphan are quite different, with ...
(l-3-methoxy-17-methylmorphinan) #
Levorphanol Levorphanol (brand name Levo-Dromoran) is an opioid medication used to treat moderate to severe pain. It is the levorotatory enantiomer of the compound racemorphan. Its dextrorotatory counterpart is dextrorphan. It was first described in Ge ...
(l-3-hydroxy-17-methylmorphinan) # Levophenacylmorphan (l-3-hydroxy-17-phenacylmorphinan) #
Norlevorphanol Norlevorphanol is an opioid analgesic of the morphinan family that was never marketed. It is the ''levo''- isomer of 3-hydroxymorphinan (morphinan-3-ol). Norlevorphanol is a Schedule I Narcotic controlled substance in the United States with an ...
(l-3-hydroxymorphinan) #
Phenomorphan Phenomorphan is an opioid analgesic. It is not currently used in medicine, but has similar side-effects to other opiates, which include itching, nausea and respiratory depression. Phenomorphan is a highly potent drug due to the N-phenethyl group, ...
(3-hydroxy-17-(2-phenylethyl)morphinan) # Race
methorphan Methorphan comes in two isomeric forms, each with differing pharmacology and effects: * Dextromethorphan - An over-the-counter cough suppressant, as well as dissociative hallucinogen. * Levomethorphan - A potent opioid analgesic that was ne ...
(d,1-3-methoxy-17-methylmorphinan) #
Racemorphan Racemorphan, or morphanol, is the racemic mixture of the two stereoisomers of 17-methylmorphinan-3-ol, each with differing pharmacology and effects: * Dextrorphan - an antitussive and dissociative hallucinogen ( NMDA receptor antagonist) * L ...
(d,l-3-hydroxy-N-methylmorphinan)but not including: #
Dextromethorphan Dextromethorphan (DXM) is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines. It is sold in syrup, tablet, spray, and lozenge forms. In 2022, the FDA approved a formulation of it combined with bu ...
(d-1,2,3,9,10,10a-hexahydro-6-methoxy-11-methyl-4H-10,4a-iminoethano-phenanthren) and its salts #
Dextrorphan Dextrorphan (DXO) is a psychoactive drug of the morphinan class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextrorotatory enantiomer of racemorphan; the levorotatory enantiomer is levorphanol. D ...
(d-1,2,3,9,10,10a-hexahydro-11-methyl-4H-10,4a-iminoethanophenanthren-6-ol) and its salts #
Levallorphan Levallorphan ( INN, BAN) (brand names Lorfan, Naloxifan, Naloxiphan), also known as levallorphan tartrate (USAN), is an opioid modulator of the morphinan family used as an opioid analgesic and opioid antagonist/antidote. It acts as an antagonist ...
(l-11-allyl-1,2,3,9,10,10a-hexahydro-4H-10,4a-iminoethanophenanthren-6-ol) and its salts # Levargorphan (l-11-propargyl-1,2,3,9,10,10a-hexahydro-4H-10,4a-iminoethanophenanthren-6-ol) and its salts #
Butorphanol Butorphanol is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers. Butorphanol is most closely structurally related to levorphanol. Butorphanol is available as the tartrate salt in injectable, tablet, and ...
(17-(cyclobutylmethyl)morphinan-3,14-diol) and its salts #
Nalbuphine Nalbuphine, sold under the brand names Nubain among others, is an opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamm ...
(17-(cyclobutylmethyl)-4,5α-epoxymorphinan-3,6α, 14-triol) and its salts *
Benzazocine Benzazocine, also known as benzoazocine, is a chemical compound. It consists of a benzene ring bound to an azocine ring. A related compound is benzomorphan. See also * Azocine * Benzomorphan Benzomorphan is a chemical compound that is the ...
s, their salts, derivatives and salts of derivatives including: #
Phenazocine Phenazocine (brand names Prinadol, Narphen) is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects. Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at ...
(1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-phenethyl-2,6-methano-3-benzazocin-8-ol) # Metazocine (1,2,3,4,5,6-hexahydro-3,6,11-trimethyl-2,6-methano-3-benzazocin-8-ol) #
Pentazocine Pentazocine, sold under the brand name Talwin among others, is a painkiller used to treat moderate to severe pain. It is believed to work by activating (agonizing) κ-opioid receptors (KOR) and μ-opioid receptors (MOR). As such it is called an ...
(1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol)but not including: #
Cyclazocine Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. This family of opioid drugs is called the benzomorphans or benzazocines. It is a KOR agonist and MOR partial agonist, and also has high affinit ...
(1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(cyclopropylmethyl)-2,6-methano-3-benzazocin-8-ol) and its salts * Ampromides, their salts, derivatives and salts of derivatives including: #
Diampromide Diampromide is an opioid analgesic from the ampromide family of drugs, related to other drugs such as propiram and phenampromide. It was invented in the 1960s by American Cyanamid, and can be described as a ring-opened analogue of fentanyl. Diamp ...
(N- -(methylphenethylamino)propylpropionanilide) #
Phenampromide Phenampromide is an opioid analgesic from the ampromide family of drugs, related to other drugs such as propiram and diampromide. It was invented in the 1960s by American Cyanamid Co. Although never given a general release, it was trialled and ...
(N-(1-methyl-2-piperidino) ethyl) propionanilide) #
Propiram Propiram (Algeril, Dirame, Bay 4503) is a partial mu opioid receptor agonist and weak mu antagonist analgesic from the ampromide family of drugs related to other drugs such as phenampromide and diampromide. It was invented in 1963 in the United ...
(N-(1-methyl-2-piperidinoethyl)-N-2-pyridylpropionamide) *
Benzimidazole Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a colorless solid. Preparation Benzimidazole is produced by condensation of o ...
s, their salts, derivatives and salts of derivatives including: #
Clonitazene Clonitazene is an opioid analgesic of approximately three times the potency of morphine. It is related to etonitazene Etonitazene is an analgesic drug, first reported in 1957, that has been shown to have approximately 1,000 to 1,500 times the po ...
(2-(p-chlorobenzyl)-1-diethylaminoethyl-5-nitrobenzimidazole) #
Etonitazene Etonitazene is an analgesic drug, first reported in 1957, that has been shown to have approximately 1,000 to 1,500 times the potency of morphine in animals. Because it is characterized by a strong dependency potential and a tendency to produce pr ...
(2-(p-ethoxybenzyl)-1-diethylaminoethyl-5-nitrobenzimidazole) #
Bezitramide Bezitramide is an opioid analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its active metabolite, despropionyl-bezitramide. Bezitramide was discovered at Janssen Pharmaceutica in 1961. It is m ...
(1-(3-cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)-piperidine) *
Phencyclidine Phencyclidine or phenylcyclohexyl piperidine (PCP), also known as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects. PCP may cause hallucinations, distorted percept ...
(1-(1-phenylcyclohexyl)piperidine), its salts, derivatives and analogues and salts of derivatives and analogues, including: #
Ketamine Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ...
(2-(2-chlorophenyl)-2-(methylamino)cyclohexanone) * Piritramide (1-(3-cyano-3,3-diphenylpropyl)-4-(1-piperidino)piperidine-4-carboxylic acid amide), its salts, derivatives and salts of derivatives *
Fentanyl Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
s, their salts, derivatives, and analogues and salts of derivatives and analogues, including: # Acetyl-α-methylfentanyl (N- -(α-methylphenethyl)-4-piperidylacetanilide) #
Alfentanil Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around one-fourth to one-tenth the potency, one-third ...
(N- -[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl4-(methoxymethyl)-4-piperidyl.html" ;"title="-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl">-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl4-(methoxymethyl)-4-piperidyl">-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl">-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl4-(methoxymethyl)-4-piperidylropionanilide) # Carfentanil (methyl 4-[(1-oxopropyl)phenylamino]-1-(2-phenethyl)-4-piperidinecarboxylate) # Parafluorofentanyl, p-Fluorofentanyl (4′fluoro-N-(1-phenethyl-4-piperidyl) propionanilide) #
Fentanyl Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
(N-(1-phenethyl-4-piperidyl) propionanilide) # β-Hydroxyfentanyl (N- -(β-hydroxyphenethyl)-4-piperidylpropionanilide) # β-Hydroxy-3-methylfentanyl (N- -(β-hydroxyphenethyl)-3-methyl-4-piperidylpropionanilide) # α-Methylfentanyl (N- -(α-methylphenethyl)-4-piperidylpropionanilide) # α-Methylthiofentanyl (N- -[1-methyl-2-(2-thienyl)_ethyl4-piperidyl.html" ;"title="-methyl-2-(2-thienyl)_ethyl.html" ;"title="-[1-methyl-2-(2-thienyl) ethyl">-[1-methyl-2-(2-thienyl) ethyl4-piperidyl">-methyl-2-(2-thienyl)_ethyl.html" ;"title="-[1-methyl-2-(2-thienyl) ethyl">-[1-methyl-2-(2-thienyl) ethyl4-piperidylpropionanilide) # 3-Methylfentanyl (N-(3-methyl-1-phenethyl-4-piperidyl) propionanilide) # 3-Methylthiofentanyl (N-[3-methyl-1-[2-(2-thienyl) ethyl]-4-piperidyl] propionanilide) ## Remifentanil (dimethyl 4-carboxy-4-(N-phenylpropionamido)-1-piperidinepropionate) #
Sufentanil Sufentanil, sold under the brand names Dsuvia and Sufenta, is a synthetic opioid analgesic drug approximately 5 to 10 times as potent as its parent drug, fentanyl, and 500 times as potent as morphine. Structurally, sufentanil differs from fen ...
(N- -(methoxymethyl)-1-[2-(2-thienyl)ethyl4-piperidyl.html" ;"title="-(2-thienyl)ethyl.html" ;"title="-(methoxymethyl)-1-[2-(2-thienyl)ethyl">-(methoxymethyl)-1-[2-(2-thienyl)ethyl4-piperidyl">-(2-thienyl)ethyl.html" ;"title="-(methoxymethyl)-1-[2-(2-thienyl)ethyl">-(methoxymethyl)-1-[2-(2-thienyl)ethyl4-piperidylpropionanilide) # Thiofentanyl (N-[1-[2-(2-thienyl)ethyl]-4-piperidyl] propionanilide) * Tilidine (ethyl2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate), its salts, derivatives and salts of derivatives # Methylenedioxypyrovalerone (MDPV), its salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues * Methamphetamine (N,α-dimethylbenzeneethanamine), its salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues *
Amphetamines Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with sub ...
, their salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues including: #
Amphetamine Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used ...
(α-methylbenzene-ethanamine) # N-ethylamphetamine (N-ethyl-α-methylbenzeneethanamine) #
4-methyl-2,5-dimethoxyamphetamine 2,5-Dimethoxy-4-methylamphetamine (DOM; known as STP, standing for "Serenity, Tranquility and Peace") is a psychedelic and a substituted amphetamine. It was first synthesized by Alexander Shulgin, and later reported in his book '' PiHKAL: A Che ...
(STP) (2,5-dimethoxy-4,α-dimethylbenzeneethanamine) # 3,4-Methylenedioxyamphetamine (MDA) (α-methyl-1,3-benzodioxole-5-ethanamine) # 2,5-dimethoxyamphetamine (2,5-dimethoxy-α-methylbenzene-ethanamine) #
4-methoxyamphetamine ''para''-Methoxyamphetamine (PMA), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. Unlike other similar drugs of this family, PMA does not produce stimulant, euphoriant, or ent ...
(4-methoxy-α-methylbenzeneethanamine) # 2,4,5-
trimethoxyamphetamine Trimethoxyamphetamines (TMAs) are a family of isomeric psychedelic hallucinogenic drugs. There exist six different TMAs that differ only in the position of the three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. The TMAs are anal ...
(2,4,5-trimethoxy-α-methylbenzeneethanamine) # N-methyl-3,4-methylenedioxy- amphetamine (N,α-dimethyl-1,3-benzodioxole-5-ethanamine) # 4-ethoxy-2,5-dimethoxyamphetamine (4-ethoxy-2,5-dimethoxy-α-methylbenzeneethanamine) # 5-methoxy-3,4-methylenedioxy- amphetamine (7-methoxy-α-methyl-1,3-benzodioxole-5-ethanamine) # N,N-dimethyl-3,4-methylenedioxyamphetamine (N,N, α-trimethyl-1,3-benzodioxole-5-ethanamine) # N-ethyl-3,4-methylenedioxyamphetamine (N-ethyl-α-methyl-1,3-benzodioxole-5-ethanamine) # 4-ethyl-2,5-dimethoxyamphetamine (DOET) (4-ethyl-2,5-dimethoxy-α-methylbenzeneethanamine) # 4-bromo-2,5-dimethoxyamphetamine (4-bromo-2,5-dimethoxy-α-methylbenzeneethanamine) # 4-chloro-2,5-dimethoxyamphetamine (4-chloro-2,5-dimethoxy-α-methyl-benzeneethanamine) # 4-ethoxyamphetamine (4-ethoxy-α-methylbenzeneethanamine) #
Benzphetamine Benzphetamine (brand name Didrex) is a substituted amphetamine used short-term along with a doctor-approved, reduced- calorie diet, exercise, and behavioral program for weight loss. It is prescribed for obesity to people who have been unable to ...
(N-benzyl-N,α-dimethylbenzeneethanamine) # N-Propyl-3,4-methylenedioxy- amphetamine (α-methyl-N-propyl-1,3-benzodioxole-5-ethanamine) # N-(2-Hydroxyethyl)-α-meth-ylbenzeneethanamine # N-hydroxy-3,4-methylenedioxy- amphetamine (N- ±-methyl-3,4-(methylenedioxy)phenethylydroxylamine) # 3,4,5-trimethoxyamphetamine (3,4,5-trimethoxy-α-methylbenzeneethanamine) *
Flunitrazepam Flunitrazepam, also known as Rohypnol among other names, is a benzodiazepine used to treat severe insomnia and assist with anesthesia. As with other hypnotics, flunitrazepam has been advised to be prescribed only for short-term use or by thos ...
(5-(o-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one) and any of its salts or derivatives * 4-hydroxybutanoic acid (GHB) and any of its salts *
Tapentadol Tapentadol, brand names Nucynta among others, is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Analgesia occurs wit ...
(3- 1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropylphenol), its salts, derivatives and isomers and salts of derivatives and isomers *
AH-7921 AH-7921 is an opioid analgesic drug selective for the μ-opioid receptor, having around 90% the potency of morphine when administered orally. It was discovered in the 1970s by a team at Allen and Hanburys located in the United Kingdom. The drug ...
(1-(3,4-dichlorobenzamidomethyl)cyclohexyldimethylamine), its salts, isomers and salts of isomers *
MT-45 MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl) piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-4 ...
(1-cyclohexyl-4-(1,2-diphenylethyl)piperazine), its salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues, including: #
Diphenidine Diphenidine (1,2-DEP, DPD, DND) is a dissociative anesthetic that has been sold as a designer drug. The synthesis of diphenidine was first reported in 1924, and employed a Bruylants reaction analogous to the one that would later be used to discov ...
(DEP) (1-(1,2-diphenylethyl)piperidine) #
Methoxphenidine Methoxphenidine (methoxydiphenidine, 2-MeO-Diphenidine, MXP) is a dissociative of the diarylethylamine class that has been sold online as a designer drug. Methoxphenidine was first reported in a 1989 patent where it was tested as a treatment for ...
(2-MeO-Diphenidine, MXP) (1- -(2-methoxyphenyl)-2-phenylethyliperidine) #
Ephenidine Ephenidine (also known as NEDPA and EPE) is a dissociative anesthetic that has been sold online as a designer drug. It is illegal in some countries as a structural isomer of the banned opioid drug lefetamine, but has been sold in countries wher ...
(NEDPA, EPE) (N-ethyl-1,2-diphenylethylamine) # Isophenidine (NPDPA) (N-isopropyl-1,2-diphenylethylamine)but not including: #
Lefetamine Lefetamine (Santenol) is a drug which is a stimulant and also an analgesic with effects comparable to codeine. Discovery Lefetamine-related 1,2-diphenylethylamines were invented in the 1940s and showed weak analgesic activity. It was inv ...
((-)-N,N-dimethyl-α-phenylbenzeneethanamine), its salts, derivatives and isomers and salts of derivatives and isomers * W-18 (-chloro-N- -[2-(4-nitrophenyl)ethyl2-piperidinylidene.html" ;"title="-(4-nitrophenyl)ethyl.html" ;"title="-[2-(4-nitrophenyl)ethyl">-[2-(4-nitrophenyl)ethyl2-piperidinylidene">-(4-nitrophenyl)ethyl.html" ;"title="-[2-(4-nitrophenyl)ethyl">-[2-(4-nitrophenyl)ethyl2-piperidinylideneenzenesulfonamide), its salts, derivatives, isomers and analogues and salts of derivatives, isomers and analogues * U-47700 (3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide), its salts, derivatives, isomers and analogues, and salts of derivatives, isomers and analogues, including: # Bromadoline (4-bromo-N-(2-(dimethylamino)cyclohexyl)benzamide) # U-47109 (3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)benzamide) # U-48520 (4-chloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide) # U-50211 (N-(2-(dimethylamino)cyclohexyl)-4-hydroxy-N-methylbenzamide) # U-77891 (3,4-dibromo-N-methyl-N-(1-methyl-1-azaspiro .5ecan-6-yl)benzamide) *
Tramadol Tramadol, sold under the brand name Ultram among others, is an opioid pain medication used to treat moderate to moderately severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an ...
(2- dimethylamino)methyl1-(3-methoxyphenyl)cyclohexanol), its salts, isomers and salts of isomers and the following derivatives of tramadol and the salts, isomers and salts of isomers of those derivatives: #
O-desmethyltramadol Desmetramadol (), also known as ''O''-desmethyltramadol (''O''-DSMT), is an opioid analgesic and the main active metabolite of tramadol. Tramadol is demethylated by the liver enzyme CYP2D6 in the same way as codeine, and so similarly to the varia ...
(3- dimethylamino)methyl1-hydroxycyclohexyl.html" ;"title="- dimethylamino)methyl1-hydroxycyclohexyl">- dimethylamino)methyl1-hydroxycyclohexylphenol) # N,O-didesmethyltramadol (3- -hydroxy-2-[(methylamino)methylyclohexyl.html" ;"title="methylamino)methyl.html" ;"title="-hydroxy-2-[(methylamino)methyl">-hydroxy-2-[(methylamino)methylyclohexyl">methylamino)methyl.html" ;"title="-hydroxy-2-[(methylamino)methyl">-hydroxy-2-[(methylamino)methylyclohexylphenol)


