A10A Insulins and analogues

A10AB
Insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
s and analogues for injection, fast-acting

:A10AB01 Insulin (human) :A10AB02 Insulin (beef) :A10AB03 Insulin (pork) :A10AB04

Insulin lispro Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. It is used by injection under the skin or within an insulin pump. Onset of effects typically occu ...

:A10AB05

Insulin aspart Insulin aspart, sold under the brand name NovoLog and Fiasp, among others, is a insulin analog, modified type of Insulin (medication), medical insulin used to treat type I diabetes, type 1 and type 2 diabetes. It is generally used by injection ...

:A10AB06

Insulin glulisine Insulin glulisine is a rapid-acting modified form of medical insulin that differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. It was devel ...

:A10AB30 Combinations

A10AC Insulins and analogues for injection, intermediate-acting

:A10AC01 Insulin (human) :A10AC02 Insulin (beef) :A10AC03 Insulin (pork) :A10AC04 Insulin lispro :A10AC30 Combinations

A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting

:A10AD01 Insulin (human) :A10AD02 Insulin (beef) :A10AD03 Insulin (pork) :A10AD04

:A10AD05

:A10AD06 Insulin degludec and insulin aspart :A10AD30 Combinations

A10AE Insulins and analogues for injection, long-acting

:A10AE01 Insulin (human) :A10AE02 Insulin (beef) :A10AE03 Insulin (pork) :A10AE04

Insulin glargine Insulin glargine, sold under the brand name Lantus among others, is a long-acting modified form of medical insulin, used in the management of type I and type II diabetes. It is typically the recommended long acting insulin in the United King ...

:A10AE05

Insulin detemir Insulin detemir, sold under the brand name Levemir among others, is a long-acting modified form of medical insulin used to treat both type 1 and type 2 diabetes. It is used by injection under the skin. It is effective for up to 24 hours. C ...

:A10AE06

Insulin degludec Insulin degludec ( INN/USAN) is an ultralong-acting basal insulin analogue that was developed by Novo Nordisk under the brand name Tresiba. It is administered via subcutaneous injection once daily to help control the blood sugar level of those ...

:A10AE30 Combinations :A10AE54 Insulin glargine and lixisenatide :A10AE56 Insulin degludec and liraglutide

A10AF Insulins and analogues for inhalation

:A10AF01 Insulin (human)

A10B
Blood glucose Glycaemia, also known as blood sugar level, blood sugar concentration, or blood glucose level is the measure of glucose concentrated in the blood of humans or other animals. Approximately 4 grams of glucose, a simple sugar, is present in the blo ...
lowering drugs, excluding insulins

A10BA
Biguanide Biguanide () is the organic compound with the formula HN(C(NH)NH2)2. It is a colorless solid that dissolves in water to give highly basic solution. These solutions slowly hydrolyse to ammonia and urea. Synthesis Biguanide can be obtained from ...
s

:A10BA01

Phenformin Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was develo ...

:A10BA02

Metformin Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. ...

:A10BA03

Buformin Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin. Chemistry and animal toxicology Bufor ...

A10BB
Sulfonylurea Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture, for example as antidiabetic drugs widely used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta ...
s

:A10BB01

Glibenclamide Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. It is recommended that it be taken together with diet and exercise. It may be used with other antidiabetic medication. It is not recommended f ...

:A10BB02

Chlorpropamide Chlorpropamide is a drug in the sulfonylurea class used to treat diabetes mellitus type 2. It is a long-acting first-generation sulfonylurea. Mechanism of action Like other sulfonylureas, chlorpropamide acts to increase the secretion of insulin, ...

:A10BB03

Tolbutamide Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by ...

:A10BB04

Glibornuride Glibornuride (INN) is an anti-diabetic drug from the group of sulfonylureas. It is manufactured by MEDA Pharma and sold in Switzerland under the brand name Glutril. Synthesis Gliburnide is an endo-endo derivative made from camphor-3-carboxami ...

:A10BB05

Tolazamide Tolazamide is an Wiktionary:oral, oral blood glucose lowering medication, drug used for people with Type 2 diabetes. It is part of the sulfonylurea (medicine), sulfonylurea family (ATC A10BB). Synthesis para-toluenesulfonamide, ''para''-Toluene ...

:A10BB06

Carbutamide Carbutamide (brand name Glucidoral) is an anti-diabetic drug of the sulfonylurea class, developed by Servier. It is classified as first-generation. It was patented in 1953 and approved for medical use in 1956. See also * Hellmuth Kleinsorge ...

:A10BB07

Glipizide Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. It is used together with a diabetic diet and exercise. It is not indicated for use by itself in ...

:A10BB08

Gliquidone Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the p ...

:A10BB09

Gliclazide Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth. ...

:A10BB10

Metahexamide Metahexamide ( INN) is an anti-diabetic drug from the group of sulfonylurea Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture, for example as antidiabetic drugs widely used in the management of ...

