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Antitoxin
An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacterium, bacteria in response to toxin exposure. Although they are most effective in neutralizing toxins, they can also kill bacteria and other microorganisms. Antitoxins are made within organisms, and can be injected into other organisms, including humans, to treat an infectious disease. This procedure involves injecting an animal with a safe amount of a particular toxin. The animal's body then makes the antitoxin needed to neutralize the toxin. Later, blood is withdrawn from the animal. When the antitoxin is obtained from the blood, it is purified and injected into a human or other animal, inducing temporary passive immunity. To prevent serum sickness, it is often best to use an antitoxin obtained from the same species (e.g. use human antitoxin to treat humans). Most antitoxin preparations are prepared from donors with high titers of antibody ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxin-antitoxin System
A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that Mendelian inheritance, inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable cell division, antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' Hok/sok system, (PSK). Toxin-antitoxin systems are typically classified according to how the antitoxin neutralises the toxin. In a type I toxin-antitoxin system, the translation (genetics), translation of mRNA, messenger RNA (mRNA) that encodes the toxin is inhibited by the binding ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antitoxin Diphtheria
An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria in response to toxin exposure. Although they are most effective in neutralizing toxins, they can also kill bacteria and other microorganisms. Antitoxins are made within organisms, and can be injected into other organisms, including humans, to treat an infectious disease. This procedure involves injecting an animal with a safe amount of a particular toxin. The animal's body then makes the antitoxin needed to neutralize the toxin. Later, blood is withdrawn from the animal. When the antitoxin is obtained from the blood, it is purified and injected into a human or other animal, inducing temporary passive immunity. To prevent serum sickness, it is often best to use an antitoxin obtained from the same species (e.g. use human antitoxin to treat humans). Most antitoxin preparations are prepared from donors with high titers of antibody against th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diphtheria Antitoxin
Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer recommended for prevention of diphtheria. It is administered through injection into a vein or muscle. Side effects are common. They include serum sickness and allergic reactions including anaphylaxis. Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by neutralizing the toxins produced by ''Corynebacterium diphtheriae''. Diphtheria antitoxin was developed and came into medical use in the late 1800s. The 1901 diphtheria antitoxin contamination incident, in which the milk wagon horse used to culture the antitoxin became infected with tetanus, which contaminated vials of the antitoxin leading to the deaths of several children in the midwest United States, led to the passage of the Biologics Control Act of 1902 and the 1906 formation of the U.S. Food and Drug Administration (FDA). The cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Passive Immunity
In immunology, passive immunity is the transfer of active humoral immunity of ready-made antibodies. Passive immunity can occur naturally, when maternal antibodies are transferred to the fetus through the placenta, and it can also be induced artificially, when high levels of antibodies specific to a pathogen or toxin (obtained from humans, horses, or other animals) are transferred to non- immune persons through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. Passive immunization is used when there is a high risk of infection and insufficient time for the body to develop its own immune response, or to reduce the symptoms of ongoing or immunosuppressive diseases. Passive immunization can be provided when people cannot synthesize antibodies, and when they have been exposed to a disease that they do not have immunity against. Naturally acquired Maternal passive immunity Maternal passive immunity is a type of naturally acquired passiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serum Sickness
Serum sickness in humans is a adverse drug reaction, reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, Arthralgia, joint pain, fever, and lymphadenopathy. It is a type of hypersensitivity, specifically immune complex hypersensitivity (Type III hypersensitivity, type III). The term serum sickness–like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances, such as penicillin. Serum sickness may be diagnosed based on the symptoms, and using a blood test and a Clinical urine tests, urine test. It may be prevented by not using an antitoxin derived from animal serum, and through prophylactic antihistamines or corticosteroids. It usually resolves naturally, but may be treated with corticosteroids, antihistamines, Analgesic, analgesics, and (in severe cases) prednisone. It was first characterized in 1906. Signs and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emil Adolf Von Behring
Emil von Behring (; Emil Adolf von Behring: born Emil Adolf Behring; 15 March 1854 – 31 March 1917), was a German physiologist who received the 1901 Nobel Prize in Physiology or Medicine, the first one awarded in that field, for his discovery of a diphtheria antitoxin. He was widely known as a "saviour of children", as diphtheria used to be a major cause of child death. His work with the disease, as well as tetanus, has come to bring him most of his fame and acknowledgment. He was honoured with Prussian nobility in 1901, henceforth being known by the surname "von Behring". Biography Behring was born in Hansdorf, Kreis Rosenberg, Province of Prussia (now Ławice, Iława County, Poland). His father was a schoolmaster; the family had 13 children. Between 1874 and 1878, Behring studied medicine at the Kaiser-Wilhelm-Akademie in Berlin, an academy for military doctors, since his family could not afford the university. As a military doctor, he studied the action of iodoform. Due ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kitasato Shibasaburō