Schedule II

* Synthetic cannabinoid receptor type 1 agonists, their salts, derivatives, isomers, and salts of derivatives and isomers — with the exception of any substance that is identical to any phytocannabinoid and with the exception of ((3S)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo ,2,3-de1,4-benzoxazin-6-yl)-1-naphthalenyl-methanone (WIN 55,212-3) and its salts—including those that fall within the following core chemical structure classes: # Any substance that has a 2-(cyclohexyl)phenol structure with substitution at the 1-position of the benzene ring by a hydroxy, ether or ester group and further substituted at the 5-position of the benzene ring, whether or not further substituted on the benzene ring to any extent, and substituted at the 3'-position of the cyclohexyl ring by an alkyl, carbonyl, hydroxyl, ether or ester, and whether or not further substituted on the cyclohexyl ring to any extent, including ##
Nabilone Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It mimics tetrahydrocannabinol (THC), the primary psychoactive compound ...
((±)-trans-3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo ,dyran-9-one) ##
Parahexyl Parahexyl (Synhexyl, n-hexyl-Δ3-THC, (C6)-Δ6a(10a)-THC) is a synthetic homologue of THC which was invented in 1941 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis. Parahexyl is similar in both st ...
(3-hexyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo ,dyran-1-ol) ## 3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo ,dyran-1-ol (DMHP) ## 5-(1,1-dimethylheptyl)-2-(5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)phenol (CP 55,940) ## 5-(1,1-dimethylheptyl)-2-(3-hydroxycyclohexyl)phenol (CP 47,497) # Any substance that has a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the naphthyl ring to any extent, including ## 1-pentyl-3-(1-naphthoyl)indole (JWH-018) ## 1-butyl-3-(1-naphthoyl)indole (JWH-073) ## 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122) ## 1-hexyl-3-(1-naphthoyl)indole (JWH-019) ## 1-(4-pentenyl)-3-(1-naphthoyl)indole (JWH-022) ## 1-butyl-3-(4-methoxy-1-naphthoyl)indole (JWH-080) ## 1-pentyl-3-(4-methoxy-1-naphthoyl)indole (JWH-081) ## 1-(2-morpholin-4-ylethyl)-3-(1-naphthoyl)indole (JWH-200) ## 1-pentyl-3-(4-ethyl-1-naphthoyl)indole (JWH-210) ## 1-pentyl-3-(2-methoxy-1-naphthoyl)indole (JWH-267) ## 1- N-methylpiperidin-2-yl)methyl3-(1-naphthoyl)indole (AM-1220) ## 1-(5-fluoropentyl)-3-(1-naphthoyl)indole (AM-2201) ## 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole (MAM-2201) ## 1-(5-fluoropentyl)-3-(4-ethyl-1-naphthoyl)indole (EAM-2201) ## ((3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo ,2,3-de1,4-benzoxazin-6-yl)-1-naphthalenyl-methanone (WIN 55,212-2) # Any substance that has a 3-(1-naphthoyl)pyrrole structure with substitution at the nitrogen atom of the pyrrole ring, whether or not further substituted on the pyrrole ring to any extent and whether or not substituted on the naphthyl ring to any extent, including ## 1-pentyl-5-(2-fluorophenyl)-3-(1-naphthoyl)pyrrole (JWH-307) # Any substance that has a 3-phenylacetylindole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the phenyl ring to any extent, including ## 1-pentyl-3-(2-methoxyphenylacetyl)indole (JWH-250) ## 1-pentyl-3-(2-methylphenylacetyl)indole (JWH-251) ## 1-pentyl-3-(3-methoxyphenylacetyl)indole (JWH-302) # Any substance that has a 3-benzoylindole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the phenyl ring to any extent, including ## 1-(1-methylpiperidin-2-ylmethyl)-3-(2-iodobenzoyl)indole (AM-2233) # Any substance that has a 3-methanone(cyclopropyl)indole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the cyclopropyl ring to any extent, including ## (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone (UR-144) ## (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone (5F-UR-144) ## (1-(2-(4-morpholinyl)ethyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone (A-796,260) # Any substance that has a quinolin-8-yl 1H-indole-3-carboxylate structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the quinolin-8-yl ring to any extent, including ## 1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid (PB-22) ## 1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid (5F-PB-22) # Any substance that has a 3-carboxamideindazole structure with substitution at the nitrogen atom of the indazole ring, whether or not further substituted on the indazole ring to any extent and whether or not substituted at the carboxamide group to any extent, including ## N-(adamantan-1-yl)-1-pentyl-1H-indazole-3-carboxamide (AKB48) ## N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide (5F-AKB48) ## N-(1-(aminocarbonyl)-2-methylpropyl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) ## N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) # Any substance that has a 3-carboxamideindole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted at the carboxamide group to any extent, including ## N-(adamantan-1-yl)-1-fluoropentylindole-3-carboxamide (STS-135) ## N-(adamantan-1-yl)-1-pentylindole-3-carboxamide (APICA)


