This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the

International Union of Biochemistry and Molecular Biology The International Union of Biochemistry and Molecular Biology (IUBMB) is an international non-governmental organisation concerned with biochemistry and molecular biology. Formed in 1955 as the International Union of Biochemistry (IUB), the union ...

. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 4.1: Carbon-Carbon Lyases

EC 4.1.1: Carboxy-lyases

* : pyruvate decarboxylase * :

oxalate decarboxylase In enzymology, an oxalate decarboxylase () is an oxalate degrading enzyme that catalyzes the chemical reaction :oxalate + H+ \rightleftharpoons formate + CO2 Thus, the two substrates of this enzyme are oxalate and H+, whereas its two products ...

* EC 4.1.1.3: Now recognized to be two enzymes xaloacetate decarboxylase (Na⁺ extruding)and (oxaloacetate decarboxylase). * : acetoacetate decarboxylase * :

acetolactate decarboxylase The enzyme acetolactate decarboxylase () catalyzes the chemical reaction :(S)-2-hydroxy-2-methyl-3-oxobutanoate \rightleftharpoons (R)-2-acetoin + CO2 Hence, this enzyme has one substrate, (S)-2-hydroxy-2-methyl-3-oxobutanoate, and two product ...

* : ''cis''-aconitate decarboxylase * : benzoylformate decarboxylase * : oxalyl-CoA decarboxylase * :

malonyl-CoA decarboxylase Malonyl-CoA decarboxylase (), (which can also be called MCD and malonyl-CoA carboxyl-lyase) is found in bacteria and humans and has important roles in regulating fatty acid metabolism and food intake, and it is an attractive target for drug discove ...

* EC 4.1.1.10: Now included with , aspartate 4-decarboxylase * : aspartate 1-decarboxylase * : aspartate 4-decarboxylase * EC 4.1.1.13: deleted * : valine decarboxylase * :

glutamate decarboxylase Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (). GAD uses pyridoxal-phosphate (PLP) as a cofactor. The reaction p ...

* : hydroxyglutamate decarboxylase * :

ornithine decarboxylase The enzyme ornithine decarboxylase (, ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. This reaction is the committed step in polyamine synthesis. In humans, this protein has 461 amino acids a ...

* : lysine decarboxylase * : arginine decarboxylase * :

diaminopimelate decarboxylase The enzyme diaminopimelate decarboxylase () catalyzes the cleavage of carbon-carbon bonds in meso 2,6 diaminoheptanedioate to produce CO2 and L-lysine, the essential amino acid. It employs the cofactor pyridoxal phosphate, also known as PLP, wh ...

* :

phosphoribosylaminoimidazole carboxylase The enzyme Phosphoribosylaminoimidazole carboxylase, or AIR carboxylase () is involved in nucleotide biosynthesis and in particular in purine biosynthesis. It catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole ("AIR") into 5'-phos ...

* :

histidine decarboxylase The enzyme histidine decarboxylase (, HDC) is transcribed on chromosome 15, region 21.2, and catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmi ...

* : orotidine-5′-phosphate decarboxylase * : aminobenzoate decarboxylase * : tyrosine decarboxylase * EC 4.1.1.26: Now included with aromatic-L-amino-acid decarboxylase * EC 4.1.1.27: Now included with aromatic-L-amino-acid decarboxylase * : aromatic-L-amino-acid decarboxylase * : sulfoalanine decarboxylase * : pantothenoylcysteine decarboxylase * : phospho''enol''pyruvate carboxylase * : phospho''enol''pyruvate carboxykinase (GTP) * : diphosphomevalonate decarboxylase * : dehydro-L-gulonate decarboxylase * : UDP-glucuronate decarboxylase * :

phosphopantothenoylcysteine decarboxylase The enzyme phosphopantothenoylcysteine decarboxylase () catalyzes the chemical reaction :N- R)-4'-phosphopantothenoylL-cysteine \rightleftharpoons pantotheine 4'-phosphate + CO2 This enzyme belongs to the family of lyases, to be specific the car ...

* : uroporphyrinogen decarboxylase * : phospho''enol''pyruvate carboxykinase (diphosphate) * : ribulose-bisphosphate carboxylase * : hydroxypyruvate decarboxylase * EC 4.1.1.41: Now , (''S'')-methylmalonyl-CoA decarboxylase * : carnitine decarboxylase * : phenylpyruvate decarboxylase * : 4-carboxymuconolactone decarboxylase * : aminocarboxymuconate-semialdehyde decarboxylase * : ''o''-pyrocatechuate decarboxylase * : tartronate-semialdehyde synthase * :

indole-3-glycerol-phosphate synthase The enzyme indole-3-glycerol-phosphate synthase (IGPS) () catalyzes the chemical reaction :1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate \rightleftharpoons 1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O This enzyme belongs to the f ...

EC 4.1.2: Aldehyde-lyases

* EC 4.1.2.1: Now included with 4-hydroxy-2-oxoglutarate aldolase * : ketotetrose-phosphate aldolase * EC 4.1.2.3: deleted, was pentosealdolase. * :

deoxyribose-phosphate aldolase The enzyme deoxyribose-phosphate aldolase () catalyzes the reversible chemical reaction :2-deoxy-D-ribose 5-phosphate \rightleftharpoons D-glyceraldehyde 3-phosphate + acetaldehyde This enzyme belongs to the family of lyases, specifically the ...

* : L-threonine aldolase * EC 4.1.2.6: Deleted, reaction is due to , glycine hydroxymethyltransferase * EC 4.1.2.7: Now included with fructose-bisphosphate aldolase * : indole-3-glycerol-phosphate lyase * :

phosphoketolase The enzyme phosphoketolase() catalyzes the chemical reactions :D-xylulose 5-phosphate + phosphate \rightleftharpoons acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O () :D-fructose 6-phosphate + phosphate \rightleftharpoons acetyl phospha ...

* : (''R'')-mandelonitrile lyase * : hydroxymandelonitrile lyase * : 2-dehydropantoate aldolase * :

fructose-bisphosphate aldolase Fructose-bisphosphate aldolase (), often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate ( ...

