Calcium Citrate
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Calcium Citrate
Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive ( E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal or Caltrate). Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass. The tetrahydrate occurs in nature as the mineral Earlandite. In 2020, calcium was the 204th most commonly prescribed medication in the United States, with more than 2million prescriptions. Chemical properties Calcium citrate is sparingly soluble in water. Needle-shaped crystals of tricalcium dicitrate tetrahydrate a3(C6H5O7)2(H2O)2·2H2O were obtained by hydrothermal synthesis. The crystal structure comprises a three-dimensional network in which eightfold coordinated Ca2+ cations are linked by citrate anions and hydrogen bonds between two non-coordinating crystal water molecu ...
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Ethanol
Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an Alcohol (chemistry), alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a hydroxyl group). Ethanol is a Volatility (chemistry), volatile, Combustibility and flammability, flammable, colorless liquid with a characteristic wine-like odor and pungent taste. It is a psychoactive recreational drug, the active ingredient in alcoholic drinks. Ethanol is naturally produced by the fermentation process of Carbohydrate, sugars by yeasts or via Petrochemistry, petrochemical processes such as ethylene hydration. It has medical applications as an antiseptic and disinfectant. It is used as a chemical solvent and in the Chemical synthesis, synthesis of organic compounds, and as a Alcohol fuel, fuel source. Ethanol also can be dehydrated to make ethylene, an important chemical feedstock. As of 2006, world produ ...
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Earlandite
Earlandite, a3(C6H5O7)2(H2O)2·2H2O, is the mineral form of calcium citrate tetrahydrate. It was first reported in 1936 and named after the English microscopist and oceanographer Arthur Earland FRSE. Earlandite occurs as warty fine-grained nodules ca. 1 mm in size in bottom sediments of the Weddell Sea, off Antarctica Antarctica () is Earth's southernmost and least-populated continent. Situated almost entirely south of the Antarctic Circle and surrounded by the Southern Ocean, it contains the geographic South Pole. Antarctica is the fifth-largest contine .... Its crystal symmetry was first assigned as orthorhombic, then as monoclinic, and finally as triclinic. References {{Reflist, refs= Bibliography *Palache, P.; Berman H.; Frondel, C. (1960). "''Dana's System of Mineralogy, Volume II: Halides, Nitrates, Borates, Carbonates, Sulfates, Phosphates, Arsenates, Tungstates, Molybdates, Etc. (Seventh Edition)"'' John Wiley and Sons, Inc., New York, pp. 1105-1106. Calcium ...
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Citrates
Citric acid is an organic compound with the chemical formula HOC(CO2H)(CH2CO2H)2. It is a colorless weak organic acid. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in the metabolism of all aerobic organisms. More than two million tons of citric acid are manufactured every year. It is used widely as an acidifier, as a flavoring, and a chelating agent. A citrate is a derivative of citric acid; that is, the salts, esters, and the polyatomic anion found in solution. An example of the former, a salt is trisodium citrate; an ester is triethyl citrate. When part of a salt, the formula of the citrate anion is written as or . Natural occurrence and industrial production Citric acid occurs in a variety of fruits and vegetables, most notably citrus fruits. Lemons and limes have particularly high concentrations of the acid; it can constitute as much as 8% of the dry weight of these fruits (about 47 g/L in ...
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Dietary Supplement
A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources or that are synthetic in order to increase the quantity of their consumption. The class of nutrient compounds includes vitamins, minerals, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential to life, but are marketed as having a beneficial biological effect, such as plant pigments or polyphenols. Animals can also be a source of supplement ingredients, such as collagen from chickens or fish for example. These are also sold individually and in combination, and may be combined with nutrient ingredients. The European Commission has also established harmonized rules to help insure that food supplements are safe and appropriately labeled. Creating an industry estimated to have a 2020 value of $ ...
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Journal Of The American College Of Nutrition
The American Nutrition Association (ANA) is a 501(c)(3) charitable non-profit organization established to encourage the scientific investigation of nutrition and metabolism. The ANA publishes the ''Journal of the American Nutrition Association'' and hosts scientific conferences in the US and in Europe. Previously known as the American College of Nutrition, in 2019 together with the Board for Certification of Nutrition Specialists, the Center for Nutrition Advocacy, and the American Nutrition Association Foundation, affiliated together as the American Nutrition Association. The four organizations remain legally independent entities but share a single website together. History The American College of Nutrition was founded in 1959 with the stated purpose of enhancing nutrition and metabolism knowledge among physicians and professionals from all disciplines with a common interest in nutrition, and to promote the application of such knowledge to the maintenance of health and treat ...
