5-Aza-7-deazapurine or imidazo
,2-''a''
The comma is a punctuation mark that appears in several variants in different languages. It has the same shape as an apostrophe or single closing quotation mark () in many typefaces, but it differs from them in being placed on the baseline o ...
1,3,5]triazine
is a
heterocyclic compound, heterocyclic aromatic organic compound that consists of a
s-triazine ring fused to an
imidazole ring. It is an
isostere and isomer of
purine. However, in 5-aza-7-deazapurine, N-9 of five-membered ring does not bond with hydrogen. So 5-aza-7-deazapurine derivatives must have an exocyclic substituent with a double bond to bind a sugar residue.
5-Aza-7-deazapurine nucleosides may have an oxo, thioxo, or a imine group.
Notable derivatives of this molecule include
5-aza-7-deazaguanine
5-Aza-7-deazaguanine or 2-aminoimidazo ,2-a1,3,5]triazin-4(1H)-one is a 5-Aza-7-deazapurine base that is an isomer of guanine. It is used as a nucleobase of hachimoji DNA, in which it pairs with 6-Amino-5-nitropyridin-2-one
6-Amino-5-nitropyri ...
,
which is a
nucleobase of
hachimoji DNA.
See also
*
Base analog
Nucleic acid analogues are compounds which are Analog (chemistry), analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.
Nucleic acids are chains of nucleotides, which are compos ...
*
Indolizine
*
Purine analogue
Purine analogues are antimetabolites that mimic the structure of metabolic purines.
Examples
* Nucleobase analogues
** Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemias.
***Azathioprin ...
References
{{DEFAULTSORT:Aza-7-deazapurine, 5-
Simple aromatic rings
Nitrogen heterocycles
Heterocyclic compounds with 2 rings