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Zwikker Test
The Zwikker reagent is used as a simple spot-test to presumptively identify barbiturates. It is composed of a mixture of two solutions. Part A is 0.5 g of copper (II) sulfate in 100 ml of distilled water. Part B consists of 5% pyridine (v/v) in chloroform. One drop of each is added to the substance to be tested and any change in colour is observed. The test turns phenobarbital, pentobarbital and secobarbital light purple. Tea and tobacco turn yellow-green. The test's lack of specificity and tendency to produce false positives means it is not widely used for presumptive drug testing, although it does still play a role as a thin layer chromatography stain. It is named after the Dutch scientist Cornelis Zwikker. See also * Drug checking * Marquis reagent * Froehde's reagent * Dille–Koppanyi reagent References Chemical tests Analytical reagents Drug testing reagents {{chem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbiturates
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects. They have been used recreationally for their anxiolytic and sedative effects, and are thus controlled in most countries due to the risks associated with such use. Barbiturates have largely been replaced by benzodiazepines and nonbenzodiazepines ("Z-drugs") in routine medical practice, particularly in the treatment of anxiety disorders and insomnia, because of the significantly lower risk of overdose, and the lack of an antidote for barbiturate overdose. Despite this, barbiturates are still in use for various purposes: in general anesthesia, epilepsy, treatment of acute migraines or cluster headaches, acute tension headaches, euthanasia, capital punishment, and assisted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Copper (II) Sulfate
Copper(II) sulfate, also known as copper sulphate, is an inorganic compound with the chemical formula . It forms hydrates , where ''n'' can range from 1 to 7. The pentahydrate (''n'' = 5), a bright blue crystal, is the most commonly encountered hydrate of copper(II) sulfate. Older names for the pentahydrate include blue vitriol, bluestone, vitriol of copper,Antoine-François de Fourcroy, tr. by Robert Heron (1796) "Elements of Chemistry, and Natural History: To which is Prefixed the Philosophy of Chemistry". J. Murray and others, Edinburgh. Page 348. and Roman vitriol.Oxford University Press,Roman vitriol, Oxford Living Dictionaries. Accessed on 2016-11-13 It exothermically dissolves in water to give the aquo complex , which has octahedral molecular geometry. The structure of the solid pentahydrate reveals a polymeric structure wherein copper is again octahedral but bound to four water ligands. The centers are interconnected by sulfate anions to form chains. Anhydrous copper sulfa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Distilled Water
Distilled water is water that has been boiled into vapor and condensed back into liquid in a separate container. Impurities in the original water that do not boil below or near the boiling point of water remain in the original container. Thus, distilled water is a type of purified water. History Drinking water has been distilled from seawater since at least about AD 200, when the process was clearly described by Alexander of Aphrodisias. Its history predates this, as a passage in Aristotle's ''Meteorologica'' refers to the distillation of water. Captain Israel Williams of the ''Friendship'' (1797) improvised a way to distill water, which he described in his journal. Applications In chemical and biological laboratories, as well as in industry, in some appliances deionised water can be used instead of distilled water as a cheaper alternative. If exceptionally high-purity water is required, double distilled water is used. In general, non-purified water could cause or interfere wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyridine
Pyridine is a basic heterocyclic organic compound with the chemical formula . It is structurally related to benzene, with one methine group replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Pyridine is colorless, but older or impure samples can appear yellow, due to the formation of extended, unsaturated polymeric chains, which show significant electrical conductivity. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. As of 2016, it is synthesized on the scale of about 20,000 tons per year worldwide. Properties Physical properties The molecular electric dipole moment is 2.2 debyes. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenobarbital
Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of epilepsy in developing countries. In the developed world, it is commonly used to treat seizures in young children, while other medications are generally used in older children and adults. In developed countries it is used for veterinary purposes. It may be used intravenously, injected into a muscle, or taken by mouth. The injectable form may be used to treat status epilepticus. Phenobarbital is occasionally used to treat trouble sleeping, anxiety, and drug withdrawal and to help with surgery. It usually begins working within five minutes when used intravenously and half an hour when administered by mouth. Its effects last for between four hours and two days. Side effects include a decreased level of consciousness along with a decreased ef ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pentobarbital