Schedule III

#
Methylphenidate Methylphenidate, sold under the brand names Ritalin and Concerta among others, is the most widely prescribed central nervous system (CNS) stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and, to a lesser exten ...
(α-phenyl-2-piperidineacetic acid methyl ester) and any salts, derivatives, isomers, and analogues and salts of derivatives, isomers, and analogues, including: ##
Ethylphenidate Ethylphenidate (EPH), also known as Baxtercaine in the United Kingdom is a psychostimulant and a close analog of methylphenidate. Ethylphenidate acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor, meaning it effecti ...
(ethyl 2-phenyl-2-(piperidin-2-yl)acetate) ##
Isopropylphenidate Isopropylphenidate (also known as IPH and IPPD) is a piperidine based stimulant drug, closely related to methylphenidate, but with the methyl ester replaced by an isopropyl ester. It has similar effects to methylphenidate but with a longer dura ...
(isopropyl 2-phenyl-2-(piperidin-2-yl)acetate) ##
Propylphenidate Propylphenidate (also known as PPH) is a piperidine based stimulant drug, closely related to methylphenidate, but with the methyl ester replaced by a propyl ester. It was banned in the UK as a Temporary Class Drug from April 2015 following its u ...
(propyl 2-phenyl-2-(piperidin-2-yl)acetate) ## 3,4-Dichloromethylphenidate (methyl 2-(3,4-dichlorophenyl)-2-(piperidin-2-yl)acetate) ## 4-Methylmethylphenidate (methyl 2-(4-methylphenyl)-2-(piperidin-2-yl)acetate) ## 4-Fluoromethylphenidate (methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate) ##
Methylnaphthidate HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenid ...
(methyl 2-(naphthalen-2-yl)-2-(piperidin-2-yl)acetate) ## Ethylnaphthidate (ethyl 2-(naphthalen-2-yl)-2-(piperidin-2-yl)acetate) #
Methaqualone Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude ( ) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg me ...
(2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone) and any salt thereof #
Mecloqualone Mecloqualone (Nubarene, Casfen) is a Quinazolinone-class GABAergic and is an analogue of methaqualone that was first made in 1960 and marketed mainly in France and some other European countries. It has sedative, hypnotic, and anxiolytic proper ...
(2-methyl-3-(2-chlorophenyl)-4(3H)-quinazolinone) and any salt thereo
11
#
LSD Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
(lysergic acid diethylamide) (N,N-diethyllysergamide) and any salt thereof # DET (N,N-Diethyltryptamine) (3- 2-diethylamino) ethylndole) and any salt thereof # DMT (N,N-Dimethyltryptamine) (3- 2-dimethylamino) ethylndole) and any salt thereof # JB-336 (N-Methyl-3-piperidyl benzilate or LBJ) (3- hydroxydiphenylacetyl)oxy1-methylpiperidine) and any salt thereof #
Harmaline Harmaline is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partly hydrogenated form of harmine. Occurrence in nature Various plants contain harmaline including ''Peganum harmala'' (Syrian rue) ...
(4,9-dihydro-7-methoxy-1-methyl-3H-pyrido(3,4-b)indole) and any salt thereof #
Harmalol Harmalol is a bioactive beta-carboline β-Carboline (9''H''- pyrido ,4-''b'' ndole) represents the basic chemical structure for more than one hundred alkaloids and synthetic compounds. The effects of these substances depend on their respective ...
(4,9-dihydro-1-methyl-3H-pyrido(3,4-b)indol-7-ol) and any salt thereof #
Psilocin Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counte ...
(3- -(dimethylamino)ethyl4-hydroxyindole) and any salt thereof #
Psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
(3- -(dimethylamino)ethyl4-phosphoryloxyindole) and any salt thereof # PCE (N-(1-phenylcyclohexyl)ethylamine) and any salt thereof # TCP (1- -(2-Thienyl) cyclohexyliperidine) and any salt thereof # PCPr (1-Phenyl-N-propylcyclohexanamine) and any salt thereof # Rolicyclidine (1-(1-phenylcyclohexyl) pyrrolidine) and any salt thereof #
Mescaline Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sou ...
(3,4,5-trimethoxybenzeneethanamine) and any salt thereof, but not peyote (lophophora) # 4-Methylaminorex (4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine) and any salt thereof # Cathinone ((-)-α-aminopropiophenone) and any salt thereof # Fenetylline (d,l-3,7-dihydro-1,3-dimethyl-7-(2- 1-methyl-2-phenethyl)aminothyl)-1H-purine-2, 6-dione) and any salt thereof #
Methcathinone Methcathinone (α-methylamino- propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash" ) is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreationa ...
(2-Methylamino-1-phenyl-1-propanone) and any salt thereof # Benzylcyclidine (1-
-(Phenylmethyl)cyclohexyl The hyphen-minus is the most commonly used type of hyphen, widely used in digital documents. It is the only character that looks like a minus sign or a dash in many character sets such as ASCII or on most keyboards, so it is also used as such. ...
iperidine) and any salt thereof # 4-Methyl-PCP (1- -(4-Methylphenyl)cyclohexyliperidine) and any salt thereof # epealed, SOR/2016-73, s. 1# epealed, 2012, c. 1, s. 46# epealed, 2012, c. 1, s. 46#
Aminorex Aminorex (Menocil, Apiquel, aminoxaphen, aminoxafen, McN-742) is a weight loss (anorectic) stimulant drug. It was withdrawn from the market after it was found to cause pulmonary hypertension. In the U.S., it is an illegal Schedule I drug, mea ...
(4,5-dihydro-5-phenyl-2-oxazolamine) and any salt thereof # Etryptamine (3-(2-aminobutyl)indole) and any salt thereof #
Lefetamine Lefetamine (Santenol) is a drug which is a stimulant and also an analgesic with effects comparable to codeine. Discovery Lefetamine-related 1,2-diphenylethylamines were invented in the 1940s and showed weak analgesic activity. It was inv ...
((-)-N,N-dimethyl-α-phenylbenzeneethanamine) and any salt thereof #
Mesocarb Mesocarb (brand names Sidnocarb, Sydnocarb) is a drug that is currently being developed for Parkinson's disease. The drug was originally developed in the USSR in the 1970s for a variety of indications including asthenia, apathy, adynamia and ...
(3-(α-methylphenethyl)-N-(phenylcarbamoyl)sydnone imine) and any salt thereof # Zipeprol (4-(2-methoxy-2-phenylethyl)-α-(methoxyphenylmethyl)-1-piperazineethanol) and any salt thereof #
Amineptine Amineptine, formerly sold under the brand name Survector among others, is an atypical antidepressant of the tricyclic antidepressant (TCA) family. It acts as a selective and mixed dopamine reuptake inhibitor and releasing agent, and to a lesser ...
(7- 10,11-dihydro-5H-dibenzo[a,dyclohepten-5-yl)amino.html" ;"title=",d.html" ;"title="10,11-dihydro-5H-dibenzo[a,d">10,11-dihydro-5H-dibenzo[a,dyclohepten-5-yl)amino">,d.html" ;"title="10,11-dihydro-5H-dibenzo[a,d">10,11-dihydro-5H-dibenzo[a,dyclohepten-5-yl)aminoeptanoic acid) and any salt thereof # BZP (Benzylpiperazine) (1-benzylpiperazine) and its salts, isomers and salts of isomers # TFMPP (Trifluoromethylphenylpiperazine) (1-(3-trifluoromethylphenyl)piperazine) and its salts, isomers and salts of isomers # 2C-phenethylamines and their salts, derivatives, isomers and salts of derivatives and isomers that correspond to the following chemical description: #: any substance that has a 1-amino-2-phenylethane structure substituted at the 2' and 5' or 2' and 6' positions of the benzene ring by an alkoxy or haloalkoxy group, or substituted at two adjacent carbon atoms of the benzene ring which results in the formation of a furan, dihydrofuran, pyran, dihydropyran or methylenedioxy group—whether or not further substituted on the benzene ring to any extent, whether or not substituted at the
amino group In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituent such ...
by one or two, or a combination of,
methyl In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula . In formulas, the group is often abbreviated as Me. This hydrocarbon group occurs in many ...
,
ethyl Ethyl may refer to: Arts and entertainment * Cold Ethyl, a Swedish rock band *Ethyl Sinclair, a character in the ''Dinosaurs'' television show Science and technology * Ethyl group, an organic chemistry moiety * Ethyl alcohol (or ethanol) * E ...
,
propyl In organic chemistry, propyl is a three-carbon alkyl substituent with chemical formula for the linear form. This substituent form is obtained by removing one hydrogen atom attached to the terminal carbon of propane. A propyl substituent is often ...
,
isopropyl In organic chemistry, propyl is a three-carbon alkyl substituent with chemical formula for the linear form. This substituent form is obtained by removing one hydrogen atom attached to the terminal carbon of propane. A propyl substituent is ofte ...
,
hydroxyl In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom. In organic chemistry, alcohols and carboxylic acids contain one or more hydroxy ...
,
benzyl In organic chemistry, benzyl is the substituent or molecular fragment possessing the structure . Benzyl features a benzene ring () attached to a methylene group () group. Nomenclature In IUPAC nomenclature, the prefix benzyl refers to a substi ...
(or benzyl substituted to any extent) or benzylene (or benzylene substituted to any extent) groups and whether or not substituted at the 2-ethyl (beta carbon) position by a hydroxyl, oxo or alkoxy group—and its salts and derivatives and salts of derivatives, including: # 4-bromo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25B-NBOMe) # 4-chloro-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25C-NBOMe) # 4-iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) # 4-bromo-2,5-dimethoxybenzeneethanamine (2C-B)