* : 2-dehydro-3-deoxy-phosphogluconate aldolase * EC 4.1.2.15: Now , 3-deoxy-7-phosphoheptulonate synthase * EC 4.1.2.16: Now , 3-deoxy-8-phosphooctulonate synthase * : L-fuculose-phosphate aldolase * : 2-dehydro-3-deoxy-L-pentonate aldolase * : rhamnulose-1-phosphate aldolase * : 2-dehydro-3-deoxyglucarate aldolase * : 2-dehydro-3-deoxy-6-phosphogalactonate aldolase * :

fructose-6-phosphate phosphoketolase The enzyme fructose-6-phosphate phosphoketolase () catalyzes the chemical reaction :D-fructose 6-phosphate + phosphate \rightleftharpoons acetyl phosphate + D-erythrose 4-phosphate + H2O This enzyme belongs to the family of lyases, specifically ...

* : 3-deoxy-D-''manno''-octulosonate aldolase * : dimethylaniline-''N''-oxide aldolase * : dihydroneopterin aldolase * : phenylserine aldolase * : sphinganine-1-phosphate aldolase * : 2-dehydro-3-deoxy-D-pentonate aldolase * : 5-dehydro-2-deoxyphosphogluconate aldolase * EC 4.1.2.30: Now }, 17α-hydroxyprogesterone deacetylase * EC 4.1.2.31: Now included with 4-hydroxy-2-oxoglutarate aldolase * : trimethylamine-oxide aldolase * : fucosterol-epoxide lyase * : 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase * : propioin synthase * : lactate aldolase * EC 4.1.2.37: Now covered by liphatic (''R'')-hydroxynitrile lyaseand ''S'')-hydroxynitrile ketone-lyase (cyanide forming)* :

benzoin aldolase The enzyme benzoin aldolase () catalyzes the chemical reaction :2-hydroxy-1,2-diphenylethanoneAlso known as benzoin. \rightleftharpoons 2 benzaldehyde This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave ...

* EC 4.1.2.39: Deleted, identical to , hydroxynitrilase * : tagatose-bisphosphate aldolase * EC 4.1.2.41: Now included with , feruloyl-CoA hydratase/lyase * : D-threonine aldolase * : 3-hexulose-6-phosphate synthase * : benzoyl-CoA-dihydrodiol lyase * : ''trans-o''-hydroxybenzylidenepyruvate hydratase-aldolase * : aliphatic (''R'')-hydroxynitrile lyase * : (''S'')-hydroxynitrile lyase * : low-specificity L-threonine aldolase * : L-''allo''-threonine aldolase * : 6-carboxytetrahydropterin synthase * * : 6-carboxytetrahydropterin synthase * * * : 2-dehydro-3-deoxy-D-gluconate aldolase * * * : 4-hydroxy-2-oxoheptanedioate aldolase * * * : 2-keto-3-deoxy-L-rhamnonate aldolase * * * : L-''threo''-3-deoxy-hexylosonate aldolase * * * : 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase * * * : 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase * * * : sulfofructosephosphate aldolase * * * : 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase * * * : dihydroneopterin phosphate aldolase * * * : dihydroneopterin triphosphate aldolase * * * : feruloyl-CoA hydratase/lyase * * * : 5-deoxyribulose 1-phosphate aldolase * * * : 2-hydroxyacyl-CoA lyase * : *No Wikipedia article

EC 4.1.3: Oxo-Acid-Lyases

* : isocitrate lyase * EC 4.1.3.2: Now , malate synthase * : ''N''-acetylneuraminate lyase * : hydroxymethylglutaryl-CoA lyase * EC 4.1.3.5: Now , hydroxymethylglutaryl-CoA synthase * : citrate (''pro''-3''S'')-lyase * EC 4.1.3.7: Now , citrate (''Si'')-synthase * EC 4.1.3.8: Now , ATP citrate synthase * EC 4.1.3.9: Now , 2-hydroxyglutarate synthase * EC 4.1.3.10: Now , 3-ethylmalate synthase * EC 4.1.3.11: Now , 3-propylmalate synthase * EC 4.1.3.12: Now , 2-isopropylmalate synthase * : oxalomalate lyase * : L-''erythro''-3-hydroxyaspartate aldolase * EC 4.1.3.15: Now , 2-hydroxy-3-oxoadipate synthase * : 4-hydroxy-2-oxoglutarate aldolase * : 4-hydroxy-4-methyl-2-oxoglutarate aldolase * EC 4.1.3.18: Now , acetolactate synthase * EC 4.1.3.19: Now * EC 4.1.3.20: Now * EC 4.1.3.21: Now * : citramalate lyase * EC 4.1.3.23: Now , decylcitrate synthase * : malyl-CoA lyase * : (''S'')-citramalyl-CoA lyase * : 3-hydroxy-3-isohexenylglutaryl-CoA lyase * : anthranilate synthase * EC 4.1.3.28: Now , citrate (''Re'')-synthase * EC 4.1.3.29: Now , decylhomocitrate synthase * :

methylisocitrate lyase The enzyme methylisocitrate lyase () catalyzes the chemical reaction :(2''S'',3''R'')-3-hydroxybutane-1,2,3-tricarboxylate \rightleftharpoons pyruvate + succinate The reaction is similar to that of isocitrate lyase, except that an additional ...

* EC 4.1.3.31: Now , 2-methylcitrate synthase * : 2,3-dimethylmalate lyase * : Now * : citryl-CoA lyase * : (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase * : naphthoate synthase * EC 4.1.3.37: Now , 1-deoxy-D-xylulose 5-phosphate synthase * :

aminodeoxychorismate lyase 4-amino-4-deoxychorismate lyase () is an enzyme that participates in folate biosynthesis by catalyzing the production of PABA by the following reaction :4-amino-4-deoxychorismate \rightleftharpoons 4-aminobenzoate + pyruvate This enzyme belongs ...

* : 4-hydroxy-2-oxovalerate aldolase * :

chorismate lyase The enzyme chorismate lyase () catalyzes the chemical reaction :chorismate \rightleftharpoons 4-hydroxybenzoate + pyruvate : : : : : : This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. ...

* : 3-hydroxy-D-aspartate aldolase * : (4''S'')-4-hydroxy-2-oxoglutarate aldolase * * : 4-hydroxy-2-oxohexanoate aldolase * * : tRNA 4-demethylwyosine synthase (AdoMet-dependent) * * : 3-hydroxybenzoate synthase * * : (''R'')-citramalyl-CoA lyase * : *No Wikipedia article

EC 4.1.99: Other Carbon-Carbon Lyases

* :

tryptophanase The enzyme tryptophanase () catalysis, catalyzes the chemical reaction :L-tryptophan + H2O \rightleftharpoons indole + pyruvate + NH3 This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. ...

* :

tyrosine phenol-lyase The enzyme tyrosine phenol-lyase () catalyzes the chemical reaction :L-tyrosine + H2O \rightleftharpoons phenol + pyruvate + NH3 This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The sys ...

* : deoxyribodipyrimidine photo-lyase * EC 4.1.99.4: Now , 1-aminocyclopropane-1-carboxylate deaminase * EC 4.1.99.5: octadecanal decarbonylase * EC 4.1.99.6: Now , trichodiene synthase * EC 4.1.99.7: Now , aristolochene synthase * EC 4.1.99.8: Now , pinene synthase * EC 4.1.99.9: Now , myrcene synthase * EC 4.1.99.10: Now , (4''S'')-limonene synthase * : benzylsuccinate synthase * : 3,4-dihydroxy-2-butanone-4-phosphate synthase * : (6-4)DNA photolyase * :

spore photoproduct lyase Spore photoproduct lyase (''SP lyase'', ''SPL'', ''SplB'', ''SplG'') is a radical SAM enzyme that repairs DNA cross linking of thymine bases caused by UV-radiation. There are several types of thymine cross linking, but SPL specifically targets 5 ...

* EC 4.1.99.15: The activity is covered by , spore photoproduct lyase * : geosmin synthase * : phosphomethylpyrimidine synthase * EC 4.1.99.18: Now known to be catalysed by the combined effect of , GTP 3,8-cyclase, and , cyclic pyranopterin monophosphate synthase * : 2-iminoacetate synthase * : 3-amino-4-hydroxybenzoate synthase * * : Now (5-formylfuran-3-yl)methyl phosphate synthase. * : GTP 3′,8-cyclase * * : 5-hydroxybenzimidazole synthase * * : L-tyrosine isonitrile synthase * * : L-tryptophan isonitrile synthase * * : 3-amino-5- 4-hydroxyphenyl)methyl4,4-dimethylpyrrolidin-2-one * : *No Wikipedia article

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

* : carbonic anhydrase * : fumarate hydratase * : aconitate hydratase * EC 4.2.1.4: Now known to be a partial reaction catalysed by , aconitate hydratase * : arabinonate dehydratase * : galactonate dehydratase * : altronate dehydratase * : mannonate dehydratase * :

dihydroxy-acid dehydratase The enzyme dihydroxy-acid dehydratase () catalyzes the chemical reaction :2,3-dihydroxy-3-methylbutanoate \rightleftharpoons 3-methyl-2-oxobutanoate + H2O This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate a ...

* : 3-dehydroquinate dehydratase * :

phosphopyruvate hydratase Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme () that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is: :2-p ...

(enolase) * : phosphogluconate dehydratase * EC 4.2.1.13: Now , L-serine ammonia-lyase * EC 4.2.1.14: Now , D-serine ammonia-lyase * EC 4.2.1.15: Identical with cystathionine γ-lyase * EC 4.2.1.16: Now , threonine ammonia-lyase * :

enoyl-CoA hydratase Enoyl-CoA hydratase (ECH) or crotonase is an enzyme that hydrates the double bond between the second and third carbons on 2-trans/cis-enoyl-CoA: ECH is essential to metabolizing fatty acids in beta oxidation to produce both acetyl CoA and e ...

* : methylglutaconyl-CoA hydratase * :

imidazoleglycerol-phosphate dehydratase The enzyme imidazoleglycerol-phosphate dehydratase () catalyzes the chemical reaction :D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate \rightleftharpoons 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O This enzyme belongs to the family of lyases ...

* :

tryptophan synthase Tryptophan synthase or tryptophan synthetase is an enzyme () that catalyses the final two steps in the biosynthesis of tryptophan. It is commonly found in Eubacteria, Archaebacteria, Protista, Fungi, and Plantae. However, it is absent from Anima ...

* EC 4.2.1.21: Now cystathionine β-synthase * : cystathionine β-synthase * EC 4.2.1.23: deleted, the reaction was due to a side-reaction of cystathionine β-synthase * :

porphobilinogen synthase Aminolevulinic acid dehydratase (porphobilinogen synthase, or ALA dehydratase, or aminolevulinate dehydratase) is an enzyme () that in humans is encoded by the ''ALAD'' gene. Porphobilinogen synthase (or ALA dehydratase, or aminolevulinate de ...

* : L-arabinonate dehydratase * EC 4.2.1.26: identical to , glucosaminate ammonia-lyase * : acetylenecarboxylate hydratase * : propanediol dehydratase * EC 4.2.1.29: Now , indoleacetaldoxime dehydratase * :

glycerol dehydratase In enzymology, a glycerol dehydratase () catalyzes the chemical reaction :glycerol \rightleftharpoons 3-hydroxypropanal + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The s ...

GDP-mannose 4,6-dehydratase The enzyme GDP-mannose 4,6-dehydratase () catalyzes the chemical reaction :GDP-mannose \rightleftharpoons GDP-4-dehydro-6-deoxy-D-mannose + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxyge ...

* : D-glutamate cyclase * : urocanate hydratase * : pyrazolylalanine synthase * :

prephenate dehydratase The enzyme prephenate dehydratase () catalyzes the chemical reaction :prephenate \rightleftharpoons phenylpyruvate + H2O + CO2 This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The sys ...

* EC 4.2.1.52: Now , 4-hydroxy-2,3,4,5-tetrahydrodipicolinate synthase. * : oleate hydratase * : lactoyl-CoA dehydratase * : 3-hydroxybutyryl-CoA dehydratase * : itaconyl-CoA hydratase * : isohexenylglutaconyl-CoA hydratase * EC 4.2.1.58: The reaction described is covered by * : 3-hydroxyacyl- cyl-carrier-proteindehydratase * EC 4.2.1.60: 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase * EC 4.2.1.61: The reaction described is covered by . * : 5α-hydroxysteroid dehydratase * EC 4.2.1.63: Now known to comprise two enzymes, microsomal epoxide hydrolase () and soluble epoxide hydrolase () * EC 4.2.1.64: Now known to comprise two enzymes, microsomal epoxide hydrolase () and soluble epoxide hydrolase () * :

3-cyanoalanine hydratase The enzyme 3-cyanoalanine hydratase () catalysis, catalyzes the chemical reaction :L-asparagine \rightleftharpoons 3-cyanoalanine + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. ...

* : cyanide hydratase * : D-fuconate dehydratase * : L-fuconate dehydratase * : cyanamide hydratase * : pseudouridylate synthase * EC 4.2.1.71: identical to , acetylenecarboxylate hydratase * EC 4.2.1.72: Now , acetylenedicarboxylate decarboxylase * : protoaphin-aglucone dehydratase (cyclizing) * : long-chain-enoyl-CoA hydratase * : uroporphyrinogen-III synthase * : UDP-glucose 4,6-dehydratase * : ''trans''-L-3-hydroxyproline dehydratase * : (''S'')-norcoclaurine synthase * : 2-methylcitrate dehydratase * : 2-oxopent-4-enoate hydratase * : D(-)-tartrate dehydratase * : xylonate dehydratase * : 4-oxalmesaconate hydratase * :

nitrile hydratase Nitrile hydratases (NHases; ) are mononuclear iron or non-corrinoid cobalt enzymes that catalyse the hydration of diverse nitriles to their corresponding amides R-C≡N + H2O → R-C(O)NH2 Metal cofactor In biochemistry, cobalt is in general ...

* : dimethylmaleate hydratase * EC 4.2.1.86: identical to , 16α-hydroxyprogesterone dehydratase * : octopamine dehydratase * : synephrine dehydratase * EC 4.2.1.89: The activity has now been shown to be due to , L-carnitine CoA-transferase and , crotonobetainyl-CoA hydratase * : L-rhamnonate dehydratase * : arogenate dehydratase * : hydroperoxide dehydratase * : ATP-dependent NAD(P)H-hydrate dehydratase * : scytalone dehydratase * : kievitone hydratase * : 4a-hydroxytetrahydrobiopterin dehydratase * : phaseollidin hydratase * : 16α-hydroxyprogesterone dehydratase * : 2-methylisocitrate dehydratase * : cyclohexa-1,5-dienecarbonyl-CoA hydratase * EC 4.2.1.101: Now included with , feruloyl-CoA hydratase/lyase * EC 4.2.1.102: Now , cyclohexa-1,5-dienecarbonyl-CoA hydratase * : cyclohexyl-isocyanide hydratase * : cyanase * : 2-hydroxyisoflavanone dehydratase * : bile-acid 7α-dehydratase * : 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase * :

ectoine synthase The enzyme ectoine synthase () catalyzes the chemical reaction :(2''S'')-4-acetamido-2-aminobutanoate \rightleftharpoons L-ectoine + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bon ...

* :

methylthioribulose 1-phosphate dehydratase The enzyme methylthioribulose 1-phosphate dehydratase () catalyzes the chemical reaction :5-(methylsulfanyl)-D)ribulose 1-phosphate \rightleftharpoons 5-(methylthio)-2,3-dioxopentyl phosphate + H2 This enzyme belongs to the family of lyases, sp ...

* : aldos-2-ulose dehydratase * : 1,5-anhydro-D-fructose dehydratase * : acetylene hydratase * : ''o''-succinylbenzoate synthase * : methanogen homoaconitase * : UDP-''N''-acetylglucosamine 4,6-dehydratase (configuration-inverting) * : 3-hydroxypropionyl-CoA dehydratase * : 2-methylcitrate dehydratase (2-methyl-''trans''-aconitate forming) * :

3-dehydroshikimate dehydratase 3-dehydroshikimate dehydratase () is an enzyme with systematic name ''3-dehydroshikimate hydro-lyase''. This enzyme catalyses the following chemical reaction A chemical reaction is a process that leads to the chemical transformation of one se ...

* : enoyl-CoA hydratase 2 * : 4-hydroxybutanoyl-CoA dehydratase * : colneleate synthase * : tryptophan synthase (indole-salvaging) * : tetrahymanol synthase * :

arabidiol synthase Arabidiol synthase (, ''PEN1 (gene)'', ''(''S'')-squalene-2,3-epoxide hydro-lyase (arabidiol forming)'') is an enzyme with systematic name ''(3''S'')-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (arabidiol forming)''. This enzyme catalyses the follow ...

* :

dammarenediol II synthase Dammarenediol II synthase (, ''dammarenediol synthase'', ''2,3-oxidosqualene (20S)-dammarenediol cyclase'', ''DDS'', ''(S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming)'') is an enzyme with systematic name ''(3S)-2,3-epoxy-2,3-dihydro ...

* : ''N''-acetylmuramic acid 6-phosphate etherase * : linalool dehydratase * : lupan-3β,20-diol synthase * : squalene—hopanol cyclase * : D-lactate dehydratase * : carotenoid 1,2-hydratase * : 2-hydroxyhexa-2,4-dienoate hydratase * : copal-8-ol diphosphate hydratase * : very-long-chain (3''R'')-3-hydroxyacyl-CoA dehydratase * : UDP-''N''-acetylglucosamine 4,6-dehydratase (configuration-retaining) * : ADP-dependent NAD(P)H-hydrate dehydratase * : sporulenol synthase * : (+)-Caryolan-1-ol synthase * : pterocarpan synthase * * : gluconate/galactonate dehydratase * * : 2-dehydro-3-deoxyD-arabinonate dehydratase * * : 5′-oxoaverantin cyclase * * : versicolorin B synthase * * : 3-amino-5-hydroxybenzoate synthase * * : capreomycidine synthase * * : L-galactonate dehydratase * * : 5,6,7,8-tetrahydromethanopterin hydro-lyase * * : 2-methylfumaryl-CoA hydratase * * : crotonobetainyl-CoA hydratase * * : short-chain-enoyl-CoA hydratase * * : chorismate dehydratase * * : hydroperoxy icosatetraenoate dehydratase * * : 3-methylfumaryl-CoA hydratase * * : tetracenomycin F2 cyclase * * : (methylthio)acryloyl-CoA hydratase * * : L-talarate dehydratase * * : (''R'')-2-hydroxyisocaproyl-CoA dehydratase * * : galactarate dehydratase (D-threo-forming) * * : dTDP-4-dehydro-6-deoxy-α-glucopyranose 2,3-dehydratase * * : 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3''H'')-one isomerase/dehydratase * * : bisanhydrobacterioruberin hydratase * * : 6-deoxy-6-sulfo-D-gluconate dehydratase * * : 2-oxo-hept-4-ene-1,7-dioate hydratase * * : dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase * * : chlorophyllide ''a'' 3¹-hydratase * * : phosphinomethylmalate isomerase * * : (''R'')-2-hydroxyglutaryl-CoA dehydratase * * : GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase * * : 3-vinyl bacteriochlorophyllide ''d'' 3¹-hydratase * * : 2-(ω-methylthio)alkylmalate dehydratase * * : ''cis''-L-3-hydroxyproline dehydratase * * : ''trans''-4-hydroxy-L-proline dehydratase * * : ''ent''-8α-hydroxylabd-13-en-15-yl diphosphate synthase * * : peregrinol diphosphate synthase * * : (''R'')-3-(aryl)lactoyl-CoA dehydratase * * : L-lyxonate dehydratase * * : (2''S'')-3-sulfopropanediol dehydratase * : *No Wikipedia article

EC 4.2.2: Acting on Polysaccharides

* : hyaluronate lyase * : pectate lyase * : mannuronate-specific alginate lyase * EC 4.2.2.4: Now known to comprise two enzymes: , chondroitin-sulfate-ABC endolyase and , chondroitin-sulfate-ABC exolyase * : chondroitin AC lyase * : oligogalacturonide lyase * : heparin lyase * : heparin-sulfate lyase * : pectate disaccharide-lyase * :

pectin lyase Pectin lyase (), also known as pectolyase, is a naturally occurring pectinase, a type of enzyme that degrades pectin. It is produced commercially for the food industry from fungi and used to destroy residual fruit starch, known as pectin, in wine ...

