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Moist Desquamation
Moist desquamation is a description of the clinical pattern seen as a consequence of radiation exposure where the skin thins and then begins to weep because of loss of integrity of the epithelial barrier and decreased oncotic pressure. Typically this occurs at doses of 15–20 Gray, far higher than any diagnostic scan and more typical of levels seen in radiotherapy or deployment of nuclear armament. Historically, this was a common phenomenon in Hiroshima and Nagasaki during World War II with the atomic bomb attacks from the United States.Huda, W. Review of Radiologic Physics. 3rd edition. Lippincott, Williams & Wilkins, 2009. The phenomenon was famously described by John Hersey John Richard Hersey (June 17, 1914 – March 24, 1993) was an American writer and journalist. He is considered one of the earliest practitioners of the so-called New Journalism, in which storytelling techniques of fiction are adapted to n ... in his 1946 article, and later book, ''Hiroshima''. Cl ...
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Ionizing Radiation
Ionizing radiation (or ionising radiation), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. Some particles can travel up to 99% of the speed of light, and the electromagnetic waves are on the high-energy portion of the electromagnetic spectrum. Gamma rays, X-rays, and the higher energy ultraviolet part of the electromagnetic spectrum are ionizing radiation, whereas the lower energy ultraviolet, visible light, nearly all types of laser light, infrared, microwaves, and radio waves are non-ionizing radiation. The boundary between ionizing and non-ionizing radiation in the ultraviolet area is not sharply defined, as different molecules and atoms ionize at different energies. The energy of ionizing radiation starts between 10 electronvolts (eV) and 33 eV. Typical ionizing subatomic particles include alpha particles, beta particles, and neutrons. ...
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Skin
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other cuticle, animal coverings, such as the arthropod exoskeleton, have different cellular differentiation, developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin ''cutis'' 'skin'). In mammals, the skin is an organ (anatomy), organ of the integumentary system made up of multiple layers of ectodermal tissue (biology), tissue and guards the underlying muscles, bones, ligaments, and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. Skin (including cutaneous and subcutaneous tissues) plays crucial roles in formation, structure, and function of extraskeletal apparatus such as horns of bovids (e.g., cattle) and rhinos, cervids' antlers, giraffids' ossicones, armadillos' osteoderm, and os penis/os clitoris. All mammals have som ...
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Oncotic Pressure
Oncotic pressure, or colloid osmotic-pressure, is a form of osmotic pressure induced by the proteins, notably albumin, in a blood vessel's plasma (blood/liquid) that causes a pull on fluid back into the capillary. Participating colloids displace water molecules, thus creating a relative water molecule deficit with water molecules moving back into the circulatory system within the lower venous pressure end of capillaries. It has the opposing effect of both hydrostatic blood pressure pushing water and small molecules out of the blood into the interstitial spaces within the arterial end of capillaries and interstitial colloidal osmotic pressure. These interacting factors determine the partition balancing of extracellular water between the blood plasma and outside the blood stream. Oncotic pressure strongly affects the physiological function of the circulatory system. It is suspected to have a major effect on the pressure across the glomerular filter. However, this concept has been ...
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Gray (unit)
The gray (symbol: Gy) is the unit of ionizing radiation dose in the International System of Units (SI), defined as the absorption of one joule of radiation energy per kilogram of matter. It is used as a unit of the radiation quantity absorbed dose that measures the energy deposited by ionizing radiation in a unit mass of matter being irradiated, and is used for measuring the delivered dose in radiotherapy, food irradiation and radiation sterilization. It is important in predicting likely acute health effects, such as acute radiation syndrome and is used to calculate equivalent dose using the sievert, which is a measure of the stochastic health effect on the human body. The gray is also used in radiation metrology as a unit of the radiation quantity kerma; defined as the sum of the initial kinetic energies of all the charged particles liberated by uncharged ionizing radiation in a sample of matter per unit mass. The gray is an important unit in ionising radiation measuremen ...
