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Antibody Solutions
Antibody Solutions is a privately held American contract research organization headquartered in Santa Clara, California. It provides research and discovery services and fit-for-purpose antibodies to biopharmaceutical and diagnostic companies and academic researchers worldwide. The company’s services include monoclonal and polyclonal antibody and antigen development, molecular modeling, antibody sequencing and engineering, bioreactor technology, pharmacokinetic studies, antibody epitope binning, peptide synthesis, immunoassay development, ligand-binding assay analysis, and support for CAR-T research. History Antibody Solutions was founded in 1995 by current president, John Kenney, PhD, Judith Lynch-Kenney, and Dennis and Bette Gould. Dr. Kenney previously managed the monoclonal antibody (MAb) development laboratory for Syntex Research (Roche) in Palo Alto, while Gould managed the MAb production facility for Syva Diagnostics. Gould left Antibody Solutions in 1997, eventually beco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Private Company
A privately held company (or simply a private company) is a company whose shares and related rights or obligations are not offered for public subscription or publicly negotiated in the respective listed markets, but rather the company's stock is offered, owned, traded, exchanged privately, or Over-the-counter (finance), over-the-counter. In the case of a closed corporation, there are a relatively small number of shareholders or company members. Related terms are closely-held corporation, unquoted company, and unlisted company. Though less visible than their public company, publicly traded counterparts, private companies have major importance in the world's economy. In 2008, the 441 list of largest private non-governmental companies by revenue, largest private companies in the United States accounted for ($1.8 trillion) in revenues and employed 6.2 million people, according to ''Forbes''. In 2005, using a substantially smaller pool size (22.7%) for comparison, the 339 companies on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hoffmann-La Roche
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth largest pharmaceutical company in the world by revenue, and the leading provider of cancer treatments globally. The company controls the American biotechnology company Genentech, which is a wholly owned affiliate, and the Japanese biotechnology company Chugai Pharmaceuticals, as well as the United States-based companies Ventana and Foundation Medicine. Roche's revenues during fiscal year 2020 were 58.32 billion Swiss francs. Descendants of the founding Hoffmann and Oeri families own slightly over half of the bearer shares with voting rights (a pool of family shareholders 45%, and Maja Oeri a further 5% apart), with Swiss pharma firm Novartis owning a furth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunogenicity
Immunogenicity is the ability of a foreign substance, such as an antigen, to provoke an immune response in the body of a human or other animal. It may be wanted or unwanted: * Wanted immunogenicity typically relates to vaccines, where the injection of an antigen (the vaccine) provokes an immune response against the pathogen, protecting the organism from future exposure. Immunogenicity is a central aspect of vaccine development. * Unwanted immunogenicity is an immune response by an organism against a therapeutic antigen. This reaction leads to production of anti-drug-antibodies (ADAs), inactivating the therapeutic effects of the treatment and potentially inducing adverse effects. A challenge in biotherapy is predicting the immunogenic potential of novel protein therapeutics. For example, immunogenicity data from high-income countries are not always transferable to low-income and middle-income countries. Another challenge is considering how the immunogenicity of vaccines changes with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacokinetics
Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models. Overview Pharmacokinetics describes how the body affects a specific xenobiotic/chemical after administration through the mechanisms of absorption and distribution, as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-idiotype Vaccine
Anti-idiotypic vaccines consist of antibodies that have three-dimensional immunogenic regions, termed idiotopes, that consist of protein sequences that bind to cell receptors. Idiotopes are aggregated into idiotypes specific to their target antigen. An example of an anti-idiotype antibody is Racotumomab. Production and use To produce an anti-idiotypic vaccine, antibodies that bind tumor-associated antigens (TAA) are isolated and injected into mice. To the murine immune system, the TAA antibodies are antigens and cause an immunogenic reaction producing murine antibodies that can bind to the "TAA idiotype" and is said to be "anti-idiotypic". The resulting murine antibodies are harvested and used to vaccinate other mice. The resulting antibodies in the second set of mice have a three-dimensional binding site that mimics the original antibodies that bind tumor-associated antigens. These antibodies are combined with an adjuvant and given as a vaccine. The murine immune system essenti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vivo
Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism. This is not to be confused with experiments done ''in vitro'' ("within the glass"), i.e., in a laboratory environment using test tubes, Petri dishes, etc. Examples of investigations ''in vivo'' include: the pathogenesis of disease by comparing the effects of bacterial infection with the effects of purified bacterial toxins; the development of non-antibiotics, antiviral drugs, and new drugs generally; and new surgical procedures. Consequently, animal testing and clinical trials are major elements of ''in vivo'' research. ''In vivo'' testing is often employed over ''in vitro'' because it is better suited for observing the overall effects of an experiment on a living subject. In dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoclonal Antibody