Baron was a Japanese physician and bacteriologist. He is remembered as the co-discoverer of the infectious agent of bubonic plague in Hong Kong during an outbreak in 1894, almost simultaneously with Alexandre Yersin. Kitasato was nominated for the first annual Nobel Prize in Physiology or Medicine in 1901. Kitasato and Emil von Behring, working together in Berlin in 1890, announced the discovery of diphtheria antitoxin serum. Von Behring was awarded the 1901 Nobel Prize because of this work, but Kitasato was not. Biography Kitasato was born in Okuni village, Higo Province, (present-day Oguni Town, Kumamoto Prefecture, Kyūshū), the son of Kitasato Korenobu, a village head, and Tei, the daughter of a samurai. His parents were strict about his education and sent him to a relative's home and requested rigid discipline. He is said to have inherited his leadership qualities from his mother. He was educated at Kumamoto Medical School and a predecessor of Tokyo Imperial U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gladys Dick
Gladys Rowena Henry Dick (December 18, 1881 – August 21, 1963) was an American physician who co-developed an antitoxin and vaccine for scarlet fever with her husband, George F. Dick. Biography Gladys Rowena Henry was born in Pawnee City, Nebraska in 1881 and earned her B.S. in zoology from the University of Nebraska–Lincoln in 1900. She was a member of the Pi Beta Phi chapter at the University of Nebraska. Because her mother initially objected to Gladys attending medical school, she took graduate classes at Nebraska until 1903, then moved to Baltimore to attend Johns Hopkins University School of Medicine. Graduating in 1907 with her M.D., she then trained for a year at the University of Berlin. Dick's years at Johns Hopkins and Berlin "marked her introduction to biomedical research" and provided opportunities to study experimental cardiac surgery and blood chemistry with Harvey Cushing, W.G. MacCallum, and Milton Winternitz. Dick moved to Chicago in 1911 and contra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annie Homer
Annie Homer (12 March 1882 – 1 January 1953) was a biochemist at Newnham College, Cambridge, University of Toronto and the Lister Institute. She developed improved methods for large-scale production of antitoxin sera during World War I. Personal life and education Annie Homer was born at West Bromwich, UK, on 3 December 1882. Her parents were Joseph and Keziah (née Skidmore) Homer. After attending King Edward VI High School for Girls in Birmingham, Homer went in 1905 to Newnham College of the University of Cambridge to study chemistry. She took the Natural Sciences Tripos in 1904 and 1905, gaining Class I, chemistry, Part II but women were not awarded degrees by this university at that time. However, she was able to obtain an MA degree from Trinity College, Dublin based on her Cambridge studies. She was awarded a DSc by Trinity College in 1913 based on research she undertook at Newnham College. She died 1 January 1953. Career From 1909 - 1914 Homer was at Newnham College, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiserum
In immunology, antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation ( plasmapheresis). For example, convalescent serum, or passive antibody transfusion from a previous human survivor, was the only known effective treatment for Ebola infection with a high success rate of 7 out of 8 patients surviving. Antisera are widely used in diagnostic virology laboratories. The most common use of antiserum in humans is as antitoxin or antivenom to treat envenomation. Serum therapy, also known as serotherapy, describes the treatment of infectious diseases using the serum of animals that have been immunized against the specific organism or components of that organism that is causing the infection. History In 1890, Emil von Behring and Kitasato Shibasaburō published their first paper on serum therapy. Behring pioneered the technique, using guinea pigs to produce serum. Based ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scarlet Fever Serum
Scarlet fever serum was used beginning in November 1900 after its development in the Sero-Therapeutic Laboratory of Rudolph Hospital in Vienna, Austria. The serum was taken from the blood of horses. Infected children were injected in their abdominal skin by Dr. Paul Moser. Mortality rates from scarlet fever (also known as scarlatina) declined significantly following the use of the blood serum. Moser at first used scarlet fever serum primarily on the most severely sick persons. After achieving positive results it was applied in the first or second day following contraction of scarlet fever. In many cases the children treated demonstrated great improvement in a very short time, with their fevers going away quickly. Moser worked with four hundred children suffering from scarlatina at St. Anne's Hospital. The mortality rate of those he treated was 8.9%. This compared quite favorably when measured against the 13.09% among children in Vienna hospitals where the scarlet fever serum was no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serum Therapy
In immunology, antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation ( plasmapheresis). For example, convalescent serum, or passive antibody transfusion from a previous human survivor, was the only known effective treatment for Ebola infection with a high success rate of 7 out of 8 patients surviving. Antisera are widely used in diagnostic virology laboratories. The most common use of antiserum in humans is as antitoxin or antivenom to treat envenomation. Serum therapy, also known as serotherapy, describes the treatment of infectious diseases using the serum of animals that have been immunized against the specific organism or components of that organism that is causing the infection. History In 1890, Emil von Behring and Kitasato Shibasaburō published their first paper on serum therapy. Behring pioneered the technique, using guinea pigs to produce serum. Based on hi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
