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Albert Renold
Albert Ernst Renold (July 10, 1923 – March 21, 1988) was a Swiss physician and clinical biochemist noted for his extensive research on diabetes. In 1986 he was awarded the King Faisal International Prize in Medicine for contributions to the understanding of diabetes. Early life Renold was born on July 10, 1923, in Karlsruhe, Germany, to a Swiss physician father and a German mother. He was also a descendant of the 19th-century German painter Georg Friedrich Kersting. He was raised in Switzerland, attending school in Montreaux and Lausanne before completing his medical studies at the University of Zurich from 1941 to 1947. He completed his MD with a thesis on diabetes caused by alloxan. Career After graduating from the University of Zurich, Renold was awarded a scholarship from the American-Swiss Foundation for Scientific Exchange, allowing him to move to Boston in 1948 as a research fellow at New England Deaconess Hospital, Peter Bent Brigham Hospital, and Harvard Medical Scho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brackets
A bracket is either of two tall fore- or back-facing punctuation marks commonly used to isolate a segment of text or data from its surroundings. Typically deployed in symmetric pairs, an individual bracket may be identified as a 'left' or 'right' bracket or, alternatively, an "opening bracket" or "closing bracket", respectively, depending on the Writing system#Directionality, directionality of the context. Specific forms of the mark include parentheses (also called "rounded brackets"), square brackets, curly brackets (also called 'braces'), and angle brackets (also called 'chevrons'), as well as various less common pairs of symbols. As well as signifying the overall class of punctuation, the word "bracket" is commonly used to refer to a specific form of bracket, which varies from region to region. In most English-speaking countries, an unqualified word "bracket" refers to the parenthesis (round bracket); in the United States, the square bracket. Glossary of mathematical sym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New England Deaconess Hospital
Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital (founded in 1916) and New England Deaconess Hospital (founded in 1896). Among independent teaching hospitals, Beth Israel Deaconess Medical Center consistently ranks in the top three recipients of biomedical research funding from the National Institutes of Health. Research funding totals nearly $200 million annually. BIDMC researchers run more than 850 active sponsored projects and 200 clinical trials. The Harvard-Thorndike General Clinical Research Center, the oldest clinical research laboratory in the United States, has been located on this site since 1973. Overview BIDMC is one of the largest hospitals in New England, is affiliated with Joslin Diabetes Center and is a research partner of Dana-Farber/Harvard Cancer Center, the largest cancer institution in the country. The hospital is part of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta Cells
Beta cells (β-cells) are a type of cell found in pancreatic islets that synthesize and secrete insulin and amylin. Beta cells make up 50–70% of the cells in human islets. In patients with Type 1 diabetes, beta-cell mass and function are diminished, leading to insufficient insulin secretion and hyperglycemia. Function The primary function of a beta cell is to produce and release insulin and amylin. Both are hormones which reduce blood glucose levels by different mechanisms. Beta cells can respond quickly to spikes in blood glucose concentrations by secreting some of their stored insulin and amylin while simultaneously producing more. Primary cilia on beta cells regulate their function and energy metabolism. Cilia deletion can lead to islet dysfunction and type 2 diabetes. Insulin synthesis Beta cells are the only site of insulin synthesis in mammals. As glucose stimulates insulin secretion, it simultaneously increases proinsulin biosynthesis, mainly through translational cont ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solomon Berson
Solomon Aaron Berson (April 22, 1918 – April 11, 1972) was an American physician and scientist whose discoveries, mostly together with Rosalyn Yalow, caused major advances in clinical biochemistry.Rall JE. ''Solomon A. Berson''. In "Biographical Memoirs". National Academy of Sciences 1990;59:54-71. Fulltext Five years after Berson's death, Yalow received a Nobel Prize, which cannot be awarded posthumously, for their joint work on the radioimmunoassay. Biography Early life Born in New York City, Berson was a keen musician and chess player. He graduated from the City College of New York in 1938. After failing to obtain a place in medical school he earned an MSc (1939) and an anatomy instructorship at New York University before finally securing a place in NYU medical school in 1941. He completed his degree (Alpha Omega Alpha) in 1945, and after internships in Boston and two years in the army he returned to New York to do an internal medicine residency at the Bronx Veterans Adm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosalyn Sussman Yalow
Rosalyn Sussman Yalow (July 19, 1921 – May 30, 2011) was an American medical physicist, and a co-winner of the 1977 Nobel Prize in Physiology or Medicine (together with Roger Guillemin and Andrew Schally) for development of the radioimmunoassay technique. She was the second woman (after Gerty Cori), and the first American-born woman, to be awarded the Nobel Prize in Physiology or Medicine. Biography Childhood Rosalyn Sussman Yalow was born in the Bronx, New York, the daughter of Clara (née Zipper) and Simon Sussman, and was raised in a Jewish household. She went to Walton High School (Bronx), New York City. After high school, she attended the all-female, tuition-free Hunter College, where her mother hoped she would learn to become a teacher. Instead, Yalow decided to study physics. College Yalow knew how to type, and was able to get a part-time position as a secretary to Dr. Rudolf Schoenheimer, a leading biochemist at Columbia University's College of Physicians and Surgeons. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radioimmunoassay
