Closs is a surname. Notable people with the surname include:
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Jayme Closs, (born 2005), American kidnapping victim
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Keith Closs, (born 1976), American basketball center
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Kevin Closs, (born 1963), Canadian singer-songwriter
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Maurice Closs, (born 1971), Argentine politician
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William Closs, (1922–2011), American basketball forward-center
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