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Xellia
Xellia ApS is a Danish multinational pharmaceutical and life sciences company headquartered in Copenhagen specialized in the production of anti-biotics, including Vancomycin and Bacitracin. The company's US base of operations is in Buffalo Grove, Illinois, with additional facilities in Ohio, and North Carolina. In 2018, Xellia's sales in the United States accounted for 60% of its total revenue. Products The company's main output is bulk drug chemicals which are wholesaled to other companies for packaging and distribution. Recently some prepackaged goods have been produced. Active drug substances manufactured are:produktet listen er hentet frApi på xellia.com 15. august 2014 og supplert med informasjon frVår arv hentes samme dag Discontinued products Previously the company also produced: Partnerships In 2019, Xellia partnered with Civica Rx to produce generic Vancomycin and Daptomycin. The partnership's stated aim is to remedy chronic drug shortages that have affec ...
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Colistin
Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as ''Pseudomonas aeruginosa'', ''Klebsiella pneumoniae'', or ''Acinetobacter''. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015. Common side effects of the injectable form include kidn ...
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Aktieselskab
''Aktieselskab'' (; Abbreviation, abbr.: A/S, or a/s, Unicode ; literally meaning: "stock company") is the Denmark, Danish name for a stock-based corporation. An ''aktieselskab'' may be either publicly traded or private. Liability The shareholders of an ''aktieselskab'' are not liable for the debts of the company. This can be used to protect the assets of the company against creditors by forming a group of companies. If an A/S is owned by a holding company (typically another A/S), the profit from the production company can be transferred to the holding company. Since there is no liability for the owners of an A/S, creditors from the production company will not be able to claim the profit in case of bankruptcy. Professional creditors, such as banks, protect themselves from this by demanding that the holding company guarantees the debts of the production company. Formation of an ''aktieselskab'' The formation of an ''aktieselskab'' requires a number of steps, including the followi ...
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ATC Code J01X
J01A Tetracyclines J01AA Tetracyclines :J01AA01 Demeclocycline :J01AA02 Doxycycline :J01AA03 Chlortetracycline :J01AA04 Lymecycline :J01AA05 Metacycline :J01AA06 Oxytetracycline :J01AA07 Tetracycline :J01AA08 Minocycline :J01AA09 Rolitetracycline :J01AA10 Penimepicycline :J01AA11 Clomocycline :J01AA12 Tigecycline :J01AA13 Eravacycline :J01AA14 Sarecycline :J01AA15 Omadacycline :J01AA20 Combinations of tetracyclines :QJ01AA53 Chlortetracycline, combinations :J01AA56 Oxytetracycline, combinations J01B Amphenicols J01BA Amphenicols :J01BA01 Chloramphenicol :J01BA02 Thiamphenicol :J01BA52 Thiamphenicol, combinations :QJ01BA90 Florfenicol :QJ01BA99 Amphenicols, combinations J01C Beta-lactam antibacterials, penicillins J01CA Penicillins with extended spectrum :J01CA01 Ampicillin :J01CA02 Pivampicillin :J01CA03 Carbenicillin :J01CA04 Amoxicillin :J01CA05 Carindacillin :J01CA06 Bacampicillin :J01CA07 Epicillin :J01CA08 Pivmecillinam :J01CA09 Azlocillin :J01CA10 Mezlocillin :J0 ...
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ATC Code S03A
S03A Anti-infectives S03AA Anti-infectives :S03AA01 Neomycin :S03AA02 Tetracycline :S03AA03 Polymyxin B :S03AA04 Chlorhexidine :S03AA05 Hexamidine :S03AA06 Gentamicin :S03AA07 Ciprofloxacin :S03AA08 Chloramphenicol :S03AA30 Antiinfectives, combinations S03B Corticosteroids S03BA Corticosteroids :S03BA01 Dexamethasone :S03BA02 Prednisolone :S03BA03 Betamethasone S03C Corticosteroids and anti-infectives in combination S03CA Corticosteroids and anti-infectives in combination :S03CA01 Dexamethasone and antiinfectives :S03CA02 Prednisolone and antiinfectives :S03CA04 Hydrocortisone and antiinfectives :S03CA05 Fludrocortisone Fludrocortisone, sold under the brand name Florinef, among others, is a corticosteroid used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. In adrenal insufficiency, it is generally taken together with hydroco ... and antiinfectives :S03CA06 Betamethasone and antiinfectives :S03CA07 Methylprednisolone and antiinfectiv ...