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Bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via routes other than intravenous, its bioavailability is generally lower than that of intravenous due to intestinal endothelium absorption and first-pass metabolism. Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. AUC is used because AUC is proportional to the dose that has entered the systemic circulation. Bioavailability of a drug is an average value; to take population variability into account, deviation range is shown as ±. To ensure that the drug taker who has poor absorption is dosed appropriately, the bottom value o ...
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Limewater
Limewater is the common name for a saturated aqueous solution of calcium hydroxide. Calcium hydroxide, Ca(OH)2, is sparsely soluble at room temperature in water (1.5 g/L at 25 Â°C). "Pure" (i.e. less than or fully saturated) limewater is clear and colorless, with a slight earthy smell and an astringent/bitter taste. It is basic in nature with a pH of 12.4. Limewater may be prepared by mixing calcium hydroxide (Ca(OH)2) with water and removing excess undissolved solute (e.g. by filtration). When excess calcium hydroxide is added (or when environmental conditions are altered, e.g. when its temperature is raised sufficiently), a milky solution results due to the homogeneous suspension of excess calcium hydroxide. This liquid has been known traditionally as milk of lime. Chemistry An experiment commonly used to demonstrate the interaction of CO2 and Ca(OH)2 is as follows. Resultant carbon dioxide passed through limewater in the right tube, producing a milky solution due ...
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Fermentation
Fermentation is a metabolic process that produces chemical changes in organic substrates through the action of enzymes. In biochemistry, it is narrowly defined as the extraction of energy from carbohydrates in the absence of oxygen. In food production, it may more broadly refer to any process in which the activity of microorganisms brings about a desirable change to a foodstuff or beverage. The science of fermentation is known as zymology. In microorganisms, fermentation is the primary means of producing adenosine triphosphate (ATP) by the degradation of organic nutrients anaerobically. Humans have used fermentation to produce foodstuffs and beverages since the Neolithic age. For example, fermentation is used for preservation in a process that produces lactic acid found in such sour foods as pickled cucumbers, kombucha, kimchi, and yogurt, as well as for producing alcoholic beverages such as wine and beer. Fermentation also occurs within the gastrointestinal tracts of all a ...
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Calcium In Biology
Calcium ions (Ca2+) contribute to the physiology and biochemistry of organisms' cell (biology), cells. They play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in fertilization. Many enzymes require calcium ions as a Cofactor (biochemistry), cofactor, including several of the coagulation factors. Extracellular calcium is also important for maintaining the potential difference across excitable cell cell membrane, membranes, as well as proper bone formation. Plasma calcium levels in mammals are tightly regulated, electronic-book electronic- with bone acting as the major mineral storage site. Calcium ions, Ca2+, are released from bone into the bloodstream under controlled conditions. Calcium is transported through the bloodstream as dissolved ions or bound to proteins such as serum albumin. Parathyroid hormone secreted by the parathyroid gland regulates ...
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Caltrate
Caltrate is a brand name calcium supplement sold by Haleon. The brand was originally owned by Pfizer (formerly Wyeth) and GSK and in Japan by Hisamitsu Pharmaceutical. The Caltrate brand is supplied in many different formulas; calcium carbonate (NOT calcium citrate) is the common ingredient serving as the calcium supplement source. Caltrate contains 600 mg of calcium carbonate as opposed to 200 mg in a typical multivitamin product. Caltrate Plus also contains 800 IU of vitamin D (cholecalciferol), 20 mcg vitamin K1, 50 mg magnesium, 7.5 mg zinc oxide, 1 mg copper Copper is a chemical element with the symbol Cu (from la, cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pinkis ..., and 1.8 mg of manganese (II) sulfate monohydrate. References External linksCaltrate- Official websitePfizer- Official corporate website Haleon {{product ...
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Magnesium Citrate
Magnesium citrate is a magnesium preparation in salt form with citric acid in a 1:1 ratio (1 magnesium atom per citrate molecule). The name "magnesium citrate" is ambiguous and sometimes may refer to other salts such as trimagnesium citrate which has a magnesium:citrate ratio of 3:2. Magnesium citrate is used medicinally as a saline laxative and to completely empty the bowel prior to a major surgery or colonoscopy. It is available without a prescription, both as a generic and under various brand names. It is also used in the pill form as a magnesium dietary supplement. It contains 11.23% magnesium by weight. Compared to trimagnesium citrate, it is much more water-soluble, less alkaline, and contains less magnesium. As a food additive, magnesium citrate is used to regulate acidity and is known as E number E345. Mechanism of action Magnesium citrate works by attracting water through the tissues by a process known as osmosis. Once in the intestine, it can attract enough water ...
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