Arbaclofen placarbil ( , also known as XP19986) is a
prodrug of ''R''-
baclofen
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. It may also be used for hiccups and muscle spasms near the end of life. It is ta ...
. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with
GERD Gerd or GERD may refer to:
* Gerd (given name), a list of people with the given name or nickname
* Gerd (moon), a moon of Saturn
* Gerd Island, South Orkney Islands, Antarctica
* Gastroesophageal reflux disease, a chronic symptom of mucosal damage ...
and spasticity due to
multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in
phase III clinical trials.
It is being developed as an addiction medicine to treat alcoholism. It is also studied as a potential therapeutic for some autistic subjects.
[ ]
See also
*
Gabapentin enacarbil
Gabapentin enacarbil (Horizant () (), Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. It was designed for increased oral bioavailability over gabapentin, and human trials show ...
*
Lesogaberan
References
Abandoned drugs
Amino acids
Calcium channel blockers
Chloroarenes
GABA analogues
GABAB receptor agonists
Prodrugs
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