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Sierra Sciences
Sierra Sciences, LLC is a biotechnology company founded by William H. Andrews, former director of molecular biology at Geron Corporation. Andrews founded Sierra Sciences in 1999 in Reno, Nevada with the goal of preventing and/or reversing cellular senescence, and ultimately curing diseases associated with human aging, including the aging process itself. Background In humans, aging is strongly correlated with the length of an individual's telomeres, the repetitive DNA at the ends of each chromosome. Each time a cell in the body divides, its telomeres become shorter. Eventually, telomeres shorten to the point where the cell is unable to divide (the " Hayflick limit"). The enzyme telomerase adds these DNA sequence repeats to the telomere, re-lengthening it. In humans, telomerase is expressed in embryonic stem cells and some other cells, but most somatic cells do not express it. While working at Geron Corporation, Andrews co-discovered the RNA component of human telomerase (" hT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Somatic (biology)
The term somatic - etymologically from the Ancient Greek words of "σωματικός" (sōmatikós, “bodily”) and σῶμα (sôma, “body”) - is often used in biology to refer to the cells of the body in contrast to the reproductive (germline) cells, which usually give rise to the egg or sperm (or other gametes in other organisms). These somatic cells are diploid, containing two copies of each chromosome, whereas germ cells are haploid, as they only contain one copy of each chromosome (in preparation for fertilisation). Although under normal circumstances all somatic cells in an organism contain identical DNA, they develop a variety of tissue-specific characteristics. This process is called differentiation, through epigenetic and regulatory alterations. The grouping of similar cells and tissues creates the foundation for organs. Somatic mutations are changes to the genetics of a multicellular organism that are not passed on to its offspring through the germline. Most canc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chief Executive Officer
A chief executive officer (CEO), also known as a central executive officer (CEO), chief administrator officer (CAO) or just chief executive (CE), is one of a number of corporate executives charged with the management of an organization especially an independent legal entity such as a company or nonprofit institution. CEOs find roles in a range of organizations, including public and private corporations, non-profit organizations and even some government organizations (notably state-owned enterprises). The CEO of a corporation or company typically reports to the board of directors and is charged with maximizing the value of the business, which may include maximizing the share price, market share, revenues or another element. In the non-profit and government sector, CEOs typically aim at achieving outcomes related to the organization's mission, usually provided by legislation. CEOs are also frequently assigned the role of main manager of the organization and the highest-ranking offic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Logitech
Logitech International S.A. ( ; often shortened to Logi) is a Swiss multinational manufacturer of computer peripherals and software, with headquarters in Lausanne, Switzerland, and Newark, California. The company has offices throughout Europe, Asia, Oceania, and the Americas, and is one of the world's leading manufacturers of input and interface devices for personal computers (PCs) and other digital products. It is a component of the flagship Swiss Market Index. The company develops and markets personal peripherals for PC navigation, video communication and collaboration, music and smart homes. This includes products like keyboards, mice, tablet accessories, headphones and headsets, webcams, Bluetooth speakers, universal remotes and more. Its name is derived from ''logiciel'', the French word for software. History Logitech was founded in Apples, Vaud, Switzerland, in 1981 by Stanford alumni Daniel Borel and Pierluigi Zappacosta, and former Olivetti engineer Giacomo Marin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chief Operating Officer
A chief operating officer or chief operations officer, also called a COO, is one of the highest-ranking executive positions in an organization, composing part of the "C-suite". The COO is usually the second-in-command at the firm, especially if the highest-ranking executive is the chairperson and CEO. The COO is responsible for the daily operation of the company and its office building and routinely reports to the highest-ranking executive—usually the chief executive officer (CEO). Responsibilities and similar titles Unlike other C-suite positions, which tend to be defined according to commonly designated responsibilities across most companies, a COO's job tends to be defined in relation to the specific CEO with whom they work, given the close working relationship of these two individuals. The selection of a COO is similar in many ways to the selection of a vice president or chief of staff of the United States: power and responsibility structures vary in government and priva ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chair (official)