Pentobarbital (previously known as pentobarbitone in Britain and Australia) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies. It can also be used for short-term treatment of insomnia but has been largely replaced by the benzodiazepine family of drugs. In high doses, pentobarbital causes death by respiratory arrest. It is used for veterinary euthanasia and is used by some U.S. states and the U.S. federal government for executions of convicted criminals by lethal injection. In some countries and states, it is also used for physician-assisted suicide. Pentobarbital was widely abused and sometimes known as "yellow jackets" due to the yellow capsule of the Nembutal brand. Pentobarbital in oral (pill) form is no longer commercially available. Uses Medical Typical applications for pentobarbital are sedative, short term hypnotic, preanesthetic, insomnia treatment, and control of convulsions in emergencies. Abbott P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secobarbital
Secobarbital (as the sodium salt, originally marketed by Eli Lilly and Company for the treatment of insomnia, and subsequently by other companies as described below, under the brand name Seconal) is a short-acting barbiturate derivative drug that was patented in 1934 in the United States. It possesses anaesthetic, anticonvulsant, anxiolytic, sedative, and hypnotic properties. In the United Kingdom, it was known as quinalbarbitone. It is the most frequently used drug in physician-assisted suicide within the United States. Secobarbital is considered to be an obsolete sedative-hypnotic (sleeping pill), and as a result, it has largely been replaced by the benzodiazepine family. Seconal was widely abused, known on the street as "red devils" or "reds". Indications Secobarbital is indicated for: *Treatment of epilepsy *Temporary treatment of insomnia *Use as a preoperative medication to produce anaesthesia and anxiolysis in short surgical, diagnostic, or therapeutic procedures which are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thin Layer Chromatography
Thin-layer chromatography (TLC) is a chromatography technique used to separate non-volatile mixtures. Thin-layer chromatography is performed on a sheet of an inert substrate such as glass, plastic, or aluminium foil, which is coated with a thin layer of adsorbent material, usually silica gel, aluminium oxide (alumina), or cellulose. This layer of adsorbent is known as the stationary phase. After the sample has been applied on the plate, a solvent or solvent mixture (known as the mobile phase) is drawn up the plate via capillary action. Because different analytes ascend the TLC plate at different rates, separation is achieved. It may be performed on the analytical scale as a means of monitoring the progress of a reaction, or on the preparative scale to purify small amounts of a compound. TLC is an analytical tool widely used because of its simplicity, relative low cost, high sensitivity, and speed of separation. TLC functions on the same principle as all chromatography: a com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornelis Zwikker
Cornelis Zwikker (19 August 1900 – 20 April 1985) was a Dutch scientist.Biography by H. K. Nagtegaal. (in Dutch) Zwikker was born in as the son of Klaartje Dil and the shopkeeper Klaas Cornelisz Zwikker. He married Johanna Dorothea Theinert (*1901, Zaandam) in 1924 in Zaandam. In 1918 he had started studying chemistry and later physics at the , where in 1925 he obtained his PhD with the thesis "Physical properties of [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Checking
Drug checking or pill testing is a way to reduce the harm from drug consumption by allowing users to find out the content and purity of substances that they intend to consume. This empowers users to make safer choices: to avoid more dangerous substances, to use smaller quantities, and to avoid dangerous combinations. Drug checking services have developed over the last twenty-five years in twenty countries and are being considered in more countries, although attempts to implement them in some countries have been hindered by local laws. Drug checking initially focused on MDMA users in electronic dance music events but the services have broadened as drug use has become more complex. These developments have been strongly affected by local laws and culture, resulting in a diverse range of services, both for mobile services that attend events and festivals and fixed sites in town centres and entertainment districts. For instance, staff may or may not be able to handle illegal substances, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marquis Reagent
Marquis reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of formaldehyde and concentrated sulfuric acid, which is dripped onto the substance being tested. The United States Department of Justice method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 5 mL of 40% formaldehyde. Different compounds produce different color reactions. Methanol may be added to slow down the reaction process to allow better observation of the colour change. It was first discovered in 1896Toxicology. Volume 2 : mechanisms and analytical methods — New York, New York ; San Francisco, California : Academic Press, 1961 — p. 247. and described by the Russian (Estonian) pharmacologist, [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Froehde's Reagent
The Froehde reagent is used as a simple spot-test to presumptively identify alkaloids, especially opioids, as well as other compounds. It is composed of a mixture of molybdic acid or a molybdate salt dissolved in hot, concentrated sulfuric acid, which is then dripped onto the substance being tested. The United States Department of Justice method for producing the reagent is the addition of 100 ml of hot, concentrated (95–98%) sulfuric acid to 0.5 g of sodium molybdate or molybdic acid. The Virginia Department of Forensic Science method uses 0.5 g ammonium molybdate per 100 ml H2SO4 (conc.) Unheated sulfuric acid can be used to prepare the reagent in a less dangerous manner, but 2–4 hours must be allowed for the molybdate to dissolve. See also *Reagent testing *Drug checking *Dille–Koppanyi reagent *Folin's reagent *Liebermann reagent *Mandelin reagent *Marquis reagent *Mecke reagent *Simon's reagent *Zwikker reagent The Zwikker reagent is used as a simple spot-test to pre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
