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α-PHP
α-Pyrrolidinohexiophenone (α-PHP, A-PHP, Aphp, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s which has been reported as a novel designer drug. Similar chemical compounds α-Pyrrolidinohexiophenone is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain. Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann) of the National Institute on Drug Abuse stated: "alpha-PHP might be even more potent than alpha-PVP"; this statement is based on laboratory tests of chemical reactivity. Pyrovalerone is a structural isomer of alpha-PHP. Legality In the United States, α-PHP in the past has been assigned to Schedule I on a Temporary Placement basis, although the order has expired without renewal or permanent placement and is no longer Scheduled at the Federal level as of July 2021. Despite this however, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
α-Pyrrolidinoheptaphenone
α-Pyrrolidinoheptaphenone (PV8, α-PEP, α-PHPP, Aphpp, A-PHPP) is a designer drug of the pyrrolidinophenone class of cathinones. It is the higher homolog of α-pyrrolidinohexiophenone (α-PHP). In the United States, α-pyrrolidinoheptaphenone is a Schedule I Controlled Substance. See also * α-PHP * α-PHiP * α-PCyP * 4F-PV9 * MDPV * N-Ethylheptedrone ''N''-Ethylheptedrone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethcathinone, ''N''-ethylbuphedrone and ''N''-ethylhexedrone but with a longer pen ... References {{DEFAULTSORT:Pyrrolidinoheptaphenone, α- Pyrrolidinophenones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
α-PHiP
α-PHiP (also known as α-PiHP), is a stimulant drug of the cathinone class that has been sold online as a designer drug. It is a positional isomer of pyrovalerone, with the methyl group shifted from the 4-position of the aromatic ring to the 4-position of the acyl chain. In a classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et al. at Organix, the alpha-isobutyl derivative of pyrovalerone, O-2494, was found to have the highest potency ''in vitro'' as an inhibitor of the dopamine transporter of the alpha substituted derivatives tested, however it was not until ten years later in July 2016 that α-PHiP was first identified as a designer drug, when it was reported to the EMCDDA by a forensic laboratory in Slovenia. See also * 3F-PiHP * Aletamine * α-PHP * α-PCYP * Solriamfetol Solriamfetol, sold under the brand name Sunosi, is a wakefulness-promoting medication used in the treatment of excessive sleepiness related to narcolepsy and sleep apnea. It is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4F-PHP
4-Fluoro-alpha-PHP (4F-PHP) is a recreational designer drug from the substituted cathinone family with stimulant effects, which first appeared on the illicit market in around 2017. See also * α-PHP * 3F-PVP * 3F-NEH * 3F-PiHP * 4F-PVP * 4Cl-PVP * 4F-POP * MFPVP * MDPHP * N-Ethylhexedrone * N-Ethylhexylone ''N''-Ethylhexylone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Poland in August 2019. It is illegal in Taiwan since July 2020, where it had been sold mixed with plant ... References Pyrrolidinophenones Designer drugs Fluoroarenes {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4'-Methyl-α-pyrrolidinohexiophenone
4'-Methyl-α-pyrrolidinohexiophenone (MPHP) is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-lengthened homologue. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant, while the alkyl backbone can be varied anywhere between three and as many as seven carbons, with highest potency usually seen with the pentyl or isohexyl backbone, and a variety of substituents are tolerated on the aromatic ring. In 2010 a group of researchers from the Institute of Forensic Medicine, University Hospital Jena, Germany concluded that MPHP can lead to serious poisoning with toxic liver damage and rhabdomyolysis. Legality In the United States, MPHP is a Schedule I Controlled Substance. Sweden's public health agency suggested to classify MPHP as narcotic on June 1, 2015. See also * α-PBP * α-PHP * α-PPP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-Pyrrolidinobutiophenone
α-Pyrrolidinobutiophenone (α-PBP) is a stimulant compound developed in the 1960s which has been reported as a novel designer drug. It can be thought of as the homologue lying between the two better known drugs α-PPP and α-PVP. Legality In the United States, it is a Schedule I controlled substance. Sweden's public health agency suggested to classify α-PBP as hazardous substance on November 10, 2014. As of October 2015 α-PBP is a controlled substance in China. See also * α-Pyrrolidinopropiophenone (α-PPP) * α-Pyrrolidinopentiophenone (α-PVP) * α-Pyrrolidinopentiothiophenone (α-PVT) * α-Pyrrolidinohexiophenone (α-PHP) * 4'-Methyl-α-pyrrolidinobutiophenone (MPBP) * 3',4'-Methylenedioxy-α-pyrrolidinobutiophenone 3',4'-Methylenedioxy-α-pyrrolidinobutyrophenone (MDPBP) is a stimulant of the cathinone class developed in the 1960s, which has been reported as a novel designer drug. MDPBP is sometimes sold under the name "NRG-1" as a mixture with other cathi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-Pyrrolidinopentiophenone
