Acacetin is a 4′- ''O''-methylated flavone of the parent compound

apigenin Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool. S ...

, found in ''

Robinia pseudoacacia ''Robinia pseudoacacia'', commonly known in its native territory as black locust, is a medium-sized hardwood deciduous tree, belonging to the tribe Robinieae of the legume family Fabaceae. It is endemic to a few small areas of the United States, ...

'' (black locust), ''

Turnera diffusa ''Turnera diffusa'', known as damiana, is a shrub native to southern Texas in the United States, Central America, Mexico, South America, and the Caribbean. It belongs to the family Passifloraceae. Damiana is a relatively small, woody shrub tha ...

'' (damiana), shows moderate aromatase inhibition, ''

Betula pendula ''Betula pendula'', commonly known as silver birch, warty birch, European white birch, or East Asian white birch, is a species of tree in the family Betulaceae, native to Europe and parts of Asia, though in southern Europe, it is only found a ...

'' (silver birch), and in the fern ''

Asplenium normale ''Asplenium'' is a genus of about 700 species of ferns, often treated as the only genus in the family Aspleniaceae, though other authors consider '' Hymenasplenium'' separate, based on molecular phylogenetic analysis of DNA sequences, a different ...

''. In plant synthesis the enzyme apigenin 4′-''O''-methyltransferase uses ''S''-adenosyl methionine and 5,7,4′-trihydroxyflavone (apigenin) to produce ''S''-adenosylhomocysteine and 4′-methoxy-5,7-dihydroxyflavone (acacetin).

References

Aromatase inhibitors O-methylated flavones {{aromatic-stub

See also

References