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WDR18
WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. Function This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 forms a nucleolar complex with LAS1L, PELP-1, PELP1, TEX10 called the rixosome which is involved in RNA degradation. The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the Polycomb repressive complex 1, Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA. References {{NLM content ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PELP-1
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) also known as modulator of non-genomic activity of estrogen receptor (MNAR) and transcription factor HMX3 is a protein that in humans is encoded by the PELP1 gene. is a Transcription (genetics), transcriptional corepressor for Intracellular receptor, nuclear receptors such as glucocorticoid receptors and a coactivator for estrogen receptors. Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is transcription coregulator and modulates functions of several hormonal receptors and transcription factors. PELP1 plays essential roles in hormonal signaling, cell cycle progression, and ribosomal biogenesis. PELP1 expression is upregulated in several cancers; its deregulation contributes to hormonal therapy resistance and metastasis; therefore, PELP1 represents a novel therapeutic target for many cancers. Gene PELP1 is located on chromosome 17p13.2 and PELP1 is expressed in a wide variety of tissues; its highest express ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TEX10
Testis-expressed sequence 10 protein is a protein that in humans is encoded by the ''TEX10'' gene. TEX10 forms part of a complex with WDR18 WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. Function This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically brackete ..., LAS1L called the rixosome that participates in RNA degradation, ribosomal RNA (rRNA) processing and ribosome biogenesis. References Further reading * * * * {{gene-9-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
