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William C. Campbell (scientist)
William Cecil Campbell (born 28 June 1930) is an Irish biologist and parasitologist with United States citizenship, known for his work in discovering a novel therapy against infections caused by roundworms, for which he was jointly awarded the 2015 Nobel Prize in Physiology or Medicine. He helped to discover a class of drugs called avermectins, whose derivatives have been shown to have "extraordinary efficacy" in treating River blindness and Lymphatic filariasis, among other parasitic diseases affecting animals and humans. Campbell worked at the Merck Institute for Therapeutic Research 1957–1990, and is currently a research fellow emeritus at Drew University. Biography Campbell was born in Ramelton, County Donegal, Ireland in 1930, the third son of R. J. Campbell, a farm supplier. He studied at Trinity College, Dublin with James Desmond Smyth, graduating in 1952 with first class honours in Zoology. He then attended the University of Wisconsin–Madison on a Fulbri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ramelton
Ramelton (; ), also Rathmelton, is a town and townland in County Donegal, Ireland. , its population was 1,266. History Ramelton is situated at the mouth of the River Lennon, 11 km north of Letterkenny and 4 km south of Milford, on the western shores of Lough Swilly. The town is named from ''Ráth Mealtain'', (Irish for "the fort of Mealtan"), an early Gaelic chieftain. The fort is said to lie under the ruins of a medieval castle of the O'Donnells, the ruling family of West Donegal before their exile to mainland Europe in 1607. Ramelton was settled by English and Scots planters during the Ulster Plantation of the 17th century and is the site of the oldest Presbyterian church in Ireland. Facilities Ramelton is serviced by many shops and services within the town. The Town Hall in Ramelton was built in the late 19th century and still has a vital role in the community today. The town has many grocery stores including Kernan's Spar Supermarket, Whoriskey's Eurospar and M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trinity College, Dublin
, name_Latin = Collegium Sanctae et Individuae Trinitatis Reginae Elizabethae juxta Dublin , motto = ''Perpetuis futuris temporibus duraturam'' (Latin) , motto_lang = la , motto_English = It will last into endless future times , founder = Queen Elizabeth I , established = , named_for = Trinity, The Holy Trinity.The Trinity was the patron of The Dublin Guild Merchant, primary instigators of the foundation of the University, the arms of which guild are also similar to those of the College. , previous_names = , status = , architect = , architectural_style =Neoclassical architecture , colours = , gender = , sister_colleges = St. John's College, CambridgeOriel College, Oxford , freshman_dorm = , head_label = , head = , master = , vice_head_label = , vice_head = , warden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World Health Organization
The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level of health". Headquartered in Geneva, Switzerland, it has six regional offices and 150 field offices worldwide. The WHO was established on 7 April 1948. The first meeting of the World Health Assembly (WHA), the agency's governing body, took place on 24 July of that year. The WHO incorporated the assets, personnel, and duties of the League of Nations' Health Organization and the , including the International Classification of Diseases (ICD). Its work began in earnest in 1951 after a significant infusion of financial and technical resources. The WHO's mandate seeks and includes: working worldwide to promote health, keeping the world safe, and serve the vulnerable. It advocates that a billion more people should have: universal health care coverag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces Avermitilis
''Streptomyces avermitilis'' is a species of bacteria in the genus ''Streptomyces''. This bacterium was discovered by Satoshi Ōmura in Shizuoka Prefecture, Japan. The first complete genome sequence of ''S. avermitilis'' was completed in 2003. The genome consists of a single chromosome with a linear structure, unlike most bacterial genomes, which exist in the form of circular chromosomes. Avermectins are industrially produced from ''S. avermitilis''. Avermectin itself was discovered by the Satoshi Ōmura group and first disclosed in Burg ''et al.'' 1979. One of the most widely employed drugs against nematode and arthropod infestations is the avermectin derivative ivermectin, as well as abamectin, a widely used insecticide and antihelmintic. See also * List of Streptomyces species, List of ''Streptomyces'' species References External links *Type strain of ''Streptomyces avermitilis'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Streptomyces, avermitilis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces
''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Streptomycetes are characterised by a complex secondary metabolism. They produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin, streptomycin, cypemycin, grisemycin, bottromycins and chloramphenicol). The antibiotic streptomycin takes its name directly from ''Streptomyces''. Streptomycetes are infrequent pathogens, though infections in humans, such as mycetoma, can be caused by '' S. somaliensis'' and '' S. sudanensis'', and in plants can be caused by '' S. cavi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Satoshi Ōmura
is a Japanese biochemist. He is known for the discovery and development of hundreds of pharmaceuticals originally occurring in microorganisms. In 2015, he was awarded the Nobel Prize in Physiology or Medicine jointly with William C. Campbell for their role in the discovery of avermectins and ivermectin, the world's first endectocide and a safe and highly effective microfilaricide. It is believed that the large molecular size of ivermectin prevents it from crossing the blood/aqueous humour barrier, and renders the drug an important treatment of helminthically-derived blindness. Early life and education Satoshi Ōmura was born in Nirasaki, Yamanashi Japan in 1935, the second son of Ōmura family. After graduating from the University of Yamanashi in 1958, he was appointed to science teacher at Tokyo Metropolitan Sumida Tech High School. In 1960, he became an auditor of Koji Nakanishi’s course at Tokyo University of Education, one year later, he enrolled in the Tokyo Universit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trichinosis
Trichinosis, also known as trichinellosis, is a parasitic disease caused by roundworms of the ''Trichinella'' type. During the initial infection, invasion of the intestines can result in diarrhea, abdominal pain, and vomiting. Migration of larvae to muscle, which occurs about a week after being infected, can cause swelling of the face, inflammation of the whites of the eyes, fever, muscle pains, and a rash. Minor infection may be without symptoms. Complications may include inflammation of heart muscle, central nervous system involvement, and inflammation of the lungs. Trichinosis is mainly spread when undercooked meat containing ''Trichinella'' cysts is eaten. In North America this is most often bear, but infection can also occur from pork, boar, and dog meat. Several species of ''Trichinella'' can cause disease, with ''T. spiralis'' being the most common. After the infected meat has been eaten, the larvae are released from their cysts in the stomach. They then invade the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Great Famine (Ireland)
The Great Famine ( ga, an Gorta Mór ), also known within Ireland as the Great Hunger or simply the Famine and outside Ireland as the Irish Potato Famine, was a period of starvation and disease in Ireland from 1845 to 1852 that constituted a historical social crisis which subsequently had a major impact on Irish society and history as a whole. With the most severely affected areas in the west and south of Ireland, where the Irish language was dominant, the period was contemporaneously known in Irish as , literally translated as "the bad life" (and loosely translated as "the hard times"). The worst year of the period was 1847, which became known as "Black '47".Éamon Ó Cuív – the impact and legacy of the Great Irish Famine During the Great Hunger, roughly 1 million people died and more than 1 million Irish diaspora, fled the country, causing the country's population to fall by 20–25% (in some towns falling as much as 67%) between 1841 and 1871.Carolan, MichaelÉireann's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Potato Blight
''Phytophthora infestans'' is an oomycete or water mold, a fungus-like microorganism that causes the serious potato and tomato disease known as late blight or potato blight. Early blight, caused by ''Alternaria solani'', is also often called "potato blight". Late blight was a major culprit in the 1840s European, the 1845–1852 Irish, and the 1846 Highland potato famines. The organism can also infect some other members of the Solanaceae. The pathogen is favored by moist, cool environments: sporulation is optimal at in water-saturated or nearly saturated environments, and zoospore production is favored at temperatures below . Lesion growth rates are typically optimal at a slightly warmer temperature range of . Etymology The genus name ''Phytophthora'' comes from the Greek –(), meaning : "plant" – plus the Greek (), meaning : "decay, ruin, perish". The species name ''infestans'' is the present participle of the Latin verb , meaning : "attacking, destroying", from which w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiabendazole
Tiabendazole (INN, BAN), also known as thiabendazole (AAN, USAN) or TBZ and the trade names Mintezol, Tresaderm, and Arbotect, is a preservative, an antifungal agent, and an antiparasitic agent. Uses Preservative Tiabendazole is used primarily to control mold, blight, and other fungal diseases in fruits (e.g. oranges) and vegetables; it is also used as a prophylactic treatment for Dutch elm disease. Tiabendazole is also used as a food additive, a preservative with E number E233 (INS number 233). For example, it is applied to bananas to ensure freshness, and is a common ingredient in the waxes applied to the skins of citrus fruits. It is not approved as a food additive in the EU, Australia and New Zealand. Use in treatment of aspergillosis has been reported. It is also used in anti-fungal wallboards as a mixture with azoxystrobin. Parasiticide As an antiparasitic, tiabendazole is able to control roundworms (such as those causing strongyloidiasis), hookworms, and other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
News 12 New Jersey
News is information about current events. This may be provided through many different media: word of mouth, printing, postal systems, broadcasting, electronic communication, or through the testimony of observers and witnesses to events. News is sometimes called "hard news" to differentiate it from soft media. Common topics for news reports include war, government, politics, education, health, the environment, economy, business, fashion, entertainment, and sport, as well as quirky or unusual events. Government proclamations, concerning royal ceremonies, laws, taxes, public health, and criminals, have been dubbed news since ancient times. Technological and social developments, often driven by government communication and espionage networks, have increased the speed with which news can spread, as well as influenced its content. Throughout history, people have transported new information through oral means. Having developed in China over centuries, newspapers became estab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