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ATC Code S02A
S02A Anti-infectives S02AA Anti-infectives :S02AA01 Chloramphenicol :S02AA02 Nitrofural :S02AA03 Boric acid :S02AA04 Aluminium acetotartrate :S02AA05 Clioquinol :S02AA06 Hydrogen peroxide :S02AA07 Neomycin :S02AA08 Tetracycline :S02AA09 Chlorhexidine :S02AA10 Acetic acid :S02AA11 Polymyxin B :S02AA12 Rifamycin :S02AA13 Miconazole :S02AA14 Gentamicin :S02AA15 Ciprofloxacin :S02AA16 Ofloxacin :S02AA17 Fosfomycin :S02AA18 Cefmenoxime :S02AA30 Antiinfectives, combinations :QS02AA57 Neomycin, combinations S02B Corticosteroids S02BA Corticosteroids :S02BA01 Hydrocortisone :S02BA03 Prednisolone :S02BA06 Dexamethasone :S02BA07 Betamethasone :S02BA08 Fluocinolone acetonide :QS02BA99 Corticosteroids, combinations S02C Corticosteroids and anti-infectives in combination S02CA Corticosteroids and anti-infectives in combination :S02CA01 Prednisolone and antiinfectives :S02CA02 Flumetasone and antiinfectives :S02CA03 Hydrocortisone and antiinfectives :S02CA04 Triamcinolone and ant ...
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ATC Code S01A
S01A Anti-infectives S01AA Antibiotics :S01AA01 Chloramphenicol :S01AA02 Chlortetracycline :S01AA03 Neomycin :S01AA04 Oxytetracycline :S01AA05 Tyrothricin :S01AA07 Framycetin :S01AA09 Tetracycline :S01AA10 Natamycin :S01AA11 Gentamicin :S01AA12 Tobramycin :S01AA13 Fusidic acid :S01AA14 Benzylpenicillin :S01AA15 Dihydrostreptomycin :S01AA16 Rifamycin :S01AA17 Erythromycin :S01AA18 Polymyxin B :S01AA19 Ampicillin :S01AA20 Antibiotics in combination with other drugs :S01AA21 Amikacin :S01AA22 Micronomicin :S01AA23 Netilmicin :S01AA24 Kanamycin :S01AA25 Azidamfenicol :S01AA26 Azithromycin :S01AA27 Cefuroxime :S01AA28 Vancomycin :S01AA29 Dibekacin :S01AA30 Combinations of different antibiotics :S01AA31 Cefmenoxime :QS01AA90 Cloxacillin S01AB Sulfonamides :S01AB01 Sulfamethizole :S01AB02 Sulfafurazole :S01AB03 Sulfadicramide :S01AB04 Sulfacetamide :S01AB05 Sulfafenazol S01AD Antivirals :S01AD01 Idoxuridine :S01AD02 Trifluridine :S01AD03 Aciclovir :S01AD05 Interferon :S01 ...
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Gramicidin
Gramicidin, also called gramicidin D, is a mix of ionophoric antibiotics, gramicidin A, B and C, which make up about 80%, 5%, and 15% of the mix, respectively. Each has 2 isoforms, so the mix has 6 different types of gramicidin molecules. They can be extracted from ''Brevibacillus brevis'' soil bacteria. Gramicidins are linear peptides with 15 amino acids. This is in contrast to unrelated gramicidin S, which is a cyclic peptide. Medical uses Gramicidins work as antibiotics against gram-positive bacteria like ''Bacillus subtilis'' and ''Staphylococcus aureus'', but not well against gram-negative ones like '' E. coli''. Gramicidins are used in medicinal lozenges for sore throat and in topical medicines to treat infected wounds. Gramicidins are often mixed with other antibiotics like tyrocidine and antiseptics. Gramicidins are also used in eye drops for bacterial eye infections. In drops, they are often mixed with other antibiotics like polymyxin B or neomycin. Multiple antibioti ...
