Arbaclofen
Arbaclofen placarbil ( , also known as XP19986) is a prodrug of ''R''-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials. It is being developed as an addiction medicine to treat alcoholism. It is also studied as a potential therapeutic for some autistic subjects. See also * Gabapentin enacarbil Gabapentin enacarbil (Horizant () (), Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. It was designed for increased oral bioavailability over gabapentin, and human trials show ... * Lesogaberan References Abandoned drugs Amino acids Calcium channel blockers Chloroarenes ...
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