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Oligopeptide P11-4
Oligopeptide P11-4 is a synthetic, pH controlled self-assembling peptide used for biomimetic mineralization e.g. for enamel regeneration or as an oral care agent. P11-4 (INCI name Oligopeptide 104) consists of the natural occurring amino acids Glutamine, Glutamic acid, Phenylalanine, Tryptophan and Arginine. The resulting higher molecular structure has a high affinity to tooth mineral. P11-4 has been developed and patented by The University of Leeds (UK). The Swiss company Credentis has licensed the peptide technology and markets it under the trade names including CUROLOX, REGENAMEL, and EMOFLUOR. They offer three products with this technology. As of June 2016 in Switzerland products are available with new Brand names from Dr. Wild & Co AG. Mechanism of action P11-4 is an α-peptide that self-assembles into β-sheet amyloids with a hydrogel appearance at low pH. It builds a 3-D bio-matrix with binding sites for calcium ions serving as nucleation point for hydroxyapatite (toot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self-assembling Peptide
Self-assembling peptides are a category of peptides which undergo spontaneous assembling into ordered nanostructures. Originally described in 1993, these designer peptides have attracted interest in the field of nanotechnology for their potential for application in areas such as biomedical nanotechnology, tissue cell culturing, molecular electronics, and more. Effectively self-assembling peptides act as building blocks for a wide range of material and device applications. The essence of this technology is to replicate what nature does: to use molecular recognition processes to form ordered assemblies of building blocks that are capable of conducting biochemical activities. Background Peptides are able to perform as excellent building blocks for a wide range of materials as they can be designed to combine with a range of other building blocks such as lipids, sugars, nucleic acids, metallic nanocrystals and so on; this gives the peptides an edge over carbon nanotubes, which are ano ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid
Amyloids are aggregates of proteins characterised by a Fibril, fibrillar morphology of 7–13 Nanometer, nm in diameter, a beta sheet (β-sheet) Secondary structure of proteins, secondary structure (known as cross-β) and ability to be Staining, stained by particular dyes, such as Congo red. In the human body, amyloids have been linked to the development of various diseases. Pathogenic amyloids form when previously healthy proteins lose their normal Protein structure, structure and physiology, physiological functions (Protein misfolding, misfolding) and form fibrous deposits in amyloid plaques around cells which can disrupt the healthy function of tissues and organs. Such amyloids have been associated with (but not necessarily as the cause of) more than 50 human diseases, known as amyloidosis, and may play a role in some neurodegenerative diseases. Some of these diseases are mainly sporadic and only a few cases are Genetic disorder, familial. Others are only Genetic disorder, fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recaldent
Amorphous calcium phosphate (ACP) is a glassy solid that is formed from the chemical decomposition of a mixture of dissolved phosphate and calcium salts (e.g. (NH4)2HPO4 + Ca(NO3)2). The resulting amorphous mixture consists mostly of calcium and phosphate, but also contains varying amounts of water and hydrogen and hydroxide ions, depending on the synthesis conditions. Such mixtures are also known as calcium phosphate cement. ACP is generally categorized into either "amorphous tricalcium phosphate" (ATCP) or calcium-deficient hydroxyapatite (CDHA). CDHA is sometimes termed " apatitic calcium triphosphate." The composition of amorphous calcium phosphate is Ca''x''H''y''(PO4)''z''·''n''H2O, where ''n'' is between 3 and 4.5. CDHA has a general formula of Ca9(HPO4)(PO4)5(OH). Precipitation from a moderately supersaturated and basic solution of a magnesium salt produces amorphous magnesium calcium phosphate (AMCP), in which magnesium incorporated into the ACP structure. A commercial pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluoride
Fluoride (). According to this source, is a possible pronunciation in British English. is an inorganic, monatomic anion of fluorine, with the chemical formula (also written ), whose salts are typically white or colorless. Fluoride salts typically have distinctive bitter tastes, and are odorless. Its salts and minerals are important chemical reagents and industrial chemicals, mainly used in the production of hydrogen fluoride for fluorocarbons. Fluoride is classified as a weak base since it only partially associates in solution, but concentrated fluoride is corrosive and can attack the skin. Fluoride is the simplest fluorine anion. In terms of charge and size, the fluoride ion resembles the hydroxide ion. Fluoride ions occur on Earth in several minerals, particularly fluorite, but are present only in trace quantities in bodies of water in nature. Nomenclature Fluorides include compounds that contain ionic fluoride and those in which fluoride does not dissociate. The nom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomimetic Materials
Biomimetic materials are materials developed using inspiration from nature. This may be useful in the design of composite materials. Natural structures have inspired and innovated human creations. Notable examples of these natural structures include: honeycomb structure of the beehive, strength of spider silks, bird flight mechanics, and shark skin water repellency. The etymological roots of the neologism "biomimetic" derive from Greek, since means "life" and means "imitative". Tissue engineering Biomimetic materials in tissue engineering are materials that have been designed such that they elicit specified cellular responses mediated by interactions with scaffold-tethered peptides from extracellular matrix (ECM) proteins; essentially, the incorporation of cell-binding peptides into biomaterials via chemical or physical modification.Shin, H., S. Jo, and A.G. Mikos, ''Biomimetic materials for tissue engineering''. Biomaterials, 2003. 24: p. 4353-5364. Amino acids located within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oligopeptide
