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Liniment
Liniment (from la, linere, meaning "to anoint"), also called embrocation and heat rub, is a medicated topical preparation for application to the skin. Some liniments have viscosity similar to that of water; others are lotion or balm; still others are in transdermal patches, soft solid sticks, and sprays. Liniment usually is rubbed in to the skin, which the active ingredients penetrate. Liniments are typically sold to relieve pain and stiffness, such as from muscular aches and strains, and arthritis. These are typically formulated from alcohol, acetone, or similar quickly evaporating solvents and contain counterirritant aromatic chemical compounds, such as methyl salicilate, benzoin resin, menthol, and capsaicin. They produce a feeling of warmth within the muscle of the area they are applied to, typically acting as rubefacients via a counterirritant effect. Methyl salicylate, which is the analgesic ingredient in some heat rubs, can be toxic if used to excess. Heating pads are als ...
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Rubefacients
A rubefacient is a substance for topical application that produces redness of the skin, e.g. by causing dilation of the capillaries and an increase in blood circulation. They have sometimes been used to relieve acute or chronic pain, but there is limited evidence as to their efficacy,Mason et al. 200''Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain''BMJ 328:995 and as of 2014 the best evidence does not support using gels and creams containing rubefacients for this purpose. Examples Common medicinal rubefacients include: *Salicylates, such as methyl salicylate (oil of wintergreen) *Nicotinate esters *Capsaicin, derived from chili pepper, ''Capsicum minimum'', "incites irritation without rubefaction" *Isopropanol (rubbing alcohol) *Menthol *Minoxidil * Thurfyl nicotinate (Trafuril) Common herbal rubefacients include:{{citation needed, date=October 2016 *Cloves (''Syzygium aromaticum'') *Garlic (''Allium sativum'' ...
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Amrutanjan (balm)
Amrutanjan is an analgesic liniment, balm owned by Amrutanjan Healthcare. History Amrutanjan was founded in 1893 by journalist and freedom fighter, Kasinathuni Nageswara Rao. He popularized the balm by distributing it free-of-cost at music concerts. Even today, the words "Bombay" are inscribed along with Amrutanjan on the lid of its most well-known product, the pain balm. In 1936, Amrutanjan became a public limited company with the name Amrutanjan Limited. Medical uses It is used as a balm for: * Headache * muscle, Muscular Pain and nociception, ache * muscle, Muscular Strain (injury), strain * Arthritis Holding company The brand is owned by the parent Amrutanjan Healthcare. It is now headed by Sambhu Prasad, the grandson of Nageshwara Rao. References {{reflist External links Official site
Analgesics Pain Drug brand names Products introduced in 1893 ...
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Methyl Salicylate
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer, but often associatively called "minty", as it is an ingredient in mint candies. It is produced by many species of plants, particularly wintergreens. It is also produced synthetically, used as a fragrance and as a flavoring agent. Biosynthesis and occurrence Methyl salicylate was first isolated (from the plant ''Gaultheria procumbens'') in 1843 by the French chemist Auguste André Thomas Cahours (1813–1891), who identified it as an ester of salicylic acid and methanol. The biosynthesis of methyl salicylate arises via the hydroxylation of benzoic acid by a cytochrome P450 followed by methylation by a methylase enzyme. Methyl salicylate as a plant metabolite Many plants produce methyl salicylate in small quantities. Methyl salicylate levels are o ...
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Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who had i ...
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Jules Bengué
Jules is the French form of the Latin "Julius" (e.g. Jules César, the French name for Julius Caesar). It is the given name of: People with the name *Jules Aarons (1921–2008), American space physicist and photographer *Jules Abadie (1876–1953), French politician and surgeon *Jules Accorsi (born 1937), French football player and manager *Jules Adenis (1823–1900), French playwright and opera librettist *Jules Adler 1865–1952), French painter *Jules Asner (born 1968), American television personality *Jules Aimé Battandier (1848–1922), French botanist *Jules Bernard (born 2000), American basketball player *Jules Bianchi (1989–2015), French Formula One driver *Jules Breton (1827–1906), French Realist painter *Jules-André Brillant (1888–1973), Canadian entrepreneur *Jules Brunet (1838–1911), French Army general *Jules Charles-Roux (1841–1918), French businessman and politician *Jules Dewaquez (1899–1971), French footballer *Jules Marie Alphonse Jacques de Dixmu ...
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Bengay
Bengay, spelled Ben-Gay before 1995, is a topical analgesic heat rub for temporary relief from muscle and joint pain associated with arthritis, bruises, simple backaches, overuse, sprains and strains. Overview Bengay was developed in France by Dr. Jules Bengué () and brought to America in 1898. The name Bengué was Anglicized and commercialized to Ben-Gay (later Bengay). It was originally produced by Pfizer Consumer Healthcare, which was acquired by Johnson & Johnson. The product is advised to be used topically for adults and children 12 years of age and older, and no more than 3 to 4 times daily. The manufacturer recommends storing it between . According to a study published by MIT Technology Review, the exact mechanism of its efficacy is not known. However, evidence indicates that it activates a neuron named TRPM8, which appears to keep minor pain signals in the brain from communicating with the spine. Hazards Bengay and similar products, such as Flexall, Mentholatu ...
