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Albert Ernst Renold (July 10, 1923 – March 21, 1988) was a
Swiss Swiss may refer to: * the adjectival form of Switzerland * Swiss people Places * Swiss, Missouri * Swiss, North Carolina *Swiss, West Virginia * Swiss, Wisconsin Other uses *Swiss-system tournament, in various games and sports *Swiss Internation ...
physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
and clinical biochemist noted for his extensive research on
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
. In 1986 he was awarded the King Faisal International Prize in Medicine for contributions to the understanding of diabetes.


Early life

Renold was born on July 10, 1923, in
Karlsruhe Karlsruhe ( , , ; South Franconian: ''Kallsruh'') is the third-largest city of the German state (''Land'') of Baden-Württemberg after its capital of Stuttgart and Mannheim, and the 22nd-largest city in the nation, with 308,436 inhabitants. ...
, Germany, to a Swiss physician father and a German mother. He was also a descendant of the 19th-century German painter
Georg Friedrich Kersting Georg Friedrich Kersting (31 October 1785 – 1 July 1847) was a German painter, best known for his Biedermeier-style interior paintings and his association with fellow artist Caspar David Friedrich. Biography Kersting came from a lar ...
. He was raised in Switzerland, attending school in
Montreaux Montreux (, , ; frp, Montrolx) is a Swiss municipality and town on the shoreline of Lake Geneva at the foot of the Alps. It belongs to the district of Riviera-Pays-d'Enhaut in the canton of Vaud in Switzerland, and has a population of approximat ...
and
Lausanne , neighboring_municipalities= Bottens, Bretigny-sur-Morrens, Chavannes-près-Renens, Cheseaux-sur-Lausanne, Crissier, Cugy, Écublens, Épalinges, Évian-les-Bains (FR-74), Froideville, Jouxtens-Mézery, Le Mont-sur-Lausanne, Lugrin (FR-74), ...
before completing his medical studies at the
University of Zurich The University of Zürich (UZH, german: Universität Zürich) is a public research university located in the city of Zürich, Switzerland. It is the largest university in Switzerland, with its 28,000 enrolled students. It was founded in 1833 f ...
from 1941 to 1947. He completed his MD with a thesis on
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...
caused by
alloxan Alloxan, sometimes referred to as ''alloxan hydrate'', is the name of the organic compound with the formula OC(N(H)CO)2C(OH)2. It is classified as a derivative of pyrimidine. The anhydrous derivative OC(N(H)CO)2CO is also known, as well as a dime ...
.


