Antibody Solutions is a privately held American

contract research organization In the life sciences, a contract research organization (CRO) is a company that provides support to the pharmaceutical, biotechnology, and medical device industries in the form of research services outsourced on a contract basis. A CRO may provid ...

headquartered in

Santa Clara, California Santa Clara (; Spanish for " Saint Clare") is a city in Santa Clara County, California. The city's population was 127,647 at the 2020 census, making it the eighth-most populous city in the Bay Area. Located in the southern Bay Area, the cit ...

. It provides research and discovery services and fit-for-purpose antibodies to biopharmaceutical and diagnostic companies and academic researchers worldwide. The company’s services include

monoclonal Monoclonality refers to the state of a line of cells that have been derived from a single clonal origin. Thus "monoclonal cells" can be said to form a single clone. The term ''monoclonal'' comes from the Ancient Greek ''monos'', meaning "alone" o ...

and

polyclonal Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of ...

antibody and

antigen In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...

development, molecular modeling, antibody sequencing and engineering,

bioreactor A bioreactor refers to any manufactured device or system that supports a biologically active environment. In one case, a bioreactor is a vessel in which a chemical reaction, chemical process is carried out which involves organisms or biochemistry, ...

technology,

pharmacokinetic Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered ...

studies, antibody

epitope An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The epitope is the specific piece of the antigen to which an antibody binds. The p ...

binning,

peptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A ...

synthesis,

immunoassay An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoass ...

development, ligand-binding assay analysis, and support for

CAR-T In biology, chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that have been engineered to give T cells the new ability to target a specific ...

research.

History

Antibody Solutions was founded in 1995 by current president, John Kenney, PhD, Judith Lynch-Kenney, and Dennis and Bette Gould. Dr. Kenney previously managed the monoclonal antibody (MAb) development laboratory for Syntex Research (

Roche F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX ...

) in

Palo Alto Palo Alto (; Spanish for "tall stick") is a charter city in the northwestern corner of Santa Clara County, California, United States, in the San Francisco Bay Area, named after a coastal redwood tree known as El Palo Alto. The city was estab ...

, while Gould managed the MAb production facility for Syva Diagnostics. Gould left Antibody Solutions in 1997, eventually becoming a vice president for Sepragen Corporation. Kenney and Gould were assisted in the startup of the company by Barry Bredt, who had the foresight to acquire the domain name
www.antibody.com
for the company. Bredt later became director of the

University of California at San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It condu ...

’s General Clinical Research Center, and was a pioneer of the HIV/AIDS Diagnostics EasyCD4; he died on April 8, 2007. Antibody Solutions was incorporated in 1998 with Dr. Kenney as president and Judith Lynch-Kenney as chief financial officer. One of the first independent antibody discovery companies, the firm focused on custom antibody discovery for therapeutics, diagnostics and critical reagents. The company pioneered the use of bioreactors in antibody research by becoming the first CRO to produce antibodies in CELLine flasks in 2000. From 2004 to 2011, Antibody Solutions was headquartered in Mountain View, a short distance from Shoreline Park,

Moffett Field Moffett Federal Airfield , also known as Moffett Field, is a joint civil-military airport located in an Local government in California#Counties, unincorporated part of Santa Clara County, California, Santa Clara County, California, United States, ...

and the

Googleplex The Googleplex is the corporate headquarters complex of Google and its parent company, Alphabet Inc. It is located at 1600 Amphitheatre Parkway in Mountain View, California. The original complex, with of office space, is the company's second la ...

. In 2011, the company moved to new facilities in

Sunnyvale Sunnyvale () is a city located in the Santa Clara Valley in northwest Santa Clara County in the U.S. state of California. Sunnyvale lies along the historic El Camino Real and Highway 101 and is bordered by portions of San Jose to the north ...

. It moved to its current 33,300-square-foot location at 3033 Scott Blvd. in Santa Clara near the San Tomas Expressway in mid-2019. A grand opening for the Scott Blvd. facility was held on January 30, 2020, to coincide with the company's Silver Anniversary.

Partnerships

Over the years, Antibody Solutions has had strategic agreements with a range of life science companies, including Open Monoclonal Technology, Inc. (OMT), Reflexion Pharmaceuticals, Guava Technologies, Single-Cell Technologies
Trianni
Harbour Antibodies, OmniAb and Alloy Therapeutics.

Research

Independent research conducted by Antibody Solutions and published or presented at scientific conferences include the following: * Generation of Neutralizing Human Monoclonal Antibodies Against a Therapeutic Target from the Alloy Therapeutics Mouse * Generation Using a Molecular Modeling Platform to Guide Therapeutic Antibody Discovery * Optimization of Therapeutic Discovery Strategies for Human Antibody Transgenic Animal Platforms * Development of Antibody and PK, and ADA Assays for a Cystine Knot Fusion Protein * A Rapid, High-Throughput Recombinant Antibody Expression System for Therapeutic Antibody Discovery and Validation * Generation of Agonist and Antagonist Human Monoclonal Antibodies Against an Immune Checkpoint Target from the H2L2 Mouse * Generation and Selection of Human Monoclonal Antibodies from the OmniRat * Therapeutic Antibody Discovery at Antibody Solutions using the OmniAb Platform * Development of human antibodies to human vascular endothelial growth factor -C (VEGF-C) and -D (VEGF-D) * Obtaining Antibodies to Difficult Membrane Targets through DNA and Cell Immunization * Next-Generation Therapeutic Antibody Discovery from Single B-cells * Generation and Selection of Human Monoclonal Antibodies from the H2L2 Mouse * Generation of Antibodies to Difficult Membrane Protein Targets * Development of Antibodies and ELISAs to measure Free and Total Obiltoxaximab (ETI-204) in the Presence of Anthrax Protective Antigen PA63 * Discovery of Therapeutic Antibodies to Difficult Membrane Proteins

Products and services

* Therapeutic antibody discovery * Cell-receptor

monoclonal antibody A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies ca ...

development *

In vivo Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and ...

animal study-grade antibodies development * Molecular modeling * Antibody sequencing * Anti-idiotype antibody production * Anti-protein antibodies for

pharmacokinetics Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered ...

studies *

Immunogenicity Immunogenicity is the ability of a foreign substance, such as an antigen, to provoke an immune response in the body of a human or other animal. It may be wanted or unwanted: * Wanted immunogenicity typically relates to vaccines, where the injectio ...

assays for

reagents In chemistry, a reagent ( ) or analytical reagent is a substance or compound added to a system to cause a chemical reaction, or test if one occurs. The terms ''reactant'' and ''reagent'' are often used interchangeably, but reactant specifies a ...

and controls *

Immunoassay An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoass ...

development * Ligand-binding

assay An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a ...

analysis * Drug potency assay analysis *

Cell bank A cell bank is a facility that stores cells of specific genome for the purpose of future use in a product or medicinal needs. They often contain expansive amounts of base cell material that can be utilized for various projects. Cell banks can be us ...

storage * Full technical and project management

References

{{Reflist, 2

External links

* Antibody Solution
Official Site
* Profile a
Science Exchange
Biotechnology companies of the United States Biotechnology companies established in 1995 Companies based in Santa Clara, California Contract research organizations Privately held companies based in California Research support companies 1995 establishments in California Reagents for biochemistry