A radioimmunoassay (RIA) is an immunoassay that uses radiolabeled molecules in a stepwise formation of immune complexes. A RIA is a very sensitive in vitro assay technique used to measure concentrations of substances, usually measuring antigen concentrations (for example, hormone levels in blood) by use of antibodies. Although the RIA technique is extremely sensitive and extremely specific, requiring specialized equipment, it remains among the least expensive methods to perform such measurements. It requires special precautions and licensing, since radioactive substances are used. In contrast, an immunoradiometric assay (IRMA) is an immunoassay that uses radiolabeled molecules but in an immediate rather than stepwise way. A radioallergosorbent test (RAST) is an example of radioimmunoassay. It is used to detect the causative allergen for an allergy. Method Classically, to perform a radioimmunoassay, a known quantity of an antigen is made radioactive, frequently by labeling it wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adipose Tissue
Adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages. Adipose tissue is derived from preadipocytes. Its main role is to store energy in the form of lipids, although it also cushions and insulates the body. Far from being hormonally inert, adipose tissue has, in recent years, been recognized as a major endocrine organ, as it produces hormones such as leptin, estrogen, resistin, and cytokines (especially TNFα). In obesity, adipose tissue is also implicated in the chronic release of pro-inflammatory markers known as adipokines, which are responsible for the development of metabolic syndrome, a constellation of diseases including, but not limited to, type 2 diabetes, cardiovascular disease and atherosclerosis. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George F
George may refer to: People * George (given name) * George (surname) * George (singer), American-Canadian singer George Nozuka, known by the mononym George * George Washington, First President of the United States * George W. Bush, 43rd President of the United States * George H. W. Bush, 41st President of the United States * George V, King of Great Britain, Ireland, the British Dominions and Emperor of India from 1910-1936 * George VI, King of Great Britain, Ireland, the British Dominions and Emperor of India from 1936-1952 * Prince George of Wales * George Papagheorghe also known as Jorge / GEØRGE * George, stage name of Giorgio Moroder * George Harrison, an English musician and singer-songwriter Places South Africa * George, Western Cape ** George Airport United States * George, Iowa * George, Missouri * George, Washington * George County, Mississippi * George Air Force Base, a former U.S. Air Force base located in California Characters * George (Peppa Pig), a 2-year-old pig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George W
George Walker Bush (born July 6, 1946) is an American politician who served as the 43rd president of the United States from 2001 to 2009. A member of the Republican Party, Bush family, and son of the 41st president George H. W. Bush, he previously served as the 46th governor of Texas from 1995 to 2000. While in his twenties, Bush flew warplanes in the Texas Air National Guard. After graduating from Harvard Business School in 1975, he worked in the oil industry. In 1978, Bush unsuccessfully ran for the House of Representatives. He later co-owned the Texas Rangers of Major League Baseball before he was elected governor of Texas in 1994. As governor, Bush successfully sponsored legislation for tort reform, increased education funding, set higher standards for schools, and reformed the criminal justice system. He also helped make Texas the leading producer of wind powered electricity in the nation. In the 2000 presidential election, Bush defeated Democratic incum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Baird Hastings
Albert Baird Hastings (November 20, 1895 – September 24, 1987) was an American biochemist and physiologist. He spent 28 years as the department chair and Hamilton Kuhn Professor of Biological Chemistry at Harvard University. After retiring from Harvard, Hastings moved to the Scripps Clinic and Research Foundation (now the Scripps Research Institute), where he became the director of the division of biochemistry and helped to establish the institution's emerging program in basic research. In 1966, he became one of the first faculty members at the University of California, San Diego's new medical school. His research focused on the biochemical underpinnings of physiology and included characterizing acid-base homeostasis in blood and pioneering the use of radioactive tracers for studying metabolism. Hastings received a number of honors and awards for his work, including election to the National Academy of Sciences in 1937 and the President's Medal for Merit in 1948 following his ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Marble
Alexander Marble (February 2, 1902 – September 13, 1992) was an American diabetologist who spent the majority of his career at the Joslin Diabetes Center. Life and career Marble was born in 1902 in Troy, Kansas. He attended the University of Kansas, completing a BA in chemistry in 1922 and an MA in bacteriology and immunology in 1924. He graduated from Harvard Medical School in 1927. After graduating from Harvard, Marble interned at Johns Hopkins Hospital then returned to Boston to complete a residency at Massachusetts General Hospital. He was awarded a traveling fellowship in the early 1930s to study in Austria, Germany and England, including at the laboratory of Henry Hallett Dale. His research subjects at this time included pentosuria, glycosuria, xylose metabolism, and vitamin D. Upon his return to the United States in 1932, he was recruited by Elliott P. Joslin to join his diabetes clinic in Boston, where Marble was given his own laboratory and was appointed Director of Rese ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
