''Streptomyces avermitilis'' is a species of bacteria in the genus ''

Streptomyces ''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, ...

''. This bacterium was discovered by

Satoshi Ōmura is a Japanese biochemist. He is known for the discovery and development of hundreds of pharmaceuticals originally occurring in microorganisms. In 2015, he was awarded the Nobel Prize in Physiology or Medicine jointly with William C. Campbell fo ...

Shizuoka Prefecture is a prefecture of Japan located in the Chūbu region of Honshu. Shizuoka Prefecture has a population of 3,637,998 and has a geographic area of . Shizuoka Prefecture borders Kanagawa Prefecture to the east, Yamanashi Prefecture to the northea ...

Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...

. The first complete genome sequence of ''S. avermitilis'' was completed in 2003. The genome consists of a single

chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

with a linear structure, unlike most bacterial genomes, which exist in the form of circular chromosomes.

Avermectin The avermectins are a series of drugs and pesticides used to treat parasitic worms and insect pests. They are a group of 16-membered macrocyclic lactone derivatives with potent anthelmintic and insecticidal properties. These naturally occurring co ...

s are industrially produced from ''S. avermitilis''. Avermectin itself was discovered by the

group and first disclosed in Burg ''et al.'' 1979. One of the most widely employed drugs against nematode and arthropod infestations is the avermectin derivative

ivermectin Ivermectin (, '' EYE-vər-MEK-tin'') is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, today it is used to treat inf ...

, as well as

abamectin Abamectin is a widely used insecticide and anthelmintic. Abamectin, is a member of the Avermectin family and is a natural fermentation product of soil dwelling actinomycete ''Streptomyces avermitilis''. Abamectin (also called Avermectin B1), differ ...

, a widely used insecticide and antihelmintic.

References

External links

*
Type strain of ''Streptomyces avermitilis'' at Bac''Dive'' - the Bacterial Diversity Metadatabase
avermitilis Bacteria described in 2002 {{Streptomyces-stub

See also

References

External links