Schedule IV

* Barbiturates, their salts and derivatives including # Allobarbital (5,5-diallylbarbituric acid) # Alphenal (5-allyl-5-phenylbarbituric acid) #
Amobarbital Amobarbital (formerly known as amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. ...
(5-ethyl-5-(3-methylbutyl)barbituric acid) # Aprobarbital (5-allyl-5-isopropylbarbituric acid) #
Barbital Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemic ...
(5,5-diethylbarbituric acid) # epealed, SOR/2017-13, s. 7#
Butabarbital Butabarbital (brand name Butisol) is a prescription barbiturate Sedative, sleep aid and anxiety medication. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful ...
(5-sec-butyl-5-ethylbarbituric acid) #
Butalbital Butalbital is a barbiturate with an intermediate duration of action. Butalbital is often combined with other medications, such as paracetamol (acetaminophen) or aspirin, for the treatment of pain and headache. The various formulations combined wi ...
(5-allyl-5-isobutylbarbituric acid) # Butallylonal (5-(2-bromoallyl)-5-sec-butylbarbituric acid) # Butethal (5-butyl-5-ethylbarbituric acid) #
Cyclobarbital Cyclobarbital, also known as cyclobarbitol or cyclobarbitone, is a barbiturate derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respec ...
(5-(1-cyclohexen-1-yl)-5-ethylbarbituric acid) #
Cyclopal Cyclopentobarbital sodium (Cyclopal, Dormisan) is a barbiturate derivative invented in the 1940s. It has sedative and anticonvulsant properties, and was used primarily as an anaesthetic in veterinary medicine. Cyclopal is considered similar i ...
(5-allyl-5-(2-cyclopenten-1-yl)barbituric acid) # Heptabarbital (5-(1-cyclohepten-1-yl)-5-ethylbarbituric acid) # Hexethal (5-ethyl-5-hexylbarbituric acid) #
Hexobarbital Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia fo ...
(5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid) # Mephobarbital (5-ethyl-1-methyl-5-phenylbarbituric acid) # Methabarbital (5,5-diethyl-1-methylbarbituric acid) #
Methylphenobarbital Methylphenobarbital (INN), also known as mephobarbital (USAN, JAN) and mephobarbitone ( BAN), marketed under brand names such as Mebaral, Mephyltaletten, Phemiton, and Prominal, is a drug which is a barbiturate derivative and is used primarily ...
(5-ethyl-1-methyl-5-phenylbarbituric acid) # Propallylonal (5-(2-bromoallyl)-5-isopropylbarbituric acid) #
Pentobarbital Pentobarbital (previously known as pentobarbitone in Britain and Australia) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies. It can also be used for short-term treatment of i ...
(5-ethyl-5-(1-methylbutyl)barbituric acid) #
Phenobarbital Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of ep ...
(5-ethyl-5-phenylbarbituric acid) # Probarbital (5-ethyl-5-isopropylbarbituric acid) # Phenylmethylbarbituric acid (5-methyl-5-phenylbarbituric acid) #
Secobarbital Secobarbital (as the sodium salt, originally marketed by Eli Lilly and Company for the treatment of insomnia, and subsequently by other companies as described below, under the brand name Seconal) is a short-acting barbiturate derivative drug that ...
(5-allyl-5-(1-methylbutyl)barbituric acid) # Sigmodal (5-(2-bromoallyl)-5-(1-methylbutyl) barbituric acid) # Talbutal (5-allyl-5-sec-butylbarbituric acid) # Vinbarbital (5-ethyl-5-(1-methyl-1-butenyl)barbituric acid) # Vinylbital (5-(1-methylbutyl)-5-vinylbarbituric acid)but not including: #
Barbituric acid Barbituric acid or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid i ...
(2,4,6(1H,3H,5H)-pyrimidinetrione) and its salts # 1,3-dimethylbarbituric acid (1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione) and its salts * Thiobarbiturates, their salts and derivatives including: #
Thialbarbital Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical anaesthesia. Thialbarbital is short acting and has less of a tendency to induce respiratory ...
(5-allyl-5-(2-cyclohexen-1-yl)-2-thiobarbituric acid) #
Thiamylal Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgica ...
(5-allyl-5-(1-methylbutyl)-2-thiobarbituric acid) #
Thiobarbituric acid Thiobarbituric acid is an organic compound and a heterocycle. It is used as a reagent in assaying malondialdehyde Malondialdehyde (MDA) is the organic compound with the nominal formula CH2(CHO)2. A colorless liquid, malondialdehyde is a highly r ...
(2-thiobarbituric acid) #
Thiopental Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic. It is the thiobarbiturate analog of p ...
(5-ethyl-5-(1-methylbutyl)-2-thiobarbituric acid) *
Chlorphentermine Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine, which is still in ...
(1-(p-chlorophenyl)-2-methyl-2-aminopropane) and any salt thereof * Diethylpropion (2-(diethylamino)propiophenone) and any salt thereof *
Phendimetrazine Phendimetrazine (Bontril, Adipost, Anorex-SR, Appecon, Melfiat, Obezine, Phendiet, Plegine, Prelu-2, Statobex) is a stimulant drug of the morpholine chemical class used as an appetite suppressant. Pharmacology Phendimetrazine functions as a p ...
(d-3,4-dimethyl-2-phenylmorpholine) and any salt thereof *
Phenmetrazine Phenmetrazine ( INN, USAN, BAN) (brand name Preludin, and many others) is a stimulant drug first synthesized in 1952 and originally used as an appetite suppressant, but withdrawn from the market in the 1980s due to widespread abuse. It was initi ...
(3-methyl-2-phenylmorpholine) and any salt thereof *
Pipradrol Pipradrol (Meratran) is a mild central nervous system stimulant ( norepinephrine-dopamine reuptake inhibitor) that is no longer widely used in most countries due to concerns about its abuse potential. Pipradrol is still used in some European cou ...
(α,α-diphenyl-2-piperidinemethanol) and any salt thereof *
Phentermine Phentermine ( phenyl- tertiary-butyl amine), with several brand names including Ionamin and Sentis, is a medication used together with diet and exercise to treat obesity. It is taken by mouth for up to a few weeks at a time, after which the ben ...
(α,α-dimethylbenzeneethanamine) and any salt thereof *
Butorphanol Butorphanol is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers. Butorphanol is most closely structurally related to levorphanol. Butorphanol is available as the tartrate salt in injectable, tablet, and ...
(l-N-cyclobutylmethyl-3,14-dihydroxymorphinan) and any salt thereof *
Nalbuphine Nalbuphine, sold under the brand names Nubain among others, is an opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamm ...
(N-cyclobutylmethyl-4,5-epoxy-morphinan-3,6,14-triol) and any salt thereof * Glutethimide (2-ethyl-2-phenylglutarimide) *
Clotiazepam Clotiazepam (marketed under brand name Clozan, Distensan, Trecalmo, Rize, Rizen and Veratran) is a thienodiazepine drug which is a benzodiazepine analog. The clotiazepam molecule differs from benzodiazepines in that the benzene ring has been ...
(5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno ,3-e1,4-diazepin-2-one) and any salt thereof * Ethchlorvynol (ethyl-2-chlorovinyl ethynyl carbinol) * Ethinamate (1-ethynylcyclohexanol carbamate) *
Mazindol Mazindol (brand names Mazanor, Sanorex) is a stimulant drug which is used as an appetite suppressant. It was developed by Sandoz Laboratories, Sandoz-Wander in the 1960s. Medical uses Mazindol is used in short-term (i.e., a few weeks) treatment ...
(5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo ,1-asoindol-5-ol) *
Meprobamate Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the be ...
(2-methyl-2-propyl-1,3-propanediol dicarbamate) * Methyprylon (3,3-diethyl-5-methyl-2,4-piperidinedione) * Benzodiazepines, their salts and derivatives, including: #
Alprazolam Alprazolam, sold under the brand name Xanax, among others, is a fast-acting, potent tranquilizer of medium duration in the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring. It is most commonly u ...
(8-chloro-1-methyl-6-phenyl-4H-s-triazolo ,3-a1,4] benzodiazepine) #
Bromazepam Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam (Valium). In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant ...
(7-bromo-1,3-dihydro-5-(2-pyridyl)-2H-1, 4-benzodiazepin-2-one) ## Brotizolam (2-bromo-4-(o-chlorophenyl)-9-methyl-6H-thieno ,2-fs-triazolo ,3-a1,4]diazepine) # Camazepam (7-chloro-1,3-dihydro-3-(N,N- dimethylcarbamoyl)-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one) #
Chlordiazepoxide Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and symptoms of withdrawal from alcohol and other drugs. Chlordiazepoxide has a medium t ...
(7-chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide) #
Clobazam Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968. Clobazam was first synthesized in 1966 and first published in 1969. Clobazam was originally marketed as an anxioselec ...
(7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione) #
Clonazepam Clonazepam, sold under the brand names Klonopin and Rivotril, is a medication used to prevent and treat seizures, panic disorder, anxiety disorders, and the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class ...
(5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one) #
Clorazepate Clorazepate, sold under the brand name Tranxene among others, is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. Clorazepate is an unusually long-lasting benzodiaz ...