* : guluronate-specific alginate lyase * : xanthan lyase * : exo-(1→4)-α-D-glucan lyase * : glucuronan lyase * : anhydrosialidase * :

levan fructotransferase (DFA-IV-forming) The enzyme levan fructotransferase (DFA-IV-forming) () catalyzes the following process: :Produces di-β-D-fructofuranose 2,6′:2′,6-dianhydride (DFA IV) by successively eliminating the diminishing (2→6)-β-D-fructan (levan) chain from the te ...

* :

inulin fructotransferase (DFA-I-forming) The enzyme inulin fructotransferase (DFA-I-forming) () catalyzes the following process: :Produces α-D-fructofuranose β-D-fructofuranose 1,2′:2,1′-dianhydride (DFA I) by successively eliminating the diminishing (2→1)-β-D-fructan (inulin) ...

* :

inulin fructotransferase (DFA-III-forming) The enzyme inulin fructotransferase (DFA-III-forming) () catalyzes the following process: :Produces α-D-fructofuranose β-D-fructofuranose 1,2′:2,3′-dianhydride (DFA III) by successively eliminating the diminishing (2→1)-β-D-fructan (inul ...

* : chondroitin B lyase * : chondroitin-sulfate-ABC endolyase * : chondroitin-sulfate-ABC exolyase * : pectate trisaccharide-lyase * : rhamnogalacturonan endolyase * : rhamnogalacturonan exolyase * : gellan lyase * : oligo-alginate lyase * * : pectin monosaccharide-lyase * : *No Wikipedia article

EC 4.2.3: Acting on phosphates

* :

threonine synthase The enzyme threonine synthase (EC 4.2.3.1) catalyzes the chemical reaction :''O''-phospho-L-homoserine + H2O \rightleftharpoons L-threonine + phosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting ...

* : ethanolamine-phosphate phospho-lyase * :

methylglyoxal synthase The enzyme methylglyoxal synthase (EC 4.2.3.3) catalyzes the chemical reaction :glycerone phosphate \rightleftharpoons 2-oxopropanalCommonly known as methylglyoxal + phosphate Attempts to observe reversibility of this reaction have been unsucc ...

* :

3-dehydroquinate synthase The enzyme 3-dehydroquinate synthase (EC 4.2.3.4) catalyzes the chemical reaction : 3-deoxy-D-''arabino''-hept-2-ulosonate 7-phosphate \rightleftharpoons 3-dehydroquinate + phosphate The protein uses NAD+ to catalyze the reaction. This react ...

* : chorismate synthase * : trichodiene synthase * :

pentalenene synthase The enzyme pentalenene synthase (EC 4.2.3.7) catalyzes the chemical reaction :(2''E'',6''E'')-farnesyl diphosphate \rightleftharpoons pentalenene + diphosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases ...

* : casbene synthase * : aristolochene synthase * : (–)-''endo''-fenchol synthase * : sabinene-hydrate synthase * : 6-pyruvoyltetrahydropterin synthase * : (+)-δ-cadinene synthase * EC 4.2.3.14: Now covered by , (–)-α-pinene synthase, and , (–)-β-pinene synthase * : myrcene synthase * : (4''S'')-limonene synthase * :

taxadiene synthase The enzyme taxadiene synthase (EC 4.2.3.17) catalyzes the chemical reaction :geranylgeranyl diphosphate \rightleftharpoons taxa-4,11-diene + diphosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases actin ...

* : abietadiene synthase * : ''ent''-kaurene synthase * : (''R'')-limonene synthase * : vetispiradiene synthase * : germacradienol synthase * : germacrene-A synthase * : amorpha-4,11-diene synthase * : ''S''-linalool synthase * : ''R''-linalool synthase * :

isoprene synthase The enzyme isoprene synthase (EC 4.2.3.27) catalyzes the chemical reaction : prenyl pyrophosphate \rightleftharpoons isoprene + diphosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphate ...

* : ''ent''-cassa-12,15-diene synthase * : ''ent''-sandaracopimaradiene synthase * : ''ent''-pimara-8(14),15-diene synthase * : ''ent''-pimara-9(11),15-diene synthase * : levopimaradiene synthase * : stemar-13-ene synthase * : stemod-13(17)-ene synthase * : ''syn''-pimara-7,15-diene synthase * : terpentetriene synthase * : ''epi''-isozizaene synthase * : α-bisabolene synthase * : ''epi''-cedrol synthase * : (''Z'')-γ-bisabolene synthase * : elisabethatriene synthase * : aphidicolan-16β-ol synthase * : fusicocca-2,10(14)-diene synthase * : isopimara-7,15-diene synthase * : phyllocladan-16α-ol synthase * : α-farnesene synthase * : β-farnesene synthase * : (3''S'',6''E'')-nerolidol synthase * : (3''R'',6''E'')-nerolidol synthase * : (+)-α-santalene synthase 2''Z'',6''Z'')-farnesyl diphosphate cyclizing* : β-phellandrene synthase (neryl-diphosphate-cyclizing) * : (4''S'')-β-phellandrene synthase (geranyl-diphosphate-cyclizing) * : (+)-endo-β-bergamotene synthase 2''Z'',6''Z'')-farnesyl diphosphate cyclizing* : (–)-endo-α-bergamotene synthase 2''Z'',6''Z'')-farnesyl diphosphate cyclizing* : (''S'')-β-bisabolene synthase * : γ-humulene synthase * : (–)-β-caryophyllene synthase * : longifolene synthase * : (''E'')-γ-bisabolene synthase * : germacrene C synthase * : 5-epiaristolochene synthase * : (–)-γ-cadinene synthase 2''Z'',6''E'')-farnesyl diphosphate cyclizing* : (+)-cubenene synthase * : (+)-epicubenol synthase * :

zingiberene synthase Zingiberene synthase (EC 4.2.3.65, α-zingiberene synthase, ZIS) is an enzyme with systematic name (2''E'',6''E'')-farnesyl-diphosphate diphosphate-lyase (zingiberene-forming). This enzyme catalyses the following chemical reaction : (2''E'',6''E ...

