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Cantharides
Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. It is a burn agent or a poison in large doses, but preparations containing it were historically used as aphrodisiacs (Spanish fly). In its natural form, cantharidin is secreted by the male blister beetle and given to the female as a copulatory gift during mating. Afterwards, the female beetle covers her eggs with it as a defense against predators. Poisoning from cantharidin is a significant veterinary concern, especially in horses, but it can also be poisonous to humans if taken internally (where the source is usually experimental self-exposure). Externally, cantharidin is a potent vesicant (blistering agent), exposure to which can cause severe chemical burns. Properly dosed and applied, the same properties have also been used therapeutically, for instance for treatment of skin conditions such as molluscum contagiosum infection of the skin. Cantharidi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cantharidin Biosynthesis2
Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. It is a burn agent or a poison in large doses, but preparations containing it were historically used as aphrodisiacs (Spanish fly). In its natural form, cantharidin is secreted by the male blister beetle and given to the female as a copulatory gift during mating. Afterwards, the female beetle covers her eggs with it as a defense against predators. Poisoning from cantharidin is a significant veterinary concern, especially in horses, but it can also be poisonous to humans if taken internally (where the source is usually experimental self-exposure). Externally, cantharidin is a potent vesicant (blistering agent), exposure to which can cause severe chemical burns. Properly dosed and applied, the same properties have also been used therapeutically, for instance for treatment of skin conditions such as molluscum contagiosum infection of the skin. Cantharidi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lytta Vesicatoria
The Spanish fly (''Lytta vesicatoria'') is an aposematic emerald-green beetle in the blister beetle family (Meloidae). It is distributed across Eurasia. The species and others in its family were used in traditional apothecary preparations as "Cantharides". The insect is the source of the terpenoid cantharidin, a toxic blistering agent once used as an exfoliating agent, anti-rheumatic drug and an aphrodisiac. The substance has also found culinary use in some blends of the North African spice mix ''ras el hanout''. Its various supposed benefits have been responsible for accidental poisonings. Etymology and taxonomy The generic name is from the Greek λύττα (''lytta''), meaning martial rage, raging madness, Bacchic frenzy, or rabies. The specific name is derived from Latin ''vesica'', blister. ''Lytta vesicatoria'' was formerly named ''Cantharis vesicatoria'', although the genus ''Cantharis'' is in an unrelated family, Cantharidae, the soldier beetles. It was class ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spanish Fly
The Spanish fly (''Lytta vesicatoria'') is an aposematic emerald-green beetle in the blister beetle family (Meloidae). It is distributed across Eurasia. The species and others in its family were used in traditional apothecary preparations as "Cantharides". The insect is the source of the terpenoid cantharidin, a toxic blistering agent once used as an exfoliating agent, anti-rheumatic drug and an aphrodisiac. The substance has also found culinary use in some blends of the North African spice mix ''ras el hanout''. Its various supposed benefits have been responsible for accidental poisonings. Etymology and taxonomy The generic name is from the Greek λύττα (''lytta''), meaning martial rage, raging madness, Bacchic frenzy, or rabies. The specific name is derived from Latin ''vesica'', blister. ''Lytta vesicatoria'' was formerly named ''Cantharis vesicatoria'', although the genus ''Cantharis'' is in an unrelated family, Cantharidae, the soldier beetles. It was class ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Priapism
Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after stimulation has ended. There are three types: ischemic (low-flow), nonischemic (high-flow), and recurrent ischemic (intermittent). Most cases are ischemic. Ischemic priapism is generally painful while nonischemic priapism is not. In ischemic priapism, most of the penis is hard; however, the glans penis is not. In nonischemic priapism, the entire penis is only somewhat hard. Very rarely, clitoral priapism occurs in women. Sickle cell disease is the most common cause of ischemic priapism. Other causes include medications such as antipsychotics, SSRIs, blood thinners and prostaglandin E1, as well as drugs such as cocaine. Ischemic priapism occurs when blood does not adequately drain from the penis. Nonischemic priapism is typically due to a connection forming between an artery and the corpus cavernosum or disruption of the parasympathetic nervous system resulting in increased ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ether
In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. A typical example of the first group is the solvent and anaesthetic diethyl ether, commonly referred to simply as "ether" (). Ethers are common in organic chemistry and even more prevalent in biochemistry, as they are common linkages in carbohydrates and lignin. Structure and bonding Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hycleus Lugens, Meloidae
''Hycleus'' is a genus of blister beetle belonging to the Meloidae family found in Africa and Asia. The genus contains over 400 species, which historically have been confused with the genus ''Mylabris''. Ecology Adults feed mainly on flowers from a wide range of plant families. The first larval instar is an active triungulin form that is a predator of soft insects such as aphids. While the young are often beneficial to crops by suppressing other plant feeders, the adults can be a problem when present in large numbers. Flower feeding leads to lower yield and this can be a problem in some leguminous crops. They are however easily controlled by manual collection. In northern Nigeria, heavy infestations of '' Hycleus terminatus'', '' Hycleus fimbriatus'', '' Hycleus hermanniae'', and '' Hycleus chevrolati'' have affected early plantings of pearl millet crops. Gallery File:Mylabris pustulata.JPG, Seen in Karnataka File:Orange_Blister_Beetle_(Mylabris_pustulata)_on_Ipomoea_carnea_W2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haemolymph