:A10BB11

Glisoxepide Glisoxepide (INN) is an orally available anti-diabetic drug from the group of sulfonylurea Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture, for example as antidiabetic drugs widely used in th ...

:A10BB12

Glimepiride Glimepiride, is an anti-diabetic medication used to treat type 2 diabetes. It is less preferred than metformin. Use is recommended together with diet and exercise. It is taken by mouth. Glimepiride takes up to three hours for maximum effect and l ...

:A10BB31

Acetohexamide Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone. Mechanism of action Acetohexamide bind to an AT ...

A10BC Sulfonamides (heterocyclic)

:A10BC01 Glymidine

A10BD Combinations of oral blood glucose lowering drugs

:A10BD01

and

sulfonylurea Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture, for example as antidiabetic drugs widely used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta ...

s :A10BD02

and sulfonylureas :A10BD03 Metformin and rosiglitazone :A10BD04

and

rosiglitazone Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutica ...

:A10BD05 Metformin and pioglitazone :A10BD06 Glimepiride and pioglitazone :A10BD07 Metformin and sitagliptin :A10BD08 Metformin and vildagliptin :A10BD09 Pioglitazone and alogliptin :A10BD10 Metformin and saxagliptin :A10BD11 Metformin and linagliptin :A10BD12

Pioglitazone Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. It may be used with metformin, a sulfonylurea, or insulin. Use is recommended together with exercise and diet. It is not re ...

and

sitagliptin Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. It is taken by mouth. It is also a ...

:A10BD13 Metformin and alogliptin :A10BD14 Metformin and

repaglinide Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus. The mech ...

:A10BD15 Metformin and dapagliflozin :A10BD16 Metformin and canagliflozin :A10BD17 Metformin and

acarbose Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Cana ...

:A10BD18 Metformin and

gemigliptin Gemigliptin ( rINN), sold under the brand name Zemiglo, is an oral anti-hyperglycemic agent ( anti-diabetic drug) of the dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) class of drugs. Glucose lowering effects of DPP-4 inhibitors are mainly m ...

:A10BD19 Linagliptin and empagliflozin :A10BD20 Metformin and empagliflozin :A10BD21 Saxagliptin and dapagliflozin :A10BD22 Metformin and evogliptin :A10BD23 Metformin and ertugliflozin :A10BD24 Sitagliptin and ertugliflozin :A10BD25 Metformin, saxagliptin and dapagliflozin :A10BD26 Metformin and

lobeglitazone Lobeglitazone (trade name Duvie, Chong Kun Dang) is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and ma ...

:A10BD27 Metformin, linagliptin and empagliflozin

A10BF Alpha
glucosidase Glucosidases are the glycoside hydrolase enzymes categorized under the EC number 3.2.1. Function Alpha-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen into their monomers. They catalyze t ...
inhibitors

:A10BF01

Acarbose Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Cana ...

:A10BF02

Miglitol Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to break down complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing ...

:A10BF03

Voglibose Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose there ...

A10BG
Thiazolidinedione The thiazolidinediones , abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring. The term usually refers to a family of drugs used in ...
s

:A10BG01

Troglitazone Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. It was patented in 1983 and approved for medical use in 1997. It ...

:A10BG02

Rosiglitazone Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutica ...

:A10BG03

:A10BG04

Lobeglitazone Lobeglitazone (trade name Duvie, Chong Kun Dang) is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and ma ...

A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors

:A10BH01

Sitagliptin Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea. It is taken by mouth. It is also a ...

:A10BH02

Vildagliptin Vildagliptin, sold under the brand name Galvus and others, is an oral anti-hyperglycemic agent (anti-diabetic drug) of the DPP-4 inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of Glucag ...

:A10BH03

Saxagliptin Saxagliptin, sold under the brand name Onglyza, is an oral hypoglycemic ( anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Early development was solely by Bristol-Myers Squibb; in 2007 AstraZeneca joined with Bristol-My ...

:A10BH04

Alogliptin Alogliptin, sold under the brand names Nesina and Vipidia,) is an oral anti-diabetic drug in the DPP-4 inhibitor (gliptin) class. Alogliptin does not decrease the risk of heart attack and stroke. Like other members of the gliptin class, it caus ...

:A10BH05

Linagliptin Linagliptin, sold under the brand name Tradjenta among others, is a medication used to treat type 2 diabetes (but not type 1) in conjunction with exercise and diet. It is generally less preferred than metformin and sulfonylureas as an initial tr ...

:A10BH06

Gemigliptin Gemigliptin ( rINN), sold under the brand name Zemiglo, is an oral anti-hyperglycemic agent ( anti-diabetic drug) of the dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) class of drugs. Glucose lowering effects of DPP-4 inhibitors are mainly m ...

:A10BH07 Evogliptin :A10BH08

Teneligliptin Teneligliptin (INN; trade name Tenelia) is a pharmaceutical drug for the treatment of type 2 diabetes mellitus. It belongs to the class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins". Creation It was created by M ...

:A10BH51 Sitagliptin and simvastatin :A10BH52 Gemigliptin and

rosuvastatin Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used together with dietary changes, exercise, ...

A10BJ Glucagon-like peptide-1 (GLP-1) analogues

:A10BJ01

Exenatide Exenatide, sold under the brand name Byetta and Bydureon among others, is a medication used to treat diabetes mellitus type 2. It is used together with diet, exercise, and potentially other antidiabetic medication. It is a treatment option after ...

:A10BJ02

Liraglutide Liraglutide, sold under the brand name Victoza among others, is an anti-diabetic medication used to treat type 2 diabetes, obesity, and chronic weight management. In diabetes it is a less preferred agent compared to metformin. Its effects on lo ...

:A10BJ03

Lixisenatide Lixisenatide (trade name Lyxumia in the European Union and Adlyxin in the U.S. and manufactured by Sanofi) is a once-daily injectable GLP-1 receptor agonist for the treatment of type 2 diabetes. Medical use Lixisenatide is used as adjunct to di ...

:A10BJ04

Albiglutide Albiglutide (trade names Eperzan in Europe and Tanzeum in the US) is a glucagon-like peptide-1 agonist (GLP-1 agonist) drug marketed by GlaxoSmithKline (GSK) for treatment of type 2 diabetes. As of 2017 it is unclear if it affects a person's risk ...

:A10BJ05

Dulaglutide Dulaglutide, sold under the brand name Trulicity among others, is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. It is also approved in the United States for the reduction of major adverse cardiova ...

:A10BJ06

Semaglutide Semaglutide, sold under the brand names Ozempic, Wegovy and Rybelsus, is an antidiabetic medication used for the treatment of type 2 diabetes and as anti-obesity medication for long-term weight management, developed by Novo Nordisk in 2012. ...

:A10BJ07 Beinaglutide

A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors

:A10BK01

Dapagliflozin Dapagliflozin, sold under the brand names Farxiga (US) and Forxiga (EU) among others, is a medication used to treat type 2 diabetes. It is also used to treat adults with heart failure and chronic kidney disease. Common side effects include hy ...

:A10BK02

Canagliflozin Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with ex ...

:A10BK03

Empagliflozin Empagliflozin, sold under the brand name Jardiance among others, is an antidiabetic medication used to improve glucose control in people with type2 diabetes, to reduce the risk of cardiovascular death in adults with type2 diabetes and establis ...

:A10BK04 Ertugliflozin :A10BK05 Ipragliflozin :A10BK06 Sotagliflozin :A10BK07

Luseogliflozin Luseogliflozin (trade name Lusefi) is a pharmaceutical drug (an SGLT2 inhibitor) used for the treatment of type 2 diabetes mellitus. It was approved for use in Japan in 2014. In a meta-analysis involving data from 10 randomized controlled trials ...

:QA10BK90 Velagliflozin

A10BX Other
blood glucose Glycaemia, also known as blood sugar level, blood sugar concentration, or blood glucose level is the measure of glucose concentrated in the blood of humans or other animals. Approximately 4 grams of glucose, a simple sugar, is present in the blo ...
lowering drugs, excluding
insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
s

:A10BX01

Guar gum Guar gum, also called guaran, is a galactomannan polysaccharide extracted from guar beans that has thickening and stabilizing properties useful in food, feed, and industrial applications. The guar seeds are mechanically dehusked, hydrated, mil ...

:A10BX02

Repaglinide Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus. The mech ...

:A10BX03

Nateglinide Nateglinide (INN, trade name Starlix) is a drug for the treatment of type 2 diabetes. Nateglinide was developed by Ajinomoto, a Japanese company and sold by the Swiss pharmaceutical company Novartis. Nateglinide belongs to the meglitinide class ...

:A10BX05

Pramlintide Pramlintide (trade name Symlin) is an injectable amylin analogue drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary of AstraZeneca). Pramlintide is sold as an acetate salt. Pharmacology Pram ...

:A10BX06

Benfluorex Benfluorex, sold under the brand name Mediator, is an anorectic and hypolipidemic agent that is structurally related to fenfluramine (a substituted amphetamine). It may improve glycemic control and decrease insulin resistance in people with poorly ...

:A10BX08

Mitiglinide Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes. Mitiglinide belongs to the meglitinide (glinide) class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North Ame ...

:A10BX15 Imeglimin :A10BX16

Tirzepatide Tirzepatide, sold under the brand name Mounjaro, is an antidiabetic medication used for the treatment of type 2 diabetes. Tirzepatide is given by weekly subcutaneous injection (under the skin). The most common side effects include nausea, vom ...

:A10BX17 Carfloglitazar :A10BX18 Dorzagliatin

A10X Other drugs used in
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

A10XA
Aldose reductase In enzymology, aldose reductase (or aldehyde reductase) () is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the re ...
inhibitors

:A10XA01 Tolrestat

References

{{Oral hypoglycemics and insulin analogs A10