Career

After graduating from the University of Zurich, Renold was awarded a scholarship from the American-Swiss Foundation for Scientific Exchange, allowing him to move to
Boston Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- mo ...
in 1948 as a research fellow at
New England Deaconess Hospital Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital (founded in 1916) and New England Deaconess Hospital (founded ...
,
Peter Bent Brigham Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two fo ...
, and
Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...
. In Boston, he worked alongside
Elliott P. Joslin Elliott Proctor Joslin (June 6, 1869 – January 28, 1962) was the first doctor in the United States to specialize in diabetes and was the founder of today's Joslin Diabetes Center. Joslin was involved for seven decades in most aspects of diabete ...
,
Alexander Marble Alexander Marble (February 2, 1902 – September 13, 1992) was an American diabetologist who spent the majority of his career at the Joslin Diabetes Center. Life and career Marble was born in 1902 in Troy, Kansas. He attended the University of Kan ...
,
Albert Baird Hastings Albert Baird Hastings (November 20, 1895 – September 24, 1987) was an American biochemist and physiologist. He spent 28 years as the department chair and Hamilton Kuhn Professor of Biological Chemistry at Harvard University. After retiring ...
, George W. Thorn and
George F. Cahill Jr. George F. Cahill Jr. (July 7, 1927 – July 30, 2012) was an American scientist who significantly advanced the diabetes mellitus research of the 20th century. He focused on metabolic research, especially concerning human glucose metabolism in diabet ...
He was appointed director of Harvard Medical School's Carbohydrate Research Laboratory in 1956 and director of New England Deaconess Hospital's Baker Clinic Research Laboratory in 1959; under his leadership the latter became internationally known for diabetes research. Renold returned to Switzerland in 1963 as a professor of medicine at the
University of Geneva The University of Geneva (French: ''Université de Genève'') is a public research university located in Geneva, Switzerland. It was founded in 1559 by John Calvin as a theological seminary. It remained focused on theology until the 17th centu ...
. He also founded the Institute of Clinical Biochemistry in Geneva, where he hosted a variety of research fellows and visiting professors, largely focusing on diabetes research. The main theme of Renold's research during his time in Boston was the effect of
insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
on
adipose tissue Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular e ...
. Based on this principle, he and his colleagues developed a method for measuring insulin levels in blood and other fluids. This technique was used widely to estimate insulin levels until the later development of a
radioimmunoassay A radioimmunoassay (RIA) is an immunoassay that uses radiolabeled molecules in a stepwise formation of immune complexes. A RIA is a very sensitive in vitro assay technique used to measure concentrations of substances, usually measuring antigen conc ...
by
Rosalyn Sussman Yalow Rosalyn Sussman Yalow (July 19, 1921 – May 30, 2011) was an American medical physicist, and a co-winner of the 1977 Nobel Prize in Physiology or Medicine (together with Roger Guillemin and Andrew Schally) for development of the radioimmunoassay ...
and
Solomon Berson Solomon Aaron Berson (April 22, 1918 – April 11, 1972) was an American physician and scientist whose discoveries, mostly together with Rosalyn Yalow, caused major advances in clinical biochemistry.Rall JE. ''Solomon A. Berson''. In "Biographical ...
. After Renold's move to Geneva, a large focus of his research was on the synthesis and secretion of insulin by pancreatic
beta cells Beta cells (β-cells) are a type of cell found in pancreatic islets that synthesize and secrete insulin and amylin. Beta cells make up 50–70% of the cells in human islets. In patients with Type 1 diabetes, beta-cell mass and function are dimini ...
. Over his career, he authored over 400 scientific publications. Renold was involved in the establishment of the
European Association for the Study of Diabetes The European Association for the Study of Diabetes (EASD) is a scientific association founded in Montecatini Terme, Italy in 1965 with Joseph Hoet as Founding President. The aims of the association are to encourage and support research in the fiel ...
(EASD) and the
European Society for Clinical Investigation The European Society for Clinical Investigation (ESCI) was founded on February 12, 1967 as a pan-European society of clinicians and scientists with a genuine interest in uncovering disease mechanisms. The term ''clinical investigation'' is interpret ...
(ESCI). He served as president of EASD and the
International Diabetes Federation The International Diabetes Federation (IDF) is an umbrella organization of over 230 national diabetes associations in more than 160 countries and territories. The Federation has been leading the global diabetes community since 1950. It is headqua ...
. He received the
Otto-Naegeli-Preis The Otto-Naegeli-Preis is a Swiss award for medical research that is awarded every two years. It is one of the most prestigious Swiss medical awards and is given with an award sum of 200,000 Swiss Francs. It was established in 1960 and is named a ...
in 1967 and the
Banting Medal The Banting Medal, officially the Banting Medal for Scientific Achievement, is an annual award conferred by the American Diabetes Association (ADA), which is the highest award of ADA. Inaugurated in 1941, the prize is given in memory of Sir Frederic ...
in 1974. In 1986, he was awarded the King Faisal International Prize in Medicine together with Lelio Orci and
Gian Franco Bottazzo Gian Franco Bottazzo (1 August 1946 – 15 September 2017) was an Italian physician who spent most of his career in London. He was a prominent researcher in the field of diabetes and autoimmunity, and demonstrated that type 1 diabetes is associat ...
for contributions to the understanding of diabetes.


Death

In his later life, Renold suffered from a recurrent neurological disease. He died unexpectedly on March 21, 1988, in a hotel in Zurich; he was traveling back to Geneva after visiting his children in Chicago.


References

{{DEFAULTSORT:Renold, Albert 1923 births 1988 deaths Swiss diabetologists Swiss biochemists Academic staff of the University of Geneva University of Zurich alumni