* : β-selinene cyclase * : ''cis''-muuroladiene synthase * : β-eudesmol synthase * : (+)-α-barbatene synthase * : patchoulol synthase * : (''E,E'')-germacrene B synthase * : α-gurjunene synthase * : valencene synthase * : presilphiperfolanol synthase * : (–)-germacrene D synthase * : (+)-δ-selinene synthase * : (+)-germacrene D synthase * : β-chamigrene synthase * : thujopsene synthase * : α-longipinene synthase * : ''exo''-α-bergamotene synthase * : α-santalene synthase * : β-santalene synthase * : 10-''epi''-γ-eudesmol synthase * : α-eudesmol synthase * : 7-''epi''-α-selinene synthase * : α-guaiene synthase * : viridiflorene synthase * : (+)-β-caryophyllene synthase * : 5-''epi''-α-selinene synthase * : cubebol synthase * : (+)-γ-cadinene synthase * : δ-guaiene synthase * : γ-curcumene synthase * : (–)-α-cuprenene synthase * : avermitilol synthase * : (–)-δ-cadinene synthase * : (+)-T-muurolol synthase * : labdatriene synthase * : bicyclogermacrene synthase * : 7-''epi''-sesquithujene synthase * : sesquithujene synthase * : ''ent''-isokaurene synthase * : α-humulene synthase * : tricyclene synthase * : (''E'')-β-ocimene synthase * : (+)-car-3-ene synthase * :

1,8-cineole synthase 1,8-Cineole synthase (EC 4.2.3.108, ''1,8-cineole cyclase'', ''geranyl pyrophoshate:1,8-cineole cyclase'', ''1,8-cineole synthetase'') is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, 1,8-cineole-forming). This en ...

* : (–)-sabinene synthase * : (+)-sabinene synthase * : (–)-α-terpineol synthase * : (+)-α-terpineol synthase * : terpinolene synthase * : γ-terpinene synthase * : α-terpinene synthase * : (+)-camphene synthase * : (–)-camphene synthase * : 2-methylisoborneol synthase * : (-)-α-pinene synthase * : (-)-β-pinene synthase * : (+)-α-pinene synthase * : (+)-β-pinene synthase * : β-sesquiphellandrene synthase * : 2-deoxy-''scyllo''-inosose synthase * : α-muurolene synthase * : γ-muurolene synthase * : β-copaene synthase * : β-cubebene synthase * : (+)-sativene synthase * : tetraprenyl-β-curcumene synthase * : miltiradiene synthase * : neoabietadiene synthase * : α-copaene synthase * : 5-phosphooxy-L-lysine phospho-lyase * : Δ⁶-protoilludene synthase * : α-isocomene synthase * : (''E'')-2-''epi''-β-caryophyllene synthase * : (+)-''epi''-α-bisabolol synthase * : valerena-4,7(11)-diene synthase * : ''cis''-abienol synthase : Enzymes from on have no Wikipedia articles * : sclareol synthase * : 7-epizingiberene synthase 2''Z'',6''Z'')-farnesyl diphosphate cyclizing * : kunzeaol synthase * : geranyllinalool synthase * : ophiobolin F synthase * : cyclooctat-9-en-7-ol synthase * : pimaradiene synthase * : cembrene C synthase * : nephthenol synthase * : cembrene A synthase * : pentamethylcyclopentadecatrienol synthase * : 2-''epi''-5-''epi''-valiolone synthase * : (5-formylfuran-3-yl)methyl phosphate synthase * : demethyl-4-deoxygadusol synthase * : 2-epi-valiolone synthase * : hydroxysqualene synthase * : (+)-isoafricanol synthase * : (–)-spiroviolene synthase * : tsukubadiene synthase * : (2''S'',3''R'',6''S'',9''S'')-(–)-protoillud-7-ene synthase * : (3''S'')-(+)-asterisca-2(9),6-diene synthase * : (–)-α-amorphene synthase * : (+)-corvol ether B synthase * : (+)-eremophilene synthase * : (1''R'',4''R'',5''S'')-(–)-guaia-6,10(14)-diene synthase * : (+)-(1''E'',4''E'',6''S'',7''R'')-germacra-1(10),4-dien-6-ol synthase * : dolabella-3,7-dien-18-ol synthase * : dolathalia-3,7,11-triene synthase * : 7-''epi''-α-eudesmol synthase * : 4-''epi''-cubebol synthase * : (+)-corvol ether A synthase * : 10-''epi''-juneol synthase * : τ-cadinol synthase * : (2''E'',6''E'')-hedycaryol synthase * : 10-''epi''-cubebol synthase * : sesterfisherol synthase * : β-thujene synthase * : stellata-2,6,19-triene synthase * : guaia-4,6-diene synthase * : pseudolaratriene synthase * : selina-4(15),7(11)-diene synthase * : pristinol synthase * : nezukol synthase * : 5-hydroxy-α-gurjunene synthase * : ''ent''-atiserene synthase * : ''ent''-13-''epi''-manoyl oxide synthase * : (2''Z'',6''E'')-hedycaryol synthase * : β-geranylfarnesene synthase * : 9,13-epoxylabd-14-ene synthase * : manoyl oxide synthase * : cycloaraneosene synthase * : labda-7,13(16),14-triene synthase * : (12''E'')-labda-8(17),12,14-triene synthase * : (–)-drimenol synthase * : rhizathalene A synthase * : dolabradiene synthase * : eudesmane-5,11-diol synthase * : α-selinene synthase * : (–)-5-epieremophilene synthase * : β-pinacene synthase * : hydropyrene synthase * : hydropyrenol synthase * : isoelisabethatriene synthase * : valerianol synthase * : sodorifen synthase