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Kasinathuni Nageswara Rao
Kasinadhuni Nageswararao, better known as Nageswara Rao Pantulu, (1 May 1867 – 11 April 1938) was an Indian journalist, nationalist, politician, businessman, and a staunch supporter of Khaddar movement. He participated in the Indian independence movement and in the Indian National Congress party, including Mahatma Gandhi’s civil disobedience movement through salt satyagraha. He was conferred with the title ''Desabandhu'' (Friend of the masses) by the people of Andhra Pradesh. He was a major financier of Congress activities in Andhra and Chennai and is also known for patenting Amrutanjan. He was conferred with the title ''Desoddhaaraka'' (Uplifter of the masses) by the Andhra Mahasabha. In 1935, the Andhra University honoured him with Kalaprapoorna, an honorary doctorate of Literature. Early life Kasinadhuni Nageswararao, popularly known as Nageswararao Pantulu garu, was born on 1 May 1867 in Pesaramilli village, Pamarru mandal in Krishna district of Andhra to a Brahmin coup ...
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Amrutanjan Healthcare
Amrutanjan Healthcare Limited is an Indian pharmaceutical company headquartered in Chennai, Tamil Nadu, India. It was founded by Kasinadhuni Nageswara Rao in Bombay (now Mumbai) in 1893. History Amrutanjan was established as a patent medicine business in Bombay (now Mumbai) in 1893 by K. Nageswara Rao Pantulu who was a journalist, social reformer and freedom fighter. Madras Rediscovered, Pg 206 The headquarters were shifted to Madras (now Chennai) in 1914. As of 2014, it is headed by Sambhu Prasad, the grandson of Nageshwara Rao. Products Amrutanjan Healthcare's main product is its pain balm. In 2002, Amrutanjan Healthcare launched a series of anti-diabetic medicines called Diakyur. In 2004, the company launched herbal mouth-fresheners under the brand name "Affair". The Amrutanjan group also includes a software company called Amrutanjan Infotech. In July 2001, Amrutanjan Infotech's call-centre began its operations. In May 2011 Amrutanjan diversified into foods, buying ...
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Toxin
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word toxic. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved in an organism's growth, development, or reproduction, instead often aiding it in matters of defense. Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. Le ...
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Chloroform
Chloroform, or trichloromethane, is an organic compound with chemical formula, formula Carbon, CHydrogen, HChlorine, Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various refrigerants. It is trihalomethane. It is a powerful anesthetic, euphoriant, anxiolytic, and sedative when inhaled or ingested. Structure The molecule adopts a tetrahedral molecular geometry with C3v symmetry group, symmetry. Natural occurrence The total global flux of chloroform through the environment is approximately tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Abiotic processes are also believed to contribute to natural chloroform productions in soils although the mechanism is still unclear. Chloroform volatilizes readily from soil and surface water and undergoes degradation in ...
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Atropa Belladonna
''Atropa belladonna'', commonly known as belladonna or deadly nightshade, is a toxic perennial herbaceous plant in the nightshade family Solanaceae, which also includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States. The foliage and berries are extremely toxic when ingested, containing tropane alkaloids. These toxins include atropine, scopolamine, and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical anticholinergics. Tropane alkaloids are of common occurrence not only in the Old World tribes Hyoscyameae (to which the genus Atropa belongs) and Mandragoreae, but also in the New World tribe Datureae - all of which belong to the subfamily Solanoideae of the plant family Solanaceae. ...
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Aconitum
''Aconitum'' (), also known as aconite, monkshood, wolf's-bane, leopard's bane, mousebane, women's bane, devil's helmet, queen of poisons, or blue rocket, is a genus of over 250 species of flowering plants belonging to the family Ranunculaceae. These herbaceous perennial plants are chiefly native to the mountainous parts of the Northern Hemisphere in North America, Europe, and Asia; growing in the moisture-retentive but well-draining soils of mountain meadows. Most ''Aconitum'' species are extremely poisonous and must be handled very carefully. Several ''Aconitum'' hybrids, such as the Arendsii form of ''Aconitum carmichaelii'', have won gardening awards—such as the Royal Horticultural Society's Award of Garden Merit. Some are used by florists. Etymology The name ''aconitum'' comes from the Greek word , which may derive from the Greek ''akon'' for dart or javelin, the tips of which were poisoned with the substance, or from ''akonae'', because of the rocky ground on which th ...
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