α-Pyrrolidinopentiophenone (also known as α-pyrrolidinovalerophenone, α-PVP, O-2387, β-keto-prolintane, prolintanone, or desmethylpyrovalerone) is a synthetic stimulant of the cathinone class developed in the 1960s that has been sold as a designer drug. Colloquially, it is sometimes called flakka. α-PVP is chemically related to pyrovalerone and is the ketone analog of prolintane. Adverse effects α-PVP, like other psychostimulants, can cause hyperstimulation, paranoia, and hallucinations. α-PVP has been reported to be the cause, or a significant contributory cause of death in suicides and overdoses caused by combinations of drugs. α-PVP has also been linked to at least one death with pulmonary edema and moderately advanced atherosclerotic coronary disease when it was combined with pentedrone. According to Craig Crespi in the journal '' Case Reports in Psychiatry'', "symptoms are known to easily escalate into frightening delusions, paranoid psychosis, extreme agitation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrovalerone
(Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes. It was developed in the late 1960s and has since been used in France and several other European countries, and although pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. It is closely related on a structural level to a number of other stimulants, such as α-PVP, MDPV and prolintane (Promotil, Katovit). Side effects of pyrovalerone include anorexia or loss of appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors. Withdrawal following abuse upon discontinuation often results in depression. The ''R''-enantiomer of pyrovalerone is devoid of activity. See also * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrovalerone
(Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes. It was developed in the late 1960s and has since been used in France and several other European countries, and although pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. It is closely related on a structural level to a number of other stimulants, such as α-PVP, MDPV and prolintane (Promotil, Katovit). Side effects of pyrovalerone include anorexia or loss of appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors. Withdrawal following abuse upon discontinuation often results in depression. The ''R''-enantiomer of pyrovalerone is devoid of activity. See also * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDPHP
MDPHP (3',4'-Methylenedioxy-α-pyrrolidinohexiophenone) is a stimulant of the cathinone class originally developed in the 1960s, which has been reported as a novel designer drug. In the UK its slang name is ''monkey dust''. It is closely related to the potent stimulant MDPV though with slightly milder effects, and has been used as an alternative in some countries following the banning of MDPV. Legal Status MDPHP is specifically listed as a controlled substance in Japan and Hungary, and is controlled under analogue provisions in a number of other jurisdictions. See also * α-Pyrrolidinohexiophenone (α-PHP) * 3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) * N-Ethylhexedrone ''N''-Ethylhexedrone (also known as α-ethylaminocaprophenone, ''N''-ethylnorhexedrone, hexen, and NEH) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI) with IC50 values of 0.0978 and 0.0 ... * N-Ethylhexylone References D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Α-PCYP
α-PCyP is a stimulant drug of the cathinone class that has been sold online as a designer drug. In a series of alpha-substituted pyrrolidinyl cathinone derivatives developed in 2015, the alpha-cyclopentyl derivative was found to have around the same potency ''in vitro'' as an inhibitor of the dopamine transporter as the alpha-propyl derivative α-PVP, while the alpha-cyclohexyl derivative α-PCyP was around twice as strong. See also * PCPy * Picilorex * α-PHP * α-PHiP * βk-Ephenidine * Diphenidine * Indapyrophenidone * UWA-101 * Zylofuramine Zylofuramine is a stimulant drug. It was developed in 1961, and was intended for use as an appetite suppressant and for the treatment of senile dementia in the elderly, but there is little information about it and it does not appear to have ever ... References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |