Chimeric Viruses
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Chimeric Viruses
A chimera or chimeric virus is a virus that contains genetic material derived from two or more distinct viruses. It is defined by the Center for Veterinary Biologics (part of the U.S. Department of Agriculture's Animal and Plant Health Inspection Service) as a "new hybrid microorganism created by joining nucleic acid fragments from two or more different microorganisms in which each of at least two of the fragments contain essential genes necessary for replication." The term ''genetic chimera'' had already been defined to mean: an individual organism whose body contained cell populations from different zygotes or an organism that developed from portions of different embryos. Chimeric flaviviruses have been created in an attempt to make novel live attenuated vaccines. Etymology In mythology, a chimera is a creature such as a hippogriff or a gryphon formed from parts of different animals, thus the name for these viruses. As a natural phenomenon Viruses are categorized in two types ...
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Virus
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898,Dimmock p. 4 more than 9,000 virus species have been described in detail of the millions of types of viruses in the environment. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or ''virions'', consisting of (i) the genetic material, i. ...
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Eukaryotes
Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacteria and Archaea (both prokaryotes) make up the other two domains. The eukaryotes are usually now regarded as having emerged in the Archaea or as a sister of the Asgard archaea. This implies that there are only two domains of life, Bacteria and Archaea, with eukaryotes incorporated among archaea. Eukaryotes represent a small minority of the number of organisms, but, due to their generally much larger size, their collective global biomass is estimated to be about equal to that of prokaryotes. Eukaryotes emerged approximately 2.3–1.8 billion years ago, during the Proterozoic eon, likely as flagellated phagotrophs. Their name comes from the Greek εὖ (''eu'', "well" or "good") and κάρυον (''karyon'', "nut" or "kernel"). Eu ...
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Soviet Union
The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen national republics; in practice, both its government and its economy were highly centralized until its final years. It was a one-party state governed by the Communist Party of the Soviet Union, with the city of Moscow serving as its capital as well as that of its largest and most populous republic: the Russian SFSR. Other major cities included Leningrad (Russian SFSR), Kiev (Ukrainian SSR), Minsk ( Byelorussian SSR), Tashkent (Uzbek SSR), Alma-Ata (Kazakh SSR), and Novosibirsk (Russian SFSR). It was the largest country in the world, covering over and spanning eleven time zones. The country's roots lay in the October Revolution of 1917, when the Bolsheviks, under the leadership of Vladimir Lenin, overthrew the Russian Provisional Government ...
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Biological Agent
A biological agent (also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon) is a bacterium, virus, protozoan, parasite, fungus, or toxin that can be used purposefully as a weapon in bioterrorism or biological warfare (BW). In addition to these living or replicating pathogens, toxins and biotoxins are also included among the bio-agents. More than 1,200 different kinds of potentially weaponizable bio-agents have been described and studied to date. Biological agents have the ability to adversely affect human health in a variety of ways, ranging from relatively mild allergic reactions to serious medical conditions, including serious injury, as well as serious or permanent disability or even death. Many of these organisms are ubiquitous in the natural environment where they are found in water, soil, plants, or animals. Bio-agents may be amenable to "weaponization" to render them easier to deploy or disseminate. Genetic modification ...
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Viral Disease
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells. Structural Characteristics Basic structural characteristics, such as genome type, virion shape and replication site, generally share the same features among virus species within the same family. * Double-stranded DNA families: three are non-enveloped (''Adenoviridae'', ''Papillomaviridae'' and ''Polyomaviridae'') and two are enveloped (''Herpesviridae'' and ''Poxviridae''). All of the non-enveloped families have icosahedral capsids. * Partly double-stranded DNA viruses: ''Hepadnaviridae''. These viruses are enveloped. * One family of single-stranded DNA viruses infects humans: ''Parvoviridae''. These viruses are non-enveloped. * Positive single-stranded RNA families: three non-enveloped (''Astroviridae'', ''Caliciviridae'' and ''Picornaviridae'') and four enveloped (''Coronaviridae'', ''Flaviviridae' ...
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Biology Direct
''Biology Direct'' is an online open access scientific journal that publishes original, peer-reviewed research papers, reviews, hypotheses, comments and discovery notes in biology. The journal is published by BioMed Central. The journal follows a peer review system which is different from the traditional peer review system, which aims to give more responsibility to authors, and reduce sources of bias. Published articles include signed reviewer reports, and responses to the reports from the authors, to provide readers with an additional guide to the article. Based on the information presented on their website: "Biology Direct's key aim is to provide authors and readers with an alternative to the traditional model of peer review Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review .... This ...
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Tombusvirus
''Tombusvirus'' is a genus of viruses, in the family ''Tombusviridae''. Plants serve as natural hosts. There are 17 species in this genus. Symptoms associated with this genus include mosaic. The name of the genus comes from ''Tomato bushy stunt virus''. Taxonomy The genus contains the following species: * ''Artichoke mottled crinkle virus'' * ''Carnation Italian ringspot virus'' * '' Cucumber Bulgarian virus'' * ''Cucumber necrosis virus'' * '' Cymbidium ringspot virus'' * '' Eggplant mottled crinkle virus'' * '' Grapevine Algerian latent virus'' * '' Havel River virus'' * '' Lato River virus'' * '' Limonium flower distortion virus'' * '' Moroccan pepper virus'' * ''Neckar River virus'' * ''Pelargonium leaf curl virus'' * ''Pelargonium necrotic spot virus'' * ''Petunia asteroid mosaic virus'' * '' Sikte waterborne virus'' * ''Tomato bushy stunt virus'' Structure Viruses in ''Tombusvirus'' are non-enveloped, with icosahedral and spherical geometries, and T=3 symmetry. The diamete ...
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Circovirus
''Circovirus'' is a genus of viruses, in the family ''Circoviridae''. Birds (such as pigeons and ducks) and pigs serve as natural hosts, though dogs have been shown to be infected as well. It is a single stranded DNA virus (ssDNA). There are 49 species in this genus. Some members of this genus cause disease: PCV-1 is non pathogenic, while PCV-2 causes postweaning multisystemic wasting syndrome (PMWS). Taxonomy The following species are recognized: *'' Barbel circovirus'' *'' Bat associated circovirus 1'' *'' Bat associated circovirus 2'' *'' Bat associated circovirus 3'' *'' Bat associated circovirus 4'' *'' Bat associated circovirus 5'' *'' Bat associated circovirus 6'' *'' Bat associated circovirus 7'' *'' Bat associated circovirus 8'' *'' Bat associated circovirus 9'' *'' Bat associated circovirus 10'' *'' Bat associated circovirus 11'' *'' Bat associated circovirus 12'' *'' Bat associated circovirus 13'' *'' Beak and feather disease virus'' *'' Bear circovirus'' *'' Canary ...
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Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ...
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Boiling Springs Lake RNA DNA Hybrid Virus
Boiling is the rapid vaporization of a liquid, which occurs when a liquid is heated to its boiling point, the temperature at which the vapour pressure of the liquid is equal to the pressure exerted on the liquid by the surrounding atmosphere. There are two main types of boiling: nucleate boiling where small bubbles of vapour form at discrete points, and critical heat flux boiling where the boiling surface is heated above a certain critical temperature and a film of vapor forms on the surface. Transition boiling is an intermediate, unstable form of boiling with elements of both types. The boiling point of water is 100 °C or 212 °F but is lower with the decreased atmospheric pressure found at higher altitudes. Boiling water is used as a method of making it potable by killing microbes and viruses that may be present. The sensitivity of different micro-organisms to heat varies, but if water is held at for one minute, most micro-organisms and viruses are inactivated. Ten mi ...
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Lassen Volcanic National Park
Lassen Volcanic National Park is an American national park in northeastern California. The dominant feature of the park is Lassen Peak, the largest lava dome, plug dome volcano in the world and the southernmost volcano in the Cascade Range. Lassen Volcanic National Park is one of the few areas in the world where all four types of volcano can be found—plug dome, shield volcano, shield, volcanic cone#Cinder cone, cinder cone, and stratovolcano. The source of heat for the volcanism in the Lassen area is subduction of the Gorda Plate diving below the North American Plate off the Northern California coast. The area surrounding Lassen Peak is still active with boiling mud pots, fumaroles, and hot springs. Lassen Volcanic National Park started as two separate U.S. National Monument, national monuments designated by President Theodore Roosevelt in 1907: Cinder Cone National Monument and Lassen Peak National Monument. Starting in May 1914 and lasting until 1917, a series of minor to ...
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Geothermal Areas In Lassen Volcanic National Park
The geothermal areas in Lassen Volcanic National Park include several groups of hot springs and fumaroles, as remnants of former volcanic activity, exist in Lassen Volcanic National Park in northeastern California. Most of these lie in or are closely adjacent to Mount Tehama's caldera. ''Bumpass Hell'' is the most spectacular of these, but others of importance are ''Sulphur Works'', ''Little Hot Springs Valley'', ''Boiling Springs Lake'' and ''Devil's Kitchen''. In each thermal area, the highest temperature of water generally is close to the boiling temperature at the altitude of the particular spring or fumarole — at Bumpass Hell and on the northwest flanks of Lassen Peak.NPS: Lassen Volcanic National Park, Nature & science, Volcanoes / Lava Flows Temperatures as high as have been recorded in the park. Spring activity varies with water supply. Abundant water results in clear springs during early summer, but as the season progresses and the water supply decreases, springs ...
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