|
WDR18
WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. Function This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP-1, PELP1, TEX10 called the rixosome which is involved in RNA degradation. The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb repressive complex 1, Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA. References {{NLM content ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PELP-1
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) also known as modulator of non-genomic activity of estrogen receptor (MNAR) and transcription factor HMX3 is a protein that in humans is encoded by the PELP1 gene. is a Transcription (genetics), transcriptional corepressor for Intracellular receptor, nuclear receptors such as glucocorticoid receptors and a coactivator for estrogen receptors. Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is transcription coregulator and modulates functions of several hormonal receptors and transcription factors. PELP1 plays essential roles in hormonal signaling, cell cycle progression, and ribosomal biogenesis. PELP1 expression is upregulated in several cancers; its deregulation contributes to hormonal therapy resistance and metastasis; therefore, PELP1 represents a novel therapeutic target for many cancers. Gene PELP1 is located on chromosome 17p13.2 and PELP1 is expressed in a wide variety of tissues; its highest express ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |