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Bufotoxin
Bufotoxins are a family of toxic steroid lactones or substituted Substituted tryptamine, tryptamines of which some are toxic. They occur in the parotoid glands, skin, and poison of many toads (True toad, Bufonidae family) and other amphibians, and in some plants and mushrooms. The exact composition varies greatly with the specific source of the toxin. Composition Bufotoxins can contain 5-MeO-DMT, bufagins, bufalin, bufotalin, bufotenin, bufothionine, dehydrobufotenine, epinephrine, norepinephrine, and serotonin. Some authors have also used the term ''bufotoxin'' to describe the conjugate of a bufagin with suberylarginine. The toxic substances found in toads can be divided by chemical structure in two groups: #bufadienolides, which are cardiac glycosides (e.g., bufotalin, bufogenin), are compounds that may be fatal if consumed. #tryptamine-related substances (e.g., bufotenin), are sought after for entheogenic and/or recreational drug, recreational purposes by some individuals. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HO-DMT
Bufotenin, also known as dimethylserotonin or as 5-hydroxy-''N'',''N''-dimethyltryptamine (5-HO-DMT), is a serotonergic psychedelic of the tryptamine family. It is a derivative of the psychedelic dimethyltryptamine (DMT) and of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). The compound is an alkaloid found in some species of mushrooms, plants, and toads. It is also found naturally in the human body in small amounts. Bufotenin, for instance derived from the trees ''Anadenanthera colubrina'' and ''Anadenanthera peregrina'', has a long history of entheogenic use as a snuff in South America. The name bufotenin originates from the toad genus '' Bufo'', which includes several species of psychoactive toads, most notably '' Incilius alvarius'' (formerly ''Bufo alvarius''), that secrete bufotoxins from their parotoid glands. However, ''Bufo'' and related species like ''Incilius alvarius'' contain only trace amounts of bufotenin, with their major active component instead ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parotoid Gland
The parotoid gland (alternatively, paratoid gland) is an external skin gland on the back, neck, and shoulder of some frogs (especially toads), and salamanders. It can secrete a number of milky alkaloid substances (depending on the species) known collectively as bufotoxins, which act as neurotoxins to deter predation. These cutaneous glands are called parotoid as they are somewhat similarly positioned to mammalian parotid glands, parotid gland, although the latter have a different function, excreting saliva within the mouth rather than externally excreted defensive chemicals. A study of the parotoid glands of the Colorado River toad in 1976 found that the parotoid glands were "composed of numerous Lobe (anatomy), lobules", each of which is a separate unit with a Lumen (anatomy), lumen surrounded by a double cell layer. The cell layers have interlocking microvilli. The study found that the outer cell layer resembled smooth muscle cells, with some organelles hypothesised to "function ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
True Toad
A true toad is any member of the family Bufonidae, in the order Anura (frogs and toads). This is the only family of anurans in which all members are known as toads, although some may be called frogs (such as harlequin frogs). The bufonids now comprise more than 35 genera, '' Bufo'' being the best known. History Bufonidae is thought to have originated in South America. Some studies date the origin of the group to after the breakup of Gondwana, about 78–99 million years ago in the Late Cretaceous. In contrast, other studies have dated the origin of the group to the early Paleocene. The bufonids likely radiated out of South America during the Eocene, with the entire radiation occurring during the Eocene to Oligocene, marking an extremely rapid divergence likely facilitated by the Paleogene's changing climatic conditions. Taxonomy The following phylogeny of most genera in the family is based on Portik and Papenfuss, 2015:, Chan ''et al.'', 2016, Chandramouli ''et al.'', 201 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufagin
Bufagin is a toxic steroid C24H34O5 obtained from toad's milk, the poisonous secretion of a skin gland on the back of the neck of a large toad (''Rhinella marina'', synonym ''Bufo marinus'', the cane toad). The toad produces this secretion when it is injured, scared or provoked. Bufagin resembles chemical substances from digitalis in physiological activity and chemical structure. ''Bufagin'' also refers to any of several similar substances found as components of the mixture bufotoxin in secretions of other toads, as well as plants and mushrooms. History The discovery of bufagin has taken place in the fall of 1910, where John Jacob Abel and David I. Macht are investigating the property of unknown substances from a tropical toad, ''Bufo agua''. They collected the "milky secretion" squirted out of toad’s parotid gland due to the control of the central nervous system while it was strongly irritated. They observed the semifluid substance is quickly dried in the air and formed a yellow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufotalin
Bufotalin is a cardiotoxic bufanolide steroid, cardiac glycoside analogue, secreted by a number of toad species. Bufotalin can be extracted from the skin parotoid glands of several types of toad. Sources '' Rhinella marina'' (Cane toad), '' Rhaebo guttatus'' (Smooth-sided toad), '' Bufo melanostictus'' (Asian toad), and ''Bufo bufo'' (common European toad) are sources of bufotalin. Traditional medicine Bufotalin is part of Ch'an Su, a traditional Chinese medicine used for cancer. It is also known as Venenum Bufonis or senso (Japanese). Toxicity Specifically, in cats the lethal median dose is 0.13 mg/kg."Datasheet: Bufotalin sc-202509" ''Santa Cruz Biotechnology, Inc.''http://datasheets.scbt.com/sc-202509.pdf and in dogs is 0.36 mg/kg (intravenous). Knowing this it is advisable to monitor those functions continuously using an EKG. As there is no antidote against bufotalin all occurring symptoms need to be treated separately or if possible in combination with others. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufotenin
Bufotenin, also known as dimethylserotonin or as 5-hydroxy-''N'',''N''-dimethyltryptamine (5-HO-DMT), is a serotonergic psychedelic of the tryptamine family. It is a derivative of the psychedelic dimethyltryptamine (DMT) and of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). The compound is an alkaloid found in some species of mushrooms, plants, and toads. It is also found naturally in the human body in small amounts. Bufotenin, for instance derived from the trees ''Anadenanthera colubrina'' and ''Anadenanthera peregrina'', has a long history of entheogenic use as a snuff in South America. The name bufotenin originates from the toad genus '' Bufo'', which includes several species of psychoactive toads, most notably '' Incilius alvarius'' (formerly ''Bufo alvarius''), that secrete bufotoxins from their parotoid glands. However, ''Bufo'' and related species like ''Incilius alvarius'' contain only trace amounts of bufotenin, with their major active component instead ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bufothionine
Bufothionine is a sulfur-containing compound which is present in the bufotoxins secreted by the parotoid gland of certain toads of the genera ''Bufo'' and '' Chaunus''. This specific compound can be found in the skin of certain species of toad such as the Asiatic Toad, '' Chaunus arunco'', '' Chaunus crucifer'', '' Chaunus spinulosus'', and '' Chaunus arenarum''. Research In ancient times, cinobufacini, which is extracted from the skin and the parotid venom glands of toad of the bufo genus was used to treat symptoms like swelling and pain. In the present time, cinobufacinin injections are used to achieve satisfactory effect on Hepatocellular carcinoma (HCC) in China. Bufothionine is a major active component of cinobufacini. Bufothionine has been shown to suppress growth of cancerous liver cells ''in vitro'' . In vivo, bufothionine has also been showing relieved symptoms and anti inflammatory activities in tumor bearing mice. Experiments were conducted in which cultured cancer c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroid
A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signal transduction, signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in Fungus, fungi, plants, and animals. All steroids are manufactured in cells from a sterols, sterol: Cholesterol, cholesterol (animals), lanosterol (opisthokonts), or cycloartenol (plants). All three of these molecules are produced via Cyclic compound, cyclization of the triterpene squalene. Structure The steroid nucleus (parent structure, core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Entheogen
Entheogens are psychoactive substances used in spiritual and religious contexts to induce altered states of consciousness. Hallucinogens such as the psilocybin found in so-called "magic" mushrooms have been used in sacred contexts since ancient times. Derived from a term meaning "generating the divine from within" entheogen have been used to facilitate transcendence, heaving, divination and mystical insight. Entheogens have been used in various ways, including as part of established religious rituals and as aids for personal spiritual development. Anthropological study has established that entheogens are used for religious, magical, shamanic, or spiritual purposes in many parts of the world. Civilizations such as the Maya and Aztecs used psilocybin mushrooms, peyote, and morning glory seeds in ceremonies meant to connect with deities and perform healing. They have traditionally been used to supplement many diverse practices geared towards achieving transcendence, including ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recreational Drug
Recreational drug use is the use of one or more psychoactive drugs to induce an altered state of consciousness, either for pleasure or for some other casual purpose or pastime. When a psychoactive drug enters the user's body, it induces an Substance intoxication, intoxicating effect. Recreational drugs are commonly divided into three categories: depressants (drugs that induce a feeling of relaxation and calmness), stimulants (drugs that induce a sense of energy and alertness), and hallucinogens (drugs that induce perceptual distortions such as hallucination). In popular practice, recreational drug use is generally tolerated as a social behaviour, rather than perceived as the medical condition of self-medication. However, drug use and drug addiction are Social stigma, severely stigmatized everywhere in the world. Many people also use prescribed and controlled depressants such as opioids, opiates, and benzodiazepines. What controlled substances are considered generally unlawful t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Responsible Drug Use
Responsible drug use seeks to maximize the benefits and minimize the risks associated with psychoactive drug use. For illegal psychoactive drugs that are not diverted prescription controlled substances, some critics believe that illegal recreational drug use is inherently irresponsible, due to the unpredictable and unmonitored strength and purity of the drugs and the risks of Substance use disorder, addiction, infection, and other side effects. Nevertheless, harm reduction advocates claim that the user can be responsible by employing the same general principles applicable to the use of alcohol (drug), alcohol: avoiding hazardous situations, excessive doses, and hazardous combinations of drugs; avoiding injection; and not using drugs at the same time as activities that may be unsafe without a sober state. Drug use can be thought of as an activity that is potentially beneficial but also potentially risky. Similar to other risky activities such as skydiving or mountain climbing, the va ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
