Ageliferin
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Ageliferin
Ageliferin is a chemical compound produced by some sponges. It was first isolated from Caribbean and then Okinawan marine sponges in the genus ''Agelas''. It often co-exists with the related compound sceptrin and other similar compounds. It has antibacterial properties and can cause biofilms to dissolve. See also * ''Agelas clathrodes'' * ''Agelas conifera ''Agelas conifera'', also known as the brown tube sponge, is a species of sponge. Its color is brown, tan, or greyish brown with a lighter interior. It is common in the Caribbean and Bahamas, and occasional in Florida. ''Agelas conifera'' contain ...'' References {{Alkaloid-stub Halogen-containing alkaloids Organobromides Pyrroles Benzimidazoles Carboxamides ...
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Sponge
Sponges, the members of the phylum Porifera (; meaning 'pore bearer'), are a basal animal clade as a sister of the diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through them, consisting of jelly-like mesohyl sandwiched between two thin layers of cells. Sponges have unspecialized cells that can transform into other types and that often migrate between the main cell layers and the mesohyl in the process. Sponges do not have nervous, digestive or circulatory systems. Instead, most rely on maintaining a constant water flow through their bodies to obtain food and oxygen and to remove wastes. Sponges were first to branch off the evolutionary tree from the last common ancestor of all animals, making them the sister group of all other animals. Etymology The term ''sponge'' derives from the Ancient Greek word ( 'sponge'). Overview Sponges are similar to other animals in that they are multicellular, he ...
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Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken and/or new bonds formed. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, using the s ...
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Agelas
''Agelas'' is a genus of sea sponge in the class Demospongiae. Ecology and distribution Members of this genus are filter feeders. and occur in the West Indies, the Mediterranean Sea, the Red Sea and the Indian Ocean in shallow tropical and subtropical waters down to a depth of or exceptionally . Spicules Some authorities report that the spongin fibres contain no coring spicules Spicules are any of various small needle-like anatomical structures occurring in organisms Spicule may also refer to: *Spicule (sponge), small skeletal elements of sea sponges *Spicule (nematode), reproductive structures found in male nematodes ( ... while others report that there are some of variable length. Fernando Parra-Velandia however, describing the Caribbean species in the group, writes that "The presence of verticillated acanthostyle spicules and a fibroreticulate skeleton of spongin fibres cored and/or echinated by spicules characterize this group." Species The World Register of Marine Speci ...
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Sceptrin
Sceptrin is a bioactive marine isolate. It has been isolated from the marine sponge ''Agelas conifera'' and appears to have affinity for the bacterial actin equivalent MreB. As such, this compound possess antibiotic potential. See also * Ageliferin * Prokaryotic cytoskeleton The prokaryotic cytoskeleton is the collective name for all structural filaments in prokaryotes. It was once thought that prokaryotic cells did not possess cytoskeletons, but advances in visualization technology and structure determination led t ... References Imidazoles Bromoarenes Halogen-containing natural products Cyclobutanes Antibiotics Carboxamides {{Antibiotic-stub ...
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Biofilm
A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. These adherent cells become embedded within a slimy extracellular matrix that is composed of extracellular polymeric substances (EPSs). The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides, proteins, lipids and DNA. Because they have three-dimensional structure and represent a community lifestyle for microorganisms, they have been metaphorically described as "cities for microbes". Biofilms may form on living or non-living surfaces and can be prevalent in natural, industrial, and hospital settings. They may constitute a microbiome or be a portion of it. The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. Biofilms can form ...
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Agelas Clathrodes
''Agelas clathrodes'', also known as the orange elephant ear sponge, is a species of sea sponge. It lives on reefs in the Caribbean, usually more than below the surface of the ocean. It takes various forms, and its color is reddish orange. Description The orange elephant ear sponge is very variable in form. It may be encrusting, developing a thickness up to thick or have large, flabby lobes or be fan-, tube- or ridge-shaped. Large specimens may combine several of these forms. The surfaces are perforated by small holes, both circular and irregularly elongate, especially on the side away from the current. The flesh is tough, firm and resilient and the thick surface skin is rough to the touch. The colour can vary from yellow, through orange to brick red or brown. This sponge can be confused with ''Agelas citrina'' but that species is usually pinkish or creamy yellow. Another similar species is ''Agelas sventres'' but that has round holes on the exposed side, each with a noticea ...
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Agelas Conifera
''Agelas conifera'', also known as the brown tube sponge, is a species of sponge. Its color is brown, tan, or greyish brown with a lighter interior. It is common in the Caribbean and Bahamas, and occasional in Florida. ''Agelas conifera'' contains bromopyrrole alkaloids, notably sceptrin and oroidin, and levels of these feeding-deterrents increase upon predation. Related species *Agelas clathrodes ''Agelas clathrodes'', also known as the orange elephant ear sponge, is a species of sea sponge. It lives on reefs in the Caribbean, usually more than below the surface of the ocean. It takes various forms, and its color is reddish orange. Desc ... References Agelasida {{Demosponge-stub ...
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Organobromides
Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. The most pervasive is the naturally produced bromomethane. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. General properties Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Carbon–halogen bond strengths, or bond dissociation energies are of 115, 83.7, 72.1, and 57.6 kc ...
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Pyrroles
Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4 H4 NH. It is a colorless volatile liquid that darkens readily upon exposure to air. Substituted derivatives are also called pyrroles, e.g., ''N''-methylpyrrole, C4H4NCH3. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme. Pyrroles are components of more complex macrocycles, including the porphyrinogens and products derived therefrom, including porphyrins of heme, the chlorins, bacteriochlorins, and chlorophylls. Properties Pyrrole is a colorless volatile liquid that darkens readily upon exposure to air, and is usually purified by distillation immediately before use. Pyrrole has a nutty odor. Pyrrole is a 5-membered aromatic heterocycle, like furan and thiophene. Unlike furan and thiophene, it has a dipole in which the positive end lies on the side of the heteroatom, with a dipole moment of 1.58  D. In CDCl3, it has chemi ...
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Benzimidazoles
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a colorless solid. Preparation Benzimidazole is produced by condensation of o-phenylenediamine with formic acid,. or the equivalent trimethyl orthoformate: :C6H4(NH2)2 + HC(OCH3)3 → C6H4N(NH)CH + 3 CH3OH 2-substituted derivatives are obtained when the condensation is conducted with aldehydes in place of formic acid, followed by oxidation.Robert A. Smiley "Phenylene- and Toluenediamines" in Ullmann's Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. Reactions Benzimidazole is a base: :C6H4N(NH)CH + H+ → 6H4(NH)2CHsup>+ It can also be deprotonated with stronger bases: :C6H4N(NH)CH + LiH → Li 6H4N2CH + H2 The imine can be alkylated and also serves as a ligand in coordination chemistry. The most prominent benzimidazole complex features ''N''-ribosyl-dimethylbenzimidazole as foun ...
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