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Cycloastragenol
Cycloastragenol is a triterpenoid isolated from various legume species in the genus ''Astragalus'' that is purported to have telomerase activation activity. A preliminary ''in vitro'' study on human CD4 and CD8 T cells found that cycloastragenol may moderately increase telomerase activity and inhibit the onset of cellular senescence. History Cycloastragenol was patented by Geron Corporation and sold to Telomerase Activation Sciences in early 2013 who are developing it as a product named TA-65. Bill Andrews of Sierra Sciences has done testing on the anti- aging aspect of TA-65;, as well as Maria Blasco in the journal ''Aging Cell'', finding no increase in murine median or mean lifespan but some physiological anti-aging effects without augmenting cancer incidence. TA sciences was served with a consent order by the Federal Trade Commission for deceptive advertising implying that TA-65 can reverse aging and repair DNA damage. Potential pharmacology Its mode of action is purpo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geron Corporation
Geron Corporation is a biotechnology company located in Foster City, California, Foster City, California, which specializes in developing and commercializing therapeutic products for cancer that inhibit telomerase. Company information Geron, based in Foster City, California, was founded by gerontologist Mary C. West and Michael D. West, now CEO of AgeX Therapeutics. They secured initial venture capital investments in the company from Kleiner Perkins Caufield & Byers and Venrock. The company was incorporated in 1990 and began doing business in 1992. John A. Scarlett was appointed CEO in 2011. The company's Scientific and Clinical Advisory Board has included Nobel laureates James Watson, Gunter Blobel, and Carol Greider, and Leonard Hayflick, known for discovering that human Cell (biology), cells divide for a limited number of times ''in vitro'' (called the Hayflick limit). In 2017, Geron staff received the highest median pay in California, at $500,250. Drug candidates Cancer t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Telomerase
Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly ''Drosophila melanogaster'' lacks telomerase, but instead uses retrotransposons to maintain telomeres. Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′- CCC AA UCCC-5′ in ''Trypanosoma brucei'') which is used as a template when it elongates telomeres. Telomerase is active in gametes and most cancer cells, but is normally absent from, or at very low levels in, most somatic cells. History The existence of a compensatory mechanism for telomere shortening was first found by Soviet biologist Alexey Olovnikov in 1973, who also suggested the telomere hypothe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triterpenoid
Triterpenes are a class of chemical compounds composed of three terpene units with the molecular formula C30H48; they may also be thought of as consisting of six isoprene units. Animals, plants and fungi all produce triterpenes, including squalene, the precursor to all steroids. Structures Triterpenes exist in a great variety of structures. Nearly 200 different skeletons have been identified. These skeletons may be broadly divided according to the number of rings present. In general pentacyclic structures (5 rings) tend to dominate. Squalene is biosynthesized through the head-to-head condensation of two farnesyl pyrophosphate units. This coupling converts a pair of C15 components into a C30 product. Squalene serves as precursor for the formation of many triterpenoids, including bacterial hopanoids and eukaryotic sterols. Triterpenoids By definition triterpenoids are triterpenes that possess heteroatoms, usually oxygen. The terms ''triterpene'' and ''triterpenoid'' ofte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Astragalus
''Astragalus'' is a large genus of over 3,000 species of herbs and small shrubs, belonging to the legume family Fabaceae and the subfamily Faboideae. It is the largest genus of plants in terms of described species. The genus is native to temperate regions of the Northern Hemisphere. Common names include milkvetch (most species), locoweed (in North America, some species) and goat's-thorn ( ''A. gummifer'', ''A. tragacantha''). Some pale-flowered vetches (''Vicia'' spp.) are similar in appearance, but they are more vine-like than ''Astragalus''. Description Most species in the genus have pinnately compound leaves. There are annual and perennial species. The flowers are formed in clusters in a raceme, each flower typical of the legume family, with three types of petals: banner, wings, and keel. The calyx is tubular or bell-shaped. Ecology ''Astragalus'' species are used as food plants by the larvae of some Lepidoptera species including many case-bearing moths of the genus ''Col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T Cell
A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells. T cell differentiation also continues after they have left the thymus. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response. One of these functions is immune-mediated cell death, and it is carried out by two major subtypes: CD8+ "killer" and CD4+ "helper" T cells. (These are named for the presence of the cell surface proteins CD8 or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William H