The chairperson, also chairman, chairwoman or chair, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the group, presides over meetings of the group, and conducts the group's business in an orderly fashion. In some organizations, the chairperson is also known as ''president'' (or other title). In others, where a board appoints a president (or other title), the two terms are used for distinct positions. Also, the chairman term may be used in a neutral manner not directly implying the gender of the holder. Terminology Terms for the office and its holder include ''chair'', ''chairperson'', ''chairman'', ''chairwoman'', ''convenor'', ''facilitator'', '' moderator'', ''president'', and ''presiding officer''. The chairperson of a parliamentary chamber is often called the ''speaker''. ''Chair'' has been used to refer to a seat or office of authority ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digi International
Digi International is an American Industrial Internet of Things (IIoT) technology company headquartered in Hopkins, Minnesota. The company was founded in 1985 and went public as Digi International in 1989. The company initially offered intelligent ISA/ PCI boards (the 'DigiBoard') with multiple asynchronous serial interfaces for PCs. Multi-port serial boards are still sold, but the company focuses on embedded and external network (wired and wireless) communications as well as scalable USB products. The company also sells radio modems and embedded modules based on LTE ( 4G) communications platforms. Acquisition history Digi International has acquired a number of companies since it went public. *2021 Digi acquired Ventus Holdings. *2021 Digi acquired Ctek, a company specializing in remote monitoring and industrial controls. *2021 Digi acquired Haxiot. *2019 Digi acquired Opengear. *2018 Digi acquired Accelerated Concepts, a provider of secure, enterprise-grade, cellular (LT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VisiCorp
VisiCorp was an early personal computer software publisher. Its most famous products were Microchess, Visi On and VisiCalc. It was founded in 1976 by Dan Fylstra and Peter R. Jennings as Personal Software, and first published Jennings' Microchess program for the MOS Technology KIM-1 computer, and later Commodore PET, Apple II, TRS-80 and Atari 8-bit. In 1979 it released VisiCalc, which would be so successful that in 1982 the company was renamed VisiCorp Personal Software, Inc.. :* VisiCalc was the first electronic spreadsheet for personal computers, developed by Software Arts and published by VisiCorp. :* Visi On was the first GUI for the IBM PC. Bill Gates came to see Visi On at a trade show, and this seems what inspired him to create a windowed GUI for Microsoft. VisiCorp was larger than Microsoft at the time, and the two companies entered negotiations to merge, but could not agree on who would sit on the board of directors. Microsoft Windows when it was released included ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dan Fylstra
Dan Fylstra is a pioneer of the software products industry. A graduate of the Massachusetts Institute of Technology, in 1975 he was a founding associate editor of ''Byte'' magazine. In 1978 he co-founded Personal Software, and that year reviewed the Commodore PET 2001 and TRS-80 Model I for ''Byte'' while studying for an MBA at the Harvard Business School, having ordered each almost immediately after release. Personal Software became the distributor of a new program called VisiCalc, the first-ever computer spreadsheet. In his marketing efforts Fylstra ran teaser ads in ''Byte'' that asked, considering electronic spreadsheets were an entirely new product category, "How did you ever do without it?" The VisiCalc-Apple connection suggested the hypothesis of the "killer app"—or the "software tail that wags the hardware dog." Once VisiCalc caught on, people came into computer stores asking for VisiCalc and then also the computer (the Apple II) they would need to run the program. Visi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug
A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insufflation (medicine), inhalation, drug injection, injection, smoking, ingestion, absorption (skin), absorption via a dermal patch, patch on the skin, suppository, or sublingual administration, dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to pharmacotherapy, treat, cure, preventive healthcare, prevent, or medical diagnosis, diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Repressor
In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. A DNA-binding repressor blocks the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes into messenger RNA. An RNA-binding repressor binds to the mRNA and prevents translation of the mRNA into protein. This blocking or reducing of expression is called repression. Function If an inducer, a molecule that initiates the gene expression, is present, then it can interact with the repressor protein and detach it from the operator. RNA polymerase then can transcribe the message (expressing the gene). A co-repressor is a molecule that can bind to the repressor and make it bind to the operator tightly, which decreases transcription. A repressor that binds with a co-repressor is termed an ''aporepressor'' or ''inactive repressor''. One type of aporepressor is the trp repressor, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Telomerase Reverse Transcriptase
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Telomerases are part of a distinct subgroup of RNA-dependent polymerases. Telomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. To be specific, TERT is responsible for catalyzing the addition of nucleotides in a TTAGGG sequence to the ends of a chromosome's telomeres. This addition of repetitive DNA sequences prevents degradation of the chromosomal ends following multiple rounds of replication. hTERT absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat. Function Telomerase is a ribonucleoprotein p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
