Macelignan
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Macelignan
Macelignan (Anwulignan) is a lignan. It can be found in ''Myristica fragrans'', the nutmeg. Medical research One study has shown that macelignan may exert antimicrobial and anticariogenic activity against ''Streptococcus mutans'', but this is not a currently used treatment. Macelignan may also act as an antidiabetic molecule via PPAR signaling and upregulate adipocyte gene expression Macelignan may contain antioxidant and anti-inflammatory properties and is marketed in breast enhancement creams for its anti-aging properties. References

Lignans Methoxy compounds {{aromatic-stub ...
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Lignan
The lignans are a large group of low molecular weight polyphenols found in plants, particularly seeds, whole grains, and vegetables. The name derives from the Latin word for "wood". Lignans are precursors to phytoestrogens. They may play a role as antifeedants in the defense of seeds and plants against herbivores. Biosynthesis and metabolism Lignans and lignin differ in their molecular weight, the former being small and soluble in water, the latter being high polymers that are undigestable. Both are polyphenolic substances derived by oxidative coupling of monolignols. Thus, most lignans feature a C18 cores, resulting from the dimerization of C9 precursors. The coupling of the lignols occurs at C8. Eight classes of lignans are: "furofuran, furan, dibenzylbutane, dibenzylbutyrolactone, aryltetralin, arylnaphthalene, dibenzocyclooctadiene, and dibenzylbutyrolactol." Many lignans are metabolized by mammalian gut microflora, producing so-called enterolignans. Food sources Flax s ...
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Myristica Fragrans
''Myristica fragrans'' is an evergreen tree indigenous to the Maluku Islands of Indonesia. It is important as the main source of the spices nutmeg and mace. It is widely grown across the tropics including Guangdong and Yunnan in China, Taiwan, Indonesia, Malaysia, Grenada in the Caribbean, Kerala in India, Sri Lanka and South America. Description ''Myristica fragrans'' is an evergreen tree, usually tall, but occasionally reaching or even on Tidore. The alternately arranged leaves are dark green, long by wide with petioles about long. The species is dioecious, i.e. "male" or staminate flowers and "female" or carpellate flowers are borne on different plants, although occasional individuals produce both kinds of flower. The flowers are bell-shaped, pale yellow and somewhat waxy and fleshy. Staminate flowers are arranged in groups of one to ten, each long; carpellate flowers are in smaller groups, one to three, and somewhat longer, up to long. Carpellate trees produce s ...
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Cariogenic
Tooth decay, also known as cavities or caries, is the breakdown of teeth due to acids produced by bacteria. The cavities may be a number of different colors from yellow to black. Symptoms may include pain and difficulty with eating. Complications may include inflammation of the tissue around the tooth, tooth loss and infection or abscess formation. The cause of cavities is acid from bacteria dissolving the hard tissues of the teeth ( enamel, dentin and cementum). The acid is produced by the bacteria when they break down food debris or sugar on the tooth surface. Simple sugars in food are these bacteria's primary energy source and thus a diet high in simple sugar is a risk factor. If mineral breakdown is greater than build up from sources such as saliva, caries results. Risk factors include conditions that result in less saliva such as: diabetes mellitus, Sjögren syndrome and some medications. Medications that decrease saliva production include antihistamines and antidepressa ...
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Streptococcus Mutans
''Streptococcus mutans'' is a facultatively anaerobic, gram-positive coccus (round bacterium) commonly found in the human oral cavity and is a significant contributor to tooth decay. It is part of the " streptococci" (plural, non-italic lowercase), an informal general name for all species in the genus ''Streptococcus''. The microbe was first described by James Kilian Clarke in 1924. This bacterium, along with the closely related species ''Streptococcus sobrinus'', can cohabit the mouth: Both contribute to oral disease, and the expense of differentiating them in laboratory testing is often not clinically necessary. Therefore, for clinical purposes they are often considered together as a group, called the mutans streptococci (plural, non-italic due to its being an informal group name). This grouping of similar bacteria with similar tropism can also be seen in the viridans streptococci, another group of ''Streptococcus'' species. Ecology ''S. mutans'' is naturally present in the hu ...
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Archives Of Pharmacal Research
''Archives of Pharmacal Research'' is a bimonthly, peer-reviewed medical journal covering research on pharmacology. It was established in 1976 and is published by Springer Science+Business Media on behalf of the Pharmaceutical Society of Korea, of which it is the official journal. The editor-in-chief is Seok-Yong Lee (Sungkyunkwan University). According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 4.946. References External links * Academic journals established in 1976 Bimonthly journals Springer Science+Business Media academic journals English-language journals {{Pharmacology-journal-stub ...
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Lignans
The lignans are a large group of low molecular weight polyphenols found in plants, particularly seeds, whole grains, and vegetables. The name derives from the Latin word for "wood". Lignans are precursors to phytoestrogens. They may play a role as antifeedants in the defense of seeds and plants against herbivores. Biosynthesis and metabolism Lignans and lignin differ in their molecular weight, the former being small and soluble in water, the latter being high polymers that are undigestable. Both are polyphenolic substances derived by oxidative coupling of monolignols. Thus, most lignans feature a C18 cores, resulting from the dimerization of C9 precursors. The coupling of the lignols occurs at C8. Eight classes of lignans are: "furofuran, furan, dibenzylbutane, dibenzylbutyrolactone, aryltetralin, arylnaphthalene, dibenzocyclooctadiene, and dibenzylbutyrolactol." Many lignans are metabolized by mammalian gut microflora, producing so-called enterolignans. Food sources Flax se ...
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