An oligopeptide, often just called peptide ('' oligo-'', "a few"), consists of two to twenty amino acids and can include dipeptides, tripeptides, tetrapeptides, and pentapeptides. Some of the major classes of naturally occurring oligopeptides include aeruginosins, cyanopeptolins, microcystins, microviridins, microginins, anabaenopeptins, and cyclamides. Microcystins are best studied, because of their potential toxicity impact in drinking water. A review of some oligopeptides found that the largest class are the cyanopeptolins (40.1%), followed by microcystins (13.4%). Production Oligopeptide classes are produced by nonribosomal peptides synthases (NRPS), except cyclamides and microviridins are synthesized through ribosomic pathways. Examples Examples of oligopeptides include: * Amanitins - Cyclic peptides taken from carpophores of several different mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, the prevent the production of mRNA a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Remineralisation Of Teeth
Tooth remineralization is the natural repair process for non-cavitated tooth decay, tooth lesions, in which calcium, phosphate and sometimes fluoride ions are deposition (chemistry), deposited into crystal voids in demineralised Tooth_enamel, enamel. Remineralization can contribute towards restoring strength and function within tooth structure. Demineralization is the removal of minerals (mainly calcium) from any of the hard tissues: Tooth enamel, enamel, dentine, and cementum.Li X, Wang J, Joiner A, Chang J. The remineralization of enamel: a review of the literature. Journal of dentistry. 2014 Jun 30;42:S12-20. It begins at the surface, and may progress into either cavitation (tooth decay) or erosion (tooth wear). Tooth decay demineralization is caused by acids from bacteria in the dental plaque biofilm whilst tooth wear is caused by acids from non-bacterial sources. These can be extrinsic in source, such as carbonated drinks, or intrinsic acids, usually from stomach acid coming ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amorphous Calcium Phosphate
Amorphous calcium phosphate (ACP) is a glassy solid that is formed from the chemical decomposition of a mixture of dissolved phosphate and calcium salts (e.g. (NH4)2HPO4 + Ca(NO3)2). The resulting amorphous mixture consists mostly of calcium and phosphate, but also contains varying amounts of water and hydrogen and hydroxide ions, depending on the synthesis conditions. Such mixtures are also known as calcium phosphate cement. ACP is generally categorized into either "amorphous tricalcium phosphate" (ATCP) or calcium-deficient hydroxyapatite (CDHA). CDHA is sometimes termed " apatitic calcium triphosphate." The composition of amorphous calcium phosphate is Ca''x''H''y''(PO4)''z''·''n''H2O, where ''n'' is between 3 and 4.5. CDHA has a general formula of Ca9(HPO4)(PO4)5(OH). Precipitation from a moderately supersaturated and basic solution of a magnesium salt produces amorphous magnesium calcium phosphate (AMCP), in which magnesium incorporated into the ACP structure. A commercial p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dentin Hypersensitivity
Dentin hypersensitivity (DH, DHS) is dental pain which is sharp in character and of short duration, arising from exposed dentin surfaces in response to stimuli, typically thermal, evaporative, tactile, osmotic, chemical or electrical; and which cannot be ascribed to any other dental disease. A degree of dentin sensitivity is normal, but pain is not usually experienced in everyday activities like drinking a cooled drink. Therefore, although the terms ''dentin sensitivity'' and ''sensitive dentin'' are used interchangeably to refer to dental hypersensitivity, the latter term is the most accurate. Signs and symptoms The pain is sharp and sudden, in response to an external stimulus. The most common trigger is cold, with 75% of people with hypersensitivity reporting pain upon application of a cold stimulus. Other types of stimuli may also trigger pain in dentin hypersensitivity, including: * Thermal – hot and cold drinks and foods, cold air, coolant water jet from a dental instrument ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomimetic Mineralization
Biomimetics or biomimicry is the emulation of the models, systems, and elements of nature for the purpose of solving complex human problems. The terms "biomimetics" and "biomimicry" are derived from grc, βίος (''bios''), life, and μίμησις ('' mīmēsis''), imitation, from μιμεῖσθαι (''mīmeisthai''), to imitate, from μῖμος (''mimos''), actor. A closely related field is bionics. Living organisms have evolved well-adapted structures and materials over geological time through natural selection. Biomimetics has given rise to new technologies inspired by biological solutions at macro and nanoscales. Humans have looked at nature for answers to problems throughout their existence. Nature has solved engineering problems such as self-healing abilities, environmental exposure tolerance and resistance, hydrophobicity, self-assembly, and harnessing solar energy. History One of the early examples of biomimicry was the study of birds to enable human flight. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Leeds
, mottoeng = And knowledge will be increased , established = 1831 – Leeds School of Medicine1874 – Yorkshire College of Science1884 - Yorkshire College1887 – affiliated to the federal Victoria University1904 – University of Leeds , type = Public , endowment = £90.5 million , budget = £751.7 million , chancellor = Jane Francis , vice_chancellor = Simone Buitendijk , students = () , undergrad = () , postgrad = () , city = Leeds , province = West Yorkshire , country = England , campus = Urban, suburban , free_label = Newspaper , free = The Gryphon , colours = , website www.leeds.ac.uk, logo = Leeds University logo.svg , logo_size = 250 , administrative_staff = 9,200 , coor = , affiliations = The University of Leeds is a public research university in Leeds, West Yorkshire, England. It was established in 1874 as the Yorkshire College of Science. In 1884 it merged with the Leeds School of Medicine (established 1831) and was renam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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