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Hiroshima
is the capital of Hiroshima Prefecture in Japan. , the city had an estimated population of 1,199,391. The gross domestic product (GDP) in Greater Hiroshima, Hiroshima Urban Employment Area, was US$61.3 billion as of 2010. Kazumi Matsui has been the city's mayor since April 2011. Hiroshima was founded in 1589 as a castle town on the Ōta River delta. Following the Meiji Restoration in 1868, Hiroshima rapidly transformed into a major urban center and industrial hub. In 1889, Hiroshima officially gained city status. The city was a center of military activities during the imperial era, playing significant roles such as in the First Sino-Japanese War, the Russo-Japanese War, and the two world wars. Hiroshima was the first military target of a nuclear weapon in human history. This occurred on August 6, 1945, at 8:15 a.m., when the United States Army Air Forces (USAAF) dropped the atomic bomb "Little Boy" on the city. Most of Hiroshima was destroyed, and by the end of th ...
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Nagasaki
is the capital and the largest city of Nagasaki Prefecture on the island of Kyushu in Japan. It became the sole port used for trade with the Portuguese and Dutch during the 16th through 19th centuries. The Hidden Christian Sites in the Nagasaki Region have been recognized and included in the UNESCO World Heritage List. Part of Nagasaki was home to a major Imperial Japanese Navy base during the First Sino-Japanese War and Russo-Japanese War. Near the end of World War II, the American atomic bombings of Hiroshima and Nagasaki made Nagasaki the second and, to date, last city in the world to experience a nuclear attack (at 11:02 am, August 9, 1945 'Japan Standard Time (UTC+9)'). , the city has an estimated population of 407,624 and a population density of 1,004 people per km2. The total area is . History Nagasaki as a Jesuit port of call The first contact with Portuguese explorers occurred in 1543. An early visitor was Fernão Mendes Pinto, who came from Sagres ...
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World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ...
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Atomic Bomb
A nuclear weapon is an explosive device that derives its destructive force from nuclear reactions, either fission (fission bomb) or a combination of fission and fusion reactions (thermonuclear bomb), producing a nuclear explosion. Both bomb types release large quantities of energy from relatively small amounts of matter. The first test of a fission ("atomic") bomb released an amount of energy approximately equal to . The first thermonuclear ("hydrogen") bomb test released energy approximately equal to . Nuclear bombs have had yields between 10 tons TNT (the W54) and 50 megatons for the Tsar Bomba (see TNT equivalent). A thermonuclear weapon weighing as little as can release energy equal to more than . A nuclear device no larger than a conventional bomb can devastate an entire city by blast, fire, and radiation. Since they are weapons of mass destruction, the proliferation of nuclear weapons is a focus of international relations policy. Nuclear weapons have been deployed ...
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United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ...
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John Hersey
John Richard Hersey (June 17, 1914 – March 24, 1993) was an American writer and journalist. He is considered one of the earliest practitioners of the so-called New Journalism, in which storytelling techniques of fiction are adapted to non-fiction reportage. In 1999, Hersey's account of the aftermath of the atomic bomb dropped on Hiroshima, Japan, was adjudged the finest piece of American journalism of the 20th century by a 36-member panel associated with New York University's journalism department. Background Hersey was born in Tientsin, China, the son of Grace Baird and Roscoe Hersey, Protestant missionaries for the YMCA in Tientsin. Hersey learned to speak Chinese before he spoke English. Later he based his novel, '' The Call'' (1985), on the lives of his parents and several other missionaries of their generation. John Hersey was a descendant of William Hersey (or Hercy, as the family name was then spelled) of Reading, Berkshire, England. William Hersey was one of ...
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Hiroshima (book)
''Hiroshima'' is a 1946 book by American author John Hersey. It tells the stories of six survivors of the atomic bomb dropped on Hiroshima. It is regarded as one of the earliest examples of New Journalism, in which the story-telling techniques of fiction are adapted to non-fiction reporting. The work was originally published in ''The New Yorker'', which had planned to run it over four issues but instead dedicated the entire edition of August 31, 1946, to a single article. Less than two months later, the article was printed as a book by Alfred A. Knopf. Never out of print, it has sold more than three million copies. "Its story became a part of our ceaseless thinking about world wars and nuclear holocaust," ''New Yorker'' essayist Roger Angell wrote in 1995. Background Before writing ''Hiroshima'', Hersey had been a war correspondent in the field, writing for ''Life'' magazine and ''The New Yorker''. He followed troops during the invasions of Italy and Sicily during World War ...
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