Escharotic
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Escharotic
An eschar (; Greek: ''ἐσχάρᾱ'', ''eskhara''; Latin: ''eschara'') is a slough or piece of dead tissue that is cast off from the surface of the skin, particularly after a burn injury, but also seen in gangrene, ulcer, fungal infections, necrotizing spider bite wounds, tick bites associated with spotted fevers and exposure to cutaneous anthrax. The term ‘eschar’ is not interchangeable with ‘scab’. An eschar contains necrotic tissue whereas a scab is composed of dried blood and exudate. Black eschars are most frequently attributed in medicine to cutaneous anthrax (infection by ''Bacillus anthracis''), which may be contracted through herd animal exposure and also from ''Pasteurella multocida'' exposure in cats and rabbits. A newly identified human rickettsial infection, ''R. parkeri'' rickettsiosis, can be differentiated from Rocky Mountain spotted fever by the presence of an eschar at the site of inoculation. Eschar is sometimes called a ''black wound'' because t ...
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Sanguinarine
Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant, from whose taxonomic name, ''Sanguinaria canadensis,'' its name is drawn; the Mexican prickly poppy (''Argemone mexicana''); ''Chelidonium majus;'' and '' Macleaya cordata.'' Toxicity Sanguinarine is a toxin that kills animal cells through its action on the Na+/K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine. If applied to the skin, sanguinarine may cause a massive scab of dead flesh where it killed the cells where it was applied, called an ''eschar''. For this reason, sanguinarine is termed an escharotic. It is said to be 2.5 times more toxic than dihydrosanguinarine. Alternative medicine Native Americans once used sanguinarine in the form of bloodroot as a medical remedy, believing it had curative properties as an emetic, respiratory aid, and for a variety of ailments. In Colonial America, sanguinarine fr ...
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Necrosis
Necrosis () is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated digestion of cell components. In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal. Cellular death due to necrosis does not follow the apoptotic signal transduction pathway, but rather various receptors are activated and result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the extracellular space. This initiates in the surrounding tissue an inflammatory response, which attracts leukocytes and nearby phagocytes which eliminate the dead cells by phagocytosis. However, microbial damaging substances released by leukocytes would crea ...
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Escharotomy
An escharotomy is a surgical procedure used to treat full-thickness (third-degree) circumferential burns. In full-thickness burns, both the epidermis and the dermis are destroyed along with sensory nerves in the dermis. The tough leathery tissue remaining after a full-thickness burn has been termed ''eschar''. Following a full-thickness burn, as the underlying tissues are rehydrated, they become constricted due to the eschar's loss of elasticity, leading to impaired circulation distal to the wound. An escharotomy can be performed as a prophylactic measure as well as to release pressure, facilitate circulation and combat burn-induced compartment syndrome. An escharotomy is performed by making an incision through the eschar to expose the fatty tissue below. Due to the residual pressure, the incision will often widen substantially. Overview Full-thickness circumferential and near-circumferential skin burns result in the formation of a tough, inelastic mass of burnt tissue (eschar). ...
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Refrigerant
A refrigerant is a working fluid used in the heat pump and refrigeration cycle, refrigeration cycle of air conditioning systems and heat pumps where in most cases they undergo a repeated phase transition from a liquid to a gas and back again. Refrigerants are heavily regulated due to their toxicity, flammability and the contribution of CFC and HCFC refrigerants to ozone depletion and that of HFC refrigerants to climate change. Refrigerants are used in a Direct Expansion (DX) system to transfer energy from one environment to another, typically from inside a building to outside (or vice versa) commonly known as an "air conditioner" or "heat pump". Refrigerants can carry per kg 10 times more energy than water and 50 times more than air. Refrigerants are controlled substances due to 1) High Pressures (100-145 psi), 2) Extreme temperatures (-50°C to 145°C), 3) Flammability A1 class non-flammable, A2/A2L class flammable & A3 class extremely flammable/explosive and 4) Toxicity B1-low ...
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Taraxacum
''Taraxacum'' () is a large genus of flowering plants in the family Asteraceae, which consists of species commonly known as dandelions. The scientific and hobby study of the genus is known as taraxacology. The genus is native to Eurasia and North America, but the two most commonplace species worldwide, '' T. officinale'' (the common dandelion) and '' T. erythrospermum'' (the red-seeded dandelion), were introduced from Europe into North America, where they now propagate as wildflowers. Both species are edible in their entirety. The common name ''dandelion'' ( , from French , meaning 'lion's tooth') is also given to specific members of the genus. Like other members of the family Asteraceae, they have very small flowers collected together into a composite flower head. Each single flower in a head is called a ''floret''. In part due to their abundance, along with being a generalist species, dandelions are one of the most vital early spring nectar sources for a wide host ...
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Carica
''Carica'' is a genus of flowering plants in the family Caricaceae including the papaya (''C. papaya'' syn. ''C. peltata'', ''C. posoposa''), a widely cultivated fruit tree native to the American tropics. The genus was formerly treated as including about 20-25 species of short-lived evergreen pachycaul shrubs or small trees growing to 5–10 m tall, native to tropical Central and South America, but recent genetic evidence has resulted in all of these species other than ''C. papaya'' being reclassified into three other genera. Taxonomy The genus name comes from the botanical name of the fig, ''Ficus carica'', because of the species' leaves or fruits resemble that of it. The ''carica'' epithet comes from Caria in southwest Anatolia (Asia Minor), Turkey, where the fig was mistakenly thought to have come from. Species According to World Flora Online, the genus ''Carica'' lists 21 species. Most of the other species have since been transferred to the genus ''Vasconcellea'', with ...
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Euphorbia
''Euphorbia'' is a very large and diverse genus of flowering plants, commonly called spurge, in the family Euphorbiaceae. "Euphorbia" is sometimes used in ordinary English to collectively refer to all members of Euphorbiaceae (in deference to the type genus), not just to members of the genus. Euphorbias range from tiny annual plants to large and long-lived trees. The genus has roughly 2,000 members, making it one of the largest genera of flowering plants. It also has one of the largest ranges of chromosome counts, along with ''Rumex'' and ''Senecio''. ''Euphorbia antiquorum'' is the type species for the genus ''Euphorbia''. It was first described by Carl Linnaeus in 1753 in ''Species Plantarum''. Some euphorbias are widely available commercially, such as poinsettias at Christmas. Some are commonly cultivated as ornamentals, or collected and highly valued for the aesthetic appearance of their unique floral structures, such as the crown of thorns plant (''Euphorbia milii''). ...
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Ficus
''Ficus'' ( or ) is a genus of about 850 species of woody trees, shrubs, vines, epiphytes and hemiepiphytes in the family Moraceae. Collectively known as fig trees or figs, they are native throughout the tropics with a few species extending into the semi-warm temperate zone. The common fig (''F. carica'') is a temperate species native to southwest Asia and the Mediterranean region (from Afghanistan to Portugal), which has been widely cultivated from ancient times for its fruit, also referred to as figs. The fruit of most other species are also edible though they are usually of only local economic importance or eaten as bushfood. However, they are extremely important food resources for wildlife. Figs are also of considerable cultural importance throughout the tropics, both as objects of worship and for their many practical uses. Description ''Ficus'' is a pantropical genus of trees, shrubs, and vines occupying a wide variety of ecological niches; most are evergreen, bu ...
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Resin
In polymer chemistry and materials science, resin is a solid or highly viscous substance of plant or synthetic origin that is typically convertible into polymers. Resins are usually mixtures of organic compounds. This article focuses on naturally occurring resins. Plants secrete resins for their protective benefits in response to injury. The resin protects the plant from insects and pathogens. Resins confound a wide range of herbivores, insects, and pathogens, while the volatile phenolic compounds may attract benefactors such as parasitoids or predators of the herbivores that attack the plant. Composition Most plant resins are composed of terpenes. Specific components are alpha-pinene, beta-pinene, delta-3 carene, and sabinene, the monocyclic terpenes limonene and terpinolene, and smaller amounts of the tricyclic sesquiterpenes, longifolene, caryophyllene, and delta-cadinene. Some resins also contain a high proportion of resin acids. Rosins on the other hand are less ...
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Latex
Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latexes are found in nature, but synthetic latexes are common as well. In nature, latex is found as a milky fluid found in 10% of all flowering plants (angiosperms). It is a complex emulsion that coagulates on exposure to air, consisting of proteins, alkaloids, starches, sugars, oils, tannins, resins, and gums. It is usually exuded after tissue injury. In most plants, latex is white, but some have yellow, orange, or scarlet latex. Since the 17th century, latex has been used as a term for the fluid substance in plants, deriving from the Latin word for "liquid". It serves mainly as defense against herbivorous insects. Latex is not to be confused with plant sap; it is a distinct substance, separately produced, and with different functions. The word latex is also used to refer to natural latex rubber, particularly non-vulcanized rubber. Such is the case in products like latex gloves, latex condoms ...
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Imiquimod
Imiquimod, sold under the brand name Aldara among others, is a medication that acts as an immune response modifier that is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis. Scientists at 3M's pharmaceuticals division discovered the drug and 3M obtained the first FDA approval in 1997. As of 2015, imiquimod is generic and is available worldwide under many brands. Medical uses Imiquimod is a patient-applied cream prescribed to treat genital warts, Bowens disease ( squamous cell carcinoma in situ), and, secondary to surgery, for basal cell carcinoma, as well as actinic keratosis. Imiquimod 5% cream is indicated for the topical treatment of: * external genital and perianal warts (condylomata acuminata) in adults; * small superficial basal-cell carcinomas (sBCCs) in adults; * clinically typical, non-hyperkeratotic, non-hypertrophic actinic keratoses (AKs) on the face or scalp in immunocompetent adults when size or number of lesions limit the effica ...
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