(7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid) # Cloxazolam (10-chloro-11b-(o-chlorophenyl)-2,3, 7,11b-tetrahydrooxazolo ,2-d1,4]benzodiazepin 6-(5H)-one) #
Delorazepam Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is marketed in Italy, where it is available under the trade name EN and Dadumir. Delorazepam (chl ...
(7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) #
Diazepam Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, ...
(7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) #
Estazolam Estazolam, sold under the brand name Prosom among others, is a tranquilizer medication of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring . It possesses anxiolytic, anticonvulsant, hypnotic, s ...
(8-chloro-6-phenyl-4H-s-triazolo ,3-a1,4]benzodiazepine) # Ethyl loflazepate, Ethyl Loflazepate (ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate) # Fludiazepam (7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one) # epealed, SOR/98-173, s. 2#
Flurazepam Flurazepam (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite w ...
(7-chloro-1- -(diethylamino) ethyl5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) # Halazepam (7-chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one) # Haloxazolam (10-bromo-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo ,2-d1,4]benzodiazepin-6(5H)-one) # Ketazolam (11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H- ,3oxazino- ,2-d1,4] benzodiazepine-4,7(6H)-dione) #
Loprazolam Loprazolam (triazulenone) marketed under many brand names is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is licensed and marketed for the short-term t ...
(6-(o-chlorophenyl)-2,4-dihydro-2- 4-methyl-1-piperazinyl)methylene8-nitro-1H-imidazo ,2-a1,4]benzodiazepin-1-one) #
Lorazepam Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, severe agitation, active seizures including status epilepticus, alcohol withdrawal, and c ...
(7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one) #
Lormetazepam Lormetazepam, sold under the brand name Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy benzodiazepine derivative and temazepam analogue. It possesses hypnotic, anxiolytic, anticonvulsant, sedative, and skel ...
(7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one) #
Medazepam Medazepam is a drug that is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It is known by the following brand names: Azepamid, Nobrium, Tranquirax (mixed with bevonium) ...
(7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine) ##
Midazolam Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia and procedural sedation, and to treat severe agitation. It works by inducing sleepiness, decreasing anxiety, and causing a loss of ...
(8-chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo ,5-a1,4]benzodiazepine) #
Nimetazepam Nimetazepam (marketed under brand name Erimin and Lavol) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized by a team at Hoffmann-La Roche in 1964. It possesses powerful hypnotic, anxiolytic, s ...
(1,3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one) #
Nitrazepam Nitrazepam, sold under the brand name Mogadon among others, is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. It also has sedative (calming) properties, as well as amnestic (i ...
(1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one) #
Nordazepam Nordazepam (international nonproprietary name, INN; marketed under brand names Nordaz, Stilny, Madar, Vegesan, and Calmday; also known as nordiazepam, desoxydemoxepam, and desmethyldiazepam) is a benzodiazepine, 1,4-benzodiazepine derivative. Lik ...
(7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one) #
Oxazepam Oxazepam is a short-to-intermediate-acting benzodiazepine. Oxazepam is used for the treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal syndrome. It is a metabolite of diazepam, prazepam, and temazepam, and ha ...
(7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one) # Oxazolam (10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyloxazolo ,2-d ,4enzodiazepin-6(5H)-one) #
Pinazepam Pinazepam (marketed under the brand name Domar and Duna) is a benzodiazepine drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Pinazepam and its metabolite ''N''-desmethyldiazepam are transferred ...
(7-chloro-1,3-dihydro-5-phenyl-1-(2-propynyl)-2H-1,4-benzodiazepin-2-one) #
Prazepam Prazepam is a benzodiazepine derivative drug developed by Warner-Lambert in the 1960s. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Prazepam is a prodrug for desmethyldiazepam which is responsible fo ...
(7-chloro-1-(cyclopropylmethyl)-1, 3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one) ##
Quazepam Quazepam, sold under brand name Doral among others, is a relatively long-acting benzodiazepine derivative drug developed by the Schering Corporation in the 1970s. Quazepam is used for the treatment of insomnia including sleep induction and sleep ...
(7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione) #
Temazepam Temazepam (sold under the brand names Restoril among others) is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. It is taken by mouth. Temazepam is rapidly absorbed, and significant hyp ...
(7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one) # Tetrazepam (7-chloro-5-(cyclohexen-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one) #
Triazolam Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepine (BZD) derivatives. It possesses pharmacological properties ...
(8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo ,3-a1,4]benzodiazepine)but not including: #
Clozapine Clozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic). It is primarily used to treat people with schizophrenia and schizoaffective disorders who have had an inadequate respo ...
(8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo ,e1,4]diazepine) and any salt thereof #
Flunitrazepam Flunitrazepam, also known as Rohypnol among other names, is a benzodiazepine used to treat severe insomnia and assist with anesthesia. As with other hypnotics, flunitrazepam has been advised to be prescribed only for short-term use or by thos ...
(5-(o-fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one) and any salts or derivatives thereof #
Olanzapine Olanzapine (sold under the trade name Zyprexa among others) is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. For schizophrenia, it can be used for both new-onset disease and long-term maintenance. It is t ...
(2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno ,3-b1,5]benzodiazepine) and its salts # Clozapine N-oxide (8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo ,e1,4]diazepine) and its salts * Khat, Catha edulis Forsk., its preparations, derivatives, alkaloids and salts, including: # Cathine (d-threo-2-amino-1-hydroxy-1-phenylpropane) * Fencamfamin (d,l-N-ethyl-3-phenylbicyclo ,2,1heptan-2-amine) and any salt thereof *
Fenproporex Fenproporex (Perphoxene) (N-2-Cyanoethylamphetamine) (3-(1-phenylpropan-2-ylamino)propanenitrile) (3- 1-Methyl-2-Phenylethyl)aminoropiononitrile) is a stimulant drug of the phenethylamine and amphetamine chemical classes that was developed in ...
(d,l-3- α-methylphenethyl)aminoropionitrile) and any salt thereof * Mefenorex (d,l-N-(3-chloropropyl)-α-methylbenzeneethanamine) and any salt thereof *
Anabolic steroid Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone (medication), testosterone as well as synthetic androgens that are structurally related ...
s and their derivatives including: #
Androisoxazole Androisoxazole (brand names Androxan, Neo-Ponden, Neo-Pondus), also known as 17α-methyl-5α-androstano,2-csoxazol-17β-ol, is an orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of dihydrotestosterone (DHT) that ...
(17ß-hydroxy-17α-methylandrostano ,2-csoxazole) # Androstanolone (17ß-hydroxy-5α-androstan-3-one) #
Androstenediol Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepia ...
(androst-5-ene-3ß,17ß-diol) #
Bolandiol Bolandiol (INN, also known as 19-nor-4-androstenediol, estr-4-ene-3β,17β-diol, or 3β-dihydronandrolone) is an anabolic-androgenic steroid (AAS) that was never marketed. However, a dipropionate ester derivative, bolandiol dipropionate, has be ...
(estr-4-ene-3ß,17ß-diol) #
Bolasterone Bolasterone (, ) (brand names Myagen, Methosarb; former developmental code name U-19763), also known as 7α,17α-dimethyltestosterone, is a 17α-alkylated androgen/anabolic steroid (AAS) which is used in veterinary medicine. It has close structu ...
(17ß-hydroxy-7α,17-dimethylandrost-4-en-3-one) #
Bolazine Bolazine (), also known as 2α-methyl-5α-androstan-17β-ol-3-one azine, is a synthetic androgen/anabolic steroid (AAS) of the dihydrotestosterone (DHT) group which was never marketed. It is not orally active and is used as the ester prodrug bol ...
(17ß-hydroxy-2α-methyl-5α-androstan-3-one azine) #
Boldenone Boldenone (developmental code name RU-18761), is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)- dehydrogenated analogue of testosterone. Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as ...
(17ß-hydroxyandrosta-1,4-dien-3-one) #
Bolenol Bolenol (, ), also known as 17α-ethyl-19-norandrost-5-en-17β-ol (ethylnorandrostenol), is a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of 19-nortestosterone (nandrolone) that was never markete ...
(19-nor-17α-pregn-5-en-17-ol) # Calusterone (17ß-hydroxy-7ß,17-dimethylandrost-4-en-3-one) # Clostebol (4-chloro-17ß-hydroxyandrost-4-en-3-one) #
Drostanolone Drostanolone, or dromostanolone, is an anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was never marketed. An androgen ester prodrug of drostanolone, drostanolone propionate, was formerly used in the treatment ...
(17ß-hydroxy-2α-methyl-5α-androstan-3-one) # Enestebol (4, 17ß-dihydroxy-17-methylandrosta-1,4-dien-3-one) #
Epitiostanol Epitiostanol, sold under the brand name Thiodrol, is an injection (medicine), injected antiestrogen and anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was described in the literature in 1965 and has been marketed ...
(2α, 3α-epithio-5α-androstan-17ß-ol) #
Ethylestrenol Ethylestrenol, also known as ethyloestrenol or ethylnandrol and sold under the brand names Maxibolin and Orabolin among others, is an androgen and anabolic steroid (AAS) medication which has been used in the past for a variety of indications such ...
(19-nor-17α-pregn-4-en-17-ol) # 4-Hydroxy-19-nor testosterone (4-HO-Nandrolone) #
Fluoxymesterone Fluoxymesterone, sold under the brand names Halotestin and Ultandren among others, is an androgen and anabolic steroid (AAS) medication which is used in the treatment of low testosterone levels in men, delayed puberty in boys, breast cancer in w ...
(9-fluoro-11ß,17ß-dihydroxy-17-methylandrost-4-en-3-one) #
Formebolone Formebolone (INN, BAN) (brand names Esiclene, Hubernol, Metanor), also known as formyldienolone, as well as 2-formyl-11α-hydroxy-17α-methyl-δ1-testosterone, is an orally active anabolic-androgenic steroid (AAS) described as an anticatabolic ...
(11α, 17ß-dihydroxy-17-methyl-3-oxoandrosta-1,4 di-en-2-carboxaldehyde) #
Furazabol Furazabol (, ) (brand names Frazalon, Miotalon, Qu Zhi Shu), also known as androfurazanol, is a synthetic, orally active anabolic-androgenic steroid which has been marketed in Japan since 1969. It is a 17α-alkylated derivative of dihydrotestos ...
(17-methyl-5α-androstano ,3-cfurazan-17ß-ol) # Mebolazine (17ß-hydroxy-2α,17-dimethyl-5α-androstan-3-one azine) #
Mesabolone Mesabolone, also known as 1-testosterone 17β-methoxycyclopentyl ether, is a synthetic anabolic–androgenic steroid (AAS) that was never marketed. It is the 17β-(1-methoxycyclohexane) ether In organic chemistry, ethers are a class of comp ...
(17ß- 1-methoxycyclohexyl)oxy5α-androst-1-en-3-one) #
Mesterolone Mesterolone, sold under the brand name Proviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels. It has also been used to treat male infertility, although this ...
(17ß-hydroxy-1α-methyl-5α-androstan-3-one) #
Metandienone Metandienone, also known as methandienone or methandrostenolone and sold under the brand name Dianabol (D-Bol) among others, is an androgen and anabolic steroid (AAS) medication which is still quite often used because of its affordability and eff ...
(17ß-hydroxy-17-methylandrosta-1,4-dien-3-one) #
Metenolone Metenolone, or methenolone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as metenolone acetate (brand name Primobolan, Nibal) and metenolone enanthate (brand name Primobolan Depot, Nibal Injection). Meten ...
(17ß-hydroxy-1-methyl-5α-androst-1-en-3-one) #
Methandriol Methandriol (brand names Anabol, Crestabolic, Cytobolin, Diandren, Durabolic, Madiol, Mestenediol, Methabolic, Methydiol, Sterabolic, Stenediol), also known as methylandrostenediol, is an androgen and anabolic steroid (AAS) medication which was ...
(17α-methylandrost-5-ene-3ß,17ß-diol) #
Methyltestosterone Methyltestosterone, sold under the brand names Android, Metandren, and Testred among others, is an androgen and anabolic steroid (AAS) medication which is used in the treatment of low testosterone levels in men, delayed puberty in boys, at low ...
(17ß-hydroxy-17-methylandrost-4-en-3-one) #
Metribolone Metribolone (developmental code R1881, also known as methyltrienolone) is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed for medical ...
(17ß-hydroxy-17-methylestra-4, 9,11-trien-3-one) #
Mibolerone Mibolerone, also known as dimethylnortestosterone (DMNT) and sold under the brand names Cheque Drops and Matenon, is a synthetic compound, synthetic, oral administration, orally active, and extremely potency (pharmacology), potent anabolic–andr ...
(17ß-hydroxy-7α,17-dimethylestr-4-en-3-one) #
Nandrolone Nandrolone, also known as 19-nortestosterone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as nandrolone decanoate (brand name Deca-Durabolin) and nandrolone phenylpropionate (brand name Durabolin). Nandrolon ...
(17ß-hydroxyestr-4-en-3-one) # Norboletone (13-ethyl-17ß-hydroxy-18, 19-dinorpregn-4-en-3-one) #
Norclostebol Norclostebol (; brand name Lentabol; former developmental code names SKF-6611, CP-73) is a synthetic androgen and anabolic steroid (AAS) that was derived from nandrolone. It was described in the literature in 1957. Norclostebol is also used as an ...
(4-chloro-17ß-hydroxyestr-4-en-3-one) #
Norethandrolone Norethandrolone, sold under the brand names Nilevar and Pronabol among others, is an androgen and anabolic steroid (AAS) medication which has been used to promote muscle growth and to treat severe burns, physical trauma, and aplastic anemia but h ...
(17α-ethyl-17ß-hydroxyestr-4-en-3-one) # Oxabolone (4,17ß-dihydroxyestr-4-en-3-one) #
Oxandrolone Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication which is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-ter ...
(17ß-hydroxy-17-methyl-2-oxa-5α-androstan-3-one) # Oxymesterone (4,17ß-dihydroxy-17-methylandrost-4-en-3-one) #
Oxymetholone Oxymetholone, sold under the brand names Anadrol and Anapolon among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemia. It is also used to treat osteoporosis, HIV/AIDS wasting syndrom ...
(17ß-hydroxy-2-(hydroxymethylene)-17-methyl-5α-androstan-3-one) #
Prasterone Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand names Intrarosa, Diandrone, and Gynodian Depot among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficienc ...
(3ß-hydroxyandrost-5-en-17-one) #
Quinbolone Quinbolone (, ), sold under the brand names Anabolicum and Anabolvis, is an androgen and anabolic steroid (AAS) which was previously marketed in Italy. It was developed by Parke-Davis as a viable orally-administered AAS with little or no liver ...
(17ß-(1-cyclopenten-1-yloxy) androsta-1,4-dien-3-one) #
Stanozolol Stanozolol (Abbreviation, abbrev. Stz), sold under many brand names, is an androgen and anabolic steroid (AAS) medication derived from dihydrotestosterone (DHT). It is used to treat hereditary angioedema. It was developed by American pharmaceuti ...
(17ß-hydroxy-17-methyl-5α-androstano ,2-cyrazole) # Stenbolone (17ß-hydroxy-2-methyl-5α-androst-1-en-3-one) #
Testosterone Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of Male reproductive system, male reproductive tissues such as testes and prostate, as well as promoting secondar ...
(17ß-hydroxyandrost-4-en-3-one) #
Tibolone Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated ...
((7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10) en-20-yn-3-one) #
Tiomesterone Tiomesterone ( INN, JAN; thiomesterone (BAN); also known as 1α,7α-bis(acetylthio)-17α-methylandrost-4-en-17β-ol-3-one; developmental code StA 307; brand names Emdabol, Embadol, Emdabolin, and Protabol) is a synthetic, orally active anabolic ...
(1α,7α-bis(acetylthio)-17ß -hydroxy-17-methylandrost-4-en-3-one) #
Trenbolone Trenbolone is an androgen and anabolic steroid (AAS) of the nandrolone group which itself was never marketed. Trenbolone ester prodrugs, including trenbolone acetate (brand names Finajet, Finaplix, others) and trenbolone hexahydrobenzylcarbonate ...
(17ß-hydroxyestra-4,9,11-trien-3-one) *
Zeranol Zeranol (, , ) (brand names Frideron, Ralabol, Ralgro, Ralone, Zerano; developmental code names MK-188, P-1496), or zearanol, also known as α-zearalanol or simply zearalanol, is a synthetic nonsteroidal estrogen of the resorcylic acid lactone R ...
(3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one) *
Zolpidem Zolpidem, sold under the brand name Ambien, among others, is a medication primarily used for the short-term treatment of sleeping problems. Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and behavior ...
(N,N,6-trimethyl-2-(4-methylphenyl)imidazo ,2-ayridine-3-acetamide) and any salt thereof #
Pemoline Pemoline, sold under the brand name Cylert among others, is a stimulant medication which has been used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy. It has been discontinued in most countries to due to rare ...
(2-amino-5-phenyl-oxazolin-4-one) and any salt thereof *
Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or letharg ...
(4′-methyl-2-(1-pyrrolidinyl)valerophenone) and any salt thereof * Salvia divinorum (S. divinorum), its preparations and derivatives, including: #
Salvinorin A Salvinorin A is the main active psychotropic molecule in ''Salvia divinorum''. Salvinorin A is considered a dissociative hallucinogen. It is structurally distinct from other naturally occurring hallucinogens (such as DMT, psilocybin, an ...
((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho ,1-cyran-7-carboxylic acid methyl ester)


Schedule V

(Sections 2, 5 to 7.1, 10, 55 and 60.1) 1996, c. 19, Sch. V; SOR/2002-361, s. 1; SOR/2003-32, s. 7; 2017, c. 7, s. 50.


Schedule VI (Precursors)


PART 1

Class A Precursors * Acetic anhydride * N-Acetylanthranilic acid (2-acetamidobenzoic acid) and its salts *
Anthranilic acid Anthranilic acid is an aromatic acid with the formula C6H4(NH2)(CO2H) and has a sweetish taste. The molecule consists of a benzene ring, ''ortho''-substituted with a carboxylic acid and an amine. As a result of containing both acidic and basic ...
(2-aminobenzoic acid) and its salts *
Ephedrine Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in ...
(erythro-2-(methylamino)-1-phenylpropan-1-ol), its salts and any plant containing ephedrine or any of its salts *
Ergometrine Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. It can be used ei ...
(9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide) and its salts *
Ergotamine Ergotamine, sold under the brand names Cafergot (with caffeine) and Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural sim ...
(12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione) and its salts *
Isosafrole Isosafrole is an organic compound that is used in the fragrance industry. Structurally, the molecule is related to phenylpropene, a type of aromatic organic chemical. Its fragrance is reminiscent of anise or licorice. It is found in small amoun ...
(5-(1-propenyl)-1,3-benzodioxole) *
Lysergic acid Lysergic acid, also known as -lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of '' Turbina corymbosa'' (ololiuhqui), '' Argyreia nervosa'' ...
(9,10-didehydro-6-methylergoline-8-carboxylic acid) and its salts * 3,4-Methylenedioxyphenyl-2-propanone (1-(1,3-benzodioxole)-2-propanone) *
Norephedrine Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It was commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to contro ...
(Phenylpropanolamine) and its salts * 1-Phenyl-2-propanone * Phenylacetic acid and its salts *
Piperidine Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor de ...
and its salts *
Piperonal Piperonal, also known as heliotropin, is an organic compound which is commonly found in fragrances and flavors.Karl-Georg Fahlbusch, Franz-Josef Hammerschmidt, Johannes Panten, Wilhelm Pickenhagen, Dietmar Schatkowski, Kurt Bauer, Dorothea Garbe a ...
(1,3-benzodioxole-5-carboxaldehyde) *
Potassium permanganate Potassium permanganate is an inorganic compound with the chemical formula KMnO4. It is a purplish-black crystalline salt, that dissolves in water as K+ and , an intensely pink to purple solution. Potassium permanganate is widely used in the c ...
*
Propionyl Chloride Propionyl chloride (also propanoyl chloride) is the organic compound In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chain ...
* Pseudoephedrine (threo-2-(methylamino)-1-phenylpropan-1-ol), its salts and any plant containing pseudoephedrine or any of its salts *
Safrole Safrole is an organic compound with the formula CH2O2C6H3CH2CH=CH2. It is a colorless oily liquid, although impure samples can appear yellow. A member of the phenylpropanoid family of natural products, it is found in sassafras plants, among oth ...
(5-(2-propenyl)-1,3-benzodioxole) and any essential oil containing more than 4% safrole * Gamma-butyrolactone (dihydro-2(3H)-furanone) * 1,4-butanediol *
Red Phosphorus Elemental phosphorus can exist in several allotropes, the most common of which are white and red solids. Solid violet and black allotropes are also known. Gaseous phosphorus exists as diphosphorus and atomic phosphorus. White phosphorus White ...
*
White Phosphorus Elemental phosphorus can exist in several allotropes, the most common of which are white and red solids. Solid violet and black allotropes are also known. Gaseous phosphorus exists as diphosphorus and atomic phosphorus. White phosphorus White ...
*
Hypophosphorous acid Hypophosphorous acid (HPA), or phosphinic acid, is a phosphorus oxyacid and a powerful reducing agent with molecular formula H3PO2. It is a colorless low-melting compound, which is soluble in water, dioxane and alcohols. The formula for this ...
, its salts and derivatives *
Hydriodic acid Hydroiodic acid (or hydriodic acid) is an aqueous solution of hydrogen iodide (HI). It is a strong acid, one that is ionized completely in an aqueous solution. It is colorless. Concentrated solutions are usually 48% to 57% HI. Reactions Hy ...
* Alpha-phenylacetoacetonitrile and its salts, isomers and salts of isomers


PART 2

Class B Precursors *
Acetone Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscib ...
*
Diethyl ether Diethyl ether, or simply ether, is an organic compound in the ether class with the formula , sometimes abbreviated as (see Pseudoelement symbols). It is a colourless, highly volatile, sweet-smelling ("ethereal odour"), extremely flammable liq ...
*
Hydrochloric acid Hydrochloric acid, also known as muriatic acid, is an aqueous solution of hydrogen chloride. It is a colorless solution with a distinctive pungent smell. It is classified as a strong acid Acid strength is the tendency of an acid, symbol ...
* Methyl ethyl ketone *
Sulfuric acid Sulfuric acid (American spelling and the preferred IUPAC name) or sulphuric acid ( Commonwealth spelling), known in antiquity as oil of vitriol, is a mineral acid composed of the elements sulfur, oxygen and hydrogen, with the molecular formu ...
*
Toluene Toluene (), also known as toluol (), is a substituted aromatic hydrocarbon. It is a colorless, water-insoluble liquid with the smell associated with paint thinners. It is a mono-substituted benzene derivative, consisting of a methyl group (CH3) a ...


PART 3

Preparations and Mixtures * Any preparation or mixture that contains a precursor set out in Part 1, except items 20 to 23 ed Phosphorus; White Phosphorus; Hypophosphorous acid, its salts and derivatives; Hydriodic acid or in Part 2.


Schedule VII

epealed, 2018, c. 16, s. 205


Schedule VIII

epealed, 2018, c. 16, s. 205


Laws – Penalties


Possession

If tried as an ''
indictable offence In many common law jurisdictions (e.g. England and Wales, Ireland, Canada, Hong Kong, India, Australia, New Zealand, Malaysia, Singapore), an indictable offence is an offence which can only be tried on an indictment after a preliminary hearing ...
'', the defendant is liable to: Schedule I: Maximum 7 years' imprisonment
Schedule II: Maximum 5 years' imprisonment
Schedule III: Maximum 3 years' imprisonment
Schedule IV: It is not an indictable offence to possess a Schedule IV substance for personal use. If tried as a '' summary conviction offence'', the defendant is liable to: Schedule I, II, or III: Maximum $1000 fine for the first offence and/or a maximum 6-month term of imprisonment, increasing to a maximum fine of $2000 for each subsequent offense and/or a maximum of 1 year in prison.
Schedule IV: It is not a summary offence to possess a Schedule IV substance for personal use. Section (4), Subsection (2) of the CDSA reads that any person who obtains or who makes any attempt to obtain a Schedule I through IV substance from a physician without fully disclosing the details of any previous instances of obtaining a Schedule I through IV substance in the preceding thirty (30) days, a practice often referred to as "
doctor shopping Doctor shopping is the practice of visiting multiple physicians to obtain multiple prescriptions. It is a common practice of people with substance use disorders, suppliers of addictive substances, hypochondriacs or patients of factitious disorder an ...
", is guilty of a summary or indictable offense, as per Section (4), Subsection (7)(a) and (b). These drugs are considered lawful (and thus without penalty) if the person from whom the substance, precursor or property was seized came into possession of it lawfully and continued to deal with it lawfully, such as through a prescription by a prescribing practitioner.


Trafficking/Possession for the Purpose of

If tried as an ''indictable offence'', the defendant is liable to: Schedule I or Schedule II: Maximum life imprisonment
Schedule III: Maximum 10 years' imprisonment
Schedule IV: Maximum 3 years' imprisonment Or, if tried as a ''summary conviction'', the defendant is liable to: Schedule III: Maximum 18 months' imprisonment
Schedule IV: Maximum 1 year's imprisonment


Smuggling/Possession for the Purpose of Distribution

If tried as an ''indictable offence'', the defendant is liable to: Schedule I or Schedule II: Maximum life imprisonment
* Mandatory minimum 1 year's imprisonment for exporting a Schedule I drug under 1 kg, 2 years if amount exceeds 1 kg Schedule III or Schedule IV: Maximum 10 years' imprisonment
Schedule V or Schedule VI: Maximum 3 years' imprisonment Or, if tried as a ''summary conviction'', the defendant is liable to: Schedule III or Schedule IV: Maximum 18 months' imprisonment
Schedule V or Schedule VI: Maximum 1 year's imprisonment


Production

If tried as an ''indictable offence'', the defendant is liable to: Schedule I or Schedule II: Maximum life imprisonment
* Mandatory minimum 2 years' imprisonment Schedule III: Maximum 10 years' imprisonment
Schedule IV: Maximum 3 years' imprisonment Or, if tried as a ''summary conviction'', the defendant is liable to: Schedule III: Maximum 18 months' imprisonment
Schedule IV: Maximum 1 year's imprisonment


See also

* ''
Controlled Substances Act The Controlled Substances Act (CSA) is the statute establishing federal government of the United States, federal drug policy of the United States, U.S. drug policy under which the manufacture, importation, possession, use, and distribution of ...
'' (US) * '' Misuse of Drugs Act 1971'' (UK)


Notes


References






External links


Controlled Drugs and Substances Act

Amendments to the Controlled Drugs and Substances Act [Bill C-10, Part 2, Clauses 32-33, 39-48 and 50-51 (Former Bill S-10)]
{{DEFAULTSORT:Controlled Drugs And Substances Act Drug control law in Canada Canadian federal legislation 1996 in Canadian law 1996 in cannabis Canadian criminal law Health Canada