Hemolymph, or haemolymph, is a fluid, analogous to the blood in vertebrates, that circulates in the interior of the arthropod (invertebrate) body, remaining in direct contact with the animal's tissues. It is composed of a fluid plasma in which hemolymph cells called hemocytes are suspended. In addition to hemocytes, the plasma also contains many chemicals. It is the major tissue type of the open circulatory system characteristic of arthropods (e.g. arachnids, crustaceans and insects). In addition, some non-arthropods such as molluscs possess a hemolymphatic circulatory system. Oxygen-transport systems were long thought unnecessary in insects, but ancestral and functional hemocyanin has been found in the hemolymph. Insect "blood" generally does not carry hemoglobin, although hemoglobin may be present in the tracheal system instead and play some role in respiration. Method of transport In the grasshopper, the closed portion of the system consists of tubular hearts and an aorta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berberomeloe Majalis
''Berberomeloe majalis'', the red-striped oil beetle, is an insect in the genus '' Berberomeloe'', in the family of Blister Beetles. It is native to the western Mediterranean Basin. Description It has a typical length around 5 cm (2 in.). Its large size and the bright red bands around its body make it unmistakable; its coloration is aposematic, reflecting its ability, in common with other oil or blister beetles in the family Meloidae, to squirt a caustic liquid if attacked. In Spain however this beetle varies extensively in color. Populations of entirely black specimens without any red markings are found scattered over much of the distribution range of ''B. majalis''. These populations are often found close to populations consisting of red-striped specimens, but both morphs seem to be spatially segregated and no mixed series have been found in the field. Entirely black and red-striped specimens of ''Berberomeloes majalis'' are equally poisonous. Distribution and habitat T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colorado
Colorado (, other variants) is a state in the Mountain West subregion of the Western United States. It encompasses most of the Southern Rocky Mountains, as well as the northeastern portion of the Colorado Plateau and the western edge of the Great Plains. Colorado is the eighth most extensive and 21st most populous U.S. state. The 2020 United States census enumerated the population of Colorado at 5,773,714, an increase of 14.80% since the 2010 United States census. The region has been inhabited by Native Americans and their ancestors for at least 13,500 years and possibly much longer. The eastern edge of the Rocky Mountains was a major migration route for early peoples who spread throughout the Americas. "''Colorado''" is the Spanish adjective meaning "ruddy", the color of the Fountain Formation outcroppings found up and down the Front Range of the Rocky Mountains. The Territory of Colorado was organized on February 28, 1861, and on August 1, 1876, U.S. President Ulyss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Farnesol
Farnesol is a natural 15-carbon organic compound which is an acyclic sesquiterpene alcohol. Under standard conditions, it is a colorless liquid. It is hydrophobic, and thus insoluble in water, but miscible with oils. Farnesol is produced from 5-carbon isoprene compounds in both plants and animals. Phosphate-activated derivatives of farnesol are the building blocks of possibly all acyclic sesquiterpenoids. These compounds are doubled to form 30-carbon squalene, which is the precursor for steroids in plants, animals, and fungi. Farnesol and its derivatives are important starting compounds for natural and artificial organic synthesis. Uses Farnesol is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam, and tolu. It is used in perfumery to emphasize the odors of sweet, floral perfumes. It enhances perfume scent by acting as a co-solvent that regulates the volatility of the odorants. It is especially used in lilac perfume ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoterpene
Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16. Monoterpenes may be linear (acyclic) or contain rings (monocyclic and bicyclic). Modified terpenes, such as those containing oxygen functionality or missing a methyl group, are called monoterpenoids. Monoterpenes and monoterpenoids are diverse. They have relevance to the pharmaceutical, cosmetic, agricultural, and food industries. Biosynthesis Monoterpenes are derived biosynthetically from units of isopentenyl pyrophosphate, which is formed from acetyl-CoA via the intermediacy of mevalonic acid in the HMG-CoA reductase pathway. An alternative, unrelated biosynthesis pathway of IPP is known in some bacterial groups and the plastids of plants, the so-called MEP-(2-methyl-D-erythritol-4-phosphate) pathway, which is initiated from C5 sugars. In both pathways, IPP is isomerized to DMAPP by the enzyme isopentenyl pyrophosphate isomerase. Geranyl pyrophosphate is the precurso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geranyl Pyrophosphate
Geranyl pyrophosphate (GPP), also known as geranyl diphosphate (GDP), is the pyrophosphate ester of the terpenoid geraniol. Its salts are colorless. It is a precursor to many natural products. Occurrence GPP is an intermediate in the isoprenoid biosynthesis pathway that produces longer prenyl chains such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate as well as many terpenes. It can be prepared in the laboratory from geraniol. Related compounds * Geraniol * Farnesyl pyrophosphate * Geranylgeranyl pyrophosphate See also * Dimethylallyltranstransferase Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyr ... References Further reading *Kulkarni RS, Pandit SS, Chidley HG, Nagel R, Schmidt A, Gershenzon J, Pujari KH, Giri AP and Gupta VS, 2013Characterization of three n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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