William is a male given name of Germanic origin.Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxford University Press, 2nd edition, , p. 276. It became very popular in the English language after the Norman conquest of England in 1066,All Things William"Meaning & Origin of the Name"/ref> and remained so throughout the Middle Ages and into the modern era. It is sometimes abbreviated "Wm." Shortened familiar versions in English include Will, Wills, Willy, Willie, Bill, and Billy. A common Irish form is Liam. Scottish diminutives include Wull, Willie or Wullie (as in Oor Wullie or the play ''Douglas''). Female forms are Willa, Willemina, Wilma and Wilhelmina. Etymology William is related to the given name ''Wilhelm'' (cf. Proto-Germanic ᚹᛁᛚᛃᚨᚺᛖᛚᛗᚨᛉ, ''*Wiljahelmaz'' > German ''Wilhelm'' and Old Norse ᚢᛁᛚᛋᛅᚼᛅᛚᛘᛅᛋ, ''Vilhjálmr''). By regular sound changes, the native, inherited English form of the name shoul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sierra Sciences
Sierra Sciences, LLC is a biotechnology company founded by William H. Andrews, former director of molecular biology at Geron Corporation. Andrews founded Sierra Sciences in 1999 in Reno, Nevada with the goal of preventing and/or reversing cellular senescence, and ultimately curing diseases associated with human aging, including the aging process itself. Background In humans, aging is strongly correlated with the length of an individual's telomeres, the repetitive DNA at the ends of each chromosome. Each time a cell in the body divides, its telomeres become shorter. Eventually, telomeres shorten to the point where the cell is unable to divide (the " Hayflick limit"). The enzyme telomerase adds these DNA sequence repeats to the telomere, re-lengthening it. In humans, telomerase is expressed in embryonic stem cells and some other cells, but most somatic cells do not express it. While working at Geron Corporation, Andrews co-discovered the RNA component of human telomerase (" hT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aging
Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes. Reaction time, for example, may slow with age, while memories and general knowledge typically increase. Ageing increases the risk of human diseases such as cancer, Alzheimer's disease, diabetes, cardiovascular disease, stroke and many more. Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. Current ageing theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA ox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maria Blasco
Maria may refer to: People * Mary, mother of Jesus * Maria (given name), a popular given name in many languages Place names Extraterrestrial *170 Maria, a Main belt S-type asteroid discovered in 1877 * Lunar maria (plural of ''mare''), large, dark basaltic plains on Earth's Moon Terrestrial *Maria, Maevatanana, Madagascar * Maria, Quebec, Canada *Maria, Siquijor, the Philippines *María, Spain, in Andalusia *Îles Maria, French Polynesia * María de Huerva, Aragon, Spain * Villa Maria (other) Arts, entertainment, and media Films * ''Maria'' (1947 film), Swedish film * ''Maria'' (1975 film), Swedish film * ''Maria'' (2003 film), Romanian film * ''Maria'' (2019 film), Filipino film * ''Maria'' (2021 film), Canadian film directed by Alec Pronovost * ''Maria'' (Sinhala film), Sri Lankan upcoming film Literature * ''María'' (novel), an 1867 novel by Jorge Isaacs * ''Maria'' (Ukrainian novel), a 1934 novel by the Ukrainian writer Ulas Samchuk * ''Maria'' (play), a 1935 p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aging Cell
''Aging Cell'' is a peer-reviewed open access scientific journal and an official journal of the Anatomical Society. It is published on their behalf by John Wiley & Sons. It was established in 2002 and the editors-in-chief are Peter Adams (Sanford Burnham Prebys Medical Discovery Institute) and Adam Antebi (Max Planck Institute for Biology of Ageing). The journal covers research on all aspects of aging, publishing research articles, reviews, minireviews, and commentaries. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 11.005. References External links * Gerontology journals Molecular and cellular biology journals Wiley ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Federal Trade Commission
The Federal Trade Commission (FTC) is an independent agency of the United States government whose principal mission is the enforcement of civil (non-criminal) antitrust law and the promotion of consumer protection. The FTC shares jurisdiction over federal civil antitrust enforcement with the Department of Justice Antitrust Division. The agency is headquartered in the Federal Trade Commission Building in Washington, DC. The FTC was established in 1914 with the passage of the Federal Trade Commission Act, signed in response to the 19th-century monopolistic trust crisis. Since its inception, the FTC has enforced the provisions of the Clayton Act, a key antitrust statute, as well as the provisions of the FTC Act, et seq. Over time, the FTC has been delegated with the enforcement of additional business regulation statutes and has promulgated a number of regulations (codified in Title 16 of the Code of Federal Regulations). The broad statutory authority granted to the FTC provide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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