EC 4.2.99: Other Carbon-Oxygen Lyases

* EC 4.2.99.1: Now , hyaluronate lyase * EC 4.2.99.2: Now , threonine synthase * EC 4.2.99.3: Now , pectate lyase * EC 4.2.99.4: Now , poly(β-D-mannuronate) lyase * EC 4.2.99.5: deleted * EC 4.2.99.6: Now included with (chondroitin ABC lyase) and (chondroitin AC lyase) * EC 4.2.99.7: Now , ethanolamine-phosphate phospho-lyase * EC 4.2.99.8: Now , cysteine synthase * EC 4.2.99.9: Now , cystathionine γ-synthase * EC 4.2.99.10: Now , ''O''-acetylhomoserine aminocarboxypropyltransferase * EC 4.2.99.11: Now , methylglyoxal synthase * : carboxymethyloxysuccinate lyase * EC 4.2.99.13: Now , zeatin 9-aminocarboxyethyltransferase * EC 4.2.99.14: Now , β-pyrazolylalanine synthase * EC 4.2.99.15: Now , L-mimosine synthase * EC 4.2.99.16: Now , uracilylalanine synthase * EC 4.2.99.17: Listed as , β-pyrazolylalanine synthase * :

DNA-(apurinic or apyrimidinic site) lyase The enzyme DNA-(apurinic or apyrimidinic site) lyase, also referred to as DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase (systematic name) or DNA AP lyase (EC 4.2.99.18) catalyzes the cleavage of the C-O-P bond 3' from the apurinic ...

* EC 4.2.99.19: Now , 2-hydroxypropyl-CoM lyase * : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase * : isochorismate lyase * : tuliposide A-converting enzyme * * : tuliposide B-converting enzyme * * : thebaine synthase * : *No Wikipedia article

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

* :

aspartate ammonia-lyase The enzyme aspartate ammonia-lyase (EC 4.3.1.1) catalyzes the chemical reaction :L-aspartate \rightleftharpoons fumarate + NH3 The reaction is the basis of the industrial synthesis of aspartate. This enzyme belongs to the family of lyases, sp ...

* : methylaspartate ammonia-lyase * :

histidine ammonia-lyase Histidine ammonia-lyase (EC 4.3.1.3, histidase, histidinase) is an enzyme that in humans is encoded by the ''HAL'' gene. It converts histidine into ammonia and urocanic acid. Its systematic name is L-histidine ammonia-lyase (urocanate-forming). ...

* : formiminotetrahydrofolate cyclodeaminase * EC 4.3.1.5: Now divided into (tyrosine ammonia-lyase), (phenylalanine ammonia-lyase) and (phenylalanine/tyrosine ammonia-lyase) * : β-alanyl-CoA ammonia-lyase * :

ethanolamine ammonia-lyase The enzyme ethanolamine ammonia-lyase (EC 4.3.1.7) catalyzes the chemical reaction :ethanolamine \rightleftharpoons acetaldehyde + NH3 This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. ...

* EC 4.3.1.8: Now , hydroxymethylbilane synthase * : glucosaminate ammonia-lyase * : serine-sulfate ammonia-lyase * EC 4.3.1.11: Deleted: inadequately characterized * :

ornithine cyclodeaminase The enzyme ornithine cyclodeaminase (EC 4.3.1.12) catalyzes the chemical reaction L-ornithine \rightleftharpoons L-proline + NH4+ This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. Th ...

* : carbamoyl-serine ammonia-lyase * : 3-aminobutyryl-CoA ammonia-lyase * : diaminopropionate ammonia-lyase * : ''threo''-3-hydroxy-L-aspartate ammonia-lyase * : L-serine ammonia-lyase * : D-serine ammonia-lyase * :

threonine ammonia-lyase Threonine ammonia-lyase (EC 4.3.1.19, systematic name L-threonine ammonia-lyase (2-oxobutanoate-forming), also commonly referred to as threonine deaminase or threonine dehydratase, is an enzyme responsible for catalyzing the conversion of L-threo ...

* : ''erythro''-3-hydroxy-L-aspartate ammonia-lyase * EC 4.3.1.21: identical to , glucosaminate ammonia-lyase * :

3,4-dihydroxyphenylalanine reductive deaminase The enzyme 3,4-dihydroxyphenylalanine reductive deaminase (EC 4.3.1.22, reductive deaminase, DOPA-reductive deaminase, DOPARDA; systematic name 3,4-dihydroxy-L-phenylalanine ammonia-lyase (3,4-dihydroxyphenylpropanoate-forming)) catalysis, cataly ...

* : tyrosine ammonia-lyase * :

phenylalanine ammonia-lyase The enzyme phenylalanine ammonia lyase (EC 4.3.1.24) catalyzes the conversion of L-phenylalanine to ammonia and ''trans''-cinnamic acid.: :L-phenylalanine = ''trans''-cinnamate + NH3 Phenylalanine ammonia lyase (PAL) is the first and committed ...

* :

phenylalanine/tyrosine ammonia-lyase Phenylalanine/tyrosine ammonia-lyase (EC 4.3.1.25, PTAL, bifunctional PAL) is an enzyme with systematic name L-phenylalanine(or L-tyrosine):''trans''-cinnamate(or ''trans-p''-hydroxycinnamate) ammonia-lyase. This enzyme catalyses the following che ...

* EC 4.3.1.26: Now , dichlorochromopyrrolate synthase * : ''threo''-3-hydroxy-D-aspartate ammonia-lyase * : L-lysine cyclodeaminase * : D-glucosaminate-6-phosphate ammonia-lyase * * : dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase * * : L-tryptophan ammonia lyase * * : 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase * : *No Wikipedia article

EC 4.3.2: Amidine-Lyases

* :

argininosuccinate lyase The enzyme argininosuccinate lyase (EC 4.3.2.1, ASL, argininosuccinase; systematic name 2-(''N'' ω-L-arginino)succinate arginine-lyase (fumarate-forming)) catalyzes the reversible breakdown of argininosuccinate: :2-(''N'' ω-L-arginino)succina ...

* : adenylosuccinate lyase * : ureidoglycolate lyase * : purine imidazole-ring cyclase * : peptidylamidoglycolate lyase * : γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase * : glutathione-specific γ-glutamylcyclotransferase * * : γ-glutamylamine cyclotransferase * * : γ-glutamylcyclotransferase * * : imidazole glycerol-phosphate synthase * : *No Wikipedia article

EC 4.3.3: Amine-Lyases

* : 3-ketovalidoxylamine C-N-lyase * :

strictosidine synthase Strictosidine synthase (EC 4.3.3.2) is an enzyme in alkaloid biosynthesis that catalyses the condensation of tryptamine with secologanin to form strictosidine in a formal Pictet–Spengler reaction: :3-α(''S'')-strictosidine + H2O = tryptamine + ...