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Gramicidin A
Gramicidin, also called gramicidin D, is a mix of ionophoric antibiotics, gramicidin A, B and C, which make up about 80%, 5%, and 15% of the mix, respectively. Each has 2 isoforms, so the mix has 6 different types of gramicidin molecules. They can be extracted from ''Brevibacillus brevis'' soil bacteria. Gramicidins are linear peptides with 15 amino acids. This is in contrast to unrelated gramicidin S, which is a cyclic peptide. Medical uses Gramicidins work as antibiotics against gram-positive bacteria like ''Bacillus subtilis'' and ''Staphylococcus aureus'', but not well against gram-negative ones like ''E. coli''. Gramicidins are used in medicinal lozenges for sore throat and in topical medicines to treat infected wounds. Gramicidins are often mixed with other antibiotics like tyrocidine and antiseptics. Gramicidins are also used in eye drops for bacterial eye infections. In drops, they are often mixed with other antibiotics like polymyxin B or neomycin. Multiple antibiotics ...
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Daptomycin
Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. Daptomycin was removed from the World Health Organization's List of Essential Medicines in 2019. The World Health Organization classifies daptomycin as critically important for human medicine. Medical uses In the United States, daptomycin is indicated for use in adults for skin and skin structure infections caused by Gram-positive infections, ''S. aureus'' bacteraemia, and right-sided ''S. aureus'' endocarditis. It binds avidly to pulmonary surfactant, so cannot be used in the treatment of pneumonia. There seems to be a difference in working daptomycin on hematogenous pneumonia. Adverse effects Common adverse drug reactions associated with daptomycin therapy include: *Cardiovascular: low blood pressure, high blood pressure, swelling *Central nervous system: insomnia *Dermatological: ra ...
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ATC Code A07A
A07A Intestinal anti-infectives A07AA Antibiotics List from 01-54 :A07AA01 Neomycin :A07AA02 Nystatin :A07AA03 Natamycin :A07AA04 Streptomycin :A07AA05 Polymyxin B :A07AA06 Paromomycin :A07AA07 Amphotericin B :A07AA08 Kanamycin :A07AA09 Vancomycin :A07AA10 Colistin :A07AA11 Rifaximin :A07AA12 Fidaxomicin :A07AA13 Rifamycin :A07AA51 Neomycin, combinations :A07AA54 Streptomycin, combinations :QA07AA90 Dihydrostreptomycin :QA07AA91 Gentamicin :QA07AA92 Apramycin :QA07AA93 Bacitracin :QA07AA94 Enramycin :QA07AA95 Avilamycin :QA07AA96 Bambermycin :QA07AA98 Colistin, combinations with other antibacterials :QA07AA99 Antibiotics, combinations A07AB Sulfonamides :A07AB02 Phthalylsulfathiazole :A07AB03 Sulfaguanidine :A07AB04 Succinylsulfathiazole :QA07AB20 Sulfonamides, combinations :QA07AB90 Formosulfathiazole :QA07AB92 Phthalylsulfathiazole, combinations :QA07AB99 Combinations A07AC Imidazole derivatives :A07AC01 Miconazole A07AX Other intestinal anti-infectives :A07AX01 ...
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Bacitracin Structure
Bacitracin is a polypeptide antibiotic. It is a mixture of related cyclic peptides produced by '' Bacillus licheniformis'' bacteria, that was first isolated from the variety "Tracy I" ( ATCC 10716) in 1945. These peptides disrupt Gram-positive bacteria by interfering with cell wall and peptidoglycan synthesis. Bacitracin is primarily used as a topical preparation, as it can cause kidney damage when used internally. It is generally safe when used topically, but in rare cases may cause hypersensitivity, allergic or anaphylactic reactions, especially in patient allergic to neomycin. Medical uses Bacitracin is used in human medicine as a polypeptide antibiotic and is "approved by the U.S. Food and Drug Administration (FDA) for use in chickens and turkeys," though use in animals contributes to antibiotic resistance. As bacitracin zinc salt, in combination with other topical antibiotics (usually polymyxin B and neomycin) as an ointment ("triple antibiotic ointment," with th ...
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