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell Lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies can have monovalent affinity, binding only to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different antibody-secreting plasma cell lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one monoclonal antibody to two epitopes. It is possible to produce monoclonal antibodies that specifically bind to virtually any suitable substance; they can then serve to detect or purify it. This capability has become an investigative tool in biochemistry, molecular biology, and medicine. Monoclonal antibodies are being used on a clinical level for both the diagnosis and therapy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical messengers which bind to a receptor and cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. Receptor proteins can be classified by their location. Transmembrane receptors include ligand-gated ion channels, G protein-coupled receptors, and enzyme-linked hormone receptors. Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. A molecule that binds to a receptor is called a ligand ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sunnyvale
Sunnyvale () is a city located in the Santa Clara Valley in northwest Santa Clara County in the U.S. state of California. Sunnyvale lies along the historic El Camino Real and Highway 101 and is bordered by portions of San Jose to the north, Moffett Federal Airfield and NASA Ames Research Center to the northwest, Mountain View to the northwest, Los Altos to the southwest, Cupertino to the south, and Santa Clara to the east. Sunnyvale's population was 155,805 at the 2020 census, making it the second most populous city in the county (after San Jose) and the seventh most populous city in the San Francisco Bay Area. As one of the major cities that make up California's high-tech area known as Silicon Valley, Sunnyvale is the birthplace of the video game industry, former location of Atari headquarters, and the location of a fictional computer game company in the 1983 film ''WarGames''. Many technology companies are headquartered in Sunnyvale and many more operate there, inc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Googleplex
The Googleplex is the corporate headquarters complex of Google and its parent company, Alphabet Inc. It is located at 1600 Amphitheatre Parkway in Mountain View, California. The original complex, with of office space, is the company's second largest square footage assemblage of Google buildings, after Google's 111 Eighth Avenue building in New York City, which the company bought in 2010. "Googleplex" is a portmanteau of ''Google'' and ''complex'' (meaning a complex of buildings) and a reference to ''googolplex'', the name given to the large number 10(10100), or 10googol. Facilities and history The original campus SGI Campus The site was previously occupied by Silicon Graphics (SGI). The office space and corporate campus is located within a larger site that contains Charleston Park, a public park; improved access to Permanente Creek; and public roads that connect the corporate site to Shoreline Park and the Bay Trail. The project, launched in 1994, was built on the site ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moffett Field
Moffett Federal Airfield , also known as Moffett Field, is a joint civil-military airport located in an Local government in California#Counties, unincorporated part of Santa Clara County, California, Santa Clara County, California, United States, between northern Mountain View, California, Mountain View and northern Sunnyvale, California, Sunnyvale. On November 10, 2014, NASA announced that it would be leasing of the airfield property to Google for 60 years. The airport is near the south end of San Francisco Bay, northwest of San Jose, California, San Jose. Formerly a US Navy facility, the former naval air station is now owned and operated by the NASA Ames Research Center. Tenant military activities include the 129th Rescue Wing of the California Air National Guard, operating the HC-130J Combat King II and HH-60G Pave Hawk aircraft, as well as the adjacent Headquarters for the 7th Psychological Operations Group of the US Army Reserve. Until 28 July 2010, the US Air Force's 21st S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shoreline Park, Mountain View
Shoreline at Mountain View is a park in Mountain View, California, United States. The city park was dedicated in 1983, some fifteen years after the City undertook the daunting task of planning a regional park that would provide citizens with environmentally savvy recreation opportunities, from a site that was originally a landfill. History The city of Mountain View bought the site in 1967 to build a recreational facility. However, the cost of importing earth to raise it by 20 feet in order to prevent flooding was too high, so it was instead operated as a landfill accepting garbage from San Francisco. Shoreline Park opened in 1983, with some initial problems from methane fires. In 1987, Shoreline won the League of California Cities' Helen Putnam Award for public works. Features and trails Shoreline Park now features an 18-hole links-style golf course with pro shop and driving range, Shoreline Golf Links, and a artificial lake. On the lake's eastern shore is the Shoreline Boathouse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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