* :

deacetylisoipecoside synthase The enzyme deacetylisoipecoside synthase (EC 4.3.3.3) catalyzes the chemical reaction :deacetylisoipecoside + H2O \rightleftharpoons dopamine + secologanin This enzyme belongs to the family of lyases, specifically amine lyases, which cleave carb ...

* : deacetylipecoside synthase * : 4′-demethylrebeccamycin synthase * : pyridoxal 5′-phosphate synthase (glutamine hydrolysing) * : 4-hydroxy-tetrahydrodipicolinate synthase

EC 4.3.99: Other Carbon-Nitrogen Lyases

* EC 4.3.99.1: Now , cyanate hydratase * EC 4.3.99.2: Now , carboxybiotin decarboxylase * : 7-carboxy-7-deazaguanine synthase * : choline trimethylamine-lyase * : *No Wikipedia article

EC 4.4: Carbon-Sulfur Lyases

EC 4.4.1: Carbon-sulfur lyases (only sub-subclass identified to date)

* : cystathionine γ-lyase * : homocysteine desulfhydrase * : dimethylpropiothetin dethiomethylase * : alliin lyase * :

lactoylglutathione lyase The enzyme lactoylglutathione lyase (EC 4.4.1.5, also known as glyoxalase I) catalyzes the isomerization of hemithioacetal adducts, which are formed in a spontaneous reaction between a glutathionyl group and aldehydes such as methylglyoxal. :(' ...

* EC 4.4.1.6: Now included in , cysteine-''S''-conjugate β-lyase * EC 4.4.1.7: Now included with glutathione transferase * EC 4.4.1.8: Now included in , cysteine-''S''-conjugate β-lyase * : L-3-cyanoalanine synthase * : cysteine lyase * : methionine γ-lyase * EC 4.4.1.12: deleted: activity due to , sulfoacetaldehyde acetyltransferase * : cysteine-''S''-conjugate β-lyase * : 1-aminocyclopropane-1-carboxylate synthase * : D-cysteine desulfhydrase * : selenocysteine lyase * : holocytochrome-''c'' synthase * EC 4.4.1.18: Now , prenylcysteine oxidase * : phosphosulfolactate synthase * : leukotriene-C₄ synthase * : ''S''-ribosylhomocysteine lyase * : ''S''-(hydroxymethyl)glutathione synthase * : 2-hydroxypropyl-CoM lyase * : (2''R'')-sulfolactate sulfo-lyase * : L-cysteate sulfo-lyase * : olivetolic acid cyclase * EC 4.4.1.27: Now , carbon disulfide hydrolase : *No Wikipedia article

EC 4.5: Carbon-Halide Lyases

EC 4.5.1: Carbon-halide lyases (only sub-subclass identified to date)

* : DDT-dehydrochlorinase * : 3-chloro-D-alanine dehydrochlorinase * : dichloromethane dehalogenase * : L-2-amino-4-chloropent-4-enoate dehydrochlorinase * : ''S''-carboxymethylcysteine synthase

EC 4.6: Phosphorus-Oxygen Lyases

EC 4.6.1: Phosphorus-oxygen lyases (only sub-subclass identified to date)

* :

adenylate cyclase Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming). It catalyzes the following reaction: :A ...

* :

guanylate cyclase Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming)) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanos ...

* EC 4.6.1.3: Now , 3-dehydroquinate synthase * EC 4.6.1.4: Now , chorismate synthase * EC 4.6.1.5: Now , pentalenene synthase * : cytidylate cyclase * EC 4.6.1.7: Now , casbene synthase * EC 4.6.1.8: Now , (-)-''endo''-fenchol synthase * EC 4.6.1.9: Now Now , sabinene-hydrate synthase * EC 4.6.1.10: Now , 6-pyruvoyltetrahydropterin synthase * EC 4.6.1.11: Now , (+)-δ-cadinene synthase * : 2-''C''-methyl-D-erythritol 2,4-cyclodiphosphate synthase * : phosphatidylinositol diacylglycerol-lyase * : glycosylphosphatidylinositol diacylglycerol-lyase * : FAD-AMP lyase (cyclizing) * : tRNA-intron lyase * : cyclic pyranopterin monophosphate synthase * * : pancreatic ribonuclease * * : ribonuclease T₂ * * : ribonuclease U₂ * * : ''Enterobacter'' ribonuclease * * : ''Bacillus subtilis'' ribonuclease * * : ribotoxin * * : ribonuclease T₁ * * : bacteriophage T₄ restriction endoribonuclease RegB * : *No Wikipedia article

EC 4.7: Carbon-phosphorus lyases

EC 4.7.1: Carbon-phosphorus lyases (only sub-subclass identified to date)

* α-D ribose 1-methylphosphonate 5-phosphate C-P-lyase * : *No Wikipedia article

EC 4.8: Nitrogen-oxygen lyases

EC 4.8.1: Hydro-lyases

* : L-piperazate synthase * * : aliphatic aldoxime dehydratase * * : indoleacetaldoxime dehydratase * * : phenylacetaldoxime dehydratase * : *No Wikipedia article

EC 4.98: ATP-independent chelatases

EC 4.98.1: Forming coordination complexes

* : protoporphyrin ferrochelatase

EC 4.99: Other Lyases

EC 4.99.1: Sole sub-subclass for lyases that do not belong in the other subclasses

* : Now EC 4.98.1.1 * : alkylmercury lyase * :

sirohydrochlorin cobaltochelatase The enzyme sirohydrochlorin cobaltochelatase (EC 4.99.1.3) catalyzes the reaction :cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+ In the forward direction of reactions towards cobalamin in anaerobic bacteria, the two substrates of t ...

* :

sirohydrochlorin ferrochelatase The enzyme sirohydrochlorin ferrochelatase (EC 4.99.1.4) catalyzes the following reaction: : siroheme + 2H+ \rightleftharpoons sirohydrochlorin + Fe2+ This enzyme belongs to the family of lyases, to be specific the "catch-all" class of lyases ...

* EC 4.99.1.5: Now , aliphatic aldoxime dehydratase * EC 4.99.1.6: Now , indoleacetaldoxime dehydratase * EC 4.99.1.7: Now , phenylacetaldoxime dehydratase * :

heme ligase Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (β-hematin-forming). This enzyme catalyses the following reaction: : 2 ferriprotoporphyrin IX \ri ...

* : coproporphyrin ferrochelatase * * : magnesium dechelatase * * : sirohydrochlorin nickelchelatase * * : pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase * : *No Wikipedia article

References

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