Biotin Carboxyl Carrier Protein (BCCP) refers to proteins containing a
biotin attachment domain that carry
biotin
Biotin (or vitamin B7) is one of the B vitamins. It is involved in a wide range of metabolic processes, both in humans and in other organisms, primarily related to the utilization of fats, carbohydrates, and amino acids. The name ''biotin'', bor ...
and carboxybiotin throughout the
ATP-dependent carboxylation by biotin-dependent carboxylases. In the case of ''
E. coli''
Acetyl-CoA carboxylase
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme () that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is ...
, the BCCP is a separate protein known as ''accB'' (). On the other hand, in ''
Haloferax mediterranei''
Propionyl-CoA carboxylase
Propionyl-CoA carboxylase (, PCC) catalyses the carboxylation reaction of propionyl-CoA in the mitochondrial matrix. PCC has been classified both as a ligase and a lyase. The enzyme is biotin-dependent. The product of the reaction is (S)-methylmal ...
, the BCCP ''pccA'' () is fused with
biotin carboxylase
In enzymology, a biotin carboxylase () is an enzyme that Catalysis, catalyzes the chemical reaction
: ATP + biotin-carboxyl-carrier protein + CO2 \rightleftharpoons ADP + phosphate + carboxybiotin-carboxyl-carrier protein
The three Substrate ...
.
Coenzymes
Enzymes
Metabolism
Proteins
{{Protein-stub