Trisporic Acid
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Trisporic Acid
Trisporic acids (TSAs) are C-18 terpenoid compounds synthesized via β-carotene and retinol pathways in the zygomycetes. They are pheromone compound responsible for sexual differentiation in those fungal species. TSAs and related compounds make up the trisporoid group of chemicals. History Trisporic acid was discovered in 1964 as a metabolite that caused enhanced carotene production in ''Blakeslea trispora''. It was later shown to be the hormone that brought about zygophore production in ''Mucor mucedo''. The American mycologist and geneticist Albert Francis Blakeslee Albert Francis Blakeslee (November 9, 1874 – November 16, 1954) was an American botanist. He is best known for his research on the poisonous jimsonweed plant and the sexuality of fungi. He was the brother of the Far East scholar George Hubbar ..., discovered that some species of ''Mucorales'' were self-sterile (heterothallic), in which interactions of two strains, designated (+) and (-), being necessary for the ...
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β-carotene
β-Carotene is an organic, strongly coloured red-orange pigment abundant in fungi, plants, and fruits. It is a member of the carotenes, which are terpenoids (isoprenoids), synthesized biochemically from eight isoprene units and thus having 40 carbons. Among the carotenes, β-carotene is distinguished by having beta-rings at both ends of the molecule. β-Carotene is biosynthesized from geranylgeranyl pyrophosphate. In some Mucoralean fungi, β-Carotene is a precursor to the synthesis of trisporic acid. β-Carotene is the most common form of carotene in plants. When used as a food coloring, it has the E number E160a. The structure was deduced by Karrer et al. in 1930. In nature, β-carotene is a precursor (inactive form) to vitamin A via the action of beta-carotene 15,15'-monooxygenase. Isolation of β-carotene from fruits abundant in carotenoids is commonly done using column chromatography. It can also be extracted from the beta-carotene rich algae, ''Dunaliella salina''. T ...
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Retinol
Retinol, also called vitamin A1, is a fat-soluble vitamin in the vitamin A family found in food and used as a dietary supplement. As a supplement it is used to treat and prevent vitamin A deficiency, especially that which results in xerophthalmia. In regions where deficiency is common, a single large dose is recommended to those at high risk twice a year. It is also used to reduce the risk of complications in measles patients. It is taken by mouth or by injection into a muscle. Retinol at normal doses is well tolerated. High doses may cause enlargement of the liver, dry skin, and hypervitaminosis A. High doses during pregnancy may harm the fetus. The body converts retinol to retinal and retinoic acid, through which it acts. Dietary sources include fish, dairy products, and meat. Retinol was discovered in 1909, isolated in 1931, and first made in 1947. It is on the World Health Organization's List of Essential Medicines. Retinol is available as a generic medication and over ...
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Zygomycota
Zygomycota, or zygote fungi, is a former division or phylum of the kingdom Fungi. The members are now part of two phyla: the Mucoromycota and Zoopagomycota. Approximately 1060 species are known. They are mostly terrestrial in habitat, living in soil or on decaying plant or animal material. Some are parasites of plants, insects, and small animals, while others form symbiotic relationships with plants. Zygomycete hyphae may be coenocytic, forming septa only where gametes are formed or to wall off dead hyphae. Zygomycota is no longer recognised as it was not believed to be truly monophyletic. Etymology The name ''Zygomycota'' refers to the zygosporangia characteristically formed by the members of this clade, in which resistant spherical spores are formed during sexual reproduction. ''Zygos'' is Greek for "joining" or "a yoke", referring to the fusion of two hyphal strands which produces these spores, and ''-mycota'' is a suffix referring to a division of fungi. Spores The ter ...
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Blakeslea Trispora
''Blakeslea trispora'' is a mould and member of the division Zygomycota. This species has been well studied for its ability to produce carotenoids, particularly, β-carotene and lycopene. β-carotene is a vitamin A precursor and both of β-carotene and lycopene play a significant role in the inhibition of oxidative stress. ''Blakeslea trispora'' is commonly isolated from soil samples throughout the Southern United States and Southern Asia. ''B. trispora'' is a pathogen of tropical plants. In vivo pathogenicity testing using animal models suggests this fungus is not a cause of animal or human disease. History The genus ''Blakeslea'' was named in honor of American botanist Albert Francis Blakeslee based on ''B. trispora''. While A.F. Blakeslee was studying another fungus called Botrytis rileyi', he collaborated with Roland Thaxter to further study this fungus. In 1914, while Thaxter was doing further research on ''Botrytis rileyi,'' ''Blakeslea trispora'' was accidentally isolated ...
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Albert Francis Blakeslee
Albert Francis Blakeslee (November 9, 1874 – November 16, 1954) was an American botanist. He is best known for his research on the poisonous jimsonweed plant and the sexuality of fungi. He was the brother of the Far East scholar George Hubbard Blakeslee. Early life and education Albert Francis Blakeslee was born on November 9, 1874 in Geneseo, New York, to Augusta Miranda Hubbard Blakeslee and Francis Durbin Blakeslee, a Methodist minister. Blakeslee attended Wesleyan University, graduating in 1896. At Wesleyan, Blakeslee played several sports and won academic prizes in mathematics and chemistry. He received a master's degree from Harvard University in 1900 and a doctorate in 1904. He also studied at the University of Halle-Wittenberg in Germany from 1904 to 1906. ''Datura'', jimsonweed, research Blakeslee used the jimsonweed plant as a model organism for his genetic research. His experiments included using colchicine to achieve an increase in the number of chromosomes, whic ...
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Postulated Biosynthesis Of Trisporic Acid B (van Den Ende, 1976; Sutter Et Al
An axiom, postulate, or assumption is a statement that is taken to be true, to serve as a premise or starting point for further reasoning and arguments. The word comes from the Ancient Greek word (), meaning 'that which is thought worthy or fit' or 'that which commends itself as evident'. The term has subtle differences in definition when used in the context of different fields of study. As defined in classic philosophy, an axiom is a statement that is so evident or well-established, that it is accepted without controversy or question. As used in modern logic, an axiom is a premise or starting point for reasoning. As used in mathematics, the term ''axiom'' is used in two related but distinguishable senses: #Logical axioms, "logical axioms" and #Non-logical axioms, "non-logical axioms". Logical axioms are usually statements that are taken to be true within the system of logic they define and are often shown in symbolic form (e.g., (''A'' and ''B'') implies ''A''), while non-l ...
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Mycoparasitism
A mycoparasite is an organism with the ability to parasitize fungi. Mycoparasites might be biotrophic or necrotrophic, depending on the type of interaction with their host. Types of mycoparasitic organisms Myco-heterotrophy Various plants may be considered mycoparasites, in that they parasitize and acquire most of their nutrition from fungi during a part or all of their life cycle. These include many orchid seedlings, as well as some plants that lack chlorophyll such as ''Monotropa uniflora''. Mycoparasitic plants are more precisely described as myco-heterotrophs. Mycoparasitic bacteria Some bacteria live on or within fungal cells as parasites or symbionts. Mycoparasitic viruses Some viruses, called mycoviruses live on or within fungal cells as parasites or symbionts. Mycoparasitic fungi Many mycoparasites are fungi, though not all fungicolous fungi are parasites (some are commensals or saprobes.) Biotrophic mycoparasites acquire nutrients from living host cells. Necr ...
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Carotenoids
Carotenoids (), also called tetraterpenoids, are yellow, orange, and red organic pigments that are produced by plants and algae, as well as several bacteria, and fungi. Carotenoids give the characteristic color to pumpkins, carrots, parsnips, corn, tomatoes, canaries, flamingos, salmon, lobster, shrimp, and daffodils. Carotenoids can be produced from fats and other basic organic metabolic building blocks by all these organisms. It is also produced by endosymbiotic bacteria in whiteflies. Carotenoids from the diet are stored in the fatty tissues of animals, and exclusively carnivorous animals obtain the compounds from animal fat. In the human diet, absorption of carotenoids is improved when consumed with fat in a meal. Cooking carotenoid-containing vegetables in oil and shredding the vegetable both increase carotenoid bioavailability. There are over 1,100 known carotenoids which can be further categorized into two classes, xanthophylls (which contain oxygen) and carote ...
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