Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''BIRC2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
cIAP1 is a member of the
Inhibitor of Apoptosis
Inhibitors of apoptosis are a group of proteins that mainly act on the intrinsic pathway that block programmed cell death, which can frequently lead to cancer or other effects for the cell if mutated or improperly regulated. Many of these inhibit ...
family that inhibit
apoptosis by interfering with the activation of
caspases.
Interactions
BIRC2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CASP9
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues. Caspase-9 homologs have been identified in all mammals for which they are known to exist, such ...
,
*
DIABLO,
GSPT1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the ''GSPT1'' gene.
Interactions
GSPT1 has been shown to interact with BIRC2
Baculoviral IAP repeat-containing protein 2 (also known a ...
,[
* ]HSP90B1
Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the ''HSP90B1'' gene.
HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. ...
,RIPK1
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in apoptosis and necroptosis. Some of the cell survival ...
,RIPK2
Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the ''RIPK2'' gene.
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded prot ...
TNFSF14
LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3.
Nomenclature
LIGHT stands for "homolo ...
,TRAF1
TNF receptor-associated factor 1 is a protein that in humans is encoded by the ''TRAF1'' gene.
Function
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate wit ...
,TRAF2
TNF receptor-associated factor 2 is a protein that in humans is encoded by the ''TRAF2'' gene.
Function
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, an ...
,UBC
The University of British Columbia (UBC) is a public research university with campuses near Vancouver and in Kelowna, British Columbia. Established in 1908, it is British Columbia's oldest university. The university ranks among the top three ...
.
References
Further reading
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External links
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{{PDB Gallery, geneid